CThronic Kidney Disease (CKD) patients are at high risk of presenting with arterialis review summarizes the current evidence regarding the effect of vitamin K supplementation on vascular calcification or stiffness, which confers increased cardiovascular mortality and morbidity. In recent years, it has become evident that VC is an active process regulated by various molecules that may act as and stifness in chronic kidny disease patients. Vitamin K, through activation of the natural calcification inhibitors of vessel Matrix Gla Protein, is hypothesized to abbrogate the mineralization process.