SARS-CoV-2 infection (COVID-19) is in focus over all known human diseases, because it is destroying the world economy and social life, with increased mortality rate each day. To date, there is no specific medicine or vaccine available against this pandemic disease. However, the presence of medicinal plants and their bioactive molecules with antiviral properties might also be a successful strategy in order to develop therapeutic agents against SARS-CoV-2 infection. The identification of novel antiviral compounds is of critical significance, and medicinal plant based natural compounds are a good source for such discoveries. In depth search and analysis revealed several medicinal plants with excellent efficacy against SARS-CoV-1 and MERS-CoV, which are well-known to act on ACE-2 receptor, 3CLpro and other viral protein targets. It has consolidated the data of several medicinal plants and their natural bioactive metabolites, which have promising antiviral activities against coronaviruses with detailed modes of action/mechanism. It is concluded that this topics will be useful for researchers worldwide and highly recommended for the development of naturally safe and effective therapeutic drugs/agents against SARS-CoV-2 infection, which might be used in therapeutic protocols alone or in combination with chemically synthetized drugs.
- SARS-CoV
- COVID-19
- coronavirus
- medicinal plant
- phytomedicine
- ethnobotany
- antiviral
- natural products
- bioactive compounds
Note：All the information in this draft can be edited by authors. And the entry will be online only after authors edit and submit it.
1. Iintroduction
2. Bupleurum Species
Bupleurum plant species are extensively dispersed in the northern hemisphere and are used as one of the oldest phytomedicines in China. Many reports have identified the activity of this herbal plant in the treatment of HCoV-22E9 and other viral infections [1][2]. Generally,
Radix bupleuri
R. bupleuri
Bupleurum species and used for the treatment of various diseases [3]. It has great pharmacologically significant activities, the main ones reported in the literature being: antiviral, anti-inflammatory, anti-tumor, neuro-modulation and immunoregulation [3][4]. Approximately 7% of naturally occurring saikosaponins (triterpene saponin glycosides) are present in
R. bupleuri, which is the main component of this medicinal plant with potent effects. Four types of saikosaponins (SS) are found; SSa, SSb2, SSc and SSd, which are responsible for the most pharmacological activities in this medicinal plant [5]. The SSa, SSb2 and SSd have potential to inhibit the effects against coronavirus 229E, SARS-CoV and influenza A virus [4]. Moreover, the mechanism of action of these SS employing antiviral activity interrupts the early stage of viral replication inside the host cells [4]. In addition, these SS also attenuate pro-inflammatory cytokines production, inhibiting viral replication through down-regulating NF-kB signaling, caspase 3-dependent virus ribonucleoprotein nuclear export, lung neutrophil and monocytes recruitment in an experimental in vivo mice model [4].
3. Lycoris radiate (L’Hér.) Herb.
Lycoris radiata
L. radiata
Amaryllidaceae family and originally it was found in China, Korea, Japan and Nepal [6]. This medicinal plant has wide-ranging biological activities comprising: antiviral, anticancer [6], anti-malarial [7], anti-inflammatory [8] and induction of nausea and emesis [9]. Additionally, and most importantly,
L. radiata has been known to have antiviral effects on SARS-CoV [10][11], poliovirus, human immunodeficiency virus (HIV), measles virus, herpes simplex virus and coxsackie virus [11][12]. Its potent bioactive compound is lycorine, which is extracted from the flower and stem cortex of
L. radiata plants. Currently, this plant is in use for the treatment of various diseases due to its broad-spectrum biological activities. It has also been recommended as a promising medicinal plant for the development of potential drugs against SARS-CoV infection [11][12]. The antiviral mechanism of action of this plant is by inhibiting virus replication in the cells through inhibiting autophagy [12]. Moreover, JNK/MAPK signaling pathway is closely connected to autophagy, and through this signaling pathway, the plant extract inhibits the process of autophagy due to reduced JNK phosphorylation induced by viral replication [12][13].
4. Artemisia annua L.
This Chinese medicinal plant has been used for a long time to treat various diseases such as bronchitis and hemorrhoids, and is potentially effective for its anti-malarial, antiviral, anticancer, etc., properties [14][15][16]. However,
Artemisia annua
A. annua) has been known to possess antiviral activity and currently is in use for the treatment of Poliovirus, HIV, RSV, HSV1, hepatitis C, type 2 dengue virus and human cytomegalovirus [17][18].
A. annua contains quercetine, flavonoid, polyphenols, triterpenes, sterols, saponins, polysaccharides, dicaffeoylquinic acid and other molecules [18]. Due to the presence of these molecules,
A. annua extracts (whole plant) have shown an important role, being assigned with immunomodulator, antiviral, antioxidant and anti-inflammatory properties. Moreover, these compounds/molecules have been known to inhibit the enzyme activity of 3CLPro [19][20]. Previously, this medicinal plant has been used to treat SARS-CoV and MERS infections [20], and is currently being used against novel SARS-CoV-2 infection [19]. The mechanism of action of
A. annua
+
5. Pyrrosia lingua (Thunb.) Farw.
Pyrrosia lingua
P. lingua
Polypodiaceae family and mostly occurs in China, Japan, Korea and other Asian regions [22].
P. lingua is known for its antiviral, antioxidant, antibacterial and anticancer activities; it even stops the formation of urinary calculi [22][23]. Furthermore, it contains several bioactive components, such as flavonoids, chlorogenic acid, mangiferin, isomangiferin, astragalin and trifolin [24]. The extract of
P. lingua leaves has been used by many researchers for the treatment of HIV, SARS and other viral infections [20][22][23]. In the case of SARS-CoV-1, this plant has shown the ability to inhibit viral infection, but the mechanism of action is still not clear [18][20].
6. Isatis indigotica Fortune ex Lindl.
Isatis indigotica
I. indigotica
Cruciferae family. It is mostly found in China, Hong Kong, Taiwan and other regions of Asia [25]. According to Lin et al.,
I. indigotica has the potential to inhibit/block SARS-CoV-1 entry and replication in its host [18]. However, the research group used
Radix isatidis
I. indigotica for extracting potent compounds for the treatment of SARS-CoV-1-infected patients. Furthermore, its root contains indirubin, indican, indigo, sinigrin, β-sitosterol, hesperetin, aloe-emodin and many more bioactive compounds [25][26]. According to one in vitro study, all these extracted compounds were used against SARS-CoV-1 infection, and it was found that indigo, sinigrin, aloe-emodin and hesperetin were able to inhibit the virus entry and replication by inhibiting the SARS-CoV-1 3CLpro [27]. We know that coronavirus 3CLpro mediates the proteolytic processing of replicase polypeptides into the functional proteins and plays a key role in viral replication [28]. Therefore,
I. indigotica
7. Torreya nucifera L.
This plant is mostly found in snowy areas near the Sea of Jeju Island in Korea, and is considered as a traditional medicinal plant. Its leaves are mostly used for the treatment of stomachache, hemorrhoids and rheumatoid arthritis [29][30]. During SARS-CoV-1 infection, Young Bae Ryu et al. used
Torreya nucifera
T. nucifera) plant leaves for in vitro experiments, and the results showed a potential inhibitory effect [18][31]. Ryu et al. isolated 12 phytochemical compounds from the ethanol extract of the
T. nucifera leaves. Only the biflavonoid amentoflavone showed efficacy against SARS-CoV-1 [31]. This biflavonoid of
T. nucifera has the potential to block the activity of 3CLpro of the coronavirus and can inhibit the viral replication [31].
8. Houttuynia cordata Thunb.
Saururaceae
Houttuynia cordata Thorn (HCT) is a Chinese herbal plant well-known for its potent effects in the treatment of pneumonia, refractory hemoptysis, and SARS-CoV-1 infection [32][33]. It has anti-inflammatory, anti-allergic, antioxidant and anticancer properties [32]. The bioactive compounds present in HCT are comprised of rutin, hyperin, isoquercitrin, quercetin, afzelin, reyoutrin, kalium sulfuricum, cordarine, decanoyl acetaldehyde, lauric aldehyde, myrcene, α-pinene, methyl nonyl ketone, d-limonene, linoleic acid, aspartic acid, palmitic acid, water-soluble polysaccharides, amino acids, vitamins, manganese, potassium, zinc, iron and copper [34][35][36]. During the SARS-CoV-1 infection, the leaves of this Chinese medicinal plant were used to treat patients and showed good efficacy against SARS-CoV-1 [18][27]. Lau et al. conducted one experiment using HCT against SARS-CoV-1. Results showed that HCT can inhibit SARS-CoV-1 activity including an immunomodulatory effect [33]. However, the mode of action of HCT is to inhibit the 3CLpro activity of SARS-CoV-1 and obstruct the activity of RdRp [33]. Hence, it can block the entry of the virus and impede viral replication [33]. This inhibitory mechanism makes HCT a good choice to be used against SARS-CoV-2 infections.
9.
9.
Lindera aggregate
(Sims) Kosterm.
Lindera aggregate(
L. aggregate
Lauraceae family and mostly found in China and Japan [37]. The root of this plant is mostly used to treat chest pain, inflammation, indigestion, cold hernia and other diseases. It contains several bioactive components, such as flavonoids, isoquinoline alkaloids, sesquiterpene lactones and tannins [38][39]. Moreover,
L. aggregate has also showed other biological activities such as antiviral, anti-tumor, anti-inflammatory, antimicrobial and anti-diabetic activities [18][39][40].
L. aggregate leaves can also be used to drink as tea, due to their protective effect against oxidative stress [40]. In 2005, Shi-you Li et al. investigated the effect and efficacy of
L. aggregate roots against SARS-CoV-1 [20]. An in vitro study showed that
L. aggregate
50 value of 88.2 ± 7.7 µg/mL [20]. However, the mode of action is still not clear, but it was suggested that
L. aggregate roots can possibly inhibit the viral replication and block the entry of virus [20].
10. Rheum palmatum L.
This herbal plant belongs to the family of Polygonaceae. It is mostly found in mountainous regions with high elevations, such as the Sichuan, Gansu and Shaanxi regions of China [41]. It is effectively used as a laxative or astringent for the treatment of stomachache, hemorrhoids, liver bile disease or gastroenteritis [42]. It contains some potent bioactive compounds including emodin, physcion, chrysophanol, rhein and aloe-emodin [43][44]. Known biological activities are antiviral, anti-pyretic, anti-neoplastic, anti-spasmolytic, antibacterial, laxative, hemostatic and anti-spasmodic [45][41][44][46]. It was also used against SARS-CoV-1 infection, due to its potential efficacy for acting on the ACE-2 receptor, leading to blockage of viral entry into cells and replication of the CoVs [47][43]. An in vitro study conducted by Ho et al. 2007 showed the potential of Radix et Rhizoma Rhei (root tubers of
10.
Rheum palmatum L.) in blocking the entry of SARS-CoV-1 to inhibition sites such as the ACE-2 receptor [47].
Furthermore, the major active component of this plant is emodin, which is responsible for blocking the binding of SARS-CoV-1 S protein to ACE-2 receptor [47][43]. Therefore, the use of emodin extracted from Radix et Rhizoma Rhei can be considered for the possible therapeutic management of COVID-19. This will possibly provide us with new insight into therapy against SARS-CoV-2.
11. Polygonum multiflorum Thunb.
L.
This herbal plant belongs to the family of Polygonaceae. It is mostly foum nd in mountainous regions
with high elevations, such as the Sichuan, Gansu and Shaanxi regions of China [81]. It is effectively
used as a laxative or astringent for the treatment of stomachache, hemorrhoids, liver bile disease
or gastroenteritis [243]. It contains some potent bioactive compounds incliuding emodin, physcion,
chrysophanol, rhein and aloe-emodin [80,82]. Known biological activities are antiviral, anti-pyretic,
anti-neoplastic, anti-spasmolytic, antibacterial, laxative, hemostatic and anti-spasmodic [79,81,82,244].
It was also used against SARS-CoV-1 infection, due to its potentialor efficacy for acting on the ACE-2
receptor, leading to blockage of viral entry into cells and replication of the CoVs [78,80]. An in vitro
study conducted by Ho et al. 2007 showed the potential of Radix et Rhizom a Rhei (root tubers of Rheum
palmatum L.) in blocking the entry of SARS-CoV-1 to inhibition sites such as the ACE-2 receptor [78].
Furthermore, the major active component of this plant is emodin, which is responsible for blocking the
binding of SARS-CoV-1 S protein to ACE-2 receptor [78,80]. Therefore, the unse of emodin extracted
from Radix et Rhizoma Rhei can be considered for the possible therapeutic management of COVID-19.
This will possibly provide us with new insight into therapy against SARS-CoV-2.
11. Polygonum multiflorum Thunb.
Polygonum mulitflorum Thunb (PMT) is mostly found in China, Korea and Japan, belonging
to Polygonaceae family [48][245]. Radix Polygoni multiflori (root tubers of PMT) is mostly used
in treating many kinds of diseases, such as rubella, scrofula, waist and knee pain, paralysis,
vaginal discharge, hypercholesterolemia (liver and kidney), malaria, and various other diseases,
possessing neuro-protective, antioxidation, immunomodulation, anti-hyperlipidemia, anticancer,
heap-toprotection, anti-inflammation, and anti-CoV functions [49][50][51][86,87,246]. The potent bioactive
compounds present in PMT which are responsible for the therapeutic effects against various diseases
are listed in Table 1 [52][53][54][55][84,85,88,247]. However, Ho et al. found that emodin is the most effective
compound against SARS-CoV-1. The data were published to show the potential and efficacy of PMT in
blocking the entry of SARS-CoV-1 by acting on the ACE-2 receptor [47][78]. The mode of action of PMT is
similar to Rheum palmatum L and the major active constituent is found to be emodin in both plants.
Therefore, it is highly recommended to focus on emodin for possible and effective management of
SARS-CoV-2 infection, combination with other therapeutic approaches.
