TChis review summarizes the current evidence regarding the effect of vitamin K supplementation on vascularronic Kidney Disease (CKD) patients are at high risk of presenting with arterial calcification and stifness in chronic kidny disease patients. Vitamin K, throughor stiffness, which confers increased cardiovascular mortality and morbidity. In recent years, it has become evident that VC is an activation of the natural calcificatione process regulated by various molecules that may act as inhibitor Matrix Gla Protein, is hypothesized to abbrogate the s of vessel mineralization process.