Biomedical Applications of Plant-Mediated Zinc Oxide Nanoparticles: Comparison
View Latest Version
Please note this is a comparison between Version 2 by Conner Chen and Version 1 by Saad Alghamdi.

Zinc oxide nanoparticles have become one of the most popular metal oxide nanoparticles and recently emerged as a promising potential candidate in the fields of optical, electrical, food packaging, and biomedical applications due to their biocompatibility, low toxicity, and low cost. They have a role in cell apoptosis, as they trigger excessive reactive oxygen species (ROS) formation and release zinc ions (Zn2+) that induce cell death. The zinc oxide nanoparticles synthesized using the plant extracts appear to be simple, safer, sustainable, and more environmentally friendly compared to the physical and chemical routes. These biosynthesized nanoparticles possess strong biological activities and are in use for various biological applications in several industries. Initially, the present review discusses the synthesis and recent advances of zinc oxide nanoparticles from plant sources (such as leaves, stems, bark, roots, rhizomes, fruits, flowers, and seeds) and their biomedical applications (such as antimicrobial, antioxidant, antidiabetic, anticancer, anti-inflammatory, photocatalytic, wound healing, and drug delivery), followed by their mechanisms of action involved in detail. 

  • antimicrobial
  • antioxidant
  • antidiabetic
  • anticancer
  • anti-inflammatory
  • drug delivery
Please wait, diff process is still running!

References

  1. Ansari, M.A.; Murali, M.; Prasad, D.; Alzohairy, M.A.; Almatroudi, A.; Alomary, M.N.; Udayashankar, A.C.; Singh, S.B.; Asiri, S.M.M.; Ashwini, B.S.; et al. Cinnamomum verum bark extract mediated green synthesis of ZnO nanoparticles and their antibacterial potentiality. Biomolecules 2020, 10, 336.
  2. Murali, M.; Anandan, S.; Ansari, M.A.; Alzohairy, M.A.; Alomary, M.N.; Asiri, S.M.M.; Almatroudi, A.; Thrivveni, M.C.; Brijesh Singh, S.; Gowtham, H.G.; et al. Genotoxic and cytotoxic properties of Zinc oxide nanoparticles phyto-fabricated from the Obscure morning glory plant Ipomoea obscura (L.) Ker Gawl. Molecules 2021, 26, 891.
  3. Sharmila, G.; Muthukumaran, C.; Sandiya, K.; Santhiya, S.; Pradeep, R.S.; Kumar, N.M.; Suriyanarayanan, N.; Thirumarimurugan, M. Biosynthesis, characterization, and antibacterial activity of zinc oxide nanoparticles derived from Bauhinia tomentosa leaf extract. J. Nanostruct. Chem. 2018, 8, 293–299.
  4. Murali, M.; Mahendra, C.; Nagabhushan; Rajashekar, N.; Sudarshana, M.S.; Raveesha, K.A.; Amruthesh, K.N. Antibacterial and antioxidant properties of biosynthesized zinc oxide nanoparticles from Ceropegia candelabrum L.—An endemic species. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2017, 179, 104–109.
  5. Mahendra, C.; Murali, M.; Manasa, G.; Ponnamma, P.; Abhilash, M.R.; Lakshmeesha, T.R.; Satish, A.; Amruthesh, K.N.; Sudarshana, M.S. Antibacterial and antimitotic potential of bio-fabricated zinc oxide nanoparticles of Cochlospermum religiosum (L.). Microb. Pathog. 2017, 110, 620–629.
  6. Quek, J.A.; Sin, J.C.; Lam, S.M.; Mohamed, A.R.; Zeng, H.H. Bioinspired green synthesis of ZnO structures with enhanced visible light photocatalytic activity. J. Mater. Sci. Mater. Electron. 2020, 31, 1144–1158.
  7. Azizi, S.; Mohamad, R.; Shahri, M.M. Green microwave-assisted combustion synthesis of Zinc oxide nanoparticles with Citrullus colocynthis (L.) Schrad: Characterization and biomedical applications. Molecules 2017, 22, 301.
  8. Sharma, S.; Kumar, K.; Thakur, N.; Chauhan, S.; Chauhan, M.S. The effect of shape and size of ZnO nanoparticles on their antimicrobial and photocatalytic activities: A green approach. Bull. Mater. Sci. 2020, 43, 20.
