Amanita muscaria: Ecology, Chemistry, Myths: Comparison
Please note this is a comparison between Version 2 by Lindsay Dong and Version 1 by Quentin Carboué.

Amanita muscaria is the most emblematic mushroom in the popular representation. It is an ectomycorrhizal fungus endemic to the cold ecosystems of the northern hemisphere. The basidiocarp contains isoxazoles compounds that have specific actions on the central nervous system, including hallucinations. For this reason, it is considered an important entheogenic mushroom in different cultures whose remnants are still visible in some modern-day European traditions. In Siberian civilizations, it has been consumed for religious and recreational purposes for millennia, as it was the only inebriant in this region.

  • Amanita muscaria
  • ibotenic acid
  • muscimol
  • muscarine
  • ethnomycology
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References

  1. Rubel, W.; Arora, D. A Study of Cultural Bias in Field Guide Determinations of Mushroom Edibility Using the Iconic Mushroom, Amanita muscaria, as an Example. Econ. Bot. 2008, 62, 223–243.
  2. Whelan, C. “Amanita muscaria”: The Gorgeous Mushroom. Asian Folk. Stud. 1994, 53, 163.
  3. Infraspecific Taxa of Muscaria. Available online: Amanitaceae.org (accessed on 16 August 2021).
  4. Gillard, R.D.; Lancashire, R.J. Electron Spin Resonance of Vanadium in Amanita muscaria. Phytochemistry 1984, 23, 179–180.
  5. Michelot, D.; Melendez-Howell, L.M. Amanita muscaria: Chemistry, Biology, Toxicology, and Ethnomycology. Mycol. Res. 2003, 107, 131–146.
  6. Li, D.-W. Release and Dispersal of Basidiospores from Amanita muscaria var. Alba and Their Infiltration into a Residence. Mycol. Res. 2005, 109, 1235–1242.
  7. Griffin, D.H. Introduction to fungi. In Fungal Physiology; Wiley: New York, NY, USA, 1994; pp. 1–21. ISBN 978-0-471-16615-3.
  8. Reis, F.S.; Heleno, S.A.; Barros, L.; Sousa, M.J.; Martins, A.; Santos-Buelga, C.; Ferreira, I.C.F.R. Toward the Antioxidant and Chemical Characterization of Mycorrhizal Mushrooms from Northeast Portugal. J. Food Sci. 2011, 76, C824–C830.
  9. Iotti, M.; Barbieri, E.; Stocchi, V.; Zambonelli, A. Morphological and Molecular Characterisation of Mycelia of Ectomycorrhizal Fungi in Pure Culture. Fungal Divers 2005, 19, 51–68.
  10. Li, Q.; He, X.; Ren, Y.; Xiong, C.; Jin, X.; Peng, L.; Huang, W. Comparative Mitogenome Analysis Reveals Mitochondrial Genome Differentiation in Ectomycorrhizal and Asymbiotic Amanita Species. Front. Microbiol. 2020, 11, 1382.
  11. Malcolm, G.M.; López-Gutiérrez, J.C.; Koide, R.T.; Eissenstat, D.M. Acclimation to Temperature and Temperature Sensitivity of Metabolism by Ectomycorrhizal Fungi. Glob. Chang. Biol. 2008, 14, 1169–1180.
  12. Falandysz, J.; Treu, R. Amanita muscaria: Bio-Concentration and Bio-Indicative Potential for Metallic Elements. Environ. Earth Sci. 2019, 78, 722.
  13. Willmann, A.; Weiß, M.; Nehls, U. Ectomycorrhiza-Mediated Repression of the High-Affinity Ammonium Importer Gene AmAMT2 in Amanita muscaria. Curr. Genet. 2007, 51, 71–78.
  14. Geml, J.; Laursen, G.A.; O’Neill, K.; Nusbaum, H.C.; Taylor, D.L. Beringian Origins and Cryptic Speciation Events in the Fly Agaric (Amanita muscaria): Phylogeography of Amanita muscaria. Mol. Ecol. 2005, 15, 225–239.