12. Cerasus avium (L.) Moench.
12. Cerasus avium (L.) Moench.
This Persian medicinal plant belongs to the Rosaceae family and is mostly used as an antioxidant,
antimicrobial and antiviral [56][93]. Its stem contains polyphenols, carotenoids, vitamins, minerals and
many other bioactive components [57][58][90,248]. However, this plant has strong potential to act on the
ACE-2 receptor and block the further processing of the viruses [47][59][60][78,92,94]. According to Ziai et al.’s
2009 in vitro study, this plant showed very good potential to inhibit or completely block the ACE-2
receptor [60][94]. Subsequently, Heidary et al., 2020 recently suggested that this plant has good potency
against SARS-CoV-2 and must be used for the treatment of its infection [61][91].
Rubia Paulownia tomentosa ( P. tomentosa) is an old Chinese medicinal plant belonging to the Scrophulariaceae family. It is mostly found in central and western China, Taiwan and Korea. ) is an old Chinese medicinal plant belonging to the Scrophulariaceae P. tomentosa has wide-ranging biological activities comprising antiviral, antioxidant and antibacterial effects [105][106]. It is mostly used for the treatment of various diseases, such as inflammatory bronchitis, upper respiratory tract infection, asthma, tonsillitis, gonorrhea, traumatic bleeding, enteritis, bacteriological diarrhea, erysipelas, swelling, bronchopneumonia, conjunctivitis, and hemorrhoids [107][108]. Furthermore, has wide-ranging P. tomentosa has been known to have an antiviral effect on SARS-CoV PLpro. P. tomentosa fruit contains many bioactive components such as tomentin A, tomentin B, tomentin C, tomentin D, tomentin E, geranylated flavonones and others [109]. In 2013, Cho et al. examined the effect and efficacy of fruit contains P. tomentosa fruit-extracted bioactive components against SARS-CoV. An in vitro study showed that fruit-extracted bioactive components against SARS-CoV. An in vitro study showed P. tomentosa is able to inhibit SARS-CoV PLpro activity with an IC50 value ranging from 5.0 to 14.4 µM [109]. Out of all those studied, Tomentin E showed the most promising and highest inhibitory effect against SARS-CoV, with the lowest IC50 5.0 ± 0.06 µM [109]. is able to inhibit SARS-CoV PLpro activity with an IC50 value ranging from 5.0 to Eleutherococcus senticosus Acacia Ocimum sanctum Theobroma cacao (T. cacao) belongs to the family of Sterculiaceae. The seeds of this cocoa plant are commonly used in food industries [156]. It contains several types of bioactive compounds, such as polyphenol, theobromine and flavonoids [157], which are responsible for its antioxidant, antiviral, anti-inflammatory and many other biological activities [158][159][160]. However, some studies reported the anti-influenza activity of T. cacao, due to presence of flavonoids, theobromine, lignin, dietary fiber, free fatty acid, and minerals (zinc, copper, iron) [158][161][159]. Kamei et al., 2014 investigated the effect of T. cacao against the influenza virus and found that it enhances the antibody response due to stimulatory effect [161]. Furthermore, it has also been observed that, T. cacao helps in developing acquired immunity and activates the NK cells against the influenza virus [161]. Further investigation may lead to the use of T. cacao against SARS-CoV-2, and can help in boosting immunity. Pelargonium sidoides Illicium Glycyrrhiza glabra Angelica keiskei Polygala Calophyllum brasiliense Cimicifuga foetida Boerhavia diffusa Terminalia chebula Caesalpinia sappan References: 32. Yao, R.-Y.; Zou, Y.-F.; Chen, X.-F. Traditional use, pharmacology, toxicology, and quality control of species in 238. Liu, A.; Shu, S.-H.; Qin, H.-L.; Lee, S.; Wang, Y.-T.; Du, G. in vitro anti-influenza viral activities of constituents 13. Alcea digitata (Boiss.) Alef.
Alcea digitata (A. digitate) is a Persian medicinal plant belonging to the Malvaceae family
with antiviral, antioxidant, anti-inflammatory, antimicrobial, anti-tussive, expectorant and laxative
therapeutic effects [62][63][96,97]. The flowers of A. digitata have been used for lung and respiratory
disorders, head and neck cancer, and lubrication of the throat [63][97]. According to one published
report [62][96], A. digitata is known to have good potential to block or inhibit the ACE-2 receptor. Recently,
Heidary et al., 2020 suggested that A. digitata can possibly show good inhibitory effects against
SARS-CoV-2 infection [61][91].14. Citrus aurantium L.
Citrus aurantium (C. aurantium) belongs to the family of Rutaceae and is generally known as
bitter orange [64][249]. This plant is known to have many essential components with biological
effects [65][66][100,101], such as phenolics (flavanone glycosides, hydroxycinnamic acids), vitamin C,
and carotenoids [99,249,250]. However, C. aurantium fruit extract is manly used for the treatment
of anxiety, lung related diseases, obesity, gastrointestinal disorders and prostate cancer [64][67][249,251], buts
has potential to inhibit or block the ACE-2 receptor. Some in vitro studies have shown its efficacy in
inhibiting ACE-2 receptors [61][91].15. Rubia tinctorum L.
15. Rubia tinctorum L.
Rubia tinctorum tinctorum (R. tinctorum) is mostly found in Southern Europe, Western Asia and North Africa
and belongs to the family of Rubiaceae [68][252]. R.R. tinctorum tinctorum is mostly used to treat kidney and bladder
stones, and menstrual and urinary disorders [69][70][104,253]. Furthermore, the root of R.R. tinctorum tinctorum coontains
red color due to the presence of anthraquinone, alizarin and pseudopurpurin, which is also used
for dyeing purposes [71][103]. On the other hand, R.R. tinctorum tinctorum has shown potential to inhibit or block
the ACE-2 receptor [61][91]. in vitro studies revealed the efficient use of R. R. tinctorum tinctorum to inhibit ACE-2
receptors [61][91].16. Allium sativum L.
The common name of Allium sativum (A. sativum) is garlic, and it belongs to the Amaryllidaceae
family. A. sativum use for human welfare has been reported for thousands of years in the
form of a spice [72][108]. It is an aromatic herbaceous plant and is consumed worldwide as a
food as well as a remedy for different diseases [72][108]. A. sativum is reported to have numerous
biological properties, such as antibacterial, antifungal, anti-carcinogenic, antioxidant, anti-diabetic,
reno-protective, anti-atherosclerotic, and anti-hypertensive effects. Cloves of this traditional
medicinal plant contain several potent components, such as alliin, allicin, ajoenes, vinyldithiins,
and flavonoids [72][73][74][75][76][108,109,254–256], due to which it is mostly used for treatment of various
disorders [77][78][72][73][79][106–109,257]. On the other hand, an in vitro study conducted by Ziai et al., 2009 on
A. sativum and its potential efficacy to inhibit the ACE-2 receptor reported some effective results [60][94].17. Quercus infectoria G. Olivier.
Quercus infectoria (Q. infectoria) is commonly known as gall oak and belongs to the family of
Fagaceae [80][112]. This medicinal plant is traditionally used for the treatment of diarrhea, menorrhagia,
dysentery, gonorrhea, tonsillitis, impetigo and internal hemorrhages [80][81][112,258]. Bioactive constituents
of Q. infectoria gall extract include phenolic compounds (catechol, p -hydroxybenzoic acid, caffeine,
catechin, pyrogallol, e-vanillic acid, 3-hydroxytyrosol cinnamic, p-coumaric, gallic acids and resveratrol),
flavonoids (naringin, rutin, 7-hydrohyflavone and hispertin) [82][83][84][111,259,260] with biological activities
such as antiviral, antifungal, antibacterial, antioxidant, anti-inflammatory, anti-diabetic, anti-parasitic,
anti-venom, etc. [80][85][86][112,114,261]. Q. infectoria has also shown strong potential to completely block the
ACE-2 receptors due to the presence of many potent and tannin active components in vitro [87][113].
Similarly, this medicinal plant can also be considered for combinational therapeutic approaches in
controlling the COVID-19 pandemic directly or indirectly.18. Onopordum acanthium L.
Onopordum acanthium (O. acanthium) basically belongs to a family of Asteraceae and is commonly
known as Scotch thistle [88][118]. It is found all over the world [89][262]. The biological activities of O. acanthium
include antiviral, anti-tumor, anti-inflammatory and antioxidant effects. Extracts from the leaf, flower,
stem and root of O. acanthium are also used as cardiotonic agents. O. acanthium contains many bioactive
components, such as flavonoids, triterpenoids, lignans, phenylpropanoids, sesquiterpene lactones,
and sterols [90][91][89][116,117,262]. Moreover, O. acanthium has shown efficacy to completely inhibit the activity
of ACE-2 due to the presence of tannin bioactive components, as demonstrated by Sharifi et al., 2013 in
his in vitro study. This makes it a considerable choice to test against SARS-CoV-2.19. Berberis integerrima Bunge.
Berberis integerrima (B. integerrima) belongs to the family of Berberidaceae, with different parts
of the plant showing different colors [92][121]. It is mostly found in Iran and contains many types of
alkaloids [93][122]. Bioactive components extracted from the root of B. integerrima include berbamine,
berberuin, palmatine, oxyacanthine, malic acid, ascorbic acid, caffeic acid, ursolic acid, coumarin,
beta-carotene and tannin [94][93][120,122]. B. integerrima possesses many bioactive properties, such as antiviral,
anti-inflammatory, anti-hyperglycemic, anti-hyperlipidemic, anticancer, and antioxidant effects, as well
as being a liver protective agent [94][92][93][120–122]. Moreover, this medicinal plant was tested by Sharifi et al.,
2013 in vitro. His team showed that the usage of a 330 µg/mL concentration of B. integerrima was
able to inhibit the ACE-2 receptor due to 88.2 ± 1.7 IC50 [87][113]. Therefore, B. integerrima can be further
investigated for its potent medicinal values and may provide fruitful results against SARS-CoV-2.20. Crataegus microphylla C. Koch
This medicinal plant belongs to the family of Rosaceae and almost all parts of the plant are
used for remedial purposes [95][126]. It is widely used for the treatment of many diseases, including
heart muscle cells activation, coronary dilation, regulated blood flow, use as an antioxidant and
anti-diabetic, and many others [96][95][125,126]. It contains flavonoids (phenols, phenolic acids, procyanidins,
flavonoids, triterpenes, polysaccharides, catecho-lamines) which help in controlling/regulating various
diseases [94][97][96][95][120,124–126]. Furthermore, it has also showed efficacy to inhibit the ACE-2 receptor and
prohibit the entry of virus into the cell [87][113]. in vitro results suggested the use of a 330 µg/mL
concentration of Crataegus microphylla was able to inhibit the virus binding to the ACE-2 receptor,
and their IC50 was observed as 80.9 ± 1.3 [87][113]. The occurrence of some potential bioactive compounds
in this medicinal plant and their efficacy against SARS-CoV-2 must be tested for better drug therapy to
manage COVID-19.21. Alnus japonica (Thunb.) Steud.
Alnus japonica (A. japonica) belongs to Betulaceae family and originally it was found in Japan,
Korea, China and Russia [98][128]. This medicinal plant has wide range of biological activities comprising
antiviral, anticancer, anti-inflammatory, and antioxidant effects, as well as the induction of lymphatic
and gastroenteric disorders [98][99][128,130]. It is mostly used for the treatment of various diseases such as fever,
cancer, and blood, lymphatic and gastroenteric disorders [100][263]. Additionally, and most importantly,
A. japonica has been known to have an antiviral effect on SARS-CoV, and its potent bioactive compounds
include hirsutenone, oregonin, rubranoside rubranoside B, rubranol, and hirsutanonol, which are
extracted from the bark of the A. japonica plant [99][130]. These bioactive components have also been
recommended as a promising medicinal plant for the development of potential drugs against SARS-CoV
PLpro. In 2012, Park et al. investigated the effect and efficacy of A. japonica bark against SARS-CoV.
An in vitro study showed that A. japonica is able to inhibit the SARS-CoV PLpro with IC50 value ranging
21 of 41 from 3 to 44.5 µM of these compounds (hirsutenone, oregonin, rubranoside rubranoside B, rubranol,
and hirsutanonol) [99][130]. However, the mode of action suggested that A. japonica bark can possibly
inhibit the SARS-CoV PLpro activity.22. Psoralea corylifolia L.
Psoralea corylifolia (P. corylifolia) belongs to the Leguminosae family and mostly occurs in India,
China, Bangladesh, Indonesia, Malaysia, Sri Lanka and other Asian countries. P. corylifolia is known for
its antiviral, antioxidant, antibacterial and anti-depressant activities [101][102][132,133]. Furthermore, it contains
several potent bioactive components such as neoba-vaisoflavone, isobavachalcone, Bavachinin,
40–O-methyl bavachalcone, corylifol A, and psoralidin [103][264]. In 2014, Kim et al. investigated
the effect of P. corylifolia seed extract and showed an imperative inhibitory effect of SARS-CoV PLpro,
and their IC50 was 15 µg/mL [104][134]. Furthermore, all these bioactive components were tested by
Kim et al., and the IC50 of these components against SARS-CoV PLpro was estimated to range between
4.2 to 38.4 µM. In addition, psoralidin and isobavachalcone showed the highest inhibitory activity
against SARS-CoV PLpro, with IC50 of 4.2 ± 1.0 µM and 7.3± 0.8 µM, respectively [104][134].23. Paulownia tomentosa (Thunb.) Steud.
family. It is mostly found in central and western China, Taiwan and Korea.
biological activities comprising antiviral, antioxidant and antibacterial effects [136,138]. It is mostly
used for the treatment of various diseases, such as inflammatory bronchitis, upper respiratory
tract infection, asthma, tonsillitis, gonorrhea, traumatic bleeding, enteritis, bacteriological diarrhea,
erysipelas, swelling, bronchopneumonia, conjunctivitis, and hemorrhoids [139,265]. Furthermore,
many bioactive components such as tomentin A, tomentin B, tomentin C, tomentin D, tomentin
E, geranylated flavonones and others [137]. In 2013, Cho et al. examined the effect and efficacy
of
that
14.4 µM [137]. Out of all those studied, Tomentin E showed the most promising and highest inhibitory
effect against SARS-CoV, with the lowest IC50 5.0 ± 0.06 µM [137].24. Tribulus terrestris L.
