Bone Tissue Engineering: Comparison
View Latest Version
Please note this is a comparison between Version 2 by Rita Xu and Version 1 by Lei Nie.

Tissue engineering has promoted structures that can simulate the extracellular matrix and are capable of guiding natural bone repair using signaling molecules to promote osteoinduction and angiogenesis essential in the formation of new bone tissues.

  • tissue engineering
  • drug delivery
  • biomaterials
  • polymer composites
  • bone regeneration
  • growth factor
  • bone morphogenetic protein
  • bioscaffold
Please wait, diff process is still running!

References

  1. Neves, M.I.; Araújo, M.; Moroni, L.; Da Silva, R.M.P.; Barrias, C.C. Glycosaminoglycan-Inspired Biomaterials for the Development of Bioactive Hydrogel Networks. Molecules 2020, 25, 978.
  2. Wang, L.; Fang, M.; Xia, Y.; Hou, J.; Nan, X.; Zhao, B.; Wang, X. Preparation and biological properties of silk fibroin/nano-hydroxyapatite/graphene oxide scaffolds with an oriented channel-like structure. RSC Adv. 2020, 10, 10118–10128.
  3. Nie, L.; Deng, Y.; Li, P.; Hou, R.; Shavandi, A.; Yang, S. Hydroxyethyl Chitosan-Reinforced Polyvinyl Alcohol/Biphasic Calcium Phosphate Hydrogels for Bone Regeneration. ACS Omega 2020, 5, 10948–10957.
  4. Ratnayake, J.T.; Ross, E.D.; Dias, G.J.; Shanafelt, K.M.; Taylor, S.S.; Gould, M.L.; Guan, G.; Cathro, P.R. Preparation, characterisation and in-vitro biocompatibility study of a bone graft developed from waste bovine teeth for bone regeneration. Mater. Today Commun. 2020, 22, 100732.
  5. Shavandi, A.; Bekhit, A.E.-D.A.; Ali, M.A.; Sun, Z. Bio-mimetic composite scaffold from mussel shells, squid pen and crab chitosan for bone tissue engineering. Int. J. Biol. Macromol. 2015, 80, 445–454.
  6. Shavandi, A.; Bekhit, A.E.-D.A.; Sun, Z.; Ali, M.A. Injectable gel from squid pen chitosan for bone tissue engineering applications. J. Sol-Gel Sci. Technol. 2016, 77, 675–687.
  7. Bessa, P.C.; Casal, M.; Reis, R.L. Bone morphogenetic proteins in tissue engineering: The road from laboratory to clinic, part II (BMP delivery). J. Tissue Eng. Regen. Med. 2008, 2, 81–96.
  8. Khojasteh, A.; Behnia, H.; Naghdi, N.; Esmaeelinejad, M.; Alikhassy, Z.; Stevens, M. Effects of different growth factors and carriers on bone regeneration: A systematic review. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. 2013, 116, e405–e423.
  9. Termaat, M.F.; Boer, D.; Bakker, F.C.; Patka, P.; Haarman, H.J. Bone morphogenetic proteins: Development and clinical efficacy in the treatment of fractures and bone defects. J. Bone Jt. Surg. Am. 2005, 87, 1367–1378.
  10. Cochran, D.L.; Jones, A.A.; Lilly, L.C.; Fiorellini, J.P.; Howell, H. Evaluation of Recombinant Human Bone Morphogenetic Protein-2 in Oral Applications Including the Use of Endosseous Implants: 3-Year Results of a Pilot Study in Humans. J. Periodontol. 2000, 71, 1241–1257.
  11. Krishnan, L.; Priddy, L.B.; Esancy, C.; Klosterhoff, B.S.; Stevens, H.Y.; Tran, L.; Guldberg, R.E. Delivery vehicle effects on bone regeneration and heterotopic ossification induced by high dose BMP-2. Acta Biomater. 2017, 49, 101–112.
  12. Yamamoto, M.; Takahashi, Y.; Tabata, Y. Enhanced bone regeneration at a segmental bone defect by controlled release of bone morphogenetic protein-2 from a biodegradable hydrogel. Tissue Eng. 2006, 12, 1305–1311.
  13. Yuan, Q.; Kubo, T.; Doi, K.; Morita, K.; Takeshita, R.; Katoh, S.; Shiba, T.; Gong, P.; Akagawa, Y. Effect of combined application of bFGF and inorganic polyphosphate on bioactivities of osteoblasts and initial bone regeneration. Acta Biomater. 2009, 5, 1716–1724.
