MThelanin is a widespread natural pigment that is responsible for color in hair, skin, and eyes. It provides protection against the deleterious indiscriminate use of non-regulated skin lighteners among African populations has raised health concerns due to the negative side effects of ultraviolet (UV) irradiation. Melanogenesis is the physiological process of melanin formation in which TYR, a copper-dependent enzyme, initiates the first step. Tyrosinase catalyzes the rate-limiting step where L-tyrosine is converted to L-3,4,-dihydroxyphenylalanine (L-DOPA), leading to the eventual formation of the pigmentassociated with skin lightener toxicity. For this reason, there is a growing interest in the cosmetic development of plants and their metabolites as alternatives to available chemical-derived skin lightening formulations.