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Epigenetic/non-epigenetic mechanisms of HIV control: Comparison
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Please note this is a comparison between Version 3 by Bruce Ren and Version 2 by Adhikarimayum Lakhikumar Sharma.

The persistence of latent HIV provirus pools in different resting CD4+ cell subsets remains the greatest obstacle in the current efforts to treat and cure HIV infection. Recent efforts to purge out latently infected memory CD4+ T-cells using latency-reversing agents have failed in clinical trials. This review discusses the epigenetic and non-epigenetic mechanisms of HIV latency control, major limitations of the current approaches of using latency-reversing agents to reactivate HIV latency in resting CD4+ T-cells, and potential solutions to these limitations.

  • epigenetic
  • non-epigenetic
  • HIV latency
  • reactivation
  • transcription
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