GPCR signaling in the carotid-body: Comparison
Please note this is a comparison between Version 2 by Conner Chen and Version 1 by Hayyaf Aldossary.

       This article focuses on the influence of G-Protein-Coupled Receptors (GPCRs) on the Carotid Body (CB) during pathological conditions characterized by chronic hypoxia such as chronic obstructive pulmonary disease, obstructive sleep apnea and heart failure ae carotid body (CB) is a vital sensory organ, located near the carotid bifurcation, that constantly monitors blood supplying the brain. The CB is stimulated by acute hypoxia, upon which it rapidly activates vital cardiovascular and respiratory reflexes, including peripheral vasoconstriction, elevated heart rate and increased breathing. These ensure that sufficient blood-oxygen is delivered to the brain to support survival. It is now apparent that there are numerous G-protein-coupled receptors (GPCRs) expressed in the CB, and that modulation of these receptors is able to alter baseline CB activity and the ability of targeting GPCRs for treating such conditionssensitivity to hypoxia. Indeed, components of GPCR signaling pathways represent some of the most highly expressed genes in the rodent CB. 

  • G-protein
  • GPCR
  • carotid body
  • hypoxia
  • hypertension
  • drug-discovery
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