Contact Dermatitis in Nail Cosmetics: Comparison
Please note this is a comparison between Version 2 by Jessie Wu and Version 1 by Zoe Morgan Lipman.

Many ingredients found within nail cosmetic products are capable of sensitizing patients’ immune systems and causing contact dermatitis (CD). Below wthis e discusntry describes the most common allergens found within these products, how to identify them, and how to treat the contact dermatitis they’ve caused. 

  • common nail cosmetic products
  • Nail cosmetics
  • contact dermatitis

1. Common Nail Cosmetic Products and Associated Allergens

According to modern beauty standards, aesthetically pleasing nails have a glossy, smooth surface, no overhanging or ragged cuticles, a tip extending beyond the nail plate, an oval contour to the nail plate, and a gentle curve when visualized from the side [1]. A variety of products can be used to achieve these looks, including liquid nail polish, nail wraps, gel nail polish, dipping powders, and acrylics (often referred to as “tips”) [4][2]. Other nail care products include nail strengthener, cuticle softener, and nail hydrating polishes, oils, and serums. More detailed descriptions of these products can be found in Table 1. Regular manicures using nail polish and gel manicures are the two most popular nail cosmetic procedures in the USA [3].
Table 1.
Description of common nail cosmetic products.
While the products discussed above are certainly useful in enhancing nail appearance, various ingredients within these products can produce both ACD and ICD. While the list of these ingredients is extensive, a recent retrospective analysis of patch testing results performed in those diagnosed with CD secondary to nail cosmetic ingredients most frequently revealed positive reactions in response to hydroxyethyl methacrylate (56.6%), tosylamide (36.2%), methylmethacrylate (27.8%), ethyl acrylate (25.2%), and ethyl-2-cyanoacrylate (6.9%) [9][4]. We discuss these and other common ingredients below:
  • Tosylamide/formaldehyde resin (TSFR) has long been known to be the most common cause of ACD related to nail polish, with data from the North American Contact Dermatitis Group (NACDG) suggesting that 4% of all positive patch tests involved sensitivity to TSFR [13][5]. It has been found to sensitize both nail components as well as produce ectopic ACD in areas of touching, scratching, or rubbing [14][6]. Because of this, many nail polish brands have switched formulation to include tosylamide epoxy resin instead; however, this has also been shown to sensitize both locally and ectopically [15][7].
  • Methacrylates (powder and liquid) are mixed to form a flexible polymer for acrylic manicures. These ingredients can also be found in smaller quantities in both regular and gel nail polish. The three most common allergenic forms of these ingredients are 2-hydroxyethyl methacrylate (2-HEMA), 2-hydroxypropyl methacrylate (2-HPMA), and ethylene glycol dimethacrylate (EGDMA) [16,17][8][9]. These ingredients are most sensitizing in their liquid form (during application) and rarely cause reactions once hardened and cured. In addition, methacrylates are extremely cross-reactive with one another, so people are often allergic to multiple [15][7].
  • Acrylates are mainly used in gel manicure systems. These include 2-hydroxyethyl acrylate (2-HEA), 2-ethylhexyl acrylate (2-EHA), 2-hydroxypropyl acrylate (2-HPA), ethyl acrylate (EA), and triethylene glycol diacrylate (TREGDA) [18][10]. With the increasing popularity of and consumer access to “at-home” gel manicure kits, sensitization to acrylates has increased, and those that use such kits are also more likely to be sensitized [19,20][11][12].
  • Dibutyl phthalate (DBP) is considered a “plasticizer” that increases nail polish flexibility [21][13]. It has not only been seen to cause ACD, but it has also been shown to interfere with male reproductive development in animal models [22][14].
  • Benzophenone is an additive to regular and gel nail polishes that protects cosmetic products by absorbing UV light and preventing product degradation prior to use. Cases report both ACD and photocontact dermatitis as a result of contact with benzophenone [23][15].
  • Formaldehyde (also listed as formalin or methylene glycol) is the main ingredient in nail strengthening products and has been shown to cause ACD [14][6].
  • Solvents such as ethyl acetate and isopropyl alcohol have been shown to cause ICD and ACD, albeit rarely. However, more recent studies have led many to believe that reactions to isopropyl alcohol are more common than once thought [24][16]. These ingredients can be found in both nail polishes as well as nail dehydrators.
  • Ethyl Cyanoacrylate (ECA) is an ingredient in nail glue that has been associated with ACD, paronychia, and nail dystrophy [25,26][17][18]. While similar in name to (meth)acrylates (see below), evidence shows that there is no cross-sensitization between the two ingredients.
  • Methacrylic Acid (MAA) is an ingredient in acidic nail primer that is known to be an extremely corrosive chemical. It can cause ACD if it accidentally comes in contact with the skin or cuticle on application [10][19]. Non-acid primers, those that do not contain MAA, have become more popular in order to avoid this adverse reaction; however, these still contain other allergens and irritants.
Product

