GPCR signaling in the carotid-body: Comparison
Please note this is a comparison between Version 1 by Hayyaf Aldossary and Version 2 by Conner Chen.

       The carotid body (CB) is a vital sensory organ, located near the carotid bifurcation, that constantly monitors blood supplying the brain. The CB is stimulated by acute hypoxia, upon which it rapidly activates vital cardiovascular and respiratory reflexes, including peripheral vasoconstriction, elevated heart rate and increased breathing. These ensure that sufficient blood-oxygen is delivered to the brain to support survival. It is now apparent that there are numerous G-protein-coupled receptors (GPCRs) expressed in the CB, and that modulation of these receptors is able to alter baseline CB activity ais article focuses on the influence of G-Protein-Coupled Receptors (GPCRs) on the Carotid Body (CB) during pathological conditions characterized by chronic hypoxia such as chronic obstructive pulmonary disease, obstructive sleep apnea and heart failure and the sensitivity to hypoxia. Indeed, components of GPCR signaling pathways represent some of the most highly expressed genes in the rodent CBability of targeting GPCRs for treating such conditions. 

  • G-protein
  • GPCR
  • carotid body
  • hypoxia
  • hypertension
  • drug-discovery
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