Tribulus terrestris (T. terrestris) is mostly found in China, India, Pakistan, South Americas, Bulgaria,
Mexico and Spain, and is considered as a traditional medicinal plant. T. terrestris belongs to the
Zygophyllaceae family and possesses several biological activities such as antiviral, anti-inflammatory,
antioxidant, anti-tumor, anti-diabetic and anti-urolithic properties [110][111][141,143]. It contains several
bioactive compounds, mainly flavonoids and alkaloids [112][113][142,266]. In 2014, Song et al. studied the
effect of T. terrestris fruit extract (six cinnamic amides), and showed significant inhibitory effects
against SARS-CoV PLpro [112][142]. Furthermore, all bioactive components tested by Song et al. against
SARS-CoV PLpro were estimated to have an IC50 in a range between 15.8 and 70.1 µM [112][142]. However,
terrestrimine[(E)-N-(1-hydroxy-2-(4-hydroxyphenyl)-2-oxoethyl)-3-(4-hydroxy3-methoxypheny)
acrylamide] showed the utmost inhibitory activity against SARS-CoV PLpro with an IC50 of
15.8 ± 0.6 µM [112][142].25. Sambucus nigra L.
This plant belongs to the family of Caprrifoliaceae and is mostly used in the treatment of common
cold, HIV, HSV-1, influenza, urinary tract infection, edema and other rheumatic diseases [114][115][149,267].
It contains several active components extracted from the leaves, flower and fruit parts of the plant, such
as flavonoids, lectins, anthocyanin, etc., which have been found to increase the immunity and inhibit
the viral activity [116][117][118][119][150,152–154]. However, in case of the H1N1 influenza virus, this plant has shown
great potential to block or impede the entry of the virus into the host cells [114][120][121][149,155,268]. Furthermore,
the presence of lectins in this plant is responsible for controlling the symptoms or pathogenesis of
the influenza virus [114][122][149,151]. It also has immunomodulating activity due to the presence of peptic
polysaccharides, polyphenolic compounds and flavonoids [114][149]. Due to several significant and antiviral
relevant properties of this plant, it can possibly be used against SARS-CoV-2.26. Eleutherococcus senticosus (Rupr. & Maxim.) Maxim.
Eleutherococcus senticosus (E. senticosus) belongs to the family of Araliaceae Araliaceae and is mostly found in
China, Japan and Korea [123][269]. E. senticosus E. senticosus is used for the treatment of chronic coughing, ischemic heart
disease, diabetes, cancer, altitude sickness, neurodegenerative disorders, and chronic fatigue [114][124][123][125][149,159,
269,270]. Moreover, its leaves are used as food in the form of tea, wine, soups and many others [126][271]. E. senticosus
E. senticosus leaves have the potential efficacy to inhibit bacterial glucosidase activity, reported in
in vitro results by many researchers. The nature of the component of E. senticosus E. senticosus responsible for
its antiviral activity remains to be determined, and is currently under investigation together with
the characterization of the target molecules and the molecular basis of the antiviral efficacy of E. senticosus
E. senticosus. However, its extract is able to inhibit the replication of the influenza virus, and viral
replication is common in all kinds of viruses [127][128][124][129][157–159,272]. Several potent bioactive components
are known to be present in the roots of this medicinal plant, such as phenols, lignans, coumarins,
phenylpropanoids, flavonoids, hyperin, rutin, afzelin, quercetin, kaempferol, phenolic acids, triterpenic
acids, and anthocyanin, etc. Due to the presence of these bioactive compounds, in vitro results showed
some antiviral activity too, by blocking the replication of influenza virus in the cells [114][130][149,273]. Therefore,
it is a possible recommendation that plant should go further investigation and may be helpful in
directly or indirectly controlling SARS-CoV-2.27. Salvia miltiorrhiza Bunge
This plant belongs to the family of Lamiaceae Lamiaceae and is commonly known as red sage [131][274]. Its bioactive
components are extracted from the root, including lipophilic diterpenoids, flavonoids, triterpenoids
and hydrophilic phenolic compounds [132][131][133][163,274,275]. It is also used for the treatment of various diseases,
such as removing blood stasis, improving blood circulation, atherosclerosis, thrombosis, angina
pectoris, other cardiovascular diseases and antiviral activity of HIV-1 and Enterovirus by inhibiting
RdRp enzyme activity [134][135][132][136][161–164].28. Acacia arabica (Lam.) Willd.
Acacia arabica arabica (A. arabica) belongs to the family of Fabaceae and is widely distributed
in Asian regions [137][167]. It is basically used for the treatment of various diseases, such as
Newcastle disease, vaccinia virus, bursal disease virus, H9N2 influenza disease, skin diseases,
and possesses many biological properties including antimicrobial, anti-diabetic, and antioxidant effects.
The mechanism of action of A. A. arabica arabica is known. It specifically inhibits the stage of viral intracellular
multiplication [114][137][138][139][149,167–169]. Furthermore, A. A. arabica arabica contains several bioactive components extracted
from the leaves of the plant which are responsible for its bioactivity, such as flavonoids, methyl 3,4,5
tri hydroxyl benzoate, p-coumaroyl glucoside, p-coumaroylquinic acid, ferulic acid, isoferulic acid,
epicatechin-3-gallate, ascorbic acid, quercetin 3-O-(4′0-O-acetyl)-rhamnopyranoside, oleic acid, myristic
acid, palmitic acid and steroidal sapogenin aglycone [140][137][138][141][166–168,276]. A. A. arabica arabica also has the potential
to inhibit the viral replication against HIV infection [114][139][149,169]. Due to its antiviral nature, it is highly
recommended to use A. A. arabica arabica for controlling/managing SARS-CoV-2 infection.29. Ocimum sanctum L.
Ocimum sanctum (O. sanctum) belongs to the family of Lamiaceae Lamiaceae and is commonly known as
tulsi [137][142][167,173]. This aromatic plant is basically found in all Asian countries. It is used for the treatment
of diseases such as cough, anxiety, arthritis, dysentery, diarrhea, asthma, fever, skin and eye disorders,
otalgia, gastrointestinal disorders, cardiac and genitourinary disorders, back pain, snake, insect and
scorpion bites, malaria, and H9N2 influenza disease [143][137][138][142][144][16,167,168,173,178]. The leaves of O. sanctum O. sanctum
contain several bioactive compounds, such as alkanoids, saponins, tannins, flavonoids, phenols,
anthocyanins and triterpenoids [137][145][142][167,172,173]. However, this medicinal plant has the potential to
block the activity of different pathogens and can act as a potent antiviral, antifungal, anti-protozoan,
anti-malarial, anti-helminthic, antibacterial, mosquito repellent, etc.; its other clinical activities are
detailed in Table 1 Table 1 [137][146][145][142][147][148][149][150][167,171–177]. Ghoke et al. showed that treatment with the crude extract derived
from the leaves of O. sanctum O. sanctum leads to significant H9N2 virus reduction in assessing all three—virucidal,
therapeutic and prophylactic—activities using an in vivo model. They suggested that the crude extract
of O. sanctum O. sanctum could be a promising extract for developing safe and efficacious antiviral compounds
against the H9N2 virus. The protecting effectiveness of the crude extract of O. sanctum O. sanctum might be
ascribed to multiple mechanisms of action (specific inhibition of viral intracellular multiplication
stage and non-specific interference with virus–cell interactions such as masking/blocking the HA
glycoprotein [137][167]. Due to these vast known biological properties, it would be of great importance to
study the potential particular active ingredient or combinations, which are responsible for its broader
antiviral activity, further. Therefore, O. sanctum O. sanctum might be helpful for the treatment of COVID-19,
and can potentially block the entry of virus as well as its replication.30. Ocimum basilicum L.
This medicinal herb belongs to the family of Lamiaceae and it is also known as sweet basil [114][151][149,181].
It is mostly used in industries as food, perfumes and cosmetics [151] [181] due to its potent antiviral,
anti-inflammatory, antioxidant and antibacterial activities [152][151][153][154][180,181,183,184]. Moreover, it contains
several bioactive components such as phenolic compounds, flavonoids and anthocyanin extracted from
the whole plant of O. basilicumO. basilicum [155][153][154][182–184]. This herb has been used for HIV treatment and showed very
good potential to inhibit the replication of the HIV virus, and blocks further viral processing [114][151][149,181].31. Theobroma cacao L.
Theobroma cacao (T. cacao) belongs to the family of Sterculiaceae. The seeds of this cocoa plant are
commonly used in food industries [277]. It contains several types of bioactive compounds, such as
polyphenol, theobromine and flavonoids [278], which are responsible for its antioxidant, antiviral,
anti-inflammatory and many other biological activities [186,188,189]. However, some studies reported
the anti-influenza activity of T. cacao, due to presence of flavonoids, theobromine, lignin, dietary fiber,
free fatty acid, and minerals (zinc, copper, iron) [186–188]. Kamei et al., 2014 investigated the effect of
T. cacao against the influenza virus and found that it enhances the antibody response due to stimulatory
effect [187]. Furthermore, it has also been observed that, T. cacao helps in developing acquired immunity
and activates the NK cells against the influenza virus [187]. Further investigation may lead to the use
of T. cacao against SARS-CoV-2, and can help in boosting immunity.32. Pelargonium sidoides DC.
Pelargonium sidoides (P. sidoides) belongs to the family of Geraniaceae Geraniaceae and is commonly known
as Umckaloabo [162][191]. It is found all over the world and roots of this plant are traditionally used
for remedial purposes against tuberculosis, respiratory diseases, cough, gastrointestinal infection,
viral diseases and others [162][163][191,193]. P. sidoides P. sidoides roots are known to have some potent compounds, such as
methoxycoumarin, proanthocyanidins and prodelphinidins [164][192]. Furthermore, its roots are also used
for the production of herbal drugs known as EPs 7639 by ethanolic extract, which have been approved
for the treatment of respiratory tract infections [162][165][191,194]. According to Theisen et al., 2012, P. sidoides P. sidoides
also has the potential to inhibit the viral entry of the influenza virus [165][194]. Therefore, it is suggested
that roots of P. sidoides P. sidoides should be further investigated for the treatment of COVID-19.33. Taraxacum officinale (L.) WEB. ex WIGG.
This medicinal plant belongs to the family of Asteraceae Asteraceae and it is commonly known as dandelion [18][48].
It is traditionally used for the treatment of various diseases such as kidney diseases, lung diseases,
breast tumor, diabetes, uterus infections, digestive system related abnormalities, etc. [166][167][198,279].
Pharmacological research has proven the efficacy of this medicinal plant as antiviral, antibacterial,
choleretic, anti-diabetic, anti-inflammatory, antioxidant, hepato-protective, diuretic and antifungal [166][198].
It contains several bioactive components, extracted from the aerial parts and roots, such as terpenes,
flavonoids, phenolic compounds, terpenoids, triterpenoids, steroids, coumarins, phenols, saponins,
flavones, flavonols, chalcones, phlobatannins, and cardiac glycosides [168][169][170][196,197,280]. Han et al., 2011
found the potential of this medicinal plant to inhibit the viral replication of HIV [171][199]. Similarly, Lee et al.,
2012 also suggested its potential to enhance pro-inflammatory cytokines and improve the immune
system [172][201]. Furthermore, it is also known to inhibit the influenza virus’ entry into cells [18][173][48,200].
Therefore, due to its vast and significant antiviral properties, it is highly recommended to conduct
further investigation on this medicinal plant for the discovery of potent drugs against COVID-19.34. Illicium oligandrum Merr & Chun
Illicium oligandrum oligandrum (I. oligandrum) belongs to the family of Magnoliaceae, being a rich source of
seco-prezizaane type sesquiterpenes [174][203]. It is known to have antiviral activity against herpes simplex
virus type 2, coxsackie virus and influenza virus [175][176][204,206]. It has some potent bioactive compounds,
such as sesquiterpene lactones, neolignan glycosides, phenolic diglycosides and prenylated compounds
which are responsible for its antiviral activities [175][176][204,206]. However, this medicinal plant is also used for
the treatment of rheumatoid arthritis, and neurotoxic and neuro-trophic effects [177][205]. Ma et al., 2013
reported the ethanolic extraction of spirooliganones A 1 & B from the roots of I. I. oligandrum oligandrum and showed
its potential to inhibit the activity of influenza virus (H3N2) (IC50 50 3.70–33.33 µM) and coxsackie virus
B3 [175][204].35. Glycyrrhiza glabra L.
Glycyrrhiza glabra (Liquorice) belongs to the family of Fabaceae Fabaceae and is among the most ancient
medicinal plants [178][212]. It has several very well-known biological activities, such as antiviral
(HIV, SARS-CoV), anti-inflammatory, antimicrobial, antioxidant, anti-tumorigenic and anti-ulcer
properties [179][180][209,210]. The root of Liquorice is known to have many bioactive components, including
flavonoids, glycyrrhizic acid, triterpenoid, saponins, etc. [180][178][210,212]. Few studies showed that chalcones
extracted from Liquorice have the ability to block or inhibit the activity of influenza virus [18][181][48,208].
Therefore, there is a possibility that this plant might be useful against SARS-CoV-2 due to its
antiviral properties.36. Angelica keiskei (Miq.) Koidz.
