The role of nutritional support for cancer patients in palliative care is still a controversial topic. In the past, there has been limited collaboration between oncologists, clinical nutrition specialists, and palliative care physicians involved in the care of advanced cancer patients. Collaboration has been made more complex by the fact that, while it is clear what nutritional support is, there is no common or shared definition, not so much of palliative care, but of what constitutes a person who needs palliative care. In fact, there is no consensus in the literature on the definition of the palliative care patient because of the ambiguity in the common use in medicine of the adjective palliative. For many years, efforts have been made to find a screening tool to identify patients in need of palliative care in the hospital setting, as this would be very useful in both Internal Medicine and, in particular, Medical Oncology.