Poor semen quality and abnormal sperm structure or function by and large constitute a predominant presentation of male infertility and are among the major reasons why couples seek the services of assisted reproduction. Natural biomolecules, such as polyphenols or flavonoids have garnered substantial attention from the scientific community as well as public media. In the meantime, it has been suggested that administration of natural biomolecules has been shown to have a positive impact male infertility. A number of in vivo as well as in vitro studies have reported that active components isolated from natural resources could enhance blood circulation in the male reproductive system and support the synthesis and secretion of androgens. Animal and human reports also suggest that natural biomolecules may play important roles in the enhancement of semen quality, including sperm concentration, motility, vitality, and structural integrity.