(Synonyms)
Purpose Application Process Approximate Duration
Nail Polish

(lacquer, varnish)
Gives nails color and shine Painted directly onto nail plate or on top of acrylic or gel nails, with or without base or top coats. Can be applied at home or in salons <1 week
Base Coat Creates an even surface for the color coat and facilitates adhesion Applied directly to nail plate prior to application of colored nail polish N/A
Top Coat Gives a glossy finish and protects nail enamel Applied on top of colored nail polish N/A
Nail Polish Remover

(acetone)
Dissolves and removes nail polish and gel polish Nail polish: wiped onto nails using a cotton applicator (such as a cotton ball or swab)

Gel polish: poured into a bowl in which nails are soaked for several min or tightly applied to the nails using a cotton applicator and aluminum foil for several min
N/A
Nail Wraps

(silk nails, preformed nails)
Reinforce weak, brittle, or breaking nails Sheets applied directly to nail plate with cyanoacrylate-based nail glue or adhesive backing, then warmed and trimmed to accommodate the shape of the underlying nail 1–2 weeks
Press-on Nails

(fake nails, stick-ons)
Immediate color/design with durable shine and shape

Quick application that requires little to no skill
Plastic nail applied directly to nail plate with cyanoacrylate-based glue or adhesive backing 1–2 weeks
Gel Nail Polish

(long-lasting, semipermanent)
Long-lasting color

Less drying time compared to liquid nail polish
Liquid polish made of acrylic monomers is painted directly onto the nail plate or on top of acrylic nails. Each applied layer (3+) is cured with a UV or LED light (30 s–2 min) to allow for polymerization of acrylic monomers 2+ weeks
Powder Nails

(dipped nails, dipping powders)
Long-lasting color with a hard, durable finish

Appeals to many concerned about UV exposure with gel polish
Nail prepared with cyanoacrylate-based nail glue is dipped into polymer powder. A water-based activator is then applied to the nails, hardening the polish 2–4 weeks
Acrylic Nails

(tips, nail extensions, porcelain nails)
Adds length and shape to existing nail Powder polymers mixed with liquid acrylic monomers and then sculpted onto the nail plate 2–3 weeks

2. Treatment

2.1. Behavioral Interventions

Causative substance identification, removal, and avoidance is a mainstay of treatment for CD of any etiology. Ingredients that are more specific to certain products and/or nail procedures are likely easier to eliminate and, if desired, substitute. However, caution must still be taken. Patients must be aware that most polishes labeled “hypoallergenic” do not contain TSFR; however, these polishes typically still contain (meth)acrylates [38][20]. Additionally, some allergic to (meth)acrylates may find regular nail polish (that contains (meth)acrylates in much lower concentrations) to be a suitable substitution, while others continue to react. Some brands, such as CND Shellac and BRISA, claim to have created “acrylate-free” gel polishes, which have anecdotally been nonreactive in some with proven acrylate allergies. However, since cosmetics do not have ingredient regulating bodies, anyone with a history of CD secondary to nail cosmetic use should try new products with extreme caution [16][8].
For nail technicians and beauticians who occupationally come in contact with these allergens, latex gloves should be avoided as (meth)acrylates have been shown to penetrate through this material [39][21]. Rather, nitrile gloves should be used and switched every hour, as after this time frame, protection can diminish. Trilaminated polyethylene gloves are the most effective at protecting underlying skin from (meth)acrylates and other ingredients, but these are typically impractical [40][22].

