References

1. The Skin Cancer Foundation. Skin Cancer Facts & Statistics. 2020. Available online: (accessed on 5 July 2019).
2. WHO. Cancer. 2018. Available online: (accessed on 12 October 2020).
3. Tabbakh, T.; Volkov, A.; Wakefield, M.; Dobbinson, S. Implementation of the SunSmart program and population sun protection behaviour in Melbourne, Australia: Results from cross-sectional summer surveys from 1987 to 2017. PLoS Med. 2019, 16, e1002932.
4. Adler, B.L.; DeLeo, V.A. Sunscreen safety: A Review of recent studies on humans and the environment. Curr. Dermatol. Rep. 2020, 9, 1–9.
5. Sobek, A.; Bejgarn, S.; Rudén, C.; Molander, L.; Breitholtz, M. In the shadow of the cosmetic directive—Inconsistencies in EU environmental hazard classification requirements for UV-filters. Sci. Total. Environ. 2013, 461–462, 706–711.
6. IARC. CAS No. 13463-67-7 Titanium Dioxide. 12/12/2019 ed.; International Agency for Research on Cancer: Lyon, France, 2010; Volume 93.
7. Zhang, X.; Li, W.; Yang, Z. Toxicology of nanosized titanium dioxide: An update. Arch. Toxicol. 2015, 89, 2207–2217.
8. Sharma, S.; Sharma, R.K.; Gaur, K.; Torres, J.F.C.; Loza-Rosas, S.A.; Torres, A.; Saxena, M.; Julin, M.; Tinoco, A.D. Fueling a hot debate on the application of TiO2 nanoparticles in sunscreen. Materials 2019, 12, 2317.
9. Fenoglio, I.; Ponti, J.; Alloa, E.; Ghiazza, M.; Corazzari, I.; Capomaccio, R.; Rembges, D.; Oliaro-Bosso, S.; Rossi, F. Singlet oxygen plays a key role in the toxicity and DNA damage caused by nanometric TiO2 in human keratinocytes. Nanoscale 2013, 5, 6567–6576.
10. Mu, Q.; Jiang, G.; Chen, L.; Zhou, H.; Fourches, D.; Tropsha, A.; Yan, B. Chemical basis of interactions between engineered nanoparticles and biological systems. Chem. Rev. 2014, 114, 7740–7781.
11. Egambaram, O.P.; Pillai, S.K.; Ray, S.S. Materials science challenges in skin UV protection: A review. Photochem. Photobiol. 2020, 96, 779–797.
12. Al-Abed, S.R.; Virkutyte, J.; Ortenzio, J.N.R.; McCarrick, R.M.; Degn, L.L.; Zucker, R.; Coates, N.H.; Childs, K.; Ma, H.; Diamond, S.; et al. Environmental aging alters Al(OH)3 coating of TiO2 nanoparticles enhancing their photocatalytic and phototoxic activities. Environ. Sci. Nano 2016, 3, 593–601.
13. Auffan, M.; Pedeutour, M.; Rose, J.; Masion, A.; Ziarelli, F.; Borschneck, D.; Chanéac, C.; Botta, C.; Chaurand, P.; Labille, J.; et al. Structural degradation at the surface of a TiO2-based nanomaterial used in cosmetics. Environ. Sci. Technol. 2010, 44, 2689–2694.
14. Donia, D.T.; Carbone, M. Fate of the nanoparticles in environmental cycles. Int. J. Environ. Sci. Technol. 2018, 16, 583–600.
15. Minetto, D.; Libralato, G.; Ghirardini, A.V. Ecotoxicity of engineered TiO2 nanoparticles to saltwater organisms: An overview. Environ. Int. 2014, 66, 18–27.
16. Picado, A.; Paixão, S.M.; Moita, L.; Silva, L.; Diniz, M.S.; Lourenço, J.; Peres, I.; Castro, L.; Correia, J.B.; Pereira, J.; et al. A multi-integrated approach on toxicity effects of engineered TiO2 nanoparticles. Front. Environ. Sci. Eng. 2015, 9, 793–803.
