Haptoglobin (Hp) is a blood serum glycoprotein responsible for binding and removing toxic free hemoglobin from the vasculature. Understanding the role of the various Hp isoforms in patients with sickle cell disease (SCD) is critical in combating blood toxicity, inflammation, oxidative stress, and even stroke. Ischemic stroke occurs when a blocked vessel decreases oxygen delivery in the blood to cerebral tissue and is commonly associated with SCD, and Hp can potentially help to understand how this occur and how to potentially prevent the neurological damage..