  15. Di Rita, F.; Atzeni, M.; Tudino, F. The History of Conifers in Central Italy Supports Long-Term Persistence and Adaptation of Mesophilous Conifer Fungi in Arbutus-Dominated Shrublands. Rev. Palaeobot. Palynol. 2020, 282, 104300.
  16. Bagley, S.J.; Orlovich, D.A. Genet Size and Distribution of Amanita muscaria in a Suburban Park, Dunedin, New Zealand. N. Z. J. Bot. 2004, 42, 939–947.
  17. Nouhra, E.R.; Palfner, G.; Kuhar, F.; Pastor, N.; Smith, M.E. Ectomycorrhizal Fungi in South America: Their Diversity in Past, Present and Future Research. In Mycorrhizal Fungi in South America; Pagano, M.C., Lugo, M.A., Eds.; Fungal Biology; Springer International Publishing: Cham, Switzerland, 2019; pp. 73–95. ISBN 978-3-030-15227-7.
  18. Reid, D.A.; Eicker, A. South African Fungi: The Genus Amanita. Mycol. Res. 1991, 95, 80–95.
  19. Sawyer, N.A.; Chambers, S.M.; Cairney, J.W.G. Distribution and Persistence of Amanita muscaria Genotypes in Australian Pinus radiata Plantations. Mycol. Res. 2001, 105, 966–970.
  20. Vargas, N.; Gonçalves, S.C.; Franco-Molano, A.E.; Restrepo, S.; Pringle, A. In Colombia the Eurasian Fungus Amanita muscaria Is Expanding Its Range into Native, Tropical Quercus humboldtii Forests. Mycologia 2019, 111, 758–771.
  21. Maïga, Y.; Carboué, Q.; Hamrouni, R.; Tranier, M.-S.; Ben Menadi, Y.; Roussos, S. Development and Evaluation of a Disposable Solid-State Culture Packed-Bed Bioreactor for the Production of Conidia from Trichoderma asperellum Grown Under Water Stress. Waste Biomass Valor 2021, 12, 3223–3231.
  22. Schmidt, O. Wood and Tree Fungi: Biology, Damage, Protection, and Use; Springer: Berlin, Germany, 2006; ISBN 978-3-540-32138-5.
  23. Deja, S.; Wieczorek, P.P.; Halama, M.; Jasicka-Misiak, I.; Kafarski, P.; Poliwoda, A.; Młynarz, P. Do Differences in Chemical Composition of Stem and Cap of Amanita muscaria Fruiting Bodies Correlate with Topsoil Type? PLoS ONE 2014, 9, e104084.
  24. Falandysz, J. Mercury Bio-Extraction by Fungus Coprinus comatus: A Possible Bioindicator and Mycoremediator of Polluted Soils? Environ. Sci. Pollut. Res. 2016, 23, 7444–7451.
  25. Braeuer, S.; Walenta, M.; Steiner, L.; Goessler, W. Determination of the Naturally Occurring Vanadium-Complex Amavadin in Amanita muscaria with HPLC-ICPMS. J. Anal. At. Spectrom. 2021, 36, 954–967.
  26. Housecroft, C.E. The Fungus Amanita muscaria: From Neurotoxins to Vanadium Accumulation. Chimia 2019, 73, 96–97.
  27. Falandysz, J.; Hanć, A.; Barałkiewicz, D.; Zhang, J.; Treu, R. Metallic and Metalloid Elements in Various Developmental Stages of Amanita muscaria (L.) Lam. Fungal Biol. 2020, 124, 174–182.
  28. Falandysz, J.; Saniewski, M.; Zalewska, T.; Zhang, J. Radiocaesium Pollution of Fly Agaric Amanita muscaria in Fruiting Bodies Decreases with Developmental Stage. Isot. Environ. Health Stud. 2019, 55, 317–324.
  29. Beuhler, M.C. Overview of Mushroom Poisoning. In Critical Care Toxicology; Brent, J., Burkhart, K., Dargan, P., Hatten, B., Megarbane, B., Palmer, R., Eds.; Springer International Publishing: Cham, Switzerland, 2016; pp. 1–26. ISBN 978-3-319-20790-2.