17. Scown, T.M.; Van Aerle, R.; Tyler, C.R. Review: Do engineered nanoparticles pose a significant threat to the aquatic environment? Crit. Rev. Toxicol. 2010, 40, 653–670.
18. De La Vega, A.C.S.; Cruz-Alcalde, A.; Mazón, C.S.; Martí, C.B.; Diaz-Cruz, M.S. Nano-TiO2 phototoxicity in fresh and seawater: Daphnia magna and Artemia sp. as proxies. Water 2020, 13, 55.
19. Barone, A.N.; Hayes, C.E.; Kerr, J.J.; Lee, R.C.; Flaherty, D.B. Acute toxicity testing of TiO2-based vs. oxybenzone-based sunscreens on clownfish (Amphiprion ocellaris). Environ. Sci. Pollut. Res. 2019, 26, 14513–14520.
20. Fouqueray, M.; Dufils, B.; Vollat, B.; Chaurand, P.; Botta, C.; Abacci, K.; Labille, J.; Rose, J.; Garric, J. Effects of aged TiO2 nanomaterial from sunscreen on Daphnia magna exposed by dietary route. Environ. Pollut. 2012, 163, 55–61.
21. Fu, L.; Hamzeh, M.; Dodard, S.; Zhao, Y.H.; Sunahara, G.I. Effects of TiO2 nanoparticles on ROS production and growth inhibition using freshwater green algae pre-exposed to UV irradiation. Environ. Toxicol. Pharmacol. 2015, 39, 1074–1080.
22. ChemSafetyPro. How to Calculate Predicted No-Effect Concentration (PNEC). Available online: (accessed on 16 July 2020).
23. Musee, N. Simulated environmental risk estimation of engineered nanomaterials: A case of cosmetics in Johannesburg City. Hum. Exp. Toxicol. 2011, 30, 1181–1195.
24. Coll, C.; Notter, D.; Gottschalk, F.; Sun, T.; Som, C.; Nowack, B. Probabilistic environmental risk assessment of five nanomaterials (nano-TiO2, nano-Ag, nano-ZnO, CNT, and fullerenes). Nanotoxicology 2015, 10, 436–444.
25. Slijkerman, D.; Onderzoeksformatie, I.; Keur, M. Sunscreen Ecoproducts: Product Claims, Potential Effects and Environmental Risks of Applied UV Filters; Wageningen University and Research: Den Helder, The Netherlands, 2018.
26. Lead, J.R.; Batley, G.E.; Alvarez, P.J.J.; Croteau, M.-N.; Handy, R.D.; McLaughlin, M.J.; Judy, J.D.; Schirmer, K. Nanomaterials in the environment: Behavior, fate, bioavailability, and effects-An updated review. Environ. Toxicol. Chem. 2018, 37, 2029–2063.
27. Baalousha, M.; Cornelis, G.; Kuhlbusch, T.A.J.; Lynch, I.; Nickel, C.; Peijnenburg, W.; Brink, N.W.V.D. Modeling nanomaterial fate and uptake in the environment: Current knowledge and future trends. Environ. Sci. Nano 2016, 3, 323–345.
28. Sun, T.Y.; Gottschalk, F.; Hungerbühler, K.; Nowack, B. Comprehensive probabilistic modelling of environmental emissions of engineered nanomaterials. Environ. Pollut. 2014, 185, 69–76.
29. Number of Products, vs. Titanium Dioxide; Nanodatabase: DTU Environment, the Danish Ecological Council and Danish Consumer Council, 2020.
30. Jeon, S.-K.; Kim, E.-J.; Lee, J.; Lee, S. Potential risks of TiO2 and ZnO nanoparticles released from sunscreens into outdoor swimming pools. J. Hazard. Mater. 2016, 317, 312–318.
