The male reproductive system is highly susceptible to noxious influences, that can induce germ cell damage, alterations in spermatogenesis and male fertility. For this reason, it is of major importance to investigate possible ways to protect the male reproductive system. For centuries, natural products have been used by humans in folk medicine as therapeutic agents, and because of their beneficial properties for human health, plenty of them have been introduced to the pharmaceutical market as supplementary therapies. The present review aims to compile available information regarding different natural exogenous factors that demonstrate potential useful activity in the male reproductive system.