  14. Fujioka-Kobayashi, M.; Schaller, B.; Saulacic, N.; Pippenger, B.E.; Zhang, Y.; Miron, R.J. Absorbable collagen sponges loaded with recombinant bone morphogenetic protein 9 induces greater osteoblast differentiation when compared to bone morphogenetic protein 2. Clin. Exp. Dent. Res. 2017, 3, 32–40.
  15. Hertweck, J.; Ritz, U.; Götz, H.; Schottel, P.C.; Rommens, P.M.; Hofmann, A. CD34+ cells seeded in collagen scaffolds promote bone formation in a mouse calvarial defect model. J. Biomed. Mater. Res. Part B Appl. Biomater. 2018, 106, 1505–1516.
  16. Kowalczewski, C.J.; Saul, J.M. Biomaterials for the Delivery of Growth Factors and Other Therapeutic Agents in Tissue Engineering Approaches to Bone Regeneration. Front. Pharmacol. 2018, 9, 513.
  17. Dao, D.T.; Vuong, J.T.; Anez-Bustillos, L.; Pan, A.; Mitchell, P.D.; Fell, G.L.; Baker, M.A.; Bielenberg, D.R.; Puder, M. Intranasal delivery of VEGF enhances compensatory lung growth in mice. PLoS ONE 2018, 13, e0198700.
  18. Martino, M.M.; Briquez, P.S.; Maruyama, K.; Hubbell, J.A. Extracellular matrix-inspired growth factor delivery systems for bone regeneration. Adv. Drug Deliv. Rev. 2015, 94, 41–52.
  19. Hu, K.; Olsen, B.R. Vascular Endothelial Growth Factor Control Mechanisms in Skeletal Growth and Repair. Dev. Dyn. 2017, 246, 227–234.
  20. Onishi, T.; Shimizu, T.; Akahane, M.; Omokawa, S.; Okuda, A.; Kira, T.; Inagaki, Y.; Tanaka, Y. Osteogenic extracellular matrix sheet for bone tissue regeneration. Eur. Cells Mater. 2018, 36, 69–80.
  21. Yan, H.J.; Casalini, T.; Hulsart-Billström, G.; Wang, S.; Oommen, O.P.; Salvalaglio, M.; Larsson, S.; Hilborn, J.; Varghese, O.P. Synthetic design of growth factor sequestering extracellular matrix mimetic hydrogel for promoting in vivo bone formation. Biomaterials 2018, 161, 190–202.
  22. Spiller, K.L.; Vunjak-Novakovic, G. Clinical translation of controlled protein delivery systems for tissue engineering. Drug Deliv. Transl. Res. 2015, 5, 101–115.
  23. Dang, M.; Saunders, L.; Niu, X.; Fan, Y.; Ma, P.X. Biomimetic delivery of signals for bone tissue engineering. Bone Res. 2018, 6, 25.
  24. Timin, A.S.; Muslimov, A.R.; Zyuzin, M.V.; Peltek, O.O.; Karpov, T.E.; Sergeev, I.S.; Dotsenko, A.I.; Goncharenko, A.A.; Yolshin, N.D.; Sinelnik, A.; et al. Multifunctional scaffolds with improved antimicrobial properties and osteogenicity based on piezoelectric electrospun fibers decorated with bioactive composite microcapsules. ACS Appl. Mater. Interfaces 2018, 10, 34849–34868.
  25. Briquez, P.S.; Hubbell, J.A.; Martino, M.M. Extracellular matrix-inspired growth factor delivery systems for skin wound healing. Adv. Wound Care 2015, 4, 479–489.
  26. Sluzalska, K.D.; Slawski, J.; Sochacka, M.; Lampart, A.; Otlewski, J.; Zakrzewska, M. Intracellular Partners of Fibroblast Growth Factors 1 and 2—Implications for Functions. Cytokin Growth Factor Rev. 2020.
  27. Tian, H.; Zhao, J.; Brochmann, E.J.; Wang, J.C.; Murray, S.S. Bone Morphogenetic Protein-2 and Tumor Growth: Diverse Effects and Possibilities for Therapy. Cytokin Growth Factor Rev. 2017, 34, 73–91.
  28. Azevedo, H.S.; Pashkuleva, I. Biomimetic Supramolecular Designs for the Controlled Release of Growth Factors in Bone Regeneration. Adv. Drug Deliv. Rev. 2015, 94, 63–76.