31. Choi, S.; Johnston, M.; Wang, G.-S.; Huang, C. A seasonal observation on the distribution of engineered nanoparticles in municipal wastewater treatment systems exemplified by TiO2 and ZnO. Sci. Total. Environ. 2018, 625, 1321–1329.
32. EPA, U. Nanomaterial Case Studies: Nanoscale Titanium Dioxide in Water Treatment and in Topical Sunscreen (Final); US Environmental Protection Agency Research Triangle Park: Washington, DC, USA, 2010.
33. Wiechers, J.W.; Musee, N. Engineered inorganic nanoparticles and cosmetics: Facts, issues, knowledge gaps and challenges. J. Biomed. Nanotechnol. 2010, 6, 408–431.
34. Cornelis, G.; Hund-Rinke, K.; Kuhlbusch, T.; Van den Brink, N.; Nickel, C. Fate and bioavailability of engineered nanoparticles in soils: A review. Crit. Rev. Environ. Sci. Technol. 2014, 44, 2720–2764.
35. Dulger, M.; Sakallioglu, T.; Temizel, I.; Demirel, B.; Copty, N.; Onay, T.; Uyguner-Demirel, C.; Karanfil, T. Leaching potential of nano-scale titanium dioxide in fresh municipal solid waste. Chemosphere 2016, 144, 1567–1572.
36. Morgan, R.; Swimming Pool Ownership Increases in Australia. Roy Morgan Research: 2018. Available online: (accessed on 27 May 2020).
37. Nischwitz, V.; Goenaga-Infante, H. Improved sample preparation and quality control for the characterisation of titanium dioxide nanoparticles in sunscreens using flow field flow fractionation on-line with inductively coupled plasma mass spectrometry. J. Anal. At. Spectrom. 2012, 27, 1084–1092.
38. Dan, Y.; Shi, H.; Stephan, C.; Liang, X. Rapid analysis of titanium dioxide nanoparticles in sunscreens using single particle inductively coupled plasma-mass spectrometry. Microchem. J. 2015, 122, 119–126.
39. Popov, A.P.; Lademann, J.; Priezzhev, A.V.; Myllylä, R.A. Effect of size of TiO2 nanoparticles embedded into stratum corneum on ultraviolet-A and ultraviolet-B sun-blocking properties of the skin. J. Biomed. Opt. 2005, 10, 064037.
40. Walter, D. Primary Particles—Agglomerates—Aggregates. In Nanomaterials; Wiley: Bonn, Germany, 2013; pp. 9–24.
41. Lin, X.; Li, J.; Ma, S.; Liu, G.; Yang, K.; Tong, M.; Lin, D. Toxicity of TiO2 nanoparticles to escherichia coli: Effects of particle size, crystal phase and water chemistry. PLoS ONE 2014, 9, e110247.
42. Solaiman, S.M.; Algie, J.; Bakand, S.; Sluyter, R.; Sencadas, V.; Lerch, M.; Huang, X.-F.; Konstantinov, K.; Barker, P.J. Nano-sunscreens—A double-edged sword in protecting consumers from harm: Viewing Australian regulatory policies through the lenses of the European Union. Crit. Rev. Toxicol. 2019, 49, 122–139.
43. Pelclova, D.; Navratil, T.; Kacerova, T.; Zamostna, B.; Fenclova, Z.; Vlckova, S.; Kacer, P. NanoTiO2 sunscreen does not prevent systemic oxidative stress caused by UV radiation and a minor amount of NanoTiO2 is absorbed in humans. Nanomater. 2019, 9, 888.
44. Almquist, C.B.; Biswas, P. Role of synthesis method and particle size of nanostructured TiO2 on its photoactivity. J. Catal. 2002, 212, 145–156.