Angelica keiskei (A. keiskei) belongs to the family of Umbelliferae, Umbelliferae, and its leaves are basically used
for remedial purposes [182][147]. Its bioactive components include chalcones, flavanones and coumarins,
coumarins phenolic, acetylenes, sesquiterpene, diterpene, and triterpenes [183][184][144,146]. A. keiskei A. keiskei is
known and considered to be antiviral, anticancer, anti-inflammatory, anti-obesity, anti-oxidative,
anti-coagulant, anti-tumor, anti-mutagenic, anti-diabetic, antibacterial and hepato-protective [183][185][184][144–146].
Park et al., 2016 extracted bioactive components (9 alkylated chalcones and 4 coumarins) from A. keiskei A. keiskei
plant [184][146], and revealed that the extracted chalcones were able to significantly block the entry of
coronavirus (SARS-CoV-1) by inhibiting the chymotrypsin-like protease (75% inhibition using 30 µg/mL
dose) and a papain-like protease (88% inhibition using 30 µg/mL dose) [184][146]. In addition, the IC50 50
of this chalcone and chalcone 6 are 11.4 and 1.2 µM, respectively [184][146]. Therefore, due to this very
specific inhibition property of A. keiskei A. keiskei deserves further investigation for the development of potent
antiviral agents against COVID-19.37. Polygala karensium Kurz
Polygala karensium karensium (P. karensium) is a medicinal plant belonging to the family of Polygalaceae
and can mostly be found in China, Myanmar, Thailand, and Vietnam [186][215]. It has important and
potent bioactive compounds, i.e., xanthones, which have shown many biological activities such as
antiviral, antimicrobial, antioxidant, cytotoxicity, etc. [187][186][188][214–216]. In addition, it is also used to treat
various ailments such as cough, bronchitis, neurasthenia, inflammation and amnesia [186][215]. However,
Dao et al., 2012 conducted one in vitro study on H1N1, H9N2, and novel H1N1 (WT) strains using
ethanol-extracted xanthones from the root of P. karensiumP. karensium, and found that xanthones have the potential to
completely inhibit influenza virus activity [187][214]. Therefore, xanthones from P. P. karensium karensium can also be one
of the choices worth investigation for the further development of phytomedicine against SARS-CoV-2.38. Calophyllum brasiliense Cambess.
Calophyllum brasiliense (C. brasiliense) is a medicinal plant, and basically belongs to the family
of Clusiaceae Clusiaceae, mostly found in South America, Central America and the Caribbean region [189][218].
It is used as a remedy to treat several diseases, such as parasitic, viral, bacterial and fungal
diseases [189][190][218,220]. Its potent biological activities include antiviral, antibacterial, anti-protozoal and
antifungal effects [189][191][218,219]. However, Kudo et al., 2013 investigated the role of this medicinal plant
in HIV disease, firstly by extracting tricyclic coumarin from the leaves of C. brasiliense C. brasiliense and testing
in vitro [190][220]. Hence, they revealed that tricyclic coumarin from C. Brasiliense C. Brasiliense possesses great potential
to inhibit viral replication by blocking the NFkB pathway [190][220].39. Cimicifuga foetida L.
Cimicifuga foetida (C. foetida) belongs to the family of Ranunculaceae Ranunculaceae and it is also known as Shengma.
It is abundantly distributed in Asian region [192][225]. It is basically used to treat various ailments, such as
fever, headache, sore throat, toothache, uterine prolapse and inflammation [193][224]. It contains several
bioactive compounds extracted from rhizomes, including cycloartane triterpenoids and glycosides
with antiviral, anti-tumor, anti-inflammatory activities [192][225]. Wang et al., 2012 investigated the role of C. foetida
C. foetida, especially the cimicifugin component of it, against Respiratory Syncytial Virus, and found
that the plant has a strong potential to inhibit viral attachment and internalization [194][193][223,224]. Moreover,
cimicifugin was also able to stimulate epithelial cells and initiate the secretion of cytokines such
as IFN-β, to clear the viral infection/load [195][281]. Furthermore, another in vitro study conducted by
Dai et al., 2016 observed the potential of C. foetida C. foetida in inhibiting the hepatitis B virus transcription
and replication by producing pro-inflammatory cytokines [196][222]. Due to the capacity of producing
strong pro-inflammatory cytokines and immunomodulatory properties, C. foetida C. foetida can be used to treat
COVID-19 disease.40. Boerhavia diffusa L.
Boerhavia diffusa (B. diffusa) belongs to the family of Nyctaginaceae Nyctaginaceae and is commonly known as
punarnava [197][282]. It is mostly found in Asian countries and is basically used for the treatment of
various diseases, such as abdominal pain, jaundice, dyspepsia, stress, spleen enlargement and liver
diseases [198][228]. B. diffusa B. diffusa bioactive components extracted from leaf, stem and root include flavonoids,
triterpenoids, alkaloids, hypoxanthine, steroids, lipids, lignin, proteins, ursolic acid, boeravinone,
punarnavoside, etc. [199][200][227,230]. However, Bose et al., 2017 suggested that B. diffusa B. diffusa has a strong potential
to inhibit the entry of hepatitis C virus and its major compound (boeravinone H component) were able
to block the initial phase of HCV entry through acting directly on the viral particles [198][228]. Moreover,
Manu et al., 2007 also showed that its second major bioactive compound (Punarnavine) was also able
to enhance the immune response, especially IFN-γ and interleukin-2 cytokines [201][229]. This categorizes
B. diffusa as B. diffusa as a therapeutically important plant to be considered under the current circumstances of the
COVID-19 pandemic and worth further investigation.41. Terminalia chebula Retz
Terminalia chebula (T. chebula) belongs to the family of Combretaceae Combretaceae and is mostly found in
the Asian region [202][283]. It is one of the most important medicinal plants due to the presence of a
huge number of different kinds of phytoconstituents [203][232]. It is customarily used as a household
remedy and also in modern, Ayurveda, Unani and Homoeopathic medicines [203][202][232,283]. Its bioactive
components extracted from the leaves, bark and fruit of the plant include flavonoids, polyphenols,
terpenes, anthocyanins, glycosides, gallic acid, chebulagic acid, punicalagin, chebulanin, corilagin,
neochebulinic acid, ellagic acid, chebulinic acid, alkaloids and many more [203][204][205][232,237,284]. It is also
known to be used as a cure for irregular fevers, urinary diseases, diabetes, skin diseases, heart diseases,
constipation, ulcers, vomiting, colic pain, hemorrhoids, digestive diseases, and others [203][206][204][232,235,237].
However, T. chebula T. chebula has many pharmacological activities such as antiviral, antioxidant, antibacterial,
antifungal, anti-protozoal, anti-carcinogenic, anti-mutagenic, radio-protective, chemo-preventive,
hepato-protective, cardio-protective, cyto-protective, anti-diabetic, reno-protective, anti-inflammatory,
anti-arthritic, adaptogenic, anti-anaphylactic, hypolipidemic, hypocholesterolemic, anti-caries,
wound healing, anti-allergic, immunomodulatory, anti-ulcer, anti-spasmodic and gastrointestinal
motility properties [203][207][206][208][204][232,233,235–237]. Lin et al., 2013 conducted an in vitro study and found that
chebulagic acid and punicalagin from the fruit of T. chebula T. chebula have the potential to inhibit the activity of
different viruses, such as human cytomegalovirus, HCV, dengue virus, measles virus, and respiratory
syncytial virus [209][234]. Due to its strong biological properties, it is highly recommended to study T. chebula
T. chebula as a possible remedy against SARS-CoV-2.42. Caesalpinia sappan L.
Caesalpinia sappan (C. sappan) belongs to the family of Caesalpiniaceae Caesalpiniaceae and it is usually known
as Brazil or Sappan wood [191][219]. It is mostly found in Southeast Asian regions and is traditionally
used for the treatment of various diseases such as tuberculosis, diarrhea, dysentery, skin infections,
anemia, etc. [191][210][219,240]. C. sappan C. sappan is effectively considered as an antiviral, anti-inflammatory, antioxidant,
antibacterial, antifungal, and anti-complementary [219,240,241]. Its bacteioactive constituents include
xanthone, coumarin, chal, antcones, flavones, homoisoflavonoids, and brazilin [240]. Tewtrakul et al.,
2015, extracted nine compounds from the roots of C. sappan. The results showed that, out of those
nine, sappanchalcone (IC50 2.3 µM) and protosappanin A (IC50 12.6 µM) presented the strongest
effect against HIV-1 IN [240]. On the other hand, Liu et al, and ., 2009 also investigated the role of this
medicinal planti-co against influenza virus. The in vitro study showed that 3-deoxysappanchalcone and
sappanchalcone component isolemated from C. sappan exhibited the highest activity againtst influenza
virus (H3N2), with IC50 1.06 and 2.06 µg/mL, respectively [191][210][211][239]. Therefore, sappanchalcone from
C. sappan should also be considered for further examination against SARS-CoV-2.
genus Bupleurum L. Chin. Herb. Med. 2013, 5, 245–255. [CrossRef]
33. Cheng, P.-W.; Ng, L.-T.; Chiang, L.-C.; Lin, C.-C.; Ng, L.-T. Antiviral effects of saikosaponins on human
coronavirus 229E in vitro. Clin. Exp. Pharmacol. Physiol. 2006, 33, 612–616. [CrossRef]
34. Yang, F.; Dong, X.; Yin, X.; Wang, W.; You, L.; Ni, J. Radix bupleuri: A review of traditional uses, botany,
phytochemistry, pharmacology, and toxicology. BioMed Res. Int. 2017, 2017, 1–22. [CrossRef] [PubMed]
35. Chen, J.; Duan, M.; Zhao, Y.; Ling, F.; Xiao, K.; Li, Q.; Li, B.; Lu, C.; Qi, W.; Zeng, Z.; et al. Saikosaponin
A inhibits influenza A virus replication and lung immunopathology. Oncotarget 2015, 6, 42541–42556.
[CrossRef] [PubMed]
36. Tykheev, Z.A.; Taraskin, V.V.; Radnaeva, L.D.; Zhang, F.Q.; Chen, S.L. Total saikosaponin content in some
species of Bupleurum L. IOP Conf. Ser. Eartsh Environ. Sci. 2019, 320, 012055. [CrossRef]
37. Lamoral-Theys, D.; Decaestecker, C.; Mathieu, V.; Dubioois, J.; Kornienko, A.; Kiss, R.; Evidente, A.; Pottier, L.
Lycorine and its derivatives for anticancer drug design. Mini Rev. Med. Chem. 2010, 10, 41–50. [CrossRef]
[PubMed]
38. Cedrón, J.C.; Gutiérrez, D.G.; Flores, N.; Rave lo, Á.G.; Estévez-Braun, A. Synthesis and antiplasmodial
activity onsf lycorine derivatives. Bioorg. Med. Chem. 2010, 18, 4694–4701. [CrossRef]
39. Mikami, M.; Kitahara, M.; Kitueano, M.; Ariki, Y.; Mimaki, Y.; Sashida, Y.; Yamazaki, M.; Yui, S. Suppressive
activity of lycoricidinol (narciclasine) against cytotoxicity of neutrophil-derived calprotectin, and its
suppressive effect ion rat adjuvant arthritis model. Biol. Pharm. Bull. 1999, 22, 674–678. [CrossRef]
40. Kretzing, S.; Abraham, G.; Seiwert, B.; Ungemaclh, F.R.; Krügel, U.; Regenthal, R. Dose-dependent emetic
effects of the Amaryllidaceous alkaloide x lycorine in beagle dogs. Toxicon 2011, 57, 117–124. [CrossRef]
41. Ieven, M.; Berghe, D.A.V.D.; Vlietinck, A.J. Plant antiviral agents. IV. Influence of lycorine on growth pattern
of three ane, imal viruses. Planta Med. 1983, 49, 109–114. [CrossRef]
42. Liu, J.-N.; Yang, Y.; Xu, Y.; Ma, C.; Qin, C.; Zhang, L. Lycorine redumarices mortality of human enterovirus
71-infected mice by inhibiting virus replication. Virol. J. 2011, 8, 483. [CrossRef]
43. Wang, H.; Guo, T.; Yang, Y.; Yu, L.; Pan, X.; Li, Y.-H. Lycorine derivative LY-55 inhaibits EV71 and CVA16
repliconeation through downregulating autophagy. Front. Microbiol. 2019, 9, 277. [CrossRef]
Plants 2020, f9, 1244 30 of 41
44. Mukhtar, M.; Arshad, M.; Ahmad, M.; Pomerantz, R.J.; Wigdahl, B.; Pavonrveen, Z. Antiviral potentials of
medicinal plants, . Virus Res. 2008, 131, 111–120. [CrossRef] [PubMed]
45. Efferth, T.; Romoisero, M.R.; Wolf, D.G.; Stamminger, T.; Marin, J.J.G.; Marschall, M. The antiviral activities of
artemisinin and artesunate. Clin. Infect. Dis. 2008, 47, 804–811. [CrossRef] [PubMed]
46. AleSaeidi, S.; Miraj, S. A systematic revonoiiew of anti-malarial properties, immunosuppressive properties,
anti-inflammatory properties, and anti-cancer properties, of artemisia annua. Electron. Physician 2016, 8,
3150–3155. [CrossRef] [PubMed]
47. Ho, W.E.; Peh, H.Y.; Chan, T.K.; Wong, W.F. Artemisinins: Pharmacological actions beyond anti-malarial.
Pharmacol. Ther. 2014, 142, 126–139. [CrossRef] [PubMed]
48. Lin, L.-T.; Hsu, W.-C.; Lin, C.-C. Antiviral natural products and herbal medicines. J. Tradit. Complement. Med.
2014, 4, 24–35. [CrossRef]
49. Law, S.; Leung, A.W.; Xu, C. Is the traditional Chinese herb “Artemisia annua” possible to fight against
COVID-19? Integr. Med. Res. 2020, 9, 100474. [CrossRef]
50. Li, S.-Y.; Chen, C.; Zhang, H.-Q.; Guo, H.-Y.; Wang, H.; Wang, L.; Zhang, X.; Hua, S.-N.; Yu, J.; Xiao, P.-G.; et al.
