: We have witnessed noteworthy progress in our understanding of prostate cancer over

the past decades. This basic knowledge has been translated into efficient diagnostic and treatment

approaches leading to the improvement in patient survival. However, the molecular pathogenesis of

prostate cancer appears to be complex, and histological findings often do not provide an accurate

assessment of disease aggressiveness and future course. Moreover, we also witness tremendous racial

disparity in prostate cancer incidence and clinical outcomes necessitating a deeper understanding

of molecular and mechanistic bases of prostate cancer. Biological research heavily relies on model

systems that can be easily manipulated and tested under a controlled experimental environment.

Over the years, several cancer cell lines have been developed representing diverse molecular subtypes

of prostate cancer. In addition, several animal models have been developed to demonstrate the

etiological molecular basis of the prostate cancer. In recent years, patient-derived xenograft and 3-D

culture models have also been created and utilized in preclinical research. This review is an attempt

to succinctly discuss existing information on the cellular and molecular progression of prostate cancer.

We also discuss available model systems and their tested and potential utility in basic and preclinical

prostate cancer research.