Calorie restriction (CR) is a commonly used food restriction (FR) strategy that restricts everyday energy intake without incurring malnutrition. Intermittent fasting (IF) refers to cycles of fasting and intermittent feeding window over a given time schedule. Traumatic brain injury (TBI), a temporary or permanent disruption of normal brain function due to damage incurred by external forces, is a major burden on those effected. Various CR and IF regimens have recently been reported to exert neuroprotective effects in TBI through variable mechanisms.