MaIny authors have recognized that a variety of barriers can hinder the implementation of inddustrial symbiosis (IS) and eco-industrial development. It is imperative to prioritize the barriers which will provide guidance for the realization of IS projects and assist practitioners and stakeholders with more effective implementation. This, in turn, will contribute to development ofcan contribute to achieving a win-win situation between industry and environment for local and regional circular economies. Through an extensive literature review, this paper proposes a model which combines the Analytic Hierarchy Process (AHP) and the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) to evaluate the IS barriers semi-quantitatively. This model assists in identifying and prioritizing the fundamental barriers for implementation of IS Industrial symbiosis (IS) has been well-recognized as a key subfield of industrial ecology (IE). A widely cited definition of IS is presented by Chertow:“engaging traditionally separate entities in a comprehensive manner. An operating IS, the Hai Hua Group (HHG), in Shandong Province, China is used as a case study to test the proposed model. The results show that the top four generic barriers are technological, economic, safetyllective approach to competitive advantage involving physical exchange of materials, energy, water, and informational barriers. More specifically, the barriers are informby-products. The keys to IS are collaboration platforms, human safety and health, technology involved with extending industrial chains, product added value, and costs. The paper concludes by discussing managerial implications for promoting the establishment and operation of ISand the synergistic possibilities offered by geographic proximity” (p. 314).