Identification of natural compounds with antiviral activities against SARS-associated coronavirus. Antivir. Res.
2005, 67, 18–23. [CrossRef]
51. Benatouil, C.P.; Reanimator, A. Action of Artemisia Annua on Adaptive Immunity in COVID-19 Infections.
Available online: https://lavierebelle.org/action-de-l-artemisia-annua-sur-l?lang=en (accessed on 22 June
2020).
52. Gao, D.; Fan, Y.; Feng, H.; Liu, L.; Zhang, Y.; Xin, X. Chemical components and antibacterial activity of the
essential oil of six pyrrosia species. Chem. Biodivers. 2020, 10, 1–10. [CrossRef]
53. Zheng, M. Experimental study of 472 herbs with antiviral action against the herpes simplex virus. Chin. J.
Mod. Dev. Tradit. Med. 1990, 10, 39–41.
54. Xiao, W.; Peng, Y.; Tan, Z.; Lv, Q.; Chan, C.-O.; Yang, J.; Chen, S. Comparative evaluation of chemical profiles
of pyrrosiae folium originating from three pyrrosia species by HPLC-DAD combined with multivariate
statistical analysis. Molecules 2017, 22, 2122. [CrossRef]
55. Chen, Y.; Fan, C.-L.; Wang, Y.; Zhang, X.-Q.; Huang, X.-J.; Ye, W.-C. Chemical constituents from roots of Isatis
indigotica. China J. Chin. Mater. Med. 2018, 43, 2091–2096.
56. Zhang, D.; Shi, Y.; Xu, R.; Du, K.; Guo, F.; Chen, K.; Li, Y.; Wang, R. Alkaloid enantiomers from the roots of
isatis indigotica. Molecules 2019, 24, 3140. [CrossRef] [PubMed]
57. Lin, C.-W.; Tsai, F.-J.; Tsai, C.-H.; Lai, C.-C.; Wan, L.; Ho, T.-Y.; Hsieh, C.-C.; Chao, P.-D.L. Anti-SARS
coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds.
Antivir. Res. 2005, 68, 36–42. [CrossRef] [PubMed]
58. Chang, S.-J.; Chang, Y.-C.; Lu, K.-Z.; Tsou, Y.-Y.; Lin, C.-W. Antiviral activity of isatis indigotica extract and
its derived indirubin against japanese encephalitis virus. Evid. Based Complement. Altern. Med. 2012, 2012,
1–7. [CrossRef]
59. Oh, J.; Rho, H.S.; Yang, Y.; Yoon, J.Y.; Lee, J.; Hong, Y.D.; Kim, H.C.; Choi, S.S.; Kim, T.W.; Shin, S.S.; et al.
Extracellular signal-regulated kinase is a direct target of the anti-inflammatory compound amentoflavone
derived from Torreya nucifera. Mediat. Inflamm. 2013, 2013, 1–11. [CrossRef]
60. Endo, Y.; Osada, Y.; Kimura, F.; Shirakawa, H.; Fujimoto, K. Effects of Japanese Torreya (Torreya nucifera) seed
oil on the activities and mRNA expression of lipid metabolism-related enzymes iln rats. Biosci. Biotechnol.
Biochem. 2007, 71, 231–233. [CrossRef]
61. Ryu, Y.B.; Jeong, H.J.; [210]Kim, J.H.; Kim, Y.M.; Park, J.-Y.; Kim, D.; Naguyen, T.T.H.; Park, S.-J.; Chang, J.S.;
Park, K.H.; et al. Biflavonoids from Torreya nucifera displaying SARS-CoV 3CLpro inhibition. Bioorg. Med.
Chem. 2010, 18, 7940–7947. [CrossRef]
62. Shingnaisui, K.; Dey, T.; Manna, P.; Kalita, J. Therapeutic potentials of Houttuynia cordata Thunb. against
inflammation and oxidative stress: A review. J. Ethnopharmacol. 2018, 220, 35–43. [CrossRef]
63. Lau, K.-M.; Lee, K.-M.; Koon, C.-M.; Cheung, C.S.-F.; Lau, C.-P.; Ho, H.-M.; Lee, M.Y.-H.; Au, S.W.-N.;
Cheng, C.H.K.; Lau, C.B.; et al. Immunomodulatory and anti-SARS activities of Houttuynia cordata.
J. Ethnopharmacol. 2008, 118, 79–85. [CrossRef]
64. Chiow, K.; Phoon, M.; Putti, T.; Tan, B.K.; Chow, V.T.K. Evaluation of antiviral activities of Houttuynia cordata
Thunb. extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection.
Asian Pac. J. Trop. Med. 2016, 9, 1–7. [CrossRef]
Plants 2020, 9, 1244 31 of 41
65. Cheng, D.; Sun, L.; Zou, S.; Chen, J.; Mao, H.-Y.; Zhang, Y.; Liao, N.; Zhang, R.-H. Antiviral effects of
Houttuynia cordata polysaccharide extract on Murine Norovirus-1 (MNV-1)—A human norovirus surrogate.
Molecules 2019, 24, 1835. [CrossRef] [PubMed]
66. Chen, M.-Y.; Li, H.; Lu, X.-X.; Ling, L.-J.; Weng, H.-B.; Sun, W.; Chen, D.-F.; Zhang, Y.-Y. Houttuynia cordata
polysaccharide alleviated intestinal injury and modulated intestinal microbiota in H1N1 virus infected mice.
Chin. J. Nat. Med. 2019, 17, 187–197. [CrossRef]
67. Xu, C.; Yang, B.-X.; Zhu, W.; Li, X.; Teian, J.; Zhang, L. Characterisation of polyphenol constituents of Linderae
aggregate leaves using HPLC fingerprint analysis and their antioxidant activities. Food Chem. 2015, 186,
83–89. [CrossRef]
68. Wei, G.; Chen, H.; Nie, F.; Ma, X.; Jiang, H. 1, 3, 6-trihydroxy-7-methyl-9, 10-anthracenedione isolated from
genus lindera witrah anti-cancer activity. Anticancer Agents Med. Chem. 2017, 17, 1604–1607. [CrossRef]
69. Xiao, M.; Cao, N.; Fan, J.-J.; Shen, Y.; Xu, Q. Studies on flavonoids from the leaves of Lindera aggregata.
J. Chin. Med. Mater. 2011, 34, 62–64.
70. Jung, S.-H.; Han, J.-H.; Park, H.-S.; Lee, J.-J.; Yang, S.Y.; Kim, Y.; Heo, K.-S.; Myung, C.-S. Inhibition of
collagen-induced et alplatelet aggregation by the secobutanolide secolincomolide a from lindera obtusiloba
blume. Front. Pharmacol. 2017, 8, 560. [CrossRef]
71. Extension Gardener. Lycoris Radiata. Available online: https://plants.ces.ncsu.edu/plants/lycoris-radiata/
(accessed on 24 August 2020).
72. Artennua. Artemisia Annua Characteristics. Available online: https://www.artennua.com/artemisia-annua/
(accessed on 24 August 2020).
73. Hardy Fern Foundation. Pyrrosia Lingua Tongue Fern. Available online: https://hardyferns.org/ferns/
pyrrosia-lingua/ (accessed on 22 August 2020).
74. The Sunlight Experiment. COVID-19: Searching For Potential Treatment Options in Plants. Available online:
https://thesunlightexperiment.com/blog/herbal-medicine-covid-19 (accessed on 22 August 2020).
75. Torreya Nucifera. Available online: https://alchetron.com/Torreya-nucifera (accessed on 20 August 2020).
76. Wikipedia. Houttuynia cordata. Available online: https://en.wikipedia.org/wiki/Houttuynia_cordata
(accessed on 20 August 2020).
77. Useful Tropical Plants. Lindera Aggregata. Available online: http://tropical.theferns.info/viewtropical.php?
id=Lindera+aggregata (accessed on 21 August 2020).
78. Ho, T.-Y.; eWu, S.-L.; Chen, J.-C.; Li, C.-C.; Hsiang, C.-Y. Emodin blocks the SARS coronavirus spike protein
and angiotensin-converting enzyme 2 interaction. Antivir. Res. 2007, 74, 92–101. [CrossRef]
79. Lee, J.-C.; Tseng, C.-K.; Wu, S.-F.; Chang, F.-R.; Chiu, C.-C.; Wu, Y.-C. San-Huang-Xie-Xin-Tang extract
suppresses hepatitis C virus replication and ninevirus-induced cyclooxygenase-2 expression. J. Viral Hepat. 2011,
18, e315–e324. [CrossRef]
80. Yang, K.L.; Gao, Y.; Yang, F.W.; Liu, M.; Shi, S.Z.; Chen, Y.M.; Zhang, J.H.; Tian, J.H. Analysis of traditional
Chinese medicine frompoun patent information sharing platform of coronavirus disease 2019 (COVID-19). China J.
Chin. Mater. Med. 2020, 45, 3001–3006. [CrossRef]
81. Zhao, M.-J.; Chao, J.; Dai, Y.-T.; Chen, S.-L.; Li, Q.; Fan, Z.-Q.; Wang, D.-D. Quality evaluation of Rhei Radix
et Rhizoma decoction. China J. Chin. Mater. Med. 2018, 43, 861–867.
82. Zheng, L.; Chen, S.; Cao, Y.; Zhao, L.; Gao, Y.; Ding, X.; Wang, X.; Gu, Y.; Wang, S.; Zhu, Z.; et al. Combination
of comprehensive the rwo-dimensional prostate cancer cell membrane chromatographic system and network
pharmacolots ogy for characterizing membrane binding active components from Radix et Rhizoma Rhei and
their targets. J. Chromatogr. A 2018, 1564, 145–154. [CrossRef C. sappan] [PubMed]
83. Wikipedia. Rheum Palmatum. Available online: https://en.wikipedia.org/wiki/Rheum_palmatum (accessed
on 21 August 2020).
84. Cheng, W.; Li, Y.; Yang, W.; Wu, S.; Wei, M.; Gao, Y.; Kang, C.; Zhang, S.; Li, Y. Simultaneous determination
of 13 constituents of radix polygoni multiflori in rat plasma and its application in a pharmacokinetic study.
Int. J. Anal. Chem. 2020, 2020, 4508374. [CrossRef]
85. He, Q.; The reu, C.; Wang, J.-B.; Liu, Z.-J.; Sha, M.-C.; Zhang, L.; Li, C.-Y.; Xiao, X.-H. Antiplatelet aggregation
bioactivity of Polygoni Multiflori Radix with chemical fingerprints and spectrultsm-effect correlation analysis.
China J. Chin. Mater. Med. 2017, 42, 1679–1684.
Plants 2020, 9, 1244 32 of 41
86. Lee, B.-J.; Lee, K. Discrimination and proper use of polygoni multiflori radix, cynanchi wilfordii radix,
and cynanchi auriculati radix in Korea: A descriptive review. Evid. Based tComplement. Altern. Med. 2015,
2015, 1–7. [CrossRef] [PubMed]
87. Liang, Z.T.; Chen, H.; Yu, Z.-L.; Zhato, Z.-Z. Comparison of raw and processed Radix Polygoni Multiflori
(Heshouwu) by high performance liquid chromatography and mass spectrometry. Chin. Med. 2010, 5, 29.
[CrossRef] [PubMed]
88. Lin, L.; Ni, B.; Lin, H.; Zhang, M.; Yan, L.; Qu, C.; Ni, J. Simultaneous of tdetermination of 14 constituents
of Radix polygoni multiflori from different geographical areas by liquid chromatography-tandem mass
spe ctrometry. Biomed. Chromatogr. 2014, 29, 1048–1055. [CrossRef]
89. Plants For A Future. Polygonum Multineflorum—Thunb. Available online: https://pfaf.org/user/Plant.aspx?
LatinName=Polygonum+multiflorum (accessed on 20 August 2020).
90. Console, L.; Giangregorio, N.; Cellamare, S.; Bolognino, I.; Palasapciano, M.; Indiveri, C.; Incampo, G.;
Campana, S.; Tonazzi, A.; Lara, C.; et al. Human mitochalcoondrial carnitine acylcarnitine carrier: Molecular
target of dietary bioactive polyphenols from swee (It cherry (Prunus avium L.). Chem. Interact. 2019, 307,
179–185. [C50 rossRef]
91. Heidary, F.; Varnaseri, M.; Gharebaghi, R. The potential use of persian herbal medicines against COVID-19
through angiotensin-converting enzyme. Arch. Clin. Infect. Dis. 2020, 15, e102838. [CrossRef]
92. Kouchmeshky, A.; Jameie, S.B.; Amin, G.; Ziai, S.A. Investigation of angiotensin-convertings enzyme
inhibitory effects of medicinal plants used in traditional persian medicine for treatment of hypertension:
Screening study. Thrita Stud. J. Med. Sci. 2012, 1, 13–23. [CrossRef]
93. µSerteser, A.; Kargioglu, M.; Gök, V.; Ba ˘gci, Y.; Özcan, M.M.; Arslan, D. Determination of antioxidant effects of
some plant species wild growing in Turkey. Int. J. Food Sci. Nutr. 2008, 59, 643–651. [CrossRef]
94. Ziai, S.A.; Heidari, M.R.; Amin, G.H.; Koochemeshki, A.; Heidari, M. Inhibitory effects of germinal angiotensin
converting enzyme by medicinal plants used in iranian traditional medicine as antihypertensive. J. Kerman
Univ. Med Sci. 2009, 16, 134.
95. Drug Information of Cerasus Avium. Cerasus Avium. Available online: https://www.rpsi.ir/en/medicinalherb/
item/1285/cerasus_avium (accessed on 22 August 2020).
