The pandemic of Coronavirus Disease 2019 (COVID-19) has shocked world health authorities generating a global health crisis. A direct impact on the normal life of people around the world was produced by the actual pandemic with restrictive policies like lockdown, the use of protective masks, and limitations of personal movement. The COVID-19 lockdown promoted unhealthy dietary changes and increases in body weight of the population, showing obesity and low physical activity levels as increased risk factors of COVID-19 affection and physiopathology. In addition, hospitalized COVID-19 patients presented malnutrition and deficiencies in vitamin C, D, B12 selenium, iron, omega-3, and medium and long-chain fatty acids highlighting the potential health effect of vitamin C and D interventions.