Energy Metabolism and Glaucoma: Comparison
Please note this is a comparison between Version 2 by Lily Guo and Version 1 by Hanhan Liu.

Glaucoma, the leading cause of irreversible blindness, is a heterogeneous group of diseases characterized by progressive loss of retinal ganglion cells (RGCs) and their axons and leads to visual loss and blindness. Risk factors for the onset and progression of glaucoma include systemic and ocular factors such as older age, lower ocular perfusion pressure, and intraocular pressure (IOP). Early signs of RGC damage comprise impairment of axonal transport, downregulation of specific genes and metabolic changes. The brain is often cited to be the highest energy-demanding tissue of the human body. The retina is estimated to have equally high demands. RGCs are particularly active in metabolism and vulnerable to energy insufficiency. Understanding the energy metabolism of the inner retina, especially of the RGCs, is pivotal for understanding glaucoma’s pathophysiology.

  • energy metabolism
  • glaucoma
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References

  1. Bagetta, G.; Nucci, C. Preface: New trends in basic and clinical research of glaucoma: A neurodegenerative disease of the visual system part B. Prog. Brain Res. 2015, 221, xxiii–xxiv.
  2. Moore, D.; Harris, A.; Wudunn, D.; Kheradiya, N.; Siesky, B. Dysfunctional regulation of ocular blood flow: A risk factor for glaucoma? Clin. Ophthalmol. 2008, 2, 849–861.
  3. Sommer, A. Intraocular pressure and glaucoma. Am. J. Ophthalmol. 1989, 107, 186–188.
  4. Kim, J.; Dally, L.G.; Ederer, F.; Gaasterland, D.E.; VanVeldhuisen, P.C.; Blackwell, B.; Sullivan, E.K.; Prum, B.; Shafranov, G.; Beck, A.; et al. The Advanced Glaucoma Intervention Study (AGIS): 14. Distinguishing progression of glaucoma from visual field fluctuations. Ophthalmology 2004, 111, 2109–2116.
  5. Ederer, F.; Gaasterland, D.A.; Dally, L.G.; Kim, J.; VanVeldhuisen, P.C.; Blackwell, B.; Prum, B.; Shafranov, G.; Allen, R.C.; Beck, A.; et al. The Advanced Glaucoma Intervention Study (AGIS): 13. Comparison of treatment outcomes within race: 10-year results. Ophthalmology 2014, 111, 651–664.
  6. Heijl, A.; Leske, M.C.; Bengtsson, B.; Hyman, L.; Bengtsson, B.; Hussein, M.; Early Manifest Glaucoma Trial, G. Reduction of intraocular pressure and glaucoma progression: Results from the Early Manifest Glaucoma Trial. Arch. Ophthalmol. 2002, 120, 1268–1279.
  7. Calkins, D.J.; Horner, P.J. The cell and molecular biology of glaucoma: Axonopathy and the brain. Investig. Ophthalmol. Vis. Sci. 2012, 53, 2482–2484.
  8. Howell, G.R.; Libby, R.T.; Jakobs, T.C.; Smith, R.S.; Phalan, F.C.; Barter, J.W.; Barbay, J.M.; Marchant, J.K.; Mahesh, N.; Porciatti, V.; et al. Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J. Cell Biol. 2007, 179, 1523–1537.
  9. Buckingham, B.P.; Inman, D.M.; Lambert, W.; Oglesby, E.; Calkins, D.J.; Steele, M.R.; Vetter, M.L.; Marsh-Armstrong, N.; Horner, P.J. Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma. J. Neurosci. 2008, 28, 2735–2744.
  10. Soto, I.; Oglesby, E.; Buckingham, B.P.; Son, J.L.; Roberson, E.D.; Steele, M.R.; Inman, D.M.; Vetter, M.L.; Horner, P.J.; Marsh-Armstrong, N. Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model. J. Neurosci. 2008, 28, 548–561.
  11. Baltan, S.; Inman, D.M.; Danilov, C.A.; Morrison, R.S.; Calkins, D.J.; Horner, P.J. Metabolic vulnerability disposes retinal ganglion cell axons to dysfunction in a model of glaucomatous degeneration. J. Neurosci. 2010, 30, 5644–5652.
  12. Rolfe, D.F.; Brown, G.C. Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol. Rev. 1997, 77, 731–758.
  13. Weber, B.; Keller, A.L.; Reichold, J.; Logothetis, N.K. The microvascular system of the striate and extrastriate visual cortex of the macaque. Cereb. Cortex 2008, 18, 2318–2330.
  14. Medrano, C.J.; Fox, D.A. Oxygen consumption in the rat outer and inner retina: Light- and pharmacologically-induced inhibition. Exp. Eye Res. 1995, 61, 273–284.
  15. Yaspelkis, B.B., III; Anderla, P.A.; Patterson, J.G.; Ivy, J.L. Ventilation parallels plasma potassium during incremental and continuous variable intensity exercise. Int. J. Sports Med. 1994, 15, 460–465.
  16. Wang, L.; Tornquist, P.; Bill, A. Glucose metabolism of the inner retina in pigs in darkness and light. Acta Physiol. Scand. 1997, 160, 71–74.
  17. Werkmeister, R.M.; Schmidl, D.; Aschinger, G.; Doblhoff-Dier, V.; Palkovits, S.; Wirth, M.; Garhofer, G.; Linsenmeier, R.A.; Leitgeb, R.A.; Schmetterer, L. Retinal oxygen extraction in humans. Sci. Rep. 2015, 5, 15763.
  18. Bill, A.; Sperber, G.O. Aspects of oxygen and glucose consumption in the retina: Effects of high intraocular pressure and light. Graefe’s Arch. Clin. Exp. Ophthalmol. 1990, 228, 124–127.
  19. Ito, Y.A.; Di Polo, A. Mitochondrial dynamics, transport, and quality control: A bottleneck for retinal ganglion cell viability in optic neuropathies. Mitochondrion 2017, 36, 186–192.