45. Philippe, A.; Košík, J.; Welle, A.; Guigner, J.-M.; Clemens, O.; Schaumann, G.E. Extraction and characterization methods for titanium dioxide nanoparticles from commercialized sunscreens. Environ. Sci. Nano 2017, 5, 191–202.
46. Bairi, V.G.; Lim, J.-H.; Fong, A.; Linder, S.W. Size characterization of metal oxide nanoparticles in commercial sunscreen products. J. Nanoparticle Res. 2017, 19, 256.
47. Robertson, T.A.; Sanchez, W.Y.; Roberts, M.S. Are commercially available nanoparticles safe when applied to the skin? J. Biomed. Nanotechnol. 2010, 6, 452–468.
48. Catalano, R.; Labille, J.; Gaglio, D.; Alijagic, A.; Napodano, E.; Slomberg, D.; Campos, A.; Pinsino, A. Safety evaluation of TiO2 nanoparticle-based sunscreen UV filters on the development and the immunological state of the sea urchin Paracentrotus Lividus. Nanomaterials 2020, 10, 2102.
49. Hsiao, I.-L.; Huang, Y.-J. Effects of various physicochemical characteristics on the toxicities of ZnO and TiO2 nanoparticles toward human lung epithelial cells. Sci. Total. Environ. 2011, 409, 1219–1228.
50. Lu, P.; Fang, S.; Cheng, W.; Huang, S.; Cheng, H. Characterization of titanium dioxide and zinc oxide nanoparticles in sunscreen powder by comparing different measurement methods. J. Food Drug Anal. 2018, 26, 1192–1200.
51. He, X.; Hwang, H.-M. Engineered TiO2 Nanoparticles: Their Fate and Effects in Natural Aquatic Environments; Nova Science Publishers Inc.: Jackson, MS, USA, 2014; pp. 1–20.
52. Johnston, H.J.; Hutchison, G.R.; Christensen, F.M.; Peters, S.; Hankin, S.; Stone, V. Identification of the mechanisms that drive the toxicity of TiO2 particulates: The contribution of physicochemical characteristics. Part. Fibre Toxicol. 2009, 6, 33.
53. Corinaldesi, C.; Marcellini, F.; Nepote, E.; Damiani, E.; Danovaro, R. Impact of inorganic UV filters contained in sunscreen products on tropical stony corals (Acropora spp.). Sci. Total Environ. 2018, 637–638, 1279–1285.
54. Borm, P.J.; Robbins, D.; Haubold, S.; Kuhlbusch, T.; Fissan, H.; Donaldson, K.; Schins, R.; Stone, V.; Kreyling, W.; Lademann, J.; et al. The potential risks of nanomaterials: A review carried out for ECETOC. Part. Fibre Toxicol. 2006, 3, 11.
55. Wakefield, G.; Lipscomb, S.; Holland, E.; Knowland, J. The effects of manganese doping on UVA absorption and free radical generation of micronised titanium dioxide and its consequences for the photostability of UVA absorbing organic sunscreen components. Photochem. Photobiol. Sci. 2004, 3, 648–652.
56. Park, B.; Martin, A.P.; Harris, C.; Guest, R.; Whittingham, A.; Jenkinson, P. Preliminary in vitro investigation of the potential health effects of Optisol™, a nanoparticulate manganese modified titanium dioxide UV-filter used in certain sunscreen products. Nanotoxicology 2009, 3, 73–90.
57. Labille, J.; Catalano, R.; Slomberg, D.; Motellier, S.; Pinsino, A.; Hennebert, P.; Santaella, C.; Bartolomei, V. Assessing sunscreen lifecycle to minimize environmental risk posed by nanoparticulate UV-filters—A review for safer-by-design products. Front. Environ. Sci. 2020, 8.
58. Jacobs, J.F.; Van De Poel, I.; Osseweijer, P. Sunscreens with titanium dioxide (TiO2) nano-particles: A societal experiment. NanoEthics 2010, 4, 103–113.