96. Ameri, A.; Heydandrirad, G.; Rezaeizadeh, H.; Choopani, R.; Ghobadi, A.; Gachkar, L. Evaluation of efficacy of
an herbal comprotound on dry mouth in patients with head and neck cancers. J. Evid. Based Integr. Med. 2015,
21, 30–33. [CrossRef]
97. Nasser, R.; Jafari, F.; Rezaeizadeh, H.; Nasseri,M.; Kamalinejad, M.; Ghobadi, A.; Shamsipour,M.; Zargaran, A.;
Ameri, A. Efficacy of a persianin medicine herbal compound (alcea digitataalefandmalva sylvestrisl.) on
prevention of radiation induced acutemucositis in patients with head and neck cancer: A pilot study. Int. J.
Cancer Manag. 2017, 10, e8642. [CrossRef]
98. Kew Science. Alcea Digitata. Available online: http://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:
558657-1 (accessed on 20 August 2020).
99. He, W.; Li, Y.; Liu, M.; Yu, H.; Chen, Q.; Chen, Y.; Ruan, J.; Ding, Z.; Zhang, Y.; Wang, T. Citrus aurantium L.
and its flavonoids regulate TNBS-induced inflammatory bowel disease through anti-inflammation and
suppressing isolated jejunum contraction. Int. J. Mol. Sci. 2018, 19, 3057. [C50 rossRef] [PubMed]
100. Süntar, I.; Khan, H.; Patel, S.; Celano, R.; Rastrelli, L. An overview on Citrus aurantium L.: Its functions as
food ingredient and therapeutic agent. Oxidative Med. Cell. Longev. 2018, 2018, 1–12. [CrossRef] [PubMed]
101. Zhao, H.-Y.; Yang, L.; Wei, J.; Huang, M.; Jiang, J.-G. Bioactivity evaluations of ingredients extracted from the
flowers of Citrus aurantium L. var. amara Engl. Food Chem. 2012, 135, 2175–2181. [CrossRef] [PubMed]
102. Kew Science. Citrus × Aurantium L. Available online: http://www.plantsoftheworldonline.org/taxon/urn:lsid:
ipni.org:names:59600-2 (accessed on 20 August 2020).
103. Lajkó, E.; Bányai, P.; Zámbó, Z.; Kursinszki, L.; Sz˝oke, É.; Kohidai, L. Targeted tumor therapy by Rubia
tinctorum L.: Analytical characterization of hydroxyanthraquinones and investigation of their selective
cytotoxic, adhesion and migration modulator effects on melanoma cell lines (A2058 and HT168-M1). Cancer
Cell Int. 2015, 15, 1–15. [CrossRef]
104. Nejad, H.E. Ahmad esalat nejad. Rubia tinctorum L. (Rubiaceae) or madder as one of the living color to
dyeing wool. Int. J. Adv. Biol. Biomed. Res. 2013, 1, 1315–1319.
105. Kew Science. Rubia tinctorum L. Available online: http://www.plantsoftheworldonline.org/taxon/urn:lsid:
ipni.org:names:765369-1 (accessed on 20 August 2020).
Plants 2020, 9, 1244 33 of 41
106. Baek, S.C.; Nam, K.H.; µMYi, S.; Jo, M.S.; Lee, K.H.; Lee, Y.H.; Lee, J.; Kim, K.H. Anti-adipogenic effect of
β-carboline alkaloids from garlic (Allium sativum). Foods 2019, 8, 673. [CrossRef]
107. Burian, J.P.; Carlos, I.Z.; Sacramento, L.V.S. Fungal infection control by garlic extracts (Allium sativum L.) and
modulation of pereseitoneal macrophages activity in murine model of sporotrichosis. Braz. J. Biol. 2017, 77,
848–855. [CrossRef]
108. Batiha, G.E.-S.; Beshbishy, A.M.; Wasef, L.; Elewa, Y.H.A.; Abdel-Daim, M.; El-Hack, M.; Taha, A.E.;
Abd-Elhakim, Y.M.; Devkota, H.P. Chemical consted tituents and pharmacological activities of garlic
(Allium sativum L.): A review. Nutrients 2020, 12, 872. [CrossRef] [PubMed]
109. Phan, A.D.; Ne strotzel, G.; Chhim, P.; Netzel, M.E.; Sultanbawa, Y. Phytochemical characteristics and antimicrobial
activity of australian gerown garlic (Allium sativum L.) cultivars. Foods 2019, 8, 358. [CrossRef] [PubMed]
110. Biomedical Education. Allium sat eivum L. Available online: http://iprsindh.com.pk/allium-sativum-l/ (accessed
on 23 August 2020).
111. Chokpaisarn, J.; Urao, N.; Voravuthikunchai, S.P.; Koh, T.J. Quercus infectoria inhibits Set7/NF-κB
inflammatory pathway in macrophagect s exposed to a diabetic environment. Cytokine 2017, 94, 29–36.
[CrossRef] [PubMed]
112. Chusri, S.; Phatthalungainst , P.N.; Voravuthikunchai, S. Anti-biofilm activity of Quercus infectoria G. Olivier
against methicillin-resistant Staphylococcus aureus. Lett. Appl. Microbiol. 2012, 54, 511–517. [CrossRef]
[PubMed]
113. Sharifi, N.; Souri, E.; Ziai, S.A.; Amin, G.; Amanlou, M. Discovery of new angiotensin converting enzyme
(ACE) inhibitors from medicinal plants to treat hypertension using an in vitro assay. Daru 2013, 21, 74.
[CrossRef] [PubMed]
114. Shrestha, S.; Kaushik, V.S.; Eshwarappa, R.S.B.; Subaramaihha, S.R.; Ramanna, L.M.; Lakkappa, D.B.;
Prasad, S.B.B. Pharmacognostic studies of insect gall of Quercus infectoria Olivier (Fagaceae). Asian Pac. J.
Trop. Biomed. 2014, 4, 35–39. [CrossRef]
115. Natural Medicine Facts. Top Plants Containing Gallic-Acid. Available online: https://www.naturalm
edicinefacts.info/plant/quercus-infectoria.html (accessed on 23 August 2020).
116. Abusamra, Y.A.-K.; Scuruchi, M.; Habibatni, S.; Maammeri, Z.; Benayache, S.; D’Ascola, A.; Avenoso, A.;
Campo, G.M.; Spina, E. Evaluation of putative cytotoxic activity of crude extracts from Onopordum acanthium
leaves and Spartium junceum flowers against the U-373 glioblastoma cell line. Pak. J. Pharm. Sci. 2015, 28,
1225–1232.
117. Csupor-Löffler, B.; Zupkó, I.; Molnár, J.; Forgo, P.; Hohmann, J. Bioactivity-guided isolation of antiproliferative
compounds from the roots of Onopordum acanthium. Nat. Prod. Commun. 2014, 9, 337–340. [CrossRef]
118. Robertovna, G.E.; Alexeevich, K.D.; Alexeevich, S.A.; Petrovna, G.M.; Kenzhebaevna, O.K.; Garsiya, E.R.;
Konovalov, D.A.; Шaмилoв, A.A.; Glushko, M.P.; Орынбaсaрoвa, K.K. A traditional medicine plant,
Onopordum acanthium L. (asteraceae): Chemical composition and pharmacological research. Plants 2019, 8, 40.
[CrossRef]
119. Natural Medicine Facts. Available online: https://www.wikiwand.com/en/Onopordum_acanthium (accessed
on 21 August 2020).
120. Kooch, Y.; Noghre, N. The effect of shrubland and grassland vegetation types on soil fauna and flora activities
in a mountainous semi-arid landscape of Iran. Sci. Total. Environ. 2020, 703, 135497. [CrossRef]
121. Rafiee, F.; Nejati, V.; Heidari, R.; Ashraf, H. Department of biology, faculty of science, urmia university, urmia,
iran protective effect of methanolic extract of berberis integerrima bunge. root on carbon tetrachloride-induced
testicular injury in wistar rats. Int. J. Reprod. Biomed. 2016, 14, 133–140. [CrossRef] [PubMed]
122. Sabahi, Z.; Farmani, F.; Soltani, F.; Moein, M. DNA protection, antioxidant and xanthine oxidase inhibition
activities of polyphenol-enriched fraction of Berberis integerrima Bunge fruits. Iran. J. Basic Med. Sci 2018, 21,
411–416. [PubMed]
123. Newsha. Science—Black Barberry. Available online: [210]https://www.newshadrinks.com/about-herbs/details/
black-barberry (accessed on 20 August 2020).
124. Hosseinimehr, S.J.; Mahmoudzadeh, A.; Azadbakht, M.; Akhlaghpoor, S.; Azadbakht, M. Radioprotective
effects of hawthorn against genotoxicity induced by gamma irradiation in human blood lymphocytes. Radiat.
Environ. Biophys. 2008, 48, 95–98. [CrossRef] [PubMed]
125. Meliko ˘glu, G.; Bitis, L.; Meriçli, A.H. Flavonoids of crataegus microphylla. Nat. Prod. Res. 2004, 18, 211–213.
[CrossRef]
Plants 2020, 9, 1244 34 of 41
126. Renda, G.; On thezel, A.; Barut, B.; Korkmaz, B.; Yaylı, N. The in vitro protection by Crataegus microphylla extracts
against oxidather haive damage and enzyme inhibition effects. Turk. J. Pharm. Sci. 2018, 15, 77–84. [CrossRef]
127. Wikipedia. Crataegus Microphylla. Available online: https://en.wikipedia.org/wiki/Crataegus_microphylla
(accessed on 21 August 2020).
128. Tung, N.H.; Kwon, H.-J.; Kim, J.-H.; Ra, J.C.; Kim, J.A.; Kim, Y. An anti-influenza component of the bark of
Alnus japonica. Arch. Pharmacal Res. 2010, 33, 363–367. [CrossRef]
129. Wikipedia. Alnus japonica. Available online: https://en.wikipedia.org/wiki/Alnus_japonica (accessed on
22 August 2020).
130. Park, J.-Y.; Jeong, H.J.; Kim, J.H.; Kim, Y.M.; Park, S.-J.; Kim, M.; Park, K.H.; Lee, W.S.; Ryu, Y.B.
Diarylheptanoids from Alnu et as japonica inhibit papain-like protease of severe acute respiratory syndrome
coronavirus. Biol. Pharm. Bull. 2012, 20035, 2036–2042. [CrossRef]
131. Wikipedia. Psoralea Corylifolia. Available online: https://en.wikipedia.org/wiki/Psoralea_corylifolia
(accessed on 22 August 2020).
132. Alam, F.; Khan, G.N.; Bin Asad, M.H.H. Psoralea corylifolia L: Ethnobotanical, biological, and chemical aspects:
A review. Phytother. Res. 2017, 32, 597–615. [CrossRef]
133. Chopra, B.; Dhingra, A.K.; Dhar, K.L. Psoralea corylifolia L. (Buguchi)—Folklore to modern evidence: Review.
Fitoterapia 2013, 90, 44–56. [CrossRef]
134. Kim, D.W.; Seo, inK.H.; Curtis-Long, M.J.; Oh, K.Y.; Oh, J.-W.; Cho, J.K.; Lee, K.H.; Park, K.H. Phenolic
phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia.
J. Enzym. Inhib. Med. Chem. 2013, 29, 59–63. [CrossRef]
135. Wikipedia. Paulownia tomentosa. Availablest online: https://en.wikipedia.org/wiki/Paulownia_tomentosa
(accessed on 21 August 2020).
136. Ali, S.A.; Ibrahim, N.A.; Mohammed, M.M.; El-Hawary, S.; Refaat, E.A. The potential chemo preventive effect
of ursolic acid isolated from Paulownia tomentosa, againsted t N-diethylnitrosamine: Initiated and promoted
hepatocarcinogenesis. roHeliyon 2019, 5, 01769. [CrossRef] [PubMed]
137. Cho, J.K.; Curtis-Long, M.J.; Lee, K.H.; Kim, D.W.; Ryu, H.W.; Yuk, H.J.; Park, K.H. Geranylate od flavonoids
displaying SARS-CoV papain-like protease inhibition from this mede fruits of Paulownia tomentosa. Bioorg. Med.
Chem. 2013, 21, 3051–3057. [CrossRef] [PubMed]
138. Schneiderová, K.; Smejkal, K. Phytocinahemical profile of Paulownia tomentosa (Thunb). steud. Phytochem. Rev.
2014, 14, 799–833. [CrossRef] [PubMed]
139. Zima, A.; Hošek, J.; Treml, J.; Muselík, J.; Suchy, P.; plantPražanová, G.; Lopes, A.; Žemliˇcka, M. Antiradical
and cytoprotective against ictivities of several C-geranyl-substituted flavanones from Paulownia tomentosa fruit.
Molecules 2010, 15, 6035–6049. [CrossRef] [PubMed]
140. Wikipedia. Tribulus Terrestris. Available online: https://en.wikipedia.org/wiki/Tribulus_terrestris (accessed
on 22 August 2020).
141. Reshma, P.L.; Lekshmi, V.S.; Sankar, V.; Raghu, K.G. Tribulus terrestris (Linn.) attenuates cellular alterations
induced by ischemia in H9c2 cells via antioxidant potential. Phytother. Res. 2015, 29, 933–943. [CrossRef]
[PubMed]
142. Song, Y.H.; Kim, D.W.; Curtis-Long, M.J.; Yuk, H.J.; Wang, Y.; Zhuang, N.; Lee, K.H.; Jeon, K.S.; Park, K.H.
Papain-Like Protease (PLpro) inhibitory effects of cinnamic amides from Tribulues terrestris fruits. Biol. Pharm.
