Please note this is a comparison between Version 1 by Camillo Peracchia and Version 6 by Bruce Ren.
In the past four decades numerous findings have indicated that gap junction channel gating is mediated by intracellular calcium concentrations ([Ca2+i]) in the high nanomolar range via calmodulin (CaM). We believe that CaM directly closes the channel by a cork-like gating mechanism.