Nuts and Older Adults’ Health: Comparison
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Please note this is a comparison between Version 2 by Conner Chen and Version 1 by Sze-Yen Tan.

Although the beneficial effects of nuts on cardiometabolic diseases have been well established, little is known about the effects of nuts on age-related diseases. Given that age-related diseases share many biological pathways with cardiometabolic diseases, it is plausible that diets rich in nuts might be beneficial in ameliorating age-related conditions. Overall, the currently available evidence suggests that nut consumption, particularly when consumed as part of a healthy diet or over a prolonged period, is associated with positive outcomes such as longer telomere length, reduced risk of sarcopenia, and better cognition in older adults.

  • nuts
  • older adults
  • quality of life
  • diet quality
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References

  1. Roser, M.; Ortiz-Ospina, E.; Ritchie, H. Life Expectancy. Available online: (accessed on 16 September 2020).
  2. Cassel, C.K. Successful aging. How increased life expectancy and medical advances are changing geriatric care. Geriatrics 2001, 56, 35.
  3. Johannesson, M.; Johansson, P.-O. Quality of life and the WTP for an increased life expectancy at an advanced age. J. Public Econ. 1997, 65, 219–228.
  4. García, L.M.R.; Navarrro, J.M.R. The Impact of Quality of Life on the Health of Older People from a Multidimensional Perspective. J. Aging Res. 2018, 2018, 1–7.
  5. Tan, S.-Y.; Tey, S.L.; Brown, R. Can Nuts Mitigate Malnutrition in Older Adults? A Conceptual Framework. Nutrients 2018, 10, 1448.
  6. Akhlaghi, M.; Ghobadi, S.; Zare, M.; Foshati, S. Effect of nuts on energy intake, hunger, and fullness, a systematic review and meta-analysis of randomized clinical trials. Crit. Rev. Food Sci. Nutr. 2018, 60, 1–10.
  7. Tan, S.Y.; Dhillon, J.; Mattes, R.D. A review of the effects of nuts on appetite, food intake, metabolism, and body weight. Am. J. Clin. Nutr. 2014, 100, 412S–422S.
  8. Naghshi, S.; Sadeghian, M.; Nasiri, M.; Mobarak, S.; Asadi, M.; Sadeghi, O. Association of Total Nut, Tree Nut, Peanut, and Peanut Butter Consumption with Cancer Incidence and Mortality: A Comprehensive Systematic Review and Dose-Response Meta-Analysis of Observational Studies. Adv. Nutr. 2020.
  9. Coates, A.M.; Hill, A.M.; Tan, S.Y. Nuts and Cardiovascular Disease Prevention. Curr. Atheroscler. Rep. 2018, 20, 48.
  10. Kim, Y.; Keogh, J.B.; Clifton, P.M. Does Nut Consumption Reduce Mortality and/or Risk of Cardiometabolic Disease? An Updated Review Based on Meta-Analyses. Int. J. Environ. Res. Public Health 2019, 16, 4957.
  11. Tindall, A.M.; Johnston, E.A.; Kris-Etherton, P.M.; Petersen, K.S. The effect of nuts on markers of glycemic control: A systematic review and meta-analysis of randomized controlled trials. Am. J. Clin. Nutr. 2019, 109, 297–314.
  12. Sanders, J.L.; Newman, A.B. Telomere Length in Epidemiology: A Biomarker of Aging, Age-Related Disease, Both, or Neither? Epidemiol. Rev. 2013, 35, 112–131.
  13. Blasco, M.A. Telomeres and human disease: Ageing, cancer and beyond. Nat. Rev. Genet. 2005, 6, 611–622.
  14. Barbour, J.A.; Howe, P.R.C.; Buckley, J.D.; Bryan, J.; Coates, A.M. Nut consumption for vascular health and cognitive function. Nutr. Res. Rev. 2014, 27, 131–158.
  15. Grosso, G.; Yang, J.; Marventano, S.; Micek, A.; Galvano, F.; Kales, S.N. Nut consumption on all-cause, cardiovascular, and cancer mortality risk: A systematic review and meta-analysis of epidemiologic studies. Am. J. Clin. Nutr. 2015, 101, 783–793.
  16. Mayhew, A.J.; De Souza, R.J.; Meyre, D.; Anand, S.S.; Mente, A. A systematic review and meta-analysis of nut consumption and incident risk of CVD and all-cause mortality. Br. J. Nutr. 2016, 115, 212–225.
  17. Del Gobbo, L.C.; Falk, M.C.; Feldman, R.; Lewis, K.; Mozaffarian, D. Effects of tree nuts on blood lipids, apolipoproteins, and blood pressure: Systematic review, meta-analysis, and dose-response of 61 controlled intervention trials. Am. J. Clin. Nutr. 2015, 102, 1347–1356.