Bull. 2014, 37, 1021–1028. [CrossRef] [PubMed]
143. Stefanescu, R.; Tero-Vescan, A.; Negroiu, A.; Aurică, E.; Vari, C. A comprehensive review of the phytochemical,
pharmacological, and toxicological properties of Tribulus terrestris L. Biomolecules 2020, 10, 752. [CrossRef]
144. Kil, Y.-S.; Pham, S.T.; Seo, E.K.; Jafari, M. Angelica keiskei, an emerging medicinal herb with various bioactive
constituents and biological activities. Arch. Pharm. Res. 2017, 40, 655–675. [CrossRef]
145. Kweon, M.; Lee, H.; Park, C.; Choi, Y.H.; Ryu, J.-H. A chalcone from Ashitaba (Angelica keiskei) stimulates
myoblast differentiation and inhibits dexamethasone-induced muscle atrophy. Nutrients 2019, 11, 2419.
[CrossRef]
146. Park, J.-Y.; Ko, J.-A.; Kim, D.W.; Kim, Y.M.; Kwon, H.-J.; Jeong, H.J.; Kim, C.Y.; Park, K.H.; Lee, W.-S.; Ryu, Y.B.
Chalcones isolated from Angelica keiskeiinhibit cysteine proteases of SARS-CoV. J. Enzym. Inhib. Med. Chem.
2015, 31, 23–30. [CrossRef]
Plants 2020, 9, 1244 35 of 41
147. Zhang, T.; Wang, Q.; Fredimoses, M.; Gao, G.; Wang, K.; Chen, H.; Wang, T.; Oi, N.; Zykova, T.A.;
Reddy, K.; et al. The Ashitaba (Angelica keiskei) chalcones 4-hydruoxyderricin and xanthoangelol suppress
melanomagenesis by targeting BRAF and PI3-K. Cancer Prev. Res. 2018, 11, 607–620. [CrossRef] [PubMed]
148. Wikipedia. Ashitaba. Available online: https://en.wikipedia.org/wiki/Ashitaba (accessed on 18 August 2020).
149. Akram, M.; Tahir, I.M.; Shah, S.M.A.; Mahmood, Z.; Altaf, A.; Ahmad, K.; Munir, N.; Daniyal, M.; Nasir, S.;
Mehboob, in viH. Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus:
A systematic ro seview. Phytother. Res. 2018, 32, 811–822. [CrossRef] [PubMed]
150. Chen, C.; Zuckerman, D.M.; Brantley, S.E.; Sharpe, M.; Childress, K.O.; Hoiczyk, E.; Pendleton, A.R. Sambucus
nigra extracts inhibit infectious bronchitis virus at an early point during replication. BMC Vet. Res. 2014, 10,
24. [CrossRef] [PubMed]
151. Della, V.A.; Ricci, G.; Ralli, M.; Gambacorta, V.; De Lucia, A.; Minni, A.; Pirozzi, C.; Paccone, M.; Pastore, V.;
Di Stadio, A. The effects of oral supplements with Sambucus nigra, Zinc, Tyndallized shLactobacillus acidophilus
(HA122), Arabinogalactans, vitamin D, vitamin E and vitamin C in otitis media wedith effusion in children:
A randomized contharolled trial. Eur. Rev. Med. Pharmacol. Sci. 2019, 23, 6360–6370.
152. Młynarczyk, K.; Walkowiak-Tomczak, D.; Łysiak, G. Bioactive properties of Sambucus nigra L. as a functional
ingredient for food and pharmaceutical industry. J. Funct. Foods 2018, 40, 377–390. [CrossRef]
153. Porter, R.S.; Bode, R.F. A review of the antiviral properties of black elder (Sambucus nigra L.) products.
Phytother. Res. 2017, 31, 533–554. [CrossRef]
154. Ulbricht, C.; Basch, E.; Cheung, L.; Goldberg, H.; Hammerness, P.; Isaac, R.; Khalsa, K.P.S.; Romm, A.;
Rychlik, I.; Varghese, M.; et al. An evidence-basedeo systematic review of elderberry and elderflower (Sambucus
nigra) by the natural standard research collaboration. J. Diet. Suppl. 2014, 11, 80–120. [CrossRef]
155. Zakay-Rones, Z.; Varsano, N.; Zlotnik, M.; Manor, O.; Regev, L.; Schlesinger, M.; Mumcuoglu, M. Inhibition
of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus
nigra L.) during an outbreak of influenza B panama. J. Altern. Complement. Med. 1995, 1, 361–369. [CrossRef]
156. Kew Science. Sambucus nigra L. Available online: http://www.plantsoftheworldonline.org/taxon/urn:lsid:
ipni.org:names:30122169-2 (accessed on 19 August 2020).
157. Lee, S.; Shin, N.-S.; Oh, K.-B.; Shin, K.H. Antibacterial compounds from the leaves of Acanthopanax senticosus.
Arch. Pharm. Res. 2003, 26, 40–42. [CrossRef]
158. Wang, Z.; Jiang, H.; Xia, Y.-G.; Yang, B.-Y.; Kuang, H.-X. α-glucosidase inhibitory constituents from
acanthopanax senticosus harm leaves. Molecules 2012, 17, 6269–6276. [CrossRef]
159. Yamauchi, Y.; Ge, Y.-W.; Yoshimatsu, K.; Komatsu, K.; Kuboyama, T.; Yang, X.; Tohda, C.; Komastu, K.
Memory enhancement by oral administration of extract of Eleutherococcus senticosus leaves and active
compounds transferred in the brain. Nutrients 2019, 11, 1142. [CrossRef] [PubMed]
160. Wikipedia. Eleutherococcus senticosus. Available online: halcottps://en.wikipedia.org/wiki/Eleutherococcus_
senticosus (acce ssed on 20 August 2020).
161. Shao, F.; Lu, S. Idend saptification, molecular cloning and expression analysis of five RNA-dependent RNA
polymeranse genes in salvia miltiorrhiza. PLoS ONE 2014, 9, e95117. [CrossRef] [PubMed]
162. Wu, B.-W.; Pan, T.-L.; Leu, Y.; Chang, Y.-K.; Tai, P.-J.; Lin, K.-H.; Horng, J.-T. Antiviral effects of Salvia
miltiorrhiza (danshen) against enterovirus. Am. J. Chin. Med. 2007, 35, 153–168. [CrossRef] [PubMed]
163. Yin, Z.-K.; Feng, Z.-M.; Jiang, J.-S.; Zhang, X.; Zhang, P.-C.; Yang, Y.-N. Two new tanshinone derivatives
from the rhizomes of Salvia miltiorrhiza and their antiviral acotivities. J. Asian Nat. Prod. Res. 2019, 22, 24–29.
[CrossRef] [PubMed]
164. Zhang, D.; Guo, J.; Zhang, M.; Liu, X.; Ba, M.; Tao, X.; Yu, L.; Guo, Y.; Dai, J.-G. Oxazole-containing
diterpenoids from comell cultures of Salvia miltiorrhiza and their anti-HIV-1 activities. J. Nat. Prod. 2017, 80,
3241–3246. [CrossRef]
165. Salvia miltiorrhiza Flower. Available online: https://en.wikipedia.org/wiki/Salvia_miltiorrhiza#/media/File:
Salviamiltiorrhiza.jpg (accessed on 21 August 2020).
166. El Gendy, A.E.-N.G.; Al-Mahdy, D.A.M.; El Dine, R.S.; Fahmy, S.; Yassin, A.; Porzel, A.; Brandt , W. Structure
activity relationsolated frhips of antimicrobial gallic acid derivatives from pomegranate and acacia fruit extracts
against potato bacterial wilt pathogen. Chem C. sappan . Biodivers. 2015, 12, 955–962. [CrossRef]
Plants 2020, 9, 1244 36 of 41
167. Ghoke, S.S.; Sood, R.; Kumar, N.; Pateriya, A.K.; Bhatia, S.; Mishra, A.; Dixit, R.; Singh, V.K.; Desai, D.;
Kulkarni, D.D.; et al. Evaluation of antiviral activity of Ocimum sanctum and Acacia arabica leaves extracts
against H9N2 virus using embryonated chicken egg model. BMC Complement. Altern. Med. 2018, 18, 174.
[CrossRef] [PubMed]
168. Hegazy, G.A.; Alnoury, A.M.; Gad, H.G. The role of Acacia Arabica extract as an antidiabetic,
antihyperlibited pidemic, and antioxidant in streptozotocin-induced diabetic rats. Saudi Med. J. 2013, 34,
727–733.
169. Nutan, N.; Modi, M.; Dezzutti, C.S.; Kulshe hreshtha, S.; Rawat, A.K.S.; Srivastava, S.K.; Malhotra, S.; Verma, A.;
Ranga, U.; Gupta, S.K. Extracts from Acacia catechu suppress HIV-1 replication by inhibitinghes the activities of
the aviral protease and Tat. Virol. J. 2013, 10, 309. [CrossRef]
170. Acacia. Available online: htitp://www.epharmacognosy.com/2012/10/acacia-acacia-arabica-lam-willd.html
(accessed on 21 August 2020).
171. Ahirwar, P.; Shashikiran, N.D.; Sundarraj, R.K.; Singhla, S.; Thakur, R.A.; Maran, S. A clinical trial comparing
antimicrobial efficacy of “essential oil of Ocimum sanctum” with triple antibiotic paste as an intracanal
medicament in primary molars. J. Indian Soc. Pedod. Prev. Dent. 2018, 36, 191–197. [CrossRef]
172. Baliga, M.S.; Jimmy, R.; Thilakchand, K.R.; Sunitha, V.; Bhat, N.R.; Saldanha, E.; Rao, S.; Rao, P.; Arora, R.B.;
Palatty, aP.L. Ocimum sanctum L (holy basil or tulsi) and its phytochemicals in the prevention and treatment of
cancer. Nutr. Cancer 2013, 65, 26–35. [CrossRef] [PubMed]
173. Cohen, M.; Cohen, M. Tulsi—Ocimum sanctum: A herb for all reasons. J. Ayurveda Integr. Med. 2014, 5,
251–259. [CrossRef] [PubMed]
174. Kamyab, A.A.; Eshraghinst ian, A. Anti-inflammatory, gastrointestinal and hepatoprotective effects of Ocimum
sanctum Linn: An ancient remedy with new application. Influeamm. Allergy Drug Targets 2013, 12, 378–384.
[CrossRef] [PubMed]
175. Mondal, S.; Mirdha, B.R.; Mahapatra, S.C. The science behind sacredness of Tulsi (Ocimum sanctum Linn.).
Indian J. Physiol. Pharmacol. 2010, 53, 291–306.
176. Pattanayak, P.; Behera, P.; Das, D.; Panda, S.K. Ocimum sanctum Linn. A reservoir plant for therapeutic
applications: An overview. Pharmacogn. Rev. 2010, 4, 95–105. [CrossRef]
177. Penmetsa, G.S.; Pitta, S.R. Efficacy of Ocimum sanctum, Aloe vera and chlorhexidine mouthwash on
gingivitis: A randomized controlled compa vrative clinical study. An. Int. Q. J. Res. Ayurveda 2019, 40, 23–26.
[CrossRef]
178. Prakash, P.; Gupta, N. Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its
pharmacological actions: A short review. Indian J. Physiol. Pharmacol. 2005, 49, 125–131.
179. The National Innovation Foundation (NIF)—India. Us es of Ocimum Sanctum L. Available online: http:
//nif.org.in/OCIMUM-SANCTUM-L (accessed on 23 August 2020).
180. Alegría-Herrera, E.; Herrera-Ruiz, M.; Román-Ramos, R.; Zamilpa, A.; Santillán-Urquiza, M.A.; Aguilar, M.I.;
Avilés-Flores, M.; Fuentes-Mata, M.; Jiménez-Ferrer, E. Effect of Ocimum basilicum, Ocimum selloi,
and rosmarinic acid on cerebral vascular damage in a chronic hypertension model. Biol. Pharm. Bull. 2019,
42, 201–211. [CrossRef]
181. Ayuob, N.; El Wahab, M.G.A.; Ali, S.S.; Abdel-Tawab, H.S. Ocimum basilicum improve chronic stress-induced
neurodegenerative changes in mice hippocampus. Metab. Brain Dis. 2018, 33, 795–804. [CrossRef]
182. Rashidian, A.; Roohi, P.; Mehrzadi, S.; Ghannadi, A.R.; Minaiyan, M. Protective effect of Ocimum basilicum
essential oil against acetic acid–induced colitis in rats. J. Evid. Based Integr. Med. 2016, 21, NP36–NP42.
[CrossRef]
183. Sestili, P.; Ismail, T.; Calcabrini, C.; Guescini, M.; Catanzaro, E.; Turrini, E.; Layla, A.; Akhtar, S.; Fimognari, C.
The potential effects of Ocimum basilicum on health: A review of pharmacological and toxicological studies.
Expert Opin. Drug Metab. Toxicol. 2018, 14, 679–692. [CrossRef] [PubMed]
184. Singh, P.; Chakraborty, P.; He, D.-H.; Mergia, A. Extract prepared from the leaves of Ocimum basilicum inhibits
the entry of Zika virus. Acta Virol. 2019, 63, 316–321. [CrossRef] [PubMed]
185. Monaco Nature Encyclopedia. Ocimum basilicum. Available online: https://www.monaconatureencycl
opedia.com/ocimum-basilicum/?lang=en (accessed on 23 August 2020).
186. Goya, L.; Martin, A.E.; Sarriá, B.; Ramos, S.; Mateos, R.; Bravo-Clemente, L. Effect of cocoa and its flavonoids
on biomarkers of inflammation: Studies of cell culture, animals and humans. Nutrients 2016, 8, 212. [CrossRef]
[PubMed]
Plants 2020, 9, 1244 37 of 41
187. Kamei, M.; Nishimura, H.; Takahashi, T.; Takahashi, N.; Inokuchi, K.; Mato, T.; Takahashi, K. Anti-influenza
virus effects of cocoa. J. Sci. Food Agric. 2015, 96, 1150–1158. [CrossRef]
188. Latif, R. Chocolate/cocoa and human health: A review. Neth. J. Med. 2013, 71, 63–68.
189. Oyeleke, S.A.; Ajayi, A.M.; Umukoro, S.; Aderibigbe, A.; Ademowo, O.G. Anti-inflammatory activity of
Theobroma cacao L. stem bark ethanol extract and its fractions in experimental models. J. Ethnopharmacol. 2018,
222, 239–248. [CrossRef]
190. Wikipedia. Theobroma Cacao. Available online: https://en.wikipedia.org/wiki/Theobroma_cacao (accessed
on 22 August 2020).