  30. Łukasik-Głebocka, M.; Druzdz, A.; Naskret, M. Clinical symptoms and circumastances of acute poisonings with fly agaric (Amanita muscaria) and panther cap (Amanita pantherina). Prz. Lek. 2011, 68, 449–452.
  31. Rampolli, F.I.; Kamler, P.; Carnevale Carlino, C.; Bedussi, F. The Deceptive Mushroom: Accidental Amanita muscaria Poisoning. Eur. J. Case Rep. Intern. Med. 2021, 8, 002212.
  32. Mikaszewska-Sokolewicz, M.A.; Pankowska, S.; Janiak, M.; Pruszczyk, P.; Łazowski, T.; Jankowski, K. Coma in the Course of Severe Poisoning after Consumption of Red Fly Agaric (Amanita muscaria). Acta Biochim. Pol. 2016, 63.
  33. Størmer, F.C.; Janak, K.; Koller, G.E.B. Ibotenic Acid in Amanita muscaria Spores and Caps. Mycologist 2004, 18, 114–117.
  34. Lurie, Y.; Wasser, S.P.; Taha, M.; Shehade, H.; Nijim, J.; Hoffmann, Y.; Basis, F.; Vardi, M.; Lavon, O.; Suaed, S.; et al. Mushroom Poisoning from Species of Genus Inocybe (Fiber Head Mushroom): A Case Series with Exact Species Identification. Clin. Toxicol. 2009, 47, 562–565.
  35. VanPatten, S.; Al-Abed, Y. The Challenges of Modulating the ‘Rest and Digest’ System: Acetylcholine Receptors as Drug Targets. Drug Discov. Today 2017, 22, 97–104.
  36. Khovpachev, A.A.; Basharin, V.A.; Chepur, S.V.; Volobuev, S.V.; Yudin, M.A.; Gogolevsky, A.S.; Nikiforov, A.S.; Kalinina, L.B.; Tyunin, M.A. Actual Concepts of Higher Fungi’s Toxins: Simple Nitrogen-Containing Compounds. Biol. Bull. Rev. 2021, 11, 198–212.
  37. Parnmen, S.; Nooron, N.; Leudang, S.; Sikaphan, S.; Polputpisatkul, D.; Pringsulaka, O.; Binchai, S.; Rangsiruji, A. Foodborne Illness Caused by Muscarine-Containing Mushrooms and Identification of Mushroom Remnants Using Phylogenetics and LC-MS/MS. Food Control 2021, 128, 108182.
  38. Shen, K.; Johnson, S.W. Presynaptic Dopamine D2 and Muscarine M 3 Receptors Inhibit Excitatory and Inhibitory Transmission to Rat Subthalamic Neurones In Vitro. J. Physiol. 2000, 525, 331–341.
  39. Neely, A.; Lingle, C.J. Effects of Muscarine on Single Rat Adrenal Chromaffin Cells. J. Physiol. 1992, 453, 133–166.
  40. Meng, W.; Wang, S.; Yao, L.; Zhang, N.; Li, D. Muscarinic Receptors Are Responsible for the Cholinergic Modulation of Projection Neurons in the Song Production Brain Nucleus RA of Zebra Finches. Front. Cell. Neurosci. 2017, 11, 51.
  41. Voynova, M.; Shkondrov, A.; Kondeva-Burdina, M.; Krasteva, I. Toxicological and Pharmacological Profile of Amanita muscaria (L.) Lam.—A New Rising Opportunity for Biomedicine. Pharmacia 2020, 67, 317–323.
  42. Stříbrný, J.; Sokol, M.; Merová, B.; Ondra, P. GC/MS Determination of Ibotenic Acid and Muscimol in the Urine of Patients Intoxicated with Amanita pantherina. Int. J. Leg. Med. 2012, 126, 519–524.
  43. Ginterová, P.; Sokolová, B.; Ondra, P.; Znaleziona, J.; Petr, J.; Ševčík, J.; Maier, V. Determination of Mushroom Toxins Ibotenic Acid, Muscimol and Muscarine by Capillary Electrophoresis Coupled with Electrospray Tandem Mass Spectrometry. Talanta 2014, 125, 242–247.