  18. Sabaté, J.; Oda, K.; Ros, E. Nut Consumption and Blood Lipid Levels. Arch. Intern. Med. 2010, 170, 821–827.
  19. Tucker, L.A. Consumption of nuts and seeds and telomere length in 5,582 men and women of the National Health and Nutrition Examination Survey (NHANES). J. Nutr. Health Aging 2017, 21, 233–240.
  20. Boccardi, V.; Paolisso, G.; Mecocci, P. Nutrition and lifestyle in healthy aging: The telomerase challenge. Aging 2016, 8, 12–15.
  21. Campisi, J.; Kim, S.-H.; Lim, C.-S.; Rubio, M. Cellular senescence, cancer and aging: The telomere connection. Exp. Gerontol. 2001, 36, 1619–1637.
  22. Shay, J.W.; Wright, W.E. Telomeres and telomerase in normal and cancer stem cells. FEBS Lett. 2010, 584, 3819–3825.
  23. D’Mello, M.J.; Ross, S.A.; Briel, M.; Anand, S.S.; Gerstein, H.; Paré, G. Association Between Shortened Leukocyte Telomere Length and Cardiometabolic Outcomes. Circ. Cardiovasc. Genet. 2015, 8, 82–90.
  24. Wentzensen, I.M.; Mirabello, L.; Pfeiffer, R.M.; Savage, S.A. The Association of Telomere Length and Cancer: A Meta-analysis. Cancer Epidemiol. Biomark. Prev. 2011, 20, 1238–1250.
  25. Crous-Bou, M.; Fung, T.T.; Prescott, J.; Julin, B.; Du, M.; Sun, Q.; Rexrode, K.M.; Hu, F.B.; De Vivo, I. Mediterranean diet and telomere length in Nurses’ Health Study: Population based cohort study. BMJ 2014, 349, g6674.
  26. Galiè, S.; Canudas, S.; Muralidharan, J.; García-Gavilán, J.; Bulló, M.; Salas-Salvadó, J. Impact of Nutrition on Telomere Health: Systematic Review of Observational Cohort Studies and Randomized Clinical Trials. Adv. Nutr. 2019, 11, 576–601.
  27. Lee, J.-Y.; Jun, N.-R.; Yoon, D.; Shin, C.; Baik, I. Association between dietary patterns in the remote past and telomere length. Eur. J. Clin. Nutr. 2015, 69, 1048–1052.
  28. Marin, C.; Delgado-Lista, J.; Ramirez, R.; Carracedo, J.; Caballero, J.; Perez-Martinez, P.; Gutierrez-Mariscal, F.M.; Garcia-Rios, A.; Delgado-Casado, N.; Cruz-Teno, C.; et al. Mediterranean diet reduces senescence-associated stress in endothelial cells. AGE 2011, 34, 1309–1316.
  29. Qiao, S.; Jiang, Y.; Li, X. The Impact of Health Promotion Interventions on Telomere Length: A Systematic Review. Am. J. Health Promot. 2020, 34, 633–647.
  30. Valdes, A.M.; Andrew, T.; Gardner, J.P.; Kimura, M.; Oelsner, E.; Cherkas, L.F.; Aviv, A.; Spector, T.D. Obesity, cigarette smoking, and telomere length in women. Lancet 2005, 366, 662–664.
  31. Rusu, M.E.; Simedrea, R.; Gheldiu, A.-M.; Mocan, A.; Vlase, L.; Popa, D.-S.; Ferreira, I.C. Benefits of tree nut consumption on aging and age-related diseases: Mechanisms of actions. Trends Food Sci. Technol. 2019, 88, 104–120.
  32. Houben, J.M.; Moonen, H.J.; Van Schooten, F.J.; Hageman, G.J. Telomere length assessment: Biomarker of chronic oxidative stress? Free. Radic. Biol. Med. 2008, 44, 235–246.
  33. López-Uriarte, P.; Bulló, M.; Casas-Agustench, P.; Babio, N.; Salas-Salvadó, J. Nuts and oxidation: A systematic review. Nutr. Rev. 2009, 67, 497–508.
  34. Neale, E.P.; Tapsell, L.C.; Guan, V.; Batterham, M.J. The effect of nut consumption on markers of inflammation and endothelial function: A systematic review and meta-analysis of randomised controlled trials. BMJ Open 2017, 7, e016863.
  35. Canudas, S.; Hernández-Alonso, P.; Galié, S.; Muralidharan, J.; Morell-Azanza, L.; Zalba, G.; García-Gavilán, J.; Martí, A.; Salas-Salvadó, J.; Bulló, M. Pistachio consumption modulates DNA oxidation and genes related to telomere maintenance: A crossover randomized clinical trial. Am. J. Clin. Nutr. 2019, 109, 1738–1745.
  36. Gong, Y.; Tian, G.; Xue, H.; Zhang, X.; Zhao, Y.; Cheng, G. Higher adherence to the ‘vegetable-rich’ dietary pattern is related to longer telomere length in women. Clin. Nutr. 2018, 37, 1232–1237.
  37. Zhou, M.; Zhu, L.; Cui, X.; Feng, L.; Zhao, X.; He, S.; Ping, F.; Li, W.; Li, Y. Influence of diet on leukocyte telomere length, markers of inflammation and oxidative stress in individuals with varied glucose tolerance: A Chinese population study. Nutr. J. 2015, 15, 39.
  38. García-Calzón, S.; Zalba, G.; Ruiz-Canela, M.; Shivappa, N.; Hébert, J.R.; Martínez, J.A.; Fitó, M.; Gómez-Gracia, E.; A Martínez-González, M.; Marti, A. Dietary inflammatory index and telomere length in subjects with a high cardiovascular disease risk from the PREDIMED-NAVARRA study: Cross-sectional and longitudinal analyses over 5 y. Am. J. Clin. Nutr. 2015, 102, 897–904.
  39. Ojeda-Rodríguez, A.; Zazpe, I.; Alonso-Pedrero, L.; Zalba, G.; Guillen-Grima, F.; Martinez-Gonzalez, M.A.; Marti, A. Association between diet quality indexes and the risk of short telomeres in an elderly population of the SUN project. Clin. Nutr. 2020, 39, 2487–2494.
  40. Chan, R.; Woo, J.; Suen, E.; Leung, J.; Tang, N. Chinese tea consumption is associated with longer telomere length in elderly Chinese men. Br. J. Nutr. 2009, 103, 107–113.
  41. Boccardi, V.; Esposito, A.; Rizzo, M.R.; Marfella, R.; Barbieri, M.; Paolisso, G. Mediterranean Diet, Telomere Maintenance and Health Status among Elderly. PLoS ONE 2013, 8, e62781.
  42. Gu, Y.; Honig, L.S.; Schupf, N.; Lee, J.H.; Luchsinger, J.A.; Stern, Y.; Scarmeas, N. Mediterranean diet and leukocyte telomere length in a multi-ethnic elderly population. AGE 2015, 37.
  43. Leung, C.W.; Fung, T.T.; McEvoy, C.T.; Lin, J.; Epel, E.S. Diet Quality Indices and Leukocyte Telomere Length Among Healthy US Adults: Data From the National Health and Nutrition Examination Survey, 1999–2002. Am. J. Epidemiol. 2018, 187, 2192–2201.
  44. Marra, M.V.; Drazba, M.A.; Holásková, I.; Belden, W.J. Nutrition Risk is Associated with Leukocyte Telomere Length in Middle-Aged Men and Women with at Least One Risk Factor for Cardiovascular Disease. Nutrients 2019, 11, 508.
  45. Karimi, B.; Nabizadeh, R.; Yunesian, M.; Mehdipour, P.; Rastkari, N.; Aghaie, A. Foods, Dietary Patterns and Occupational Class and Leukocyte Telomere Length in the Male Population. Am. J. Men’s Health 2017, 12, 479–492.
  46. Milte, C.M.; Russell, A.P.; Ball, K.; Crawford, D.; Salmon, J.; McNaughton, S.A. Diet quality and telomere length in older Australian men and women. Eur. J. Nutr. 2016, 57, 363–372.
  47. Meinilä, J.; Perälä, M.-M.; Kautiainen, H.; Männistö, S.; Kanerva, N.; Shivappa, N.; Hébert, J.R.; Iozzo, P.; Guzzardi, M.A.; Eriksson, J.G. Healthy diets and telomere length and attrition during a 10-year follow-up. Eur. J. Clin. Nutr. 2019, 73, 1352–1360.
  48. Haveman-Nies, A.; De Groot, L.C.; Van Staveren, W.A. Dietary quality, lifestyle factors and healthy ageing in Europe: The SENECA study. Age Ageing 2003, 32, 427–434.
  49. Willett, W.C.; Sacks, F.; Trichopoulou, A.; Drescher, G.; Ferro-Luzzi, A.; Helsing, E.; Trichopoulos, D. Mediterranean diet pyramid: A cultural model for healthy eating. Am. J. Clin. Nutr. 1995, 61, 1402S–1406S.
  50. Trichopoulou, A.; Bamia, C.; Trichopoulos, D. Anatomy of health effects of Mediterranean diet: Greek EPIC prospective cohort study. BMJ 2009, 338, b2337.
  51. Canudas, S.; Becerra-Tomás, N.; Hernández-Alonso, P.; Galié, S.; Leung, C.; Crous-Bou, M.; De Vivo, I.; Gao, Y.; Gu, Y.; Meinilä, J.; et al. Mediterranean Diet and Telomere Length: A Systematic Review and Meta-Analysis. Adv. Nutr. 2020, 11, 1544–1554.