  20. Ju, W.K.; Liu, Q.; Kim, K.Y.; Crowston, J.G.; Lindsey, J.D.; Agarwal, N.; Ellisman, M.H.; Perkins, G.A.; Weinreb, R.N. Elevated hydrostatic pressure triggers mitochondrial fission and decreases cellular ATP in differentiated RGC-5 cells. Investig. Ophthalmol. Vis. Sci. 2007, 48, 2145–2151.
  21. Ju, W.K.; Kim, K.Y.; Lindsey, J.D.; Angert, M.; Patel, A.; Scott, R.T.; Liu, Q.; Crowston, J.G.; Ellisman, M.H.; Perkins, G.A.; et al. Elevated hydrostatic pressure triggers release of OPA1 and cytochrome C, and induces apoptotic cell death in differentiated RGC-5 cells. Mol. Vis. 2009, 15, 120–134.
  22. Kong, G.Y.; Van Bergen, N.J.; Trounce, I.A.; Crowston, J.G. Mitochondrial dysfunction and glaucoma. J. Glaucoma 2009, 18, 93–100.
  23. Liu, H.; Zhang, X.; Xiao, J.; Song, M.; Cao, Y.; Xiao, H.; Liu, X. Astaxanthin attenuates d-galactose-induced brain aging in rats by ameliorating oxidative stress, mitochondrial dysfunction, and regulating metabolic markers. Food Funct. 2020, 11, 4103–4113.
  24. Jung, H.; Kim, S.Y.; Canbakis Cecen, F.S.; Cho, Y.; Kwon, S.K. Dysfunction of Mitochondrial Ca(2+) Regulatory Machineries in Brain Aging and Neurodegenerative Diseases. Front. Cell Dev. Biol. 2020, 8, 599792.
  25. Dietrich, M.O.; Horvath, T.L. The role of mitochondrial uncoupling proteins in lifespan. Pflug. Arch. Eur. J. Physiol. 2010, 459, 269–275.
  26. Brown, M.D.; Starikovskaya, E.; Derbeneva, O.; Hosseini, S.; Allen, J.C.; Mikhailovskaya, I.E.; Sukernik, R.I.; Wallace, D.C. The role of mtDNA background in disease expression: A new primary LHON mutation associated with Western Eurasian haplogroup. J. Hum. Genet. 2002, 110, 130–138.
  27. Carelli, V.; Ross-Cisneros, F.N.; Sadun, A.A. Mitochondrial dysfunction as a cause of optic neuropathies. Prog. Retin. Eye Res. 2004, 23, 53–89.
  28. Masland, R.H. The neuronal organization of the retina. Neuron 2012, 76, 266–280.
  29. Mergenthaler, P.; Lindauer, U.; Dienel, G.A.; Meisel, A. Sugar for the brain: The role of glucose in physiological and pathological brain function. Trends Neurosci. 2013, 36, 587–597.
  30. Kety, S.S. The circulation and energy metabolism of the brain. Clin. Neurosurg. 1963, 9, 56–66.
  31. Du Plessis, S.S.; Agarwal, A.; Mohanty, G.; van der Linde, M. Oxidative phosphorylation versus glycolysis: What fuel do spermatozoa use? Asian J. Androl. 2015, 17, 230–235.
  32. Shetty, P.K.; Galeffi, F.; Turner, D.A. Cellular Links between Neuronal Activity and Energy Homeostasis. Front. Pharmacol. 2012, 3, 43.
  33. Winkler, B.S. Glycolytic and oxidative metabolism in relation to retinal function. J. Gen. Physiol. 1981, 77, 667–692.
  34. Padnick-Silver, L.; Linsenmeier, R.A. Quantification of in vivo anaerobic metabolism in the normal cat retina through intraretinal pH measurements. Vis. Neurosci. 2002, 19, 793–806.
  35. Lowry, O.H.; Roberts, N.R.; Lewis, C. The quantitative histochemistry of the retina. J. Biol. Chem. 1956, 220, 879–892.
  36. Cohen, L.H.; Noell, W.K. Glucose catabolism of rabbit retina before and after development of visual function. J. Neurochem. 1960, 5, 253–276.
  37. Joyal, J.S.; Sun, Y.; Gantner, M.L.; Shao, Z.; Evans, L.P.; Saba, N.; Fredrick, T.; Burnim, S.; Kim, J.S.; Patel, G.; et al. Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat. Med. 2016, 22, 439–445.
  38. Cohen, A.I. Electron microscopic observations of the internal limiting membrane and optic fiber layer of the retina of the Rhesus monkey (M. mulatta). Am. J. Anat. 1961, 108, 179–197.
  39. Winkler, B.S.; Pourcho, R.G.; Starnes, C.; Slocum, J.; Slocum, N. Metabolic mapping in mammalian retina: A biochemical and 3H-2-deoxyglucose autoradiographic study. Exp. Eye Res. 2003, 77, 327–337.
  40. Mantych, G.J.; Hageman, G.S.; Devaskar, S.U. Characterization of glucose transporter isoforms in the adult and developing human eye. Endocrinology 1993, 133, 600–607.
  41. Kumagai, A.K.; Glasgow, B.J.; Pardridge, W.M. GLUT1 glucose transporter expression in the diabetic and nondiabetic human eye. Investig. Ophthalmol. Vis. Sci. 1994, 35, 2887–2894.
  42. Vander Heiden, M.G.; Cantley, L.C.; Thompson, C.B. Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 2009, 324, 1029–1033.
  43. Warburg, O. On respiratory impairment in cancer cells. Science 1956, 124, 269–270.
  44. Leung, C.O.; Wong, C.C.; Fan, D.N.; Kai, A.K.; Tung, E.K.; Xu, I.M.; Ng, I.O.; Lo, R.C. PIM1 regulates glycolysis and promotes tumor progression in hepatocellular carcinoma. Oncotarget 2015, 6, 10880–10892.
  45. Chinchore, Y.; Begaj, T.; Wu, D.; Drokhlyansky, E.; Cepko, C.L. Glycolytic reliance promotes anabolism in photoreceptors. eLife 2017, 6.