59. Osterwalder, U.; Sohn, M.; Herzog, B. Global state of sunscreens. Photodermatol. Photoimmunol. Photomed. 2014, 30, 62–80.
60. Rossano, M.; Hucher, N.; Picard, C.; Colletta, D.; Le Foll, F.; Grisel, M. Effects of aging on structure and stability of TiO2 nanoparticle-containing oil-in-water emulsions. Int. J. Pharm. 2014, 461, 89–96.
61. Dréno, B.; Alexis, A.; Chuberre, B.; Marinovich, M. Safety of titanium dioxide nanoparticles in cosmetics. J. Eur. Acad. Dermatol. Venereol. 2019, 33, 34–46.
62. Wu, W.; Xiang, Q.; Wu, Z.; Shan, G.; Zhu, L. Depletion of double-layer coated nano-TiO2 and generation of reactive oxygen species in the presence of ethanol under simulated solar irradiation. NanoImpact 2018, 11, 164–169.
63. Labille, J.; Feng, J.; Botta, C.; Borschneck, D.; Sammut, M.; Cabie, M.; Auffan, M.; Rose, J.; Bottero, J.-Y. Aging of TiO2 nanocomposites used in sunscreen. Dispersion and fate of the degradation products in aqueous environment. Environ. Pollut. 2010, 158, 3482–3489.
64. Virkutyte, J.; Al-Abed, S.R. Statistical evaluation of potential damage to the Al(OH)3 layer on nTiO2 particles in the presence of swimming pool and seawater. J. Nanoparticle Res. 2012, 14, 787.
65. Virkutyte, J.; Al-Abed, S.R.; Dionysiou, D.D. Depletion of the protective aluminum hydroxide coating in TiO2-based sunscreens by swimming pool water ingredients. Chem. Eng. J. 2012, 191, 95–103.
66. Wallis, L.K.; Diamond, S.A.; Ma, H.; Hoff, D.J.; Al-Abed, S.R.; Li, S. Chronic TiO2 nanoparticle exposure to a benthic organism, Hyalella azteca: Impact of solar UV radiation and material surface coatings on toxicity. Sci. Total. Environ. 2014, 499, 356–362.
67. Morsella, M.; D’Alessandro, N.; Lanterna, A.E.; Scaiano, J.C. Improving the sunscreen properties of TiO2 through an understanding of its catalytic properties. ACS Omega 2016, 1, 464–469.
68. Yu, J.; Li, L.; Qian, Y.; Lou, H.; Yang, D.; Qiu, X. Facile and green preparation of high UV-blocking lignin/titanium dioxide nanocomposites for developing natural sunscreens. Ind. Eng. Chem. Res. 2018, 57, 15740–15748.
69. Shandilya, N.; Capron, I. Safer-by-design hybrid nanostructures: An alternative to conventional titanium dioxide UV filters in skin care products. RSC Adv. 2017, 7, 20430–20439.
70. Son, H.Y.; Koo, B.I.; Lee, J.B.; Kim, K.R.; Kim, W.; Jang, J.; Yoon, M.S.; Cho, J.-W.; Nam, Y.S. Tannin-titanium oxide multilayer as a photochemically suppressed ultraviolet filter. ACS Appl. Mater. Interfaces 2018, 10, 27344–27354.
71. Battistin, M.; Dissette, V.; Bonetto, A.; Durini, E.; Manfredini, S.; Marcomini, A.; Casagrande, E.; Brunetta, A.; Ziosi, P.; Molesini, S.; et al. A new approach to UV protection by direct surface functionalization of TiO2 with the antioxidant polyphenol dihydroxyphenyl benzimidazole carboxylic acid. Nanomater. 2020, 10, 231.
72. Åhlén, M.; Cheung, O.; Strømme, M. Amorphous mesoporous magnesium carbonate as a functional support for UV-blocking semiconductor nanoparticles for cosmetic applications. ACS Omega 2019, 4, 4429–4436.
73. Bernstein, E.F.; Sarkas, H.W.; Ba, P.B.; Bouche, D. Beyond sun protection factor: An approach to environmental protection with novel mineral coatings in a vehicle containing a blend of skincare ingredients. J. Cosmet. Dermatol. 2020, 19, 407–415.
74. Borrás, M.C.; Sluyter, R.; Barker, P.J.; Konstantinov, K.; Bakand, S. Y2O3 decorated TiO2 nanoparticles: Enhanced UV attenuation and suppressed photocatalytic activity with promise for cosmetic and sunscreen applications. J. Photochem. Photobiol. B: Biol. 2020, 207, 111883.
75. Morlando, A.; Borrás, M.C.; Rehman, Y.; Bakand, S.; Barker, P.; Sluyter, R.; Konstantinov, K. Development of CeO2 nanodot encrusted TiO2 nanoparticles with reduced photocatalytic activity and increased biocompatibility towards a human keratinocyte cell line. J. Mater. Chem. B 2020, 8, 4016–4028.
76. Derjaguin, B.; Landau, L. Theory of the stability of strongly charged lyophobic sols and of the adhesion of strongly charged particles in solutions of electrolytes. Prog. Surf. Sci. 1993, 43, 30–59.
77. Overbeek, T.; Verwey, E. Theory of the Stability of Lyophobic Colloids: The Interaction of Sol Particles Having An Electric Double Layer; Elsevier: Amsterdam, The Netherlands, 1948.
78. Beck, R.; Guterres, S.; Pohlmann, A. Nanocosmetics and Nanomedicines; Springer: Berlin/Heidelberg, Germany, 2011.
79. Stumm, W.; Morgan, J.J.; ProQuest, E. Aquatic Chemistry: Chemical Equilibria and Rates in Natural Waters, 3rd ed.; Wiley: New York, NY, USA, 1996.
80. Nobbmann, U. Nanomaterial Isoelectric Points IEPs; Malvern Panalytical Ltd: Malvern, UK, 2017.
81. Englehart, J.; Lyon, B.A.; Abriola, L.M.; Becker, M.D.; Wang, Y.; Pennell, K.D. Influence of a polymer sunscreen additive on the transport and retention of titanium dioxide nanoparticles in water-saturated porous media. Environ. Sci. Nano 2015, 3, 157–168.
82. Zhang, C.; Lohwacharin, J.; Takizawa, S. Properties of residual titanium dioxide nanoparticles after extended periods of mixing and settling in synthetic and natural waters. Sci. Rep. 2017, 7, 9943.
83. Luo, M.; Huang, Y.; Zhu, M.; Tang, Y.-N.; Ren, T.; Ren, J.; Wang, H.; Li, F. Properties of different natural organic matter influence the adsorption and aggregation behavior of TiO2 nanoparticles. J. Saudi Chem. Soc. 2018, 22, 146–154.
84. Slomberg, D.L.; Ollivier, P.; Miche, H.; Angeletti, B.; Bruchet, A.; Philibert, M.; Brant, J.; Labille, J. Nanoparticle stability in lake water shaped by natural organic matter properties and presence of particulate matter. Sci. Total. Environ. 2019, 656, 338–346.
85. Li, S.; Ma, H.; Wallis, L.K.; Etterson, M.A.; Riley, B.; Hoff, D.J.; Diamond, S.A. Impact of natural organic matter on particle behavior and phototoxicity of titanium dioxide nanoparticles. Sci. Total. Environ. 2016, 542, 324–333.
86. Labille, J.; Harns, C.; Bottero, J.-Y.; Brant, J. Heteroaggregation of titanium dioxide nanoparticles with natural clay colloids. Environ. Sci. Technol. 2015, 49, 6608–6616.
