Tumor-associated macrophages (TAMs) play major roles in solid tumor development. They can have both anti-tumor and pro-tumor properties depending on their polarization.
Cell Types and Markers | Bladder Cancer Cohorts | Types of Sample | Findings | References |
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CD68 | + | (TAM) | 40 pTa-pT1 23 ≥ pT2 |
FFPE tissue | High TAM count was associated with poor 5-year survival | Hanada et al. [29] | ||||||||||
CD68 | + | (TAM) | 81 pTa-pT1 11 pT2 |
FFPE tissue | High number of TAMs was significantly associated with risk of progression | Bostrom et al. [31] | ||||||||||
CD68 | + | (TAM) | 112 pTa 89 pT1 93 MIBC |
FFPE tissue | High CD68/CD3 ratio was associated with poor OS | Sjödahl et al. [45] | ||||||||||
CD68 | + | (TAM) | 10 low grades 34 high grades |
FFPE tissue | High TAM count was associated with poor DFS but not OS | Chai et al. [50] | ||||||||||
CD163 | + | (TAM) | 115 MIBC | FFPE tissue | High TAM count was associated with poor PFS and OS | Xu et al. [35] | ||||||||||
CD163 | + | (TAM) | 94 high grade pT1 | FFPE tissue | TAMs were associated with tumor recurrence and progression | Yang et al. [43] | ||||||||||
CD204 | + | round cells (TAM) | 155 NMIBC | FFPE tissue | High number of TAMs correlated with a high risk of recurrence | Miyake et al. [42] | ||||||||||
TAM | MIBC (no metastatic disease) | TCGA database | A signature with low T cells, low NK cells, high Treg and high TAMs is associated with poor DFS and OS | Fu et al. [24] | ||||||||||||
TAM | 406 MIBC | TCGA database | Patients in the high-risk group had a signature with low CD8 | + | T cells, CD4 | + | T cells and high abundance of M0 macrophages | Li et al. [44] | ||||||||
CD204 | + | CD68 | + | (CD204 | + | macrophages) | 212 pTa-pT1 90 pT2-pT4 |
FFPE tissue | High number of CD204 | + | macrophages in tumor stroma was associated with poor OS | Wang et al. [25] | ||||
DC-SIGN | + | CD68 | + | (DC-SIGN | + | TAM) | 257 MIBC | FFPE tissue | DC-SIGN | + | TAMs may contribute to progression and poor prognosis | Hu et al. [46] | ||||
M2-like TAM | 429 MIBC | TCGA database | High M2-like TAM signature was associated with poor OS and DFS | Xue et al. [38] | ||||||||||||
M2-like TAM | 402 MIBC | TCGA database | M2-like TAM signature was associated with significantly worse 5-year OS and DFS outcomes | Jiang et al. [47] | ||||||||||||
CD169 | + | CD68 | + | (CD169 | + | macrophages) | 44 MIBC | FFPE tissue | CD169 | + | macrophages in tumor-draining lymph nodes were positively correlated with a favorable prognosis | Asano et al. [48] | ||||
CD33 | + | (MDSC) | 70 NMIBC 27 MIBC |
FFPE tissue | The number of tumor-infiltrating CD33 | + | MDSCs was significantly inversely correlated with patient OS | Zhang et al. [27] | ||||||||
CD11b | + | CD33 | low | HLA-DR | − | (MDSC) | 71 pTa-pT1 42 pT2-pT4 |
PBMC | High numbers of circulating CD11b | + | CD33 | low | HLA-DR | − | cells were correlated with poor OS | Yang et al. [32] |