Coenzyme Q

₁₀

 (CoQ

₁₀

 or ubiquinone) is a mobile proton and electron carrier of the mitochondrial respiratory chain with antioxidant properties widely used as an antiaging health supplement and to relieve the symptoms of many pathological conditions associated with mitochondrial dysfunction. Even though the hegemony of CoQ

₁₀

 in the context of antioxidant-based treatments is undeniable, the future primacy of this quinone is hindered by the promising features of its numerous analogues. Despite the unimpeachable performance of CoQ

₁₀

 therapies, problems associated with their administration and intraorganismal delivery has led clinicians and scientists to search for alternative derivative molecules. Over the past few years, a wide variety of CoQ

₁₀

 analogues with improved properties have been developed. These analogues conserve the antioxidant features of CoQ

₁₀

 but present upgraded characteristics such as water solubility or enhanced mitochondrial accumulation.