Several biocompatible materials have been applied for managing soft tissue lesions; cerium

oxide nanoparticles (CNPs, or nanoceria) are among the most promising candidates due to their

outstanding properties, including antioxidant, anti-inflammatory, antibacterial, and angiogenic

activities. Much attention should be paid to the physical properties of nanoceria, since most of its

biological characteristics are directly determined by some of these relevant parameters, including

the particle size and shape. Nanoceria, either in bare or functionalized forms, showed the excellent

capability of accelerating the healing process of both acute and chronic wounds. The skin, heart,

nervous system, and ophthalmic tissues are the main targets of nanoceria-based therapies, and the other

soft tissues may also be evaluated in upcoming experimental studies. For the repair and regeneration

of soft tissue damage and defects, nanoceria-incorporated film, hydrogel, and nanofibrous sca olds

have been proven to be highly suitable replacements with satisfactory outcomes. Still, some concerns

have remained regarding the long-term e ects of nanoceria administration for human tissues and

organs, such as its clearance from the vital organs. Moreover, looking at the future, it seems necessary

to design and develop three-dimensional (3D) printed sca olds containing nanoceria for possible use

in the concepts of personalized medicine.