87. De La Vega, A.C.S.; Molins-Delgado, D.; Barceló, D.; Díaz-Cruz, M.S. Nanosized titanium dioxide UV filter increases mixture toxicity when combined with parabens. Ecotoxicol. Environ. Saf. 2019, 184, 109565.
88. Kim, E.; Kim, M.; Im, N.; Park, S. Photolysis of the organic UV filter, avobenzone, combined with octyl methoxycinnamate by nano-TiO2 composites. J. Photochem. Photobiol. B: Biol. 2015, 149, 196–203.
89. Holbrook, R.D.; Motabar, D.; Quiñones, O.; Stanford, B.; Vanderford, B.; Moss, D. Titanium distribution in swimming pool water is dominated by dissolved species. Environ. Pollut. 2013, 181, 68–74.
90. Sánchez-Quiles, D.; Tovar-Sánchez, A. Sunscreens as a source of hydrogen peroxide production in coastal waters. Environ. Sci. Technol. 2014, 48, 9037–9042.
91. Zhou, D.; Bennett, S.W.; Keller, A.A. Increased mobility of metal oxide nanoparticles due to photo and thermal induced disagglomeration. PLoS ONE 2012, 7, e37363.
92. Lv, X.; Tao, J.; Chen, B.; Zhu, X. Roles of temperature and flow velocity on the mobility of nano-sized titanium dioxide in natural waters. Sci. Total. Environ. 2016, 565, 849–856.
93. Hao, Z.; Yin, Y.; Wang, J.; Cao, D.; Liu, J. Formation of organobromine and organoiodine compounds by engineered TiO2 nanoparticle-induced photohalogenation of dissolved organic matter in environmental waters. Sci. Total. Environ. 2018, 631–632, 158–168.
94. Loosli, F.; Le Coustumer, P.; Stoll, S. TiO2 nanoparticles aggregation and disaggregation in presence of alginate and Suwannee River humic acids. pH and concentration effects on nanoparticle stability. Water Res. 2013, 47, 6052–6063.
95. Sendra, M.; Yeste, M.; Gatica, J.; Moreno-Garrido, I.; Blasco, J. Homoagglomeration and heteroagglomeration of TiO2, in nanoparticle and bulk form, onto freshwater and marine microalgae. Sci. Total. Environ. 2017, 592, 403–411.
96. Botta, C.; Labille, J.; Auffan, M.; Borschneck, D.; Miche, H.; Cabié, M.; Masion, A.; Rose, J.; Bottero, J.-Y. TiO2-based nanoparticles released in water from commercialized sunscreens in a life-cycle perspective: Structures and quantities. Environ. Pollut. 2011, 159, 1543–1550.
97. Rodríguez-Romero, A.; Ruiz-Gutiérrez, G.; Viguri, J.R.; Tovar-Sánchez, A. Sunscreens as a new source of metals and nutrients to coastal waters. Environ. Sci. Technol. 2019, 53, 10177–10187.
98. Fan, W.; Cui, M.; Liu, H.; Wang, C.; Shi, Z.; Tan, C.; Yang, X. Nano-TiO2 enhances the toxicity of copper in natural water to daphnia magna. Environ. Pollut. 2011, 159, 729–734.
99. Skocaj, M.; Filipic, M.; Petkovic, J.; Novak, S. Titanium dioxide in our everyday life; is it safe? Radiol. Oncol. 2011, 45, 227–247.
100. Santaella, C.; Allainmat, B.; Simonet, F.; Chanéac, C.; Labille, J.; Auffan, M.; Rose, J.; Achouak, W. Aged TiO2-based nanocomposite used in sunscreens produces singlet oxygen under long-wave UV and sensitizesescherichia colito cadmium. Environ. Sci. Technol. 2014, 48, 5245–5253.
101. Li, L.; Sillanpää, M.; Risto, M. Influences of water properties on the aggregation and deposition of engineered titanium dioxide nanoparticles in natural waters. Environ. Pollut. 2016, 219, 132–138.