  46. Burns, J.S.; Manda, G. Metabolic Pathways of the Warburg Effect in Health and Disease: Perspectives of Choice, Chain or Chance. Int. J. Mol. Sci. 2017, 18.
  47. Narayan, D.S.; Chidlow, G.; Wood, J.P.; Casson, R.J. Glucose metabolism in mammalian photoreceptor inner and outer segments. Clin. Exp. Ophthalmol. 2017, 45, 730–741.
  48. Chertov, A.O.; Holzhausen, L.; Kuok, I.T.; Couron, D.; Parker, E.; Linton, J.D.; Sadilek, M.; Sweet, I.R.; Hurley, J.B. Roles of glucose in photoreceptor survival. J. Biol. Chem. 2011, 286, 34700–34711.
  49. Poitry-Yamate, C.L.; Poitry, S.; Tsacopoulos, M. Lactate released by Muller glial cells is metabolized by photoreceptors from mammalian retina. J. Neurosci. 1995, 15, 5179–5191.
  50. Winkler, B.S.; Arnold, M.J.; Brassell, M.A.; Sliter, D.R. Glucose dependence of glycolysis, hexose monophosphate shunt activity, energy status, and the polyol pathway in retinas isolated from normal (nondiabetic) rats. Investig. Ophthalmol. Vis. Sci. 1997, 38, 62–71.
  51. Uga, S.; Smelser, G.K. Comparative study of the fine structure of retinal Muller cells in various vertebrates. Invest. Ophthalmol. 1973, 12, 434–448.
  52. Joyal, J.S.; Gantner, M.L.; Smith, L.E.H. Retinal energy demands control vascular supply of the retina in development and disease: The role of neuronal lipid and glucose metabolism. Prog. Retin. Eye Res. 2018, 64, 131–156.
  53. Acker, T.; Acker, H. Cellular oxygen sensing need in CNS function: Physiological and pathological implications. J. Exp. Biol. 2004, 207, 3171–3188.
  54. Brown, G.C. Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase. Biochim. Biophys. Acta 2001, 1504, 46–57.
  55. Wong-Riley, M.T. Energy metabolism of the visual system. Eye Brain 2010, 2, 99–116.
  56. Arnold, S. Cytochrome c oxidase and its role in neurodegeneration and neuroprotection. Adv. Exp. Med. Biol. 2012, 748, 305–339.
  57. Hollander, H.; Makarov, F.; Stefani, F.H.; Stone, J. Evidence of constriction of optic nerve axons at the lamina cribrosa in the normotensive eye in humans and other mammals. Ophthalmic Res. 1995, 27, 296–309.
  58. Andrews, R.M.; Griffiths, P.G.; Johnson, M.A.; Turnbull, D.M. Histochemical localisation of mitochondrial enzyme activity in human optic nerve and retina. Br. J. Ophthalmol. 1999, 83, 231–235.
  59. Calvetti, D.; Somersalo, E. Menage a trois: The role of neurotransmitters in the energy metabolism of astrocytes, glutamatergic, and GABAergic neurons. J. Cereb. Blood Flow Metab. 2012, 32, 1472–1483.
  60. Ames, A., 3rd; Li, Y.Y.; Heher, E.C.; Kimble, C.R. Energy metabolism of rabbit retina as related to function: High cost of Na+ transport. J. Neurosci. 1992, 12, 840–853.
  61. Forman, D.S.; Brown, K.J.; Livengood, D.R. Fast axonal transport in permeabilized lobster giant axons is inhibited by vanadate. J. Neurosci. 1983, 3, 1279–1288.
  62. Vallee, R.B.; Wall, J.S.; Paschal, B.M.; Shpetner, H.S. Microtubule-associated protein 1C from brain is a two-headed cytosolic dynein. Nature 1988, 332, 561–563.
  63. Niven, J.E.; Laughlin, S.B. Energy limitation as a selective pressure on the evolution of sensory systems. J. Exp. Biol. 2008, 211, 1792–1804.
  64. Attwell, D.; Laughlin, S.B. An energy budget for signaling in the grey matter of the brain. J. Cereb. Blood Flow Metab. 2001, 21, 1133–1145.
  65. Wong-Riley, M.T. Cytochrome oxidase: An endogenous metabolic marker for neuronal activity. Trends Neurosci. 1989, 12, 94–101.
  66. Skou, J.C. The influence of some cations on an adenosine triphosphatase from peripheral nerves. Biochim. Biophys. Acta 1957, 23, 394–401.
  67. Stahl, W.L. The Na, K-ATPase of nervous tissue. Neurochem. Int. 1986, 8, 449–476.
  68. Muzio, M.R.; Cascella, M. Histology, Axon. In StatPearls; StatPearls Publishing: Treasure Island, FL, USA, 2020.
  69. Wong-Riley, M.T.; Huang, Z.; Liebl, W.; Nie, F.; Xu, H.; Zhang, C. Neurochemical organization of the macaque retina: Effect of TTX on levels and gene expression of cytochrome oxidase and nitric oxide synthase and on the immunoreactivity of Na+ K+ ATPase and NMDA receptor subunit I. Vis. Res. 1998, 38, 1455–1477.
  70. Dowling, J.E. The Retina: An Approachable Part of the Brain; Harvard University Press: Cambridge, MA, USA, 1986.
  71. Hagins, W.A.; Penn, R.D.; Yoshikami, S. Dark current and photocurrent in retinal rods. Biophys. J. 1970, 10, 380–412.
  72. Maeda, A.; Golczak, M.; Maeda, T.; Palczewski, K. Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina. Investig. Ophthalmol. Vis. Sci. 2009, 50, 5435–5443.
  73. Rajala, R.V.S. Aerobic Glycolysis in the Retina: Functional Roles of Pyruvate Kinase Isoforms. Front. Cell Dev. Biol. 2020, 8, 266.
  74. Kageyama, G.H.; Wong-Riley, M.T. The histochemical localization of cytochrome oxidase in the retina and lateral geniculate nucleus of the ferret, cat, and monkey, with particular reference to retinal mosaics and ON/OFF-center visual channels. J. Neurosci. 1984, 4, 2445–2459.