  44. Obermaier, S.; Müller, M. Ibotenic Acid Biosynthesis in the Fly Agaric Is Initiated by Glutamate Hydroxylation. Angew. Chem. Int. Ed. 2020, 59, 12432–12435.
  45. Nelson, L.E.; Guo, T.Z.; Lu, J.; Saper, C.B.; Franks, N.P.; Maze, M. The Sedative Component of Anesthesia Is Mediated by GABAA Receptors in an Endogenous Sleep Pathway. Nat. Neurosci. 2002, 5, 979–984.
  46. Stebelska, K. Fungal Hallucinogens Psilocin, Ibotenic Acid, and Muscimol: Analytical Methods and Biologic Activities. Ther. Drug Monit. 2013, 35, 420–442.
  47. Vendramin, A.; Brvar, M. Amanita muscaria and Amanita pantherina Poisoning: Two Syndromes. Toxicon 2014, 90, 269–272.
  48. Moss, M.J.; Hendrickson, R.G. Toxicity of Muscimol and Ibotenic Acid Containing Mushrooms Reported to a Regional Poison Control Center from 2002–2016. Clin. Toxicol. 2019, 57, 99–103.
  49. Akirav, I.; Raizel, H.; Maroun, M. Enhancement of Conditioned Fear Extinction by Infusion of the GABAA Agonist Muscimol into the Rat Prefrontal Cortex and Amygdala. Eur. J. Neurosci. 2006, 23, 758–764.
  50. Hobin, J.A.; Ji, J.; Maren, S. Ventral Hippocampal Muscimol Disrupts Context-Specific Fear Memory Retrieval after Extinction in Rats. Hippocampus 2006, 16, 174–182.
  51. Young, S.Z.; Bordey, A. GABA’s Control of Stem and Cancer Cell Proliferation in Adult Neural and Peripheral Niches. Physiology 2009, 24, 171–185.
  52. Tatsuta, M.; Iishi, H.; Baba, M.; Uehara, H.; Nakaizumi, A.; Taniguchi, H. Protection by Muscimol against Gastric Carcinogenesis Induced by N-Methyl-N′-Nitro-N-Nitrosoguanidine in Spontaneously Hypertensive Rats. Int. J. Cancer 1992, 52, 924–927.
  53. Kondeva-Burdina, M.; Voynova, M.; Shkondrov, A.; Aluani, D.; Tzankova, V.; Krasteva, I. Effects of Amanita muscaria Extract on Different in Vitro Neurotoxicity Models at Sub-Cellular and Cellular Levels. Food Chem. Toxicol. 2019, 132, 110687.
  54. Bowden, K.; Drysdale, A.C.; Mogey, G.A. Constituents of Amanita muscaria. Nature 1965, 206, 1359–1360.
  55. Satora, L.; Pach, D.; Butryn, B.; Hydzik, P.; Balicka-Ślusarczyk, B. Fly Agaric (Amanita muscaria) Poisoning, Case Report and Review. Toxicon 2005, 45, 941–943.
  56. Lewis, B. Atropine in Mushrooms; Therapeutic Implications. S. Afr. Med. J. 1955, 29, 262–263.
  57. Wieland, T. Poisonous Principles of Mushrooms of the Genus Amanita: Four-Carbon Amines Acting on the Central Nervous System and Cell-Destroying Cyclic Peptides Are Produced. Science 1968, 159, 946–952.
  58. Subbaratnam, A.V.; Cook, W.B. Subsidiary Constituents from Amanita muscaria. J. Med. Chem. 1963, 6, 448–449.
  59. Osbourn, A.E.; Lanzotti, V. (Eds.) Plant-Derived Natural Products; Springer: New York, NY, USA, 2009; ISBN 978-0-387-85497-7.
  60. Volgin, A.D.; Yakovlev, O.A.; Demin, K.A.; Alekseeva, P.A.; Kalueff, A.V. Acute Behavioral Effects of Deliriant Hallucinogens Atropine and Scopolamine in Adult Zebrafish. Behav. Brain Res. 2019, 359, 274–280.