2.2. Topical Anti-Inflammatory Treatment

For immediate treatment of CD skin lesions, topical steroids can be prescribed. Caution should be taken to prescribe a steroid of appropriate potency for the affected region, such as higher potency steroids for hand lesions and lower potency steroids for the more delicate the face [41][23]. Ointments may be chosen over creams as they are less likely to contain allergenic preservatives [28][24]. Alternatively, topical calcineurin inhibitors, such as pimecrolimus, tacrolimus, and cyclosporine, can be useful for ACD of the eyelids [35][25].

2.3. Emollients and Barrier Creams

Emollients and barrier creams, such as petrolatum, dimethicone, and paraffin, should be recommended in both treatment and prevention of CD by providing an extra layer of protection from allergens above the stratum corneum [42][26]. These creams have also been shown to have some anti-inflammatory properties as well as the ability to restore the skin barrier [41][23]. Hyaluronic acids can enhance intracellular lipid production, while ceramides help to retain moisture [33][27]. Occlusive dressings with emollients placed over affected areas (when practical) may help emollient adherence to skin and decrease subsequent exposure to allergens prior to healing.

References

  1. Madnani, N.; Khan, K. Nail cosmetics. Indian J. Dermatol. Venereol. Leprol. 2012, 78, 309.
  2. Dinani, N.; George, S. Nail cosmetics: A dermatological perspective. Clin. Exp. Dermatol. 2019, 44, 599–605.
  3. Chou, M.; Dhingra, N.; Strugar, T.L. Contact sensitization to allergens in nail cosmetics. Dermatitis 2017, 28, 231–240.
  4. Warshaw, E.M.; Voller, L.M.; Silverberg, J.I.; Dekoven, J.G.; Atwater, A.R.; Maibach, H.I.; Reeder, M.J.; Sasseville, D.; Belsito, D.V.; DeLeo, V.A.; et al. Contact dermatitis associated with nail care products: Retrospective analysis of North American contact dermatitis group data, 2001–2016. Dermatitis 2020, 31, 191–201.
  5. Adams, R.M.; Maibach, H.I.; Clendenning, W.; Fisher, A.; Jordan, W.; Kanof, N.; Larsen, W.; Mitchell, J.; Rudner, E.; Schorr, W.; et al. A five-year study of cosmetic reactions. J. Am. Acad. Dermatol. 1985, 13, 1062–1069.
  6. Sainio, E.-L.; Engström, K.; Henriks-Eckerman, M.-L.; Kanerva, L. Allergenic ingredients in nail polishes. Contact Dermat. 1997, 37, 155–162.
  7. Lee, H.N.; Pokorny, C.D.; Law, S.; Pratt, M.; Sasseville, D.; Storrs, F.J. Cross-reactivity among epoxy acrylates and bisphenol F epoxy resins in patients with bisphenol A epoxy resin sensitivity. Arch. Phys. Med. Rehabilit. 2002, 13, 108–115.
  8. Dahlin, J.; Berne, B.; Dunér, K.; Hosseiny, S.; Matura, M.; Nyman, G.; Tammela, M.; Isaksson, M. Several cases of undesirable effects caused by methacrylate ultraviolet-curing nail polish for non-professional use. Contact Dermat. 2016, 75, 151–156.
  9. Roche, E.; de la Cuadra, J.; Alegre, V. Sensitization to acrylates caused by artificial acrylic nails: Review of 15 cases. Actas Dermo. Sifiliogr. 2008, 99, 788–794.
  10. Scher, R.K. Cosmetics and ancillary preparations for the care of nails: Composition, chemistry, and adverse reactions. J. Am. Acad. Dermatol. 1982, 6, 523–528.
