Land acquisition in Ghana is fraught with challenges of multiple sales, numerous unofficial charges, unnecessary bureaucracies, intrusion of unqualified middlemen, and lack of transparency among others. Studies have suggested digitization as a way forward to improve Ghana’s land management system and to address these acquisition challenges. However, none of these studies have specifically provided a clear conceptual digital framework for land acquisition. This article applies an integrative review, mixed with strengths, weaknesses, opportunities, and threats (SWOT) analysis, and deductive lessons from a digital land registry concept to develop a blockchain-based smart land acquisition framework solution in view of Ghana’s land acquisition challenges