  61. Debnath, B.; Singh, W.S.; Das, M.; Goswami, S.; Singh, M.K.; Maiti, D.; Manna, K. Role of Plant Alkaloids on Human Health: A Review of Biological Activities. Mater. Today Chem. 2018, 9, 56–72.
  62. Yamin-Pasternak, S.; Pasternak, I. Ethnomycology. In The International Encyclopedia of Anthropology; Callan, H., Ed.; Wiley: Hoboken, NJ, USA, 2018; pp. 1–2. ISBN 978-1-118-92439-6.
  63. Comandini, O.; Rinaldi, A.C. Ethnomycology in Europe: The Past, the Present, and the Future. In Mushrooms, Humans and Nature in a Changing World; Pérez-Moreno, J., Guerin-Laguette, A., Flores Arzú, R., Yu, F.-Q., Eds.; Springer International Publishing: Cham, Switzerland, 2020; pp. 341–364. ISBN 978-3-030-37377-1.
  64. Wieczorek, M. The Effect of Particular Active Substances of Hallucinogenic Mushrooms. Acta Univ. Lodz. Folia Biol. Oecol. 2014, 10, 40–48.
  65. Ruck, C.A.P.; Hoffman, M.A.; González Celdrán, J.A. Mushrooms, Myth, & Mithras: The Drug Cult That Civilized Europe; City Lights Books: San Francisco, CA, USA, 2011; ISBN 978-0-87286-470-2.
  66. Lee, M.; Dukan, E.; Milne, I. Amanita muscaria (Fly Agaric): From a Shamanistic Hallucinogen to the Search for Acetylcholine. J. R. Coll. Physicians Edinb. 2018, 48, 85–91.
  67. Nyberg, H. Religious Use of Hallucinogenic Fungi: A Comparison between Siberian and Mesoamerican Cultures. Karstenia 1992, 32, 71–80.
  68. Cunningham, N. Hallucinogenic Plants of Abuse. Emerg. Med. Australas. 2008, 20, 167–174.
  69. Lowy, B. Amanita muscaria and the Thunderbolt Legend in Guatemala and Mexico. Mycologia 1974, 66, 188–191.
  70. Wasson, R.G. The Soma of the Rig Veda: What Was It? J. Am. Orient. Soc. 1971, 91, 169.
  71. Wasson, R.G. Soma Brought Up-to-Date. J. Am. Orient. Soc. 1979, 99, 100.
  72. Wasson, R.G. Soma: Divine Mushroom of Immortality; Ethno-mycological studies; Mouton: The Hague, The Netherlands, 1968; ISBN 978-0-15-683800-9.
  73. Feeney, K. Revisiting Wasson’s Soma: Exploring the Effects of Preparation on the Chemistry of Amanita muscaria. J. Psychoact. Drugs 2010, 42, 499–506.
  74. Skarstein Kolberg, A. Did Vikings Really Go Berserk? An Interdisciplinary Critical Analysis of Berserks. J. Mil. Hist. 2018, 82, 899–908.
  75. Fatur, K. Sagas of the Solanaceae: Speculative Ethnobotanical Perspectives on the Norse Berserkers. J. Ethnopharmacol. 2019, 244, 112151.
  76. Rätsch, C.; Müller-Ebeling, C. Pagan Christmas: The Plants, Spirits, and Rituals at the Origins of Yuletide, 1st ed.; Inner Traditions: Rochester, VT, USA, 2006; ISBN 978-1-59477-092-0.
  77. Hijmans, S. Sol Invictus, the Winter Solstice, and the Origins of Christmas. Mouseion 2003, 3, 377–398.
  78. Marley, G.A. Chanterelle Dreams, Amanita Nightmares: The Love, Lore, and Mystique of Mushrooms; Chelsea Green Pub: White River Junction, VT, USA, 2010; ISBN 978-1-60358-214-8.
  79. Bouchard, M. Unknowingly Celebrating a Mushroom: The Influence of the Fly Agaric on Modern Yuletide Celebration. BIOL421 @UNBC—Insects, Fungi and Society. 2017. Available online: https://biol421.opened.ca/unknowingly-celebrating-a-mushroom-the-influence-of-the-fly-agaric-on-modern-yuletide-celebration/ (accessed on 16 August 2021).
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