  11. Sánchez-Pujol, M.J.; Docampo-Simón, A.; Sánchez-Herrero, A.; García-Martínez, E.; Silvestre-Salvador, J.F. Allergic contact dermatitis caused by an acrylic nails kit for domestic use. Dermatitis 2020, 31, e27–e28.
  12. Gatica-Ortega, M.E.; Pastor-Nieto, M.A.; Gil-Redondo, R.; Martínez-Lorenzo, E.R.; Schöendorff-Ortega, C. Non-occupational allergic contact dermatitis caused by long-lasting nail polish kits for home use: ‘The tip of the iceberg’. Contact Dermat. 2018, 78, 261–265.
  13. Chowdhury, M.; Statham, B.N. Allergic contact dermatitis from dibutyl phthalate and benzalkonium chloride in Timodine® cream. Contact Dermat. 2002, 46, 57.
  14. Fisher, J.S.; MacPherson, S.; Marchetti, N.; Sharpe, R.M. Human ‘testicular dysgenesis syndrome’: A possible model using in-utero exposure of the rat to dibutyl phthalate. Hum. Reprod. 2003, 18, 1383–1394.
  15. Goossens, A. Contact-allergic reactions to cosmetics. J. Allergy 2011, 2011, 467071.
  16. García-Gavín, J.; Lissens, R.; Timmermans, A.; Goossens, A. Allergic contact dermatitis caused by isopropyl alcohol: A missed allergen? Contact Dermat. 2011, 65, 101–106.
  17. Kanerva, L.; Estlander, T. Allergic onycholysis and paronychia caused by cyanoacrylate nail glue, but not by photo-bonded methacrylate nails. Eur. J. Dermatol. 2000, 10, 223–225.
  18. Sachse, M.M.; Junghans, T.; Rose, C.; Wagner, G. Allergic contact dermatitis caused by topical 2-octyl-cyanoacrylate. Contact Dermat. 2013, 68, 317–319.
  19. Uter, W.; Geier, J. Contact allergy to acrylates and methacrylates in consumers and nail artists—Data of the Information Network of Departments of Dermatology, 2004–2013. Contact Dermat. 2015, 72, 224–228.
  20. Ramos, L.; Cabral, R.; Gonçalo, M. Allergic contact dermatitis caused by acrylates and methacrylates—A 7-year study. Contact Dermat. 2014, 71, 102–107.
  21. Muttardi, K.; White, I.R.; Banerjee, P. The burden of allergic contact dermatitis caused by acrylates. Contact Dermat. 2016, 75, 180–184.
  22. Spencer, A.; Gazzani, P.; Thompson, D.A. Acrylate and methacrylate contact allergy and allergic contact disease: A 13-year review. Contact Dermat. 2016, 75, 157–164.
  23. Qin, R.; Lampel, H.P. Review of occupational contact dermatitis—Top allergens, best avoidance measures. Curr. Treat. Options Allergy 2015, 2, 349–364.
  24. Usatine, R.P.; Riojas, M. Diagnosis and management of contact dermatitis. Am. Fam. Physician 2010, 82, 249–255.
  25. Katsarou, A.; Armenaka, M.; Vosynioti, V.; Lagogianni, E.; Kalogeromitros, D.; Katsambas, A. Tacrolimus ointment 0.1% in the treatment of allergic contact eyelid dermatitis. J. Eur. Acad. Dermatol. Venereol. 2009, 23, 382–387.
  26. Harcharik, S.; Emer, J. Steroid-sparing properties of emollients in dermatology. Ski. Ther. Lett. 2014, 19, 5–10.
  27. Takahashi, A.; Kirst, A.; Heinrich, U.; Kiyomine, A.; Ishida, K.; Tronnier, H.; Theis, H.; Nishizaka, T.; Tanabe, H. Evaluation of a barrier repair cream containing pseudo-ceramide for practical use by hairdressers with hand skin disorders due to daily exposure to chemical irritants. J. Cosmet. Dermatol. Sci. Appl. 2013, 3, 263–270.
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