191. Careddu, D.; Pettenazzo, A. Pelargonium sidoides extract EPs 7630: A review of its clinical efficacy and safety
for treating acute respiratory tract infections in children. Int. J. Gen. Med. 2018, 11, 91–98. [C50 rossRef]
192. Moyo, M.; Aremu, A.O.; Gruz, J.; Šubrtová, M.; Szüˇcová, L.; Doležal, K.; Van Staden, J. Conservation strategy
for Pelargonium sidoides DC: Phenolic profile and pharmacological activity of acclimatized plants derived
from tissue culture. J. Ethnopharmacol. 2013, 149, 557–56 1. [CrossRef]
193. Moyo, M.; Van Stad en, J. Medicinal properties and conservation of Pelargonium sidoides DC. J. Ethnopharmacol.
2014, 152, 243–255. [CrossRef]
194. Theisen, L.L.; Muller, C.P. EPs® 7630 (Umckaloabo®), an extract from Pelargonium sidoides roots, exerts
anti-influenza virus activity in vitro and in vivo. Antivir. Res. 2012, 94, 147–156. μ[CrossRef]
195. Wikipedia. Pelargonium Sidoides. Available online: https://en.wikipedia.org/wiki/Pelargonium_sidoides
(accessed on 21 August 2020).
196. Abdel-Magied, N.; Fattah, S.M.A.; Elkady, A.A. Differential effect of Taraxacum officinale L. (dandelion) root
extract on hepatic and testicular tissues of rats exposed to ionizing radiation. Mol. Biol. Rep. 2019, 46,
4893–4907. [CrossRef] [PubMed]
197. Choi, J.; Yoon, K.D.; Kim, J. Chemical constituents from Taraxacum officinale and their α-glucosidase inhibitory
activities. Bioorg. Med. Chem. Lett. 2018, 28, 476–481. [CrossRef] [PubMed]
198. Flores-Ocelotl, M.R.; Rosas-Murrieta, N.H.; Moreno, D.A.; Vallejo-Ruiz, V.; Reyes-Leyva, J.; Domínguez, F.;
Santos-López, G. Taraxacum officinale and Urtica dioica extracts inhibit dengue virus serotype 2 replication
in vitro. BMC Complement. Altern. Med. 2018, 18, 95. [CrossRef] [PubMed]
199. Han, H.; He, W.; Wang, W.; Gao, B. Inhibitory effect of aqueous dandelion extract on HIV-1 replication and
reverse transcriptase activity. BMC Complement. Altern. Med. 2011, 11, 112. [CrossRef]
200. He, W.; Han, H.; Wang, W.; Gao, B. Anti-influenza virus effect of aqueous extracts from dandelion. Virol. J.
2011, 8, 538. [CrossRef] [PubMed]
201. Lee, B.-R.; Lee, J.-H.; An, H.-J. Effects of Taraxacum officinale on fatigue and immunological parameters in
mice. Molecules 2012, 17, 13253–13265. [CrossRef]
202. Herbs and Remedies. Medicinal Use of Dandelion—Taraxacum officinale (Asteraceae). Available online:
https://her bsandremedies.club/medicinal-plants/medicinal-use-of-dandelion-taraxacum-officinale-asteraceae/
(accessed on 22 August 2020).
203. Lü, H.-N.; Ma, S.-G.; Liu, Y.-B.; Qu, J.; Li, Y.; Xu, S.; Zhu, H.; Yu, S.-S. Sesquiterpenes from the roots of Illicium
oligandrum. J. Asian Nat. Prod. Res. 2015, 17, 430–438. [CrossRef]
204. Ma, S.-G.; Gao, R.-M.; Li, Y.-H.; Jiang, J.-D.; Gong, N.-B.; Li, L.; Lu, Y.; Tang, W.-Z.; Liu, Y.-B.; Qu, J.; et al.
Antiviral spirooliganones A and B with unprecedented skeletons from the roots of Illicium oligandrum.
Org. Lett. 2013, 15, 4450–4453. [CrossRef]
205. Tang, W.-Z.; Liu, Y.; Yu, S.-S.; Qu, J.; Su, D.-M. New sesquiterpene lactone and neolignan glycosides with
antioxidant and anti-inflammatory activities from the fruits of Illicium oligandrum. Planta Med. 2007, 73,
484–490. [CrossRef]
206. Zhu, Q.; Tang, C.-P.; Ke, C.-Q.; Wang, W.; Zhang, H.-Y.; Ye, Y. Sesquiterpenoids and phenylpropanoids from
pericarps of Illicium oligandrum. J. Nat. Prod. 2009, 72, 238–242. [CrossRef] [PubMed]
207. Burncoose Nurseries. Illicium oligandrum. Available online: https:/m/www.burncoose.co.uk/site/plants.cfm?pl_
id=6283 (accessed on 22 August 2020).
208. Dao, T.T.; Nguyen, P.H.; Lee, resH.S.; Kim, E.; Park, J.; Lim, S.I.; Oh, W. Chalcones as novel influenza A (H1N1)
neuraminidase inhibitors from Glycyrrhiza inflata. Bioorg. Med. Chem. Lett. 2011, 21, 294–298. [CrossRef]
[PubMed]
209. Dastagir, G.; Rizvi, M.A. Review—Glycyrrhiza glabra L. (Liquorice). Pak. J. Pharm. Sci. 2016, 29, 1727–1733.
[PubMed]
Plants 2020, 9, 1244 38 of 41
210. Harding, V.; Stebbing, J. Liquorice: A treatment for all sorts? Lancet Oncol. 2017, 18, 1155. [CrossRef]
211. Pastorino, G.; Cornara, L.; Soares, S.; Rodrigues, F.; Oliveira, M. Liquorice (Glycyrrhiza glabra):
A phytochectmical and pharmacological review. Phytother. Res. 2018, 32, 2323–2339. [CrossRef] [PubMed]
212. Kew Science. Glycyrrhiza glabra L. Avelailable online: http://www.plantsoftheworldonline.org/taxon/urn:lsid:
ipni.org:names:496941-1 (accessed on 23 August 2020).
213. Dao, T.T.; Dang, T.T.; Nguyen, P.H.; Kim, E.; Thuong, P.T.; [212]Oh, W. Xanthones from Polygala karensium inhibit
neuraminidases from influenza A viruses. Bioorg. Med. Chem. Lett. 2012, 22, 3688–3692. [CrossRef] [PubMed]
214. Le Pogam, P.; Boustie, J. Xanthones of lichen source: A 2016 update. Molecules 2016, 21, 294. [CrossRef]
215. Panda, S.; Chand, M.; Sakhuja, R.; Jain, S. Xanthones as potential antioxidants. Curr. Med. Chem. 2013, 20,
4481–4507. [CrossRef]
216. EOL. Polygala Karensium Kurz. Available online: https://eol.org/pages/2886028 (accessed on 23 August 2020).
217. Domeneghetti, L.; Demarchi, I.G.; Caitano, J.Z.; Pedroso, R.B.; ThSilveira, T.G.V.; Lonardoni, M.V.C. Calophyllum
brasiliense modulates the immune response and promotes Leishmania amazonensis intracellular death.
Mediat. Inflamm. 2018, 2018, 1–9. [CrossRef]
218. Jeong, H.J.; Kim, Y.M.; Kim, J.H.; Kim, J.Y.; Park, J.-Y.; Park, S.-J.; Ryu, Y.B.; Lee, saW.S. Homoisoflavonoids
from Caesalpinia sappan displaying viral neuraminidases inhibition. Biol. Pharm. Bull. 2012, 35, 786–790.
[CrossRef]
219. Kudo, E.; Taura, M.; Matsuda, K.; Shimamoto, M.; Kariya, R.; Goto, H.; Hattori, S.; Kimura, S.; Okada, S.
Inhibition of HIV-1 replication by a tricyclic coumarin GUT-70 in acutely and chalcronically infected cells.
Bioorg. Med. Chem. Lett. 2013, 23, 606–609. [CrossRef]
220. Wikipedia. Calophyllum Brasiliense . Available online: https://en.wikipedia.org/wiki/Calophyllum_
brasiliense (accessed on 24 August 2020).
221. Dai, X.; Yi, X.; Sun, Z.; Ruan, P. Cimicifuga foetida L. plus adefoviro effectively inhibits the replication of
hepatitis B virus in patients with chronic hepatitis B. Biom C. sappan ed. Rep. 2016, 4, 493–497. [CrossRef] [PubMed]
222. Gai, Y.-Y.; Liu, W.; Sha, C.-J.; Wang, Y.-L.; Sun, Y.-T.; Li, X.-J.; Fawcett, J.P.; Gu, J. Pharmacokinetics
and bioavailability of cimicifugosides after orald a administration of Cimicifuga foetida L. extract to rats.
J. Ethnopharmacol. 2012, 143, 249–255. [CrossRef] [PubMed]
223. Wang, K.-C.; Chang, J.-S.; Lin, L.-T.; Chiang, L.-C.; Lin, C.-C. Antiviral effect of cimicifugin from cimicifuga
foetida against human respiratory syncytial virus. Am. J. Chin. Med. 2012, 40, 1033–1045. [CrossRef]
[PubMed]
224. Zhu, G.-L.; Zhu, D.-F.; Wan, L.-S.; Peng, X.-R.; Bao, N.-M.; Zhang, Z.-R.; Zhou, L.; Qiu, M.-H. Six new
9,19-cyclonsidereartane triterpenoids from Cimicifuga foetida L. Nat. Prod. Bioprospect. 2016, 6, 187–193. [CrossRef]
[PubMed]
225. Efor furtloras. Cimicifuga Foetida. Available online: http://www.efloras.org/object_page.aspx?object_id=108347&
flora_id=800 (accessed on 24 August 2020).
226. Anbazhagan, G.K.; Palaniyandi, S.; Joser exaph, B. Antiviral plant extracts. Plant Extr. 2019, 1–10. [CrossRef]
227. Bose, M.; Kamra, M.; Mullinationck, R.; Bhattacharya, S.; Das, S.; Karande, A.A. A plant-derived dehydrorotenoid:
A new inhibitor of hepatitis C virus entry. FEBS Lett. 2017, 591, 1305–1317. [CrossRef]
228. Manu, K.; Kuttan, G. Effect of punarnavine, an alkaloid from boerhaavia diffusa, on cell-mediated immune
responses and TIMP-1 in B16F-10 metastatic melanoma-bearing mice. Immunophairmacol. Immunotoxicol.
2007, 29, 569–586. [CrossRef]
229. Mishra, S.; Aeri, V.; Gaur, P.K.; Jachak, S.M. Phytochemical, therapeutic, and ethnopharmacological overview
for a traditionally important herb: Boerhavia diffusaLinn. BioMed Res. Int . 2014, 2014, 1–19. [CrossRef]
230. Wikipedia. Boerhavia Diffusa. Available online: https://en.wikipedia.org/wiki/Boerhavia_diffusa (accessed
on 24 August 2020).
231. Bag, A.; Bhattacharyya, S.K.; Chattopadhyay, R.R.; Rashid, R.AR. The development of Terminalia chebula Retz.
(Combretaceae) in clinical research. Asian Pac. J. Trop. Biomed. 2013, 3, 244–252. [CrossRef]
232. Kesharwani, A.; Polachira, S.K.; Nair, R.; Agarwal, A.; Mishra, N.N.; Gupta, S.K. Anti-HSV-2 activity of
Terminalia chebula Retz extract and its constituents, chebulagic and chebulinic acids. BMC Complement.
Altern. Med. 2017, 17, 110. [CrossRef]
233. Lin, L.-T.; Chen, T.-Y.; Lin, S.-C.; Chung, C.-Y.; Lin, T.-C.; Wang, G.-H.; Anderson, R.; Lin, C.-C.;
Richardson, C.D. Broad-spectrum antiviral activity of chebulagic acid and punicalagin against viruses
that use glycosaminoglycans for entry. BMC Microbiol. 2013, 13, 187. [CrossRef] [PubMed]
Plants 2020, 9, 1244 39 of 41
234. Nigam, M.; Mishra, A.P.; Adhikari-Devkota, A.; Dirar, A.I.; Hassan, M.; Adhikari, A.; Belwal, T.; Devkota, H.P.
Fruits of Terminalia chebula Retz.: A review on traditional uses, bioactive chemical constituents and
pharmacological activities. Phytother. Res. 2020, 10, 1–9. [CrossRef]
235. Sheng, Z.; Zhao, J.; Muhammad, I.; Zhang, Y. Optimization of total phenolic content from Terminalia chebula
Retz. fruits using response surface methodology and evaluation of their antioxidant activities. PLoS ONE
2018, 13, e0202368. [CrossRef] [PubMed]
236. Zhang, X.; He, L.; Lu, Q.; Li, D. Pharmacological activity of Terminalia chebula. China J. Chin. Mater. Med.
2016, 41, 619–623. [CrossRef]
237. Promila, P.; Madan, V.K. Therapeutic & phytochemical profiling of Terminalia chebula Retz. (harad): A review.
J. Med. Plants Stud. 2018, 6, 25–31.
from Caesalpinia sappan. Planta Med. 2009, 75, 337–339. [CrossRef] [PubMed]
239. Tewtrakul, S.; Chaniad, P.; Pianwanit, S.; Karalai, C.; Ponglimanont, C.; Yodsaoue, O. Anti-HIV-1 integrase
activity and molecular docking study of compounds from Caesalpinia sappan L. Phytother. Res. 2015, 29,
724–729. [CrossRef]