  29. Katagiri, T.; Watabe, T. Bone morphogenetic proteins. Cold Spring Harb. Perspect. Biol. 2016, 8.
  30. Tong, Z.; Guo, J.; Glen, R.C.; Morrell, N.W.; Li, W. A bone morphogenetic protein (BMP)-derived peptide based on the type I receptor-binding site modifies cell-type dependent BMP signalling. Sci. Rep. 2019, 9, 13446.
  31. Schmidt-Bleek, K.; Willie, B.M.; Schwabe, P.; Seemann, P.; Duda, G.N. BMPs in Bone Regeneration: Less is More Effective, a Paradigm-Shift. Cytokin Growth Factor Rev. 2016, 27, 141–148.
  32. Botega, I.I.; Zamarioli, A.; Guedes, P.M.S.G.; da Silva, R.A.B.; Issa, J.P.M.; Butezloff, M.M.; Sousa, Y.T.C.S.; Ximenez, J.P.B.; Volpon, J.B. Bone callus formation is highly disrupted by dietary restriction in growing rats sustaining a femoral fracture. Acta Cir. Bras. 2019, 34.
  33. Shah, N.J.; Hyder, M.N.; Quadir, M.A.; Courchesne, N.M.D.; Seeherman, H.J.; Nevins, M.; Spector, M.; Hammond, P.T. Adaptive growth factor delivery from a polyelectrolyte coating promotes synergistic bone tissue repair and reconstruction. Proc. Natl. Acad. Sci. USA 2014, 111, 12847–12852.
  34. Udomluck, N.; Lee, H.; Hong, S.; Lee, S.-H.; Park, H. Surface functionalization of dual growth factor on hydroxyapatite-coated nanofibers for bone tissue engineering. Appl. Surf. Sci. 2020, 520, 146311.
  35. Scarfì, S. Use of Bone Morphogenetic Proteins in Mesenchymal Stem Cell Stimulation of Cartilage and Bone Repair. World J. Stem Cells 2016, 8, 1–12.
  36. Sun, N.; Chen, Y.; Yu, F.; Zhixin, F.; Lin, J.; Sun, B.; Yu, B.; Cheng, X.; Zheng, X.; Wu, B. Monocrotaline pyrrole enhanced bone morphogenetic protein 7 signaling transduced by alternative activin A receptor type 2A in pulmonary arterial smooth muscle cells. Eur. J. Pharmacol. 2019, 863.
  37. Huang, B.; Yuan, Y.; Liu, C. Biomaterial-guided immobilization and osteoactivity of bone morphogenetic protein-2. Appl. Mater. Today 2020, 19, 1–22.
  38. Cui, Y.; Xu, B.; Yin, Y.; Chen, B.; Zhao, Y.; Xiao, Z.; Yang, B.; Shi, Y.; Fang, Y.; Ma, X.; et al. Collagen particles with collagen-binding bone morphogenetic protein-2 promote vertebral laminar regeneration in infant rabbits. Biomed. Mater. 2020, 15, 055008.
  39. Subbiah, R.; Guldberg, R.E. Materials science and design principles of growth factor delivery systems in tissue engineering and regenerative medicine. Adv. Healthc. Mater. 2019, 8, 1801000.
  40. El Bialy, I.; Jiskoot, W.; Reza Nejadnik, M. Formulation, Delivery and Stability of Bone Morphogenetic Proteins for Effective Bone Regeneration; Springer: New York, NY, USA, 2017; Volume 34, pp. 1152–1170.
  41. Chen, D.; Zhang, C.; Huo, H.; Ji, C.; Sun, M.; Nie, L. Injectable temperature-sensitive hydrogel with VEGF loaded microspheres for vascularization and bone regeneration of femoral head necrosis. Mater. Lett. 2018, 229, 138–141.
  42. Nie, L.; Chen, D.; Zhong, S.; Shi, Q.; Sun, Y.; Politis, C.; Shavandi, A. Injectable cell-laden poly(N-isopropylacrylamide)/chitosan hydrogel reinforced via graphene oxide and incorporated with dual-growth factors. Mater. Lett. 2020, 280, 128572.
  43. Farokhi, M.; Mottaghitalab, F.; Shokrgozar, M.A.; Ou, K.L.; Mao, C.; Hosseinkhani, H. Importance of dual delivery systems for bone tissue engineering. J. Control. Release 2016, 225, 152–169.
  44. Kitasato, S.; Tanaka, T.; Chazono, M.; Komaki, H.; Kakuta, A.; Inagaki, N.; Akiyama, S.; Marumo, K. Local application of alendronate controls bone formation and β-tricalcium phosphate resorption induced by recombinant human bone morphogenetic protein-2. J. Biomed. Mater. Res. Part A 2020, 108, 528–536.