  52. Nettleton, J.A.; Schulze, M.B.; Jiang, R.; Jenny, N.S.; Burke, G.L.; Jacobs, D.R. A priori–defined dietary patterns and markers of cardiovascular disease risk in the Multi-Ethnic Study of Atherosclerosis (MESA). Am. J. Clin. Nutr. 2008, 88, 185–194.
  53. Freitas-Simoes, T.-M.; Cofán, M.; Blasco, M.A.; Soberón, N.; Foronda, M.; Serra-Mir, M.; Roth, I.; Valls-Pedret, C.; Doménech, M.; Ponferrada-Ariza, E.; et al. Walnut Consumption for Two Years and Leukocyte Telomere Attrition in Mediterranean Elders: Results of a Randomized Controlled Trial. Nutrients 2018, 10, 1907.
  54. García-Calzón, S.; Martínez-González, M.A.; Razquin, C.; Corella, D.; Salas-Salvadó, J.; Martínez, J.A.; Zalba, G.; Marti, A. Pro12Ala Polymorphism of the PPARγ2 Gene Interacts with a Mediterranean Diet to Prevent Telomere Shortening in the PREDIMED-NAVARRA Randomized Trial. Circ. Cardiovasc. Genet. 2015, 8, 91–99.
  55. Cruz-Jentoft, A.J.; Bahat, G.; Bauer, J.; Boirie, Y.; Bruyère, O.; Cederholm, T.; Cooper, C.; Landi, F.; Rolland, Y.; Sayer, A.A.; et al. Sarcopenia: Revised European consensus on definition and diagnosis. Age Ageing 2019, 48, 16–31.
  56. Cruz-Jentoft, A.J.; Sayer, A.A. Sarcopenia. Lancet 2019, 393, 2636–2646.
  57. Robinson, S.; Reginster, J.; Rizzoli, R.; Shaw, S.; Kanis, J.; Bautmans, I.; Bischoff-Ferrari, H.; Bruyère, O.; Cesari, M.; Dawson-Hughes, B.; et al. Does nutrition play a role in the prevention and management of sarcopenia? Clin. Nutr. 2018, 37, 1121–1132.
  58. Lee, S.-Y.; Tung, H.-H.; Liu, C.-Y.; Chen, L.-K. Physical Activity and Sarcopenia in the Geriatric Population: A Systematic Review. J. Am. Med. Dir. Assoc. 2018, 19, 378–383.
  59. Woo, J. Nutritional interventions in sarcopenia. Curr. Opin. Clin. Nutr. Metab. Care 2018, 21, 19–23.
  60. Arias-Fernández, L.; Machado-Fragua, M.D.; Graciani, A.; Guallar-Castillón, P.; Banegas, J.R.; Rodríguez-Artalejo, F.; Lana, A.; Lopez-Garcia, E. Prospective Association Between Nut Consumption and Physical Function in Older Men and Women. J. Gerontol. Ser. A Boil. Sci. Med. Sci. 2018, 74, 1091–1097.
  61. Ballesteros, J.-M.; Struijk, E.A.; Rodríguez-Artalejo, F.; Lopez-Garcia, E. Mediterranean diet and risk of falling in community-dwelling older adults. Clin. Nutr. 2020, 39, 276–281.
  62. Bradlee, M.L.; Mustafa, J.; Singer, M.R.; Moore, L.L. High-Protein Foods and Physical Activity Protect Against Age-Related Muscle Loss and Functional Decline. J. Gerontol. Ser. A Boil. Sci. Med. Sci. 2018, 73, 88–94.
  63. Hai, S.; Wang, H.; Cao, L.; Liu, P.; Zhou, J.; Yang, Y.; Dong, B. Association between sarcopenia with lifestyle and family function among community-dwelling Chinese aged 60 years and older. BMC Geriatr. 2017, 17, 1–7.
  64. Hashemi, R.; Motlagh, A.D.; Heshmat, R.; Esmaillzadeh, A.; Payab, M.; Yousefinia, M.; Siassi, F.; Pasalar, P.; Baygi, F. Diet and its relationship to sarcopenia in community dwelling Iranian elderly: A cross sectional study. Nutrients 2015, 31, 97–104.
  65. Lim, H.-S. Association of Dietary Variety Status and Sarcopenia in Korean Elderly. J. Bone Metab. 2020, 27, 143–149.
  66. Schacht, S.R.; Lind, M.V.; Mertz, K.H.; Bülow, J.; Bechshøft, R.; Højfeldt, G.; Schucany, A.; Hjulmand, M.; Sidoli, C.; Andersen, S.B.; et al. Development of a Mobility Diet Score (MDS) and Associations with Bone Mineral Density and Muscle Function in Older Adults. Front. Nutr. 2019, 6, 114.
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