Caloric Restriction: Comparison
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Caloric restriction (CR) is a traditional but scientifically verified approach to promoting health and increasing lifespan. CR exerts its effects through multiple molecular pathways that trigger major metabolic adaptations. It influences key nutrient and energy-sensing pathways including mammalian target of rapamycin, Sirtuin 1, AMP-activated protein kinase, and insulin signaling, ultimately resulting in reductions in basic metabolic rate, inflammation, and oxidative stress, as well as increased autophagy and mitochondrial efficiency.Caloric restriction is one of several restrictive approaches leading to weight loss accompanied by increased health span and life span.

  • Caloric restriction
  • Nutrition
  • Diet
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References

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