  45. Visser, R.; Rico-Llanos, G.A.; Pulkkinen, H.; Becerra, J. Peptides for Bone Tissue Engineering. J. Control. Release 2016, 244, 122–135.
  46. Bien, N.D.; Miura, K.-I.; Sumita, Y.; Nakatani, Y.; Shido, R.; Kajii, F.; Kamakura, S.; Asahina, I. Bone regeneration by low-dose recombinant human bone morphogenetic protein-2 carried on octacalcium phosphate collagen composite. J. Hard Tissue Biol. 2020, 29, 123–130.
  47. Hettiaratchi, M.H.; Chou, C.; Servies, N.; Smeekens, J.M.; Cheng, A.; Esancy, C.; Wu, R.; McDevitt, T.C.; Guldberg, R.E.; Krishnan, L. Competitive protein binding influences heparin-based modulation of spatial growth factor delivery for bone regeneration. Tissue Eng. Part A 2017, 23, 683–695.
  48. Newman, M.R.; Benoit, D.S.W. Local and Targeted Drug Delivery for Bone Regeneration. Curr. Opin. Biotechnol. 2016, 40, 125–132.
  49. De Witte, T.-M.; Fratila-Apachitei, L.E.; Zadpoor, A.A.; Peppas, N.A. Bone tissue engineering via growth factor delivery: From scaffolds to complex matrices. Regen. Biomater. 2018, 5, 197–211.
  50. Fernandez-Yague, M.A.; Abbah, S.A.; McNamara, L.; Zeugolis, D.I.; Pandit, A.; Biggs, M.J. Biomimetic approaches in bone tissue engineering: Integrating biological and physicomechanical strategies. Adv. Drug Deliv. Rev. 2015, 84, 1–29.
  51. Gan, Q.; Zhu, J.; Yuan, Y.; Liu, H.; Qian, J.; Li, Y.; Liu, C. A dual-delivery system of pH-responsive chitosan-functionalized mesoporous silica nanoparticles bearing BMP-2 and dexamethasone for enhanced bone regeneration. J. Mater. Chem. B 2015, 3, 2056–2066.
  52. Hussein, K.H.; Park, K.M.; Kang, K.S.; Woo, H.M. Biocompatibility Evaluation of Tissue-Engineered Decellularized Scaffolds for Biomedical Application. Mater. Sci. Eng. C 2016, 67, 766–778.
  53. Mishra, R.; Sefcik, R.S.; Bishop, T.J.; Montelone, S.M.; Crouser, N.; Welter, J.F.; Caplan, A.I.; Dean, D. Growth factor dose tuning for bone progenitor cell proliferation and differentiation on Resorbable Poly(propylene fumarate) Scaffolds. Tissue Eng. Part C Methods 2016, 22, 904–913.
  54. Turnbull, G.; Clarke, J.; Picard, F.; Riches, P.; Jia, L.; Han, F.; Li, B.; Shu, W. 3D Bioactive Composite Scaffolds for Bone Tissue Engineering. Bioprinting 2018, 3, 278–314.
  55. Song, R.; Murphy, M.; Li, C.; Ting, K.; Soo, C.; Zheng, Z. Current Development of Biodegradable Polymeric Materials for Biomedical Applications. Drug Des. Dev. Ther. 2018, 12, 3117–3145.
  56. Boskey, A.L. Bone composition: Relationship to bone fragility and antiosteoporotic drug effects. BoneKEy Rep. 2013, 2.
  57. Shavandi, A.; Bekhit, A.E.-D.A.; Sun, Z.F.; Ali, A. A Review of Synthesis Methods, Properties and Use of Hydroxyapatite as a Substitute of Bone. J. Biomim. Biomater. Biomed. Eng. 2015, 25, 98–117.
  58. Pina, S.; Ribeiro, V.P.; Marques, C.F.; Maia, F.R.; Silva, T.H.; Reis, R.L.; Oliveira, J.M. Scaffolding Strategies for Tissue Engineering and Regenerative Medicine Applications. Materials 2019, 12, 1824.
  59. Venkataraman, N.; Bansal, S.; Bansal, P.; Narayan, S. Dynamics of bone graft healing around implants. J. Int. Clin. Dent. Res. Organ. 2015, 7, 40.
  60. Chocholata, P.; Kulda, V.; Babuska, V. Fabrication of Scaffolds for Bone-Tissue Regeneration. Materials 2019, 12, 568.
  61. Roseti, L.; