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S-Nitrosylation in Tumor Microenvironment: Comparison
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Please note this is a comparison between Version 2 by Nora Tang and Version 1 by Saori Furuta.

S-nitrosylation is a selective and reversible post-translational modification of protein thiols by nitric oxide (NO), which is a bioactive signaling molecule, to exert a variety of effects. These effects include the modulation of protein conformation, activity, stability, and protein-protein interactions. S-nitrosylation plays a central role in propagating NO signals within a cell, tissue, and tissue microenvironment, as the nitrosyl moiety can rapidly be transferred from one protein to another upon contact. This modification has also been reported to confer either tumor-suppressing or tumor-promoting effects and is portrayed as a process involved in every stage of cancer progression. In particular, S-nitrosylation has recently been found as an essential regulator of the tumor microenvironment (TME), the environment around a tumor governing the disease pathogenesis. 

  • NO
  • S-nitrosylation
  • NOS
  • microenvironment
  • tumor-associated immune cells
  • microbiome
  • cancer therapeutics
  • ECM
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