  75. Wimmers, S.; Karl, M.O.; Strauss, O. Ion channels in the RPE. Prog. Retin. Eye Res. 2007, 26, 263–301.
  76. Boulton, M.; Dayhaw-Barker, P. The role of the retinal pigment epithelium: Topographical variation and ageing changes. Eye 2001, 15, 384–389.
  77. Catalani, E.; Cervia, D. Diabetic retinopathy: A matter of retinal ganglion cell homeostasis. Neural Regen. Res. 2020, 15, 1253–1254.
  78. Yang, T.C.; Yarmishyn, A.A.; Yang, Y.P.; Lu, P.C.; Chou, S.J.; Wang, M.L.; Lin, T.C.; Hwang, D.K.; Chou, Y.B.; Chen, S.J.; et al. Mitochondrial transport mediates survival of retinal ganglion cells in affected LHON patients. Hum. Mol. Genet. 2020, 29, 1454–1464.
  79. Liu, H.; Mercieca, K.; Prokosch, V. Mitochondrial Markers in Aging and Primary Open-Angle Glaucoma. J. Glaucoma 2020, 29, 295–303.
  80. Williams, P.A.; Harder, J.M.; John, S.W.M. Glaucoma as a Metabolic Optic Neuropathy: Making the Case for Nicotinamide Treatment in Glaucoma. J. Glaucoma 2017, 26, 1161–1168.
  81. Erecinska, M.; Silver, I.A. Tissue oxygen tension and brain sensitivity to hypoxia. Respir. Physiol. 2001, 128, 263–276.
  82. Pournaras, C.J.; Rungger-Brandle, E.; Riva, C.E.; Hardarson, S.H.; Stefansson, E. Regulation of retinal blood flow in health and disease. Prog. Retin. Eye Res. 2008, 27, 284–330.
  83. Iwasaki, M.; Inomata, H. Relation between superficial capillaries and foveal structures in the human retina. Investig. Ophthalmol. Vis. Sci. 1986, 27, 1698–1705.
  84. Linsenmeier, R.A.; Zhang, H.F. Retinal oxygen: From animals to humans. Prog. Retin. Eye Res. 2017, 58, 115–151.
  85. Flammer, J.; Orgul, S.; Costa, V.P.; Orzalesi, N.; Krieglstein, G.K.; Serra, L.M.; Renard, J.P.; Stefansson, E. The impact of ocular blood flow in glaucoma. Prog. Retin. Eye Res. 2002, 21, 359–393.
  86. Grunwald, J.E.; Sinclair, S.H.; Riva, C.E. Autoregulation of the retinal circulation in response to decrease of intraocular pressure below normal. Investig. Ophthalmol. Vis. Sci. 1982, 23, 124–127.
  87. Pournaras, C.J. Retinal oxygen distribution. Its role in the physiopathology of vasoproliferative microangiopathies. Retina 1995, 15, 332–347.
  88. Yu, D.Y.; Cringle, S.J.; Alder, V.A.; Su, E.N. Intraretinal oxygen distribution in rats as a function of systemic blood pressure. Am. J. Physiol. 1994, 267, H2498–H2507.
  89. Hayreh, S.S. Posterior ciliary artery circulation in health and disease: The Weisenfeld lecture. Investig. Ophthalmol. Vis. Sci. 2004, 45, 749–757.
  90. Collignon, N.J. Emergencies in glaucoma: A review. Bull. Soc. Belg. Ophtalmol. 2005, 296, 71–81.
  91. Hughes, W.F. Quantitation of ischemic damage in the rat retina. Exp. Eye Res. 1991, 53, 573–582.
  92. Hitchings, R.A.; Spaeth, G.L. Fluorescein angiography in chronic simple and low-tension glaucoma. Br. J. Ophthalmol. 1977, 61, 126–132.
  93. Sugiyama, T.; Schwartz, B.; Takamoto, T.; Azuma, I. Evaluation of the circulation in the retina, peripapillary choroid and optic disk in normal-tension glaucoma. Ophthalmic Res. 2000, 32, 79–86.
  94. Hamard, P.; Hamard, H.; Dufaux, J.; Quesnot, S. Optic nerve head blood flow using a laser Doppler velocimeter and haemorheology in primary open angle glaucoma and normal pressure glaucoma. Br. J. Ophthalmol. 1994, 78, 449–453.
  95. Park, J.W.; Kwon, H.J.; Chung, W.S.; Kim, C.Y.; Seong, G.J. Short-term effects of Ginkgo biloba extract on peripapillary retinal blood flow in normal tension glaucoma. Korean J. Ophthalmol. 2011, 25, 323–328.
  96. Jonas, J.B.; Nguyen, X.N.; Naumann, G.O. Parapapillary retinal vessel diameter in normal and glaucoma eyes. I. Morphometric data. Investig. Ophthalmol. Vis. Sci. 1989, 30, 1599–1603.
  97. Guyton, D.L.; Hambrecht, F.T. Capacitor electrode stimulates nerve or muscle without oxidation-reduction reactions. Science 1973, 181, 74–76.
  98. Harris, A.; Ciulla, T.A.; Chung, H.S.; Martin, B. Regulation of retinal and optic nerve blood flow. Arch. Ophthalmol. 1998, 116, 1491–1495.
  99. Yamanishi, S.; Katsumura, K.; Kobayashi, T.; Puro, D.G. Extracellular lactate as a dynamic vasoactive signal in the rat retinal microvasculature. Am. J. Physiol. Heart Circ. Physiol. 2006, 290, H925–H934.
  100. Toda, N.; Nakanishi-Toda, M. Nitric oxide: Ocular blood flow, glaucoma, and diabetic retinopathy. Prog. Retin. Eye Res. 2007, 26, 205–238.
  101. Tezel, G.; Kass, M.A.; Kolker, A.E.; Becker, B.; Wax, M.B. Plasma and aqueous humor endothelin levels in primary open-angle glaucoma. J. Glaucoma 1997, 6, 83–89.
