Abstract: Diabetes mellitus (DM) is a common endocrine disease characterized by a state of

hyperglycemia (higher level of glucose in the blood than usual). DM and its complications can lead

to diabetic foot ulcer (DFU). DFU is associated with impaired wound healing, due to inappropriate

cellular and cytokines response, infection, poor vascularization, and neuropathy. Effective therapeutic

strategies for the management of impaired wound could be attained through a better insight of

molecular mechanism and pathophysiology of diabetic wound healing. Nanotherapeutics-based

agents engineered within 1–100 nm levels, which include nanoparticles and nanoscaffolds, are recent

promising treatment strategies for accelerating diabetic wound healing. Nanoparticles are smaller in

size and have high surface area to volume ratio that increases the likelihood of biological interaction

and penetration at wound site. They are ideal for topical delivery of drugs in a sustained manner,

eliciting cell-to-cell interactions, cell proliferation, vascularization, cell signaling, and elaboration of biomolecules necessary for effective wound healing. Furthermore, nanoparticles have the ability to

deliver one or more therapeutic drug molecules, such as growth factors, nucleic acids, antibiotics,

and antioxidants, which can be released in a sustained manner within the target tissue. This review

focuses on recent approaches in the development of nanoparticle-based therapeutics for enhancing

diabetic wound healing.