  9. Sana, S.S.; Kumbhakar, D.V.; Pasha, A.; Pawar, S.C.; Grace, A.N.; Singh, R.P.; Nguyen, V.H.; Le, Q.V.; Peng, W. Crotalaria verrucosa leaf extract mediated synthesis of Zinc oxide nanoparticles: Assessment of antimicrobial and anticancer activity. Molecules 2020, 25, 4896.
  10. Naseer, M.; Aslam, U.; Khalid, B.; Chen, B. Green route to synthesize Zinc oxide Nanoparticles using leaf extracts of Cassia fistula and Melia azadarach and their antibacterial potential. Sci. Rep. 2020, 10, 9055.
  11. Faisal, S.; Jan, H.; Shah, S.A.; Shah, S.; Khan, A.; Akbar, M.T.; Rizwan, M.; Jan, F.; Wajidullah; Akhtar, N.; et al. Green synthesis of Zinc oxide (ZnO) nanoparticles using aqueous fruit extracts of Myristica fragrans: Their characterizations and biological and environmental applications. ACS Omega 2021, 6, 9709–9722.
  12. Gao, Y.; Xu, D.; Ren, D.; Zeng, K.; Wu, X. Green synthesis of zinc oxide nanoparticles using Citrus sinensis peel extract and application to strawberry preservation: A comparison study. LWT 2020, 126, 109297.
  13. Vijayakumar, S.; Mahadevan, S.; Arulmozhi, P.; Sriram, S.; Praseetha, P.K. Green synthesis of zinc oxide nanoparticles using Atalantia monophylla leaf extracts: Characterization and antimicrobial analysis. Mater. Sci. Semicond. Process. 2018, 82, 39–45.
  14. Saemi, R.; Taghavi, E.; Jafarizadeh-Malmiri, H.; Anarjan, N. Fabrication of green ZnO nanoparticles using walnut leaf extract to develop an antibacterial film based on polyethylene–starch–ZnO NPs. Green Process. Synthesis 2021, 10, 112–124.
  15. Sun, Q.; Li, J.; Le, T. Zinc oxide nanoparticle as a novel class of antifungal agents: Current advances and future perspectives. J. Agric. Food Chem. 2018, 66, 11209–11220.
  16. Jamdagni, P.; Khatri, P.; Rana, J.S. Green synthesis of zinc oxide nanoparticles using flower extract of Nyctanthes arbor-tristis and their antifungal activity. J. King Saud Univ. Sci. 2018, 30, 168–175.
  17. Khan, Z.U.H.; Sadiq, H.M.; Shah, N.S.; Khan, A.U.; Muhammad, N.; Hassan, S.U.; Tahir, K.; Safi, S.Z.; Khan, F.U.; Imran, M.; et al. Greener synthesis of zinc oxide nanoparticles using Trianthema portulacastrum extract and evaluation of its photocatalytic and biological applications. J. Photochem. Photobiol. B Biol. 2019, 192, 147–157.
  18. Pillai, A.M.; Sivasankarapillai, V.S.; Rahdar, A.; Joseph, J.; Sadeghfar, F.; Ronaldo Anuf, A.; Rajesh, K.; Kyzas, G.Z. Green synthesis and characterization of zinc oxide nanoparticles with antibacterial and antifungal activity. J. Mol. Struct. 2020, 1211, 128107.
  19. Siripireddy, B.; Mandal, B.K. Facile green synthesis of zinc oxide nanoparticles by Eucalyptus globulus and their photocatalytic and antioxidant activity. Adv. Powder Technol. 2017, 28, 785–797.
  20. Nagajyothi, P.C.; Cha, S.J.; Yang, I.J.; Sreekanth, T.V.M.; Kim, K.J.; Shin, H.M. Antioxidant and anti-inflammatory activities of zinc oxide nanoparticles synthesized using Polygala tenuifolia root extract. J. Photochem. Photobiol. B Biol. 2015, 146, 10–17.
  21. Alamdari, S.; Ghamsari, M.S.; Lee, C.; Han, W.; Park, H.H.; Tafreshi, M.J.; Afarideh, H.; Ara, M.H.M. Preparation and characterization of Zinc oxide nanoparticles using leaf extract of Sambucus ebulus. Appl. Sci. 2020, 10, 3620.
  22. Vinotha, V.; Iswarya, A.; Thaya, R.; Govindarajan, M.; Alharbi, N.S.; Kadaikunnan, S.; Khaled, J.M.; Al-Anbr, M.N.; Vaseeharan, B. Synthesis of ZnO nanoparticles using insulin-rich leaf extract: Anti-diabetic, antibiofilm and anti-oxidant properties. J. Photochem. Photobiol. B Biol. 2019, 197, 111541.