  102. Noske, W.; Hensen, J.; Wiederholt, M. Endothelin-like immunoreactivity in aqueous humor of patients with primary open-angle glaucoma and cataract. Graefe’s Arch. Clin. Exp. Ophthalmol. 1997, 235, 551–552.
  103. Nicolela, M.T.; Ferrier, S.N.; Morrison, C.A.; Archibald, M.L.; LeVatte, T.L.; Wallace, K.; Chauhan, B.C.; LeBlanc, R.P. Effects of cold-induced vasospasm in glaucoma: The role of endothelin-1. Investig. Ophthalmol. Vis. Sci. 2003, 44, 2565–2572.
  104. Polak, K.; Luksch, A.; Berisha, F.; Fuchsjaeger-Mayrl, G.; Dallinger, S.; Schmetterer, L. Altered nitric oxide system in patients with open-angle glaucoma. Arch. Ophthalmol. 2007, 125, 494–498.
  105. Tunny, T.J.; Richardson, K.A.; Clark, C.V. Association study of the 5′ flanking regions of endothelial-nitric oxide synthase and endothelin-1 genes in familial primary open-angle glaucoma. Clin. Exp. Pharmacol. Physiol. 1998, 25, 26–29.
  106. Wang, L.; Burgoyne, C.F.; Cull, G.; Thompson, S.; Fortune, B. Static blood flow autoregulation in the optic nerve head in normal and experimental glaucoma. Investig. Ophthalmol. Vis. Sci. 2014, 55, 873–880.
  107. Cunha-Vaz, J.; Bernardes, R.; Lobo, C. Blood-retinal barrier. Eur. J. Ophthalmol. 2011, 21 (Suppl. S6), S3–S9.
  108. Bharadwaj, A.S.; Appukuttan, B.; Wilmarth, P.A.; Pan, Y.; Stempel, A.J.; Chipps, T.J.; Benedetti, E.E.; Zamora, D.O.; Choi, D.; David, L.L.; et al. Role of the retinal vascular endothelial cell in ocular disease. Prog. Retin. Eye Res. 2013, 32, 102–180.
  109. Hosoya, K.; Tachikawa, M. The inner blood-retinal barrier: Molecular structure and transport biology. Adv. Exp. Med. Biol. 2012, 763, 85–104.
  110. Gupta, N.; Motlagh, M.; Singh, G. Anatomy, Head and Neck, Eye Arteries. In StatPearls; StatPearls Publishing: Treasure Island, FL, USA, 2020.
  111. Bernstein, M.H.; Hollenberg, M.J. Fine structure of the choriocappillaris and retinal capillaries. Investig. Ophthalmol. 1965, 4, 1016–1025.
  112. Cunha-Vaz, J. The blood-ocular barriers. Surv. Ophthalmol. 1979, 23, 279–296.
  113. Campbell, M.; Humphries, P. The blood-retina barrier: Tight junctions and barrier modulation. Adv. Exp. Med. Biol. 2012, 763, 70–84.
  114. Doll, D.N.; Hu, H.; Sun, J.; Lewis, S.E.; Simpkins, J.W.; Ren, X. Mitochondrial crisis in cerebrovascular endothelial cells opens the blood-brain barrier. Stroke 2015, 46, 1681–1689.
  115. Resch, H.; Garhofer, G.; Fuchsjager-Mayrl, G.; Hommer, A.; Schmetterer, L. Endothelial dysfunction in glaucoma. Acta Ophthalmol. 2009, 87, 4–12.
  116. Haefliger, I.O.; Flammer, J.; Luscher, T.F. Nitric oxide and endothelin-1 are important regulators of human ophthalmic artery. Investig. Ophthalmol. Vis. Sci. 1992, 33, 2340–2343.
  117. Meyer, P.; Flammer, J.; Luscher, T.F. Endothelium-dependent regulation of the ophthalmic microcirculation in the perfused porcine eye: Role of nitric oxide and endothelins. Investig. Ophthalmol. Vis. Sci. 1993, 34, 3614–3621.
  118. Meyer, P.; Flammer, J.; Luscher, T.F. Local action of the renin angiotensin system in the porcine ophthalmic circulation: Effects of ACE-inhibitors and angiotensin receptor antagonists. Investig. Ophthalmol. Vis. Sci. 1995, 36, 555–562.
  119. Riva, C.E.; Grunwald, J.E.; Petrig, B.L. Autoregulation of human retinal blood flow. An investigation with laser Doppler velocimetry. Investig. Ophthalmol. Vis. Sci. 1986, 27, 1706–1712.
  120. Naylor, A.; Hopkins, A.; Hudson, N.; Campbell, M. Tight Junctions of the Outer Blood Retina Barrier. Int. J. Mol. Sci. 2019, 21.
  121. Simo, R.; Villarroel, M.; Corraliza, L.; Hernandez, C.; Garcia-Ramirez, M. The retinal pigment epithelium: Something more than a constituent of the blood-retinal barrier--implications for the pathogenesis of diabetic retinopathy. J. Biomed. Biotechnol. 2010, 2010, 190724.
  122. Sparrow, J.R.; Hicks, D.; Hamel, C.P. The retinal pigment epithelium in health and disease. Curr. Mol. Med. 2010, 10, 802–823.
  123. Rohrer, B.; Bandyopadhyay, M.; Beeson, C. Reduced Metabolic Capacity in Aged Primary Retinal Pigment Epithelium (RPE) is Correlated with Increased Susceptibility to Oxidative Stress. Adv. Exp. Med. Biol. 2016, 854, 793–798.
  124. Leung, C.K.; Tham, C.C.; Mohammed, S.; Li, E.Y.; Leung, K.S.; Chan, W.M.; Lam, D.S. In vivo measurements of macular and nerve fibre layer thickness in retinal arterial occlusion. Eye 2007, 21, 1464–1468.
  125. Hofman, P.; Hoyng, P.; van der Werf, F.; Vrensen, G.F.; Schlingemann, R.O. Lack of blood-brain barrier properties in microvessels of the prelaminar optic nerve head. Investig. Ophthalmol. Vis. Sci. 2001, 42, 895–901.
