The main cardiovascular risk factors in diabetes mellitus (DM) are hyperglycaemia, hypertension and dyslipidaemia; all of them share the same substrate: insulin-resistance. Primary prevention of cardiovascular events that compose the 3P-MACE (non-fatal acute coronary events, non-fatal stroke, cardiovascular-death) is the universal desiderate in DM patients. The modern management of cardiovascular risk factors includes: early identification, addressing all the cardiovascular risk factors, use of moderate to intensive therapy in order to ensure the safety of the patients and the adequate risk-benefit ratio, usage of therapeutic agents proven to decrease cardiovascular risk such as GLP-1 agonists, SGLT2-inhibitors, ACEI inhibitors or statins.