  23. Suresh, J.; Pradheesh, G.; Alexramani, V.; Sundrarajan, M.; Hong, S.I. Green synthesis and characterization of zinc oxide nanoparticle using insulin plant (Costus pictus D. Don) and investigation of its antimicrobial as well as anticancer activities. Adv. Nat. Sci. Nanosci. Nanotechnol. 2018, 9, 015008.
  24. Bala, N.; Saha, S.; Chakraborty, M.; Maiti, M.; Das, S.; Basu, R.; Nandy, P. Green synthesis of zinc oxide nanoparticles using Hibiscus subdariffa leaf extract: Effect of temperature on synthesis, anti-bacterial activity and anti-diabetic activity. RSC Adv. 2015, 5, 4993–5003.
  25. Tang, K.S. The current and future perspectives of zinc oxide nanoparticles in the treatment of diabetes mellitus. Life Sci. 2019, 239, 117011.
  26. Rehana, D.; Mahendiran, D.; Kumar, R.S.; Rahiman, A.K. In vitro antioxidant and antidiabetic activities of zinc oxide nanoparticles synthesized using different plant extracts. Bioprocess Biosyst. Eng. 2017, 40, 943–957.
  27. Rajakumar, G.; Thiruvengadam, M.; Mydhili, G.; Gomathi, T.; Chung, I.M. Green approach for synthesis of zinc oxide nanoparticles from Andrographis paniculata leaf extract and evaluation of their antioxidant, anti-diabetic, and anti-inflammatory activities. Bioprocess Biosyst. Eng. 2018, 41, 21–30.
  28. Cheng, J.; Wang, X.; Qiu, L.; Li, Y.; Marraiki, N.; Elgorban, A.M.; Xue, L. Green synthesized zinc oxide nanoparticles regulates the apoptotic expression in bone cancer cells MG-63 cells. J. Photochem. Photobiol. B Biol. 2020, 202, 111644.
  29. Tettey, C.O.; Shin, H.M. Evaluation of the antioxidant and cytotoxic activities of zinc oxide nanoparticles synthesized using Scutellaria baicalensis root. Sci. Afr. 2019, 6, e00157.
  30. Zhang, H.; Liang, Z.; Zhang, J.; Wang, W.P.; Zhang, H.; Lu, Q. Zinc oxide nanoparticle synthesized from Euphorbia fischeriana root inhibits the cancer cell growth through modulation of apoptotic signaling pathways in lung cancer cells. Arab. J. Chem. 2020, 13, 6174–6183.
  31. Umar, H.; Kavaz, D.; Rizaner, N. Biosynthesis of zinc oxide nanoparticles using Albizia lebbeck stem bark, and evaluation of its antimicrobial, antioxidant, and cytotoxic activities on human breast cancer cell lines. Int. J. Nanomedicine 2019, 14, 87–100.
  32. Umamaheswari, A.; Prabu, S.L.; John, S.A.; Puratchikody, A. Green synthesis of zinc oxide nanoparticles using leaf extracts of Raphanus sativus var. longipinnatus and evaluation of their anticancer property in A549 cell lines. Biotechnol. Rep. 2021, 29, e00595.
  33. Majeed, S.; Danish, M.; Ismail, M.H.B.; Ansari, M.T.; Ibrahim, M.N.M. Anticancer and apoptotic activity of biologically synthesized zinc oxide nanoparticles against human colon cancer HCT-116 cell line- in vitro study. Sustain. Chem. Pharm. 2019, 14, 100179.
  34. Selim, Y.A.; Azb, M.A.; Ragab, I.; Abd El-Azim, M.H.M. Green synthesis of Zinc oxide nanoparticles using aqueous extract of Deverra tortuosa and their cytotoxic activities. Sci. Rep. 2020, 10, 3445.
  35. Tian, W.; Wang, C.; Li, D.; Hou, H. Novel anthraquinone compounds as anticancer agents and their potential mechanism. Future Med. Chem. 2020, 12, 627–644.
  36. Jayappa, M.D.; Ramaiah, C.K.; Kumar, M.A.P.; Suresh, D.; Prabhu, A.; Devasya, R.P.; Sheikh, S. Green synthesis of zinc oxide nanoparticles from the leaf, stem and in vitro grown callus of Mussaenda frondosa L.: Characterization and their applications. Appl. Nanosci. 2020, 10, 3057–3074.
  37. Liu, H.; Kang, P.; Liu, Y.; An, Y.; Hu, Y.; Jin, X.; Cao, X.; Qi, Y.; Ramesh, T.; Wang, X. Zinc oxide nanoparticles synthesised from the Vernonia amygdalina shows the anti-inflammatory and antinociceptive activities in the mice model. Artif. Cells Nanomed. Biotechnol. 2020, 48, 1068–1078.
  38. Agarwal, H.; Nakara, A.; Shanmugam, V.K. Anti-inflammatory mechanism of various metal and metal oxide nanoparticles synthesized using plant extracts: A review. Biomed. Pharmacother. 2019, 109, 2561–2572.
  39. Agarwal, H.; Shanmugam, V.K. Synthesis and optimization of zinc oxide nanoparticles using Kalanchoe pinnata towards the evaluation of its anti-inflammatory activity. J. Drug Deliv. Sci. Technol. 2019, 54, 101291.
  40. Chemingui, H.; Missaoui, T.; Mzali, J.C.; Yildiz, T.; Konyar, M.; Smiri, M.; Saidi, N.; Hafiane, A.; Yatmaz, H.C. Facile green synthesis of zinc oxide nanoparticles (ZnO NPs): Antibacterial and photocatalytic activities. Mater. Res. Express 2019, 6, 1050b4.
  41. Fatimah, I.; Pradita, R.Y.; Nurfalinda, A. Plant extract mediated of ZnO nanoparticles by using ethanol extract of Mimosa pudica leaves and Coffee powder. Procedia Eng. 2016, 148, 43–48.
  42. Vinayagam, R.; Pai, S.; Varadavenkatesan, T.; Pugazhendhi, A.; Selvaraj, R. Characterization and photocatalytic activity of ZnO nanoflowers synthesized using Bridelia retusa leaf extract. Appl. Nanosci. 2021, 1–10.
  43. Abdullah, F.H.; Abu Bakar, N.H.H.; Abu Bakar, M. Low temperature biosynthesis of crystalline zinc oxide nanoparticles from Musa acuminata peel extract for visible-light degradation of methylene blue. Optik 2020, 206, 164279.
  44. Golmohammadi, M.; Honarmand, M.; Ghanbari, S. A green approach to synthesis of ZnO nanoparticles using jujube fruit extract and their application in photocatalytic degradation of organic dyes. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2020, 229, 117961.
  45. Luque, P.A.; Soto-Robles, C.A.; Nava, O.; Gomez-Gutierrez, C.M.; Castro-Beltran, A.; Garrafa-Galvez, H.E.; Vilchis-Nestor, A.R.; Olivas, A. Green synthesis of zinc oxide nanoparticles using Citrus sinensis extract. J. Mater. Sci. Mater. Electron. 2018, 29, 9764–9770.
  46. Ullah, S.; Ahmad, A.; Ri, H.; Khan, A.U.; Khan, U.A.; Yuan, Q. Green synthesis of catalytic Zinc oxide nano-flowers and their bacterial infection therapy. Appl. Organomet. Chem. 2020, 34, e5298.
  47. Kahsay, M.H.; Tadesse, A.; RamaDevi, D.; Belachew, N.; Basavaiah, K. Green synthesis of zinc oxide nanostructures and investigation of their photocatalytic and bactericidal applications. RSC Adv. 2019, 9, 36967–36981.
  48. Shao, F.; Yang, A.; Yu, D.M.; Wang, J.; Gong, X.; Tian, H.X. Bio-synthesis of Barleria gibsoni leaf extract mediated zinc oxide nanoparticles and their formulation gel for wound therapy in nursing care of infants and children. J. Photochem. Photobiol. B Biol. 2018, 189, 267–273.
  49. Ezealisiji, K.M.; Siwe-Noundou, X.; Maduelosi, B.; Nwachukwu, N.; Krause, R.W.M. Green synthesis of zinc oxide nanoparticles using Solanum torvum (L) leaf extract and evaluation of the toxicological profile of the ZnO nanoparticles–hydrogel composite in Wistar albino rats. Int. Nano Lett. 2019, 9, 99–107.
  50. Khatami, M.; Varma, R.S.; Zafarnia, N.; Yaghoobi, H.; Sarani, M.; Kumar, V.G. Applications of green synthesized Ag, ZnO and Ag/ZnO nanoparticles for making clinical antimicrobial wound-healing bandages. Sustain. Chem. Pharm. 2018, 10, 9–15.
  51. Kiran Kumar, A.B.V.; Saila, E.S.; Narang, P.; Aishwarya, M.; Raina, R.; Gautam, M.; Shankar, E.G. Biofunctionalization and biological synthesis of the ZnO nanoparticles: The effect of Raphanus sativus (white radish) root extract on antimicrobial activity against MDR strain for wound healing applications. Inorg. Chem. Commun. 2019, 100, 101–106.
  52. Gao, Y.; Han, Y.; Cui, M.; Tey, H.L.; Wang, L.; Xu, C. ZnO nanoparticles as an antimicrobial tissue adhesive for skin wound closure. J. Mater. Chem. B 2017, 5, 4535–4541.
  53. Lin, C.C.; Lee, M.H.; Chi, M.H.; Chen, C.J.; Lin, H.Y. Preparation of Zinc oxide nanoparticles containing spray and barrier films for potential photoprotection on wound healing. ACS Omega 2019, 4, 1801–1809.
  54. Nosrati, H.; Khodaei, M.; Banitalebi-Dehkordi, M.; Alizadeh, M.; Asadpour, S.; Sharifi, E.; Ai, J.; Soleimannejad, M. Preparation and characterization of poly (ethylene oxide)/zinc oxide nanofibrous scaffold for chronic wound healing applications. Polim. Med. 2020, 50, 41–51.
  55. Bagheri, M.; Validi, M.; Gholipour, A.; Makvandi, P.; Sharifi, E. Chitosan nanofiber biocomposites for potential wound healing applications: Antioxidant activity with synergic antibacterial effect. Bioeng. Transl. Med. 2021, e10254.
  56. Ramesh, M.; Anbuvannan, M.; Viruthagiri, G. Green synthesis of ZnO nanoparticles using Solanum nigrum leaf extract and their antibacterial activity. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2015, 136, 864–870.
  57. Akbarian, M.; Mahjoub, S.; Elahi, S.M.; Zabihi, E.; Tashakkorian, H. Green synthesis, formulation and biological evaluation of a novel ZnO nanocarrier loaded with paclitaxel as drug delivery system on MCF-7 cell line. Colloids Surf. B Biointerfaces 2020, 186, 110686.
  58. Vimala, K.; Sundarraj, S.; Paulpandi, M.; Vengatesan, S.; Kannan, S. Green synthesized doxorubicin loaded zinc oxide nanoparticles regulates the Bax and Bcl-2 expression in breast and colon carcinoma. Process Biochem. 2014, 49, 160–172.
  59. Bazak, R.; Houri, M.; Achy, S.E.; Hussein, W.; Refaat, T. Passive targeting of nanoparticles to cancer: A comprehensive review of the literature. Mol. Clin. Oncol. 2014, 2, 904–908.
  60. Ghazali, N.A.B.; Mani, M.P.; Jaganathan, S.K. Green-synthesized Zinc oxide nanoparticles decorated nanofibrous polyurethane mesh loaded with virgin coconut oil for tissue engineering application. Curr. Nanosci. 2018, 14, 280–289.
  61. Laurenti, M.; Cauda, V. ZnO nanostructures for tissue engineering applications. Nanomaterials 2017, 7, 374.
  62. Medina-Cruz, D.; Mostafavi, E.; Vernet-Crua, A.; Cheng, J.; Shah, V.; Cholula-Diaz, J.L.; Guisbiers, G.; Tao, J.; García-Martín, J.M.; Webster, T.J. Green nanotechnology-based drug delivery systems for osteogenic disorders. Expert Opin. Drug Deliv. 2020, 17, 341–356.
  63. Cruz, D.M.; Mostafavi, E.; Vernet-Crua, A.; Barabadi, H.; Shah, V.; Cholula-Díaz, J.-L.; Guisbiers, G.; Webster, T.J. Green nanotechnology-based zinc oxide (ZnO) nanomaterials for biomedical applications: A review. J. Phys. Mater. 2020, 3, 034005.
  64. Shubha, P.; Likhith Gowda, M.; Namratha, K.; Manjunatha, H.B.; Byrappa, K. In vitro and in vivo evaluation of green-hydrothermal synthesized ZnO nanoparticles. J. Drug Deliv. Sci. Technol. 2019, 49, 692–699.
  65. Shafique, S.; Jabeen, N.; Ahmad, K.S.; Irum, S.; Anwaar, S.; Ahmad, N.; Alam, S.; Ilyas, M.; Khan, T.F.; Hussain, S.Z. Green fabricated zinc oxide nanoformulated media enhanced callus induction and regeneration dynamics of Panicum virgatum L. PLoS ONE 2020, 15, e0230464.
More
© Text is available under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
Video Production Service
Feedback