  126. Morgan, J.E. Circulation and axonal transport in the optic nerve. Eye 2004, 18, 1089–1095.
  127. O’Brart, D.P.; de Souza Lima, M.; Bartsch, D.U.; Freeman, W.; Weinreb, R.N. Indocyanine green angiography of the peripapillary region in glaucomatous eyes by confocal scanning laser ophthalmoscopy. Am. J. Ophthalmol. 1997, 123, 657–666.
  128. Plange, N.; Remky, A.; Arend, O. Absolute filling defects of the optic disc in fluorescein angiograms in glaucoma—A retrospective clinical study. Klin. Mon. Augenheilkd. 2001, 218, 214–221.
  129. Schober, M.S.; Chidlow, G.; Wood, J.P.; Casson, R.J. Bioenergetic-based neuroprotection and glaucoma. Clin. Exp. Ophthalmol. 2008, 36, 377–385.
  130. Ione, A. Introduction: Visual images and visualization in the neurosciences. J. Hist. Neurosci. 2008, 17, 257–259.
  131. Dhande, O.S.; Huberman, A.D. Retinal ganglion cell maps in the brain: Implications for visual processing. Curr. Opin. Neurobiol. 2014, 24, 133–142.
  132. Yu, D.Y.; Cringle, S.J.; Balaratnasingam, C.; Morgan, W.H.; Yu, P.K.; Su, E.N. Retinal ganglion cells: Energetics, compartmentation, axonal transport, cytoskeletons and vulnerability. Prog. Retin. Eye Res. 2013, 36, 217–246.
  133. Della Santina, L.; Inman, D.M.; Lupien, C.B.; Horner, P.J.; Wong, R.O. Differential progression of structural and functional alterations in distinct retinal ganglion cell types in a mouse model of glaucoma. J. Neurosci. 2013, 33, 17444–17457.
  134. Calkins, D.J. Critical pathogenic events underlying progression of neurodegeneration in glaucoma. Prog. Retin. Eye Res. 2012, 31, 702–719.
  135. Crish, S.D.; Calkins, D.J. Neurodegeneration in glaucoma: Progression and calcium-dependent intracellular mechanisms. Neuroscience 2011, 176, 1–11.
  136. Weber, A.J.; Kaufman, P.L.; Hubbard, W.C. Morphology of single ganglion cells in the glaucomatous primate retina. Investig. Ophthalmol. Vis. Sci. 1998, 39, 2304–2320.
  137. Pavlidis, M.; Stupp, T.; Naskar, R.; Cengiz, C.; Thanos, S. Retinal ganglion cells resistant to advanced glaucoma: A postmortem study of human retinas with the carbocyanine dye DiI. Investig. Ophthalmol. Vis. Sci. 2003, 44, 5196–5205.
  138. Shou, T.; Liu, J.; Wang, W.; Zhou, Y.; Zhao, K. Differential dendritic shrinkage of alpha and beta retinal ganglion cells in cats with chronic glaucoma. Investig. Ophthalmol. Vis. Sci. 2003, 44, 3005–3010.
  139. Jakobs, T.C.; Libby, R.T.; Ben, Y.; John, S.W.; Masland, R.H. Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice. J. Cell Biol. 2005, 171, 313–325.
  140. Fu, C.T.; Sretavan, D. Laser-induced ocular hypertension in albino CD-1 mice. Investig. Ophthalmol. Vis. Sci. 2010, 51, 980–990.
  141. Sanes, J.R.; Masland, R.H. The types of retinal ganglion cells: Current status and implications for neuronal classification. Annu. Rev. Neurosci. 2015, 38, 221–246.
  142. Della Santina, L.; Ou, Y. Who’s lost first? Susceptibility of retinal ganglion cell types in experimental glaucoma. Exp. Eye Res. 2017, 158, 43–50.
  143. Morquette, J.B.; Di Polo, A. Dendritic and synaptic protection: Is it enough to save the retinal ganglion cell body and axon? J. Neuroophthalmol. 2008, 28, 144–154.
  144. Nickells, R.W. The cell and molecular biology of glaucoma: Mechanisms of retinal ganglion cell death. Investig. Ophthalmol. Vis. Sci. 2012, 53, 2476–2481.
  145. Nickells, R.W.; Howell, G.R.; Soto, I.; John, S.W. Under pressure: Cellular and molecular responses during glaucoma, a common neurodegeneration with axonopathy. Annu. Rev. Neurosci. 2012, 35, 153–179.
  146. Whitmore, A.V.; Libby, R.T.; John, S.W. Glaucoma: Thinking in new ways-a role for autonomous axonal self-destruction and other compartmentalised processes? Prog. Retin. Eye Res. 2005, 24, 639–662.
  147. Chan, G.; Balaratnasingam, C.; Yu, P.K.; Morgan, W.H.; McAllister, I.L.; Cringle, S.J.; Yu, D.Y. Quantitative morphometry of perifoveal capillary networks in the human retina. Investig. Ophthalmol. Vis. Sci. 2012, 53, 5502–5514.
  148. Tan, P.E.; Yu, P.K.; Balaratnasingam, C.; Cringle, S.J.; Morgan, W.H.; McAllister, I.L.; Yu, D.Y. Quantitative confocal imaging of the retinal microvasculature in the human retina. Investig. Ophthalmol. Vis. Sci. 2012, 53, 5728–5736.
  149. Prior, S.; Kim, A.; Yoshihara, T.; Tobita, S.; Takeuchi, T.; Higuchi, M. Mitochondrial respiratory function induces endogenous hypoxia. PLoS ONE 2014, 9, e88911.
  150. Bereiter-Hahn, J.; Voth, M. Dynamics of mitochondria in living cells: Shape changes, dislocations, fusion, and fission of mitochondria. Microsc. Res. Tech. 1994, 27, 198–219.
  151. Kerrigan-Baumrind, L.A.; Quigley, H.A.; Pease, M.E.; Kerrigan, D.F.; Mitchell, R.S. Number of ganglion cells in glaucoma eyes compared with threshold visual field tests in the same persons. Investig. Ophthalmol. Vis. Sci. 2000, 41, 741–748.
  152. Quigley, H.A.; Dunkelberger, G.R.; Green, W.R. Chronic human glaucoma causing selectively greater loss of large optic nerve fibers. Ophthalmology 1988, 95, 357–363.
  153. Glovinsky, Y.; Quigley, H.A.; Dunkelberger, G.R. Retinal ganglion cell loss is size dependent in experimental glaucoma. Investig. Ophthalmol. Vis. Sci. 1991, 32, 484–491.
  154. Quigley, H.A. Neuronal death in glaucoma. Prog. Retin. Eye Res. 1999, 18, 39–57.
  155. Morgan, J.E. Selective cell death in glaucoma: Does it really occur? Br. J. Ophthalmol. 1994, 78, 875–879, discussion 879–880.
  156. Adrian, E.D. The all-or-none principle in nerve. J. Physiol. 1914, 47, 460–474.
  157. Wollner, D.A.; Catterall, W.A. Localization of sodium channels in axon hillocks and initial segments of retinal ganglion cells. Proc. Natl. Acad. Sci. USA 1986, 83, 8424–8428.
  158. Yu, D.Y.; Cringle, S.J. Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease. Prog. Retin. Eye Res. 2001, 20, 175–208.
  159. Yu, T.Y.; Acosta, M.L.; Ready, S.; Cheong, Y.L.; Kalloniatis, M. Light exposure causes functional changes in the retina: Increased photoreceptor cation channel permeability, photoreceptor apoptosis, and altered retinal metabolic function. J. Neurochem. 2007, 103, 714–724.
  160. Pang, J.J.; Frankfort, B.J.; Gross, R.L.; Wu, S.M. Elevated intraocular pressure decreases response sensitivity of inner retinal neurons in experimental glaucoma mice. Proc. Natl. Acad. Sci. USA 2015, 112, 2593–2598.
  161. Chebil, A.; Maamouri, R.; Ben Abdallah, M.; Ouderni, M.; Chaker, N.; El Matri, L. Foveal choroidal thickness assessment with SD-OCT in high myopic glaucoma. J. Fr. Ophtalmol. 2015, 38, 440–444.
  162. Morgan, J.E. Retina ganglion cell degeneration in glaucoma: An opportunity missed? A review. Clin. Exp. Ophthalmol. 2012, 40, 364–368.
  163. Lee, S.; Stevens, C.F. General design principle for scalable neural circuits in a vertebrate retina. Proc. Natl. Acad. Sci. USA 2007, 104, 12931–12935.
  164. El-Danaf, R.N.; Huberman, A.D. Characteristic patterns of dendritic remodeling in early-stage glaucoma: Evidence from genetically identified retinal ganglion cell types. J. Neurosci. 2015, 35, 2329–2343.
  165. Williams, P.A.; Piechota, M.; von Ruhland, C.; Taylor, E.; Morgan, J.E.; Votruba, M. Opa1 is essential for retinal ganglion cell synaptic architecture and connectivity. Brain 2012, 135 Pt 2, 493–505.
  166. Gaasterland, D.E.; Pederson, J.E.; MacLellan, H.M. Perfusate effects upon resistance to aqueous humor outflow in the rhesus monkey eye. A comparison of glutathione-bicarbonate Ringer’s solution to pooled aqueous humor as perfusate. Investig. Ophthalmol. Vis. Sci. 1978, 17, 391–397.
  167. Quigley, H.A.; Hohman, R.M.; Addicks, E.M.; Massof, R.W.; Green, W.R. Morphologic changes in the lamina cribrosa correlated with neural loss in open-angle glaucoma. Am. J. Ophthalmol. 1983, 95, 673–691.
  168. Curcio, C.A.; Allen, K.A. Topography of ganglion cells in human retina. J. Comp. Neurol. 1990, 300, 5–25.
  169. Chidlow, G.; Wood, J.P.M.; Sia, P.I.; Casson, R.J. Distribution and Activity of Mitochondrial Proteins in Vascular and Avascular Retinas: Implications for Retinal Metabolism. Investig. Ophthalmol. Vis. Sci. 2019, 60, 331–344.
  170. Wang, J.; Murray, M.; Grafstein, B. Cranial meninges of goldfish: Age-related changes in morphology of meningeal cells and accumulation of surfactant-like multilamellar bodies. Cell Tissue Res. 1995, 281, 349–358.
  171. Hollenbeck, P.J. The pattern and mechanism of mitochondrial transport in axons. Front. Biosci. 1996, 1, d91–d102.
  172. Melia, H.P.; Andrews, J.F.; McBennett, S.M.; Porter, R.K. Effects of acute leptin administration on the differences in proton leak rate in liver mitochondria from ob/ob mice compared to lean controls. FEBS Lett. 1999, 458, 261–264.
  173. Barron, M.J.; Griffiths, P.; Turnbull, D.M.; Bates, D.; Nichols, P. The distributions of mitochondria and sodium channels reflect the specific energy requirements and conduction properties of the human optic nerve head. Br. J. Ophthalmol. 2004, 88, 286–290.
  174. Cogswell, P.C.; Kashatus, D.F.; Keifer, J.A.; Guttridge, D.C.; Reuther, J.Y.; Bristow, C.; Roy, S.; Nicholson, D.W.; Baldwin, A.S., Jr. NF-kappa B and I kappa B alpha are found in the mitochondria. Evidence for regulation of mitochondrial gene expression by NF-kappa B. J. Biol. Chem. 2003, 278, 2963–2968.
  175. Henkind, P. Radial peripapillary capillaries of the retina. I. Anatomy: Human and comparative. Br. J. Ophthalmol. 1967, 51, 115–123.
  176. Alterman, M.; Henkind, P. Radial peripapillary capillaries of the retina. II. Possible role in Bjerrum scotoma. Br. J. Ophthalmol. 1968, 52, 26–31.
  177. Jia, Y.; Wei, E.; Wang, X.; Zhang, X.; Morrison, J.C.; Parikh, M.; Lombardi, L.H.; Gattey, D.M.; Armour, R.L.; Edmunds, B.; et al. Optical coherence tomography angiography of optic disc perfusion in glaucoma. Ophthalmology 2014, 121, 1322–1332.
  178. Balaratnasingam, C.; Morgan, W.H.; Bass, L.; Kang, M.; Cringle, S.J.; Yu, D.Y. Time-dependent effects of focal retinal ischemia on axonal cytoskeleton proteins. Investig. Ophthalmol. Vis. Sci. 2010, 51, 3019–3028.
  179. Wang, L.; Dong, J.; Cull, G.; Fortune, B.; Cioffi, G.A. Varicosities of intraretinal ganglion cell axons in human and nonhuman primates. Investig. Ophthalmol. Vis. Sci. 2003, 44, 2–9.
  180. Perge, J.A.; Koch, K.; Miller, R.; Sterling, P.; Balasubramanian, V. How the optic nerve allocates space, energy capacity, and information. J. Neurosci. 2009, 29, 7917–7928.
  181. Morgan, J.E.; Jeffery, G.; Foss, A.J. Axon deviation in the human lamina cribrosa. Br. J. Ophthalmol. 1998, 82, 680–683.
  182. Fitzgibbon, T.; Taylor, S.F. Retinotopy of the human retinal nerve fibre layer and optic nerve head. J. Comp. Neurol. 1996, 375, 238–251.
  183. Ogden, T.E. Nerve fiber layer of the macaque retina: Retinotopic organization. Investig. Ophthalmol. Vis. Sci. 1983, 24, 85–98.
  184. FitzGibbon, T. The human fetal retinal nerve fiber layer and optic nerve head: A DiI and DiA tracing study. Vis. Neurosci 1997, 14, 433–447.
  185. Singla, K.; Agarwal, P. Optic Ischemia. In StatPearls; StatPearls Publishing: Treasure Island, FL, USA, 2020.
  186. Mikelberg, F.S.; Drance, S.M.; Schulzer, M.; Yidegiligne, H.M.; Weis, M.M. The normal human optic nerve. Axon count and axon diameter distribution. Ophthalmology 1989, 96, 1325–1328.
  187. Hogan, M.J.; Moschini, G.B.; Zardi, O. Effects of Toxoplasma gondii toxin on the rabbit eye. Am. J. Ophthalmol. 1971, 72, 733–742.
  188. Hernandez, M.R. The optic nerve head in glaucoma: Role of astrocytes in tissue remodeling. Prog. Retin. Eye Res. 2000, 19, 297–321.
  189. Yuan, L.; Neufeld, A.H. Activated microglia in the human glaucomatous optic nerve head. J. Neurosci. Res. 2001, 64, 523–532.
  190. Liu, B.; Neufeld, A.H. Nitric oxide synthase-2 in human optic nerve head astrocytes induced by elevated pressure in vitro. Arch. Ophthalmol. 2001, 119, 240–245.
  191. Feilchenfeld, Z.; Yucel, Y.H.; Gupta, N. Oxidative injury to blood vessels and glia of the pre-laminar optic nerve head in human glaucoma. Exp. Eye Res. 2008, 87, 409–414.
  192. Hernandez, M.R.; Agapova, O.A.; Yang, P.; Salvador-Silva, M.; Ricard, C.S.; Aoi, S. Differential gene expression in astrocytes from human normal and glaucomatous optic nerve head analyzed by cDNA microarray. Glia 2002, 38, 45–64.
  193. Rungger-Brandle, E.; Messerli, J.M.; Niemeyer, G.; Eppenberger, H.M. Confocal microscopy and computer-assisted image reconstruction of astrocytes in the mammalian retina. Eur. J. Neurosci. 1993, 5, 1093–1106.
  194. Morgan, T.E.; Rozovsky, I.; Goldsmith, S.K.; Stone, D.J.; Yoshida, T.; Finch, C.E. Increased transcription of the astrocyte gene GFAP during middle-age is attenuated by food restriction: Implications for the role of oxidative stress. Free Radic. Biol. Med. 1997, 23, 524–528.
  195. Bussow, H. The astrocytes in the retina and optic nerve head of mammals: A special glia for the ganglion cell axons. Cell Tissue Res. 1980, 206, 367–378.
  196. Fukuchi, T.; Sawaguchi, S.; Hara, H.; Shirakashi, M.; Iwata, K. Extracellular matrix changes of the optic nerve lamina cribrosa in monkey eyes with experimentally chronic glaucoma. Graefe’s Arch. Clin. Exp. Ophthalmol. 1992, 230, 421–427.
  197. Nualart-Marti, A.; Solsona, C.; Fields, R.D. Gap junction communication in myelinating glia. Biochim. Biophys. Acta 2013, 1828, 69–78.
  198. Magistretti, P.J. Role of glutamate in neuron-glia metabolic coupling. Am. J. Clin. Nutr. 2009, 90, 875S–880S.
  199. Pellerin, L.; Magistretti, P.J. Glutamate uptake into astrocytes stimulates aerobic glycolysis: A mechanism coupling neuronal activity to glucose utilization. Proc. Natl. Acad. Sci. USA 1994, 91, 10625–10629.
  200. Magistretti, P.J.; Pellerin, L. Functional brain imaging: Role metabolic coupling between astrocytes and neurons. Rev. Med. Suisse Romande 2000, 120, 739–742.
  201. Chatton, J.Y.; Pellerin, L.; Magistretti, P.J. GABA uptake into astrocytes is not associated with significant metabolic cost: Implications for brain imaging of inhibitory transmission. Proc. Natl. Acad. Sci. USA 2003, 100, 12456–12461.
  202. Buono, R.J.; Lang, R.K. Hypoxic repression of lactate dehydrogenase-B in retina. Exp. Eye Res. 1999, 69, 685–693.
  203. Dienel, G.A. Brain lactate metabolism: The discoveries and the controversies. J. Cereb. Blood Flow Metab. 2012, 32, 1107–1138.
  204. Dienel, G.A. Lactate shuttling and lactate use as fuel after traumatic brain injury: Metabolic considerations. J. Cereb. Blood Flow Metab. 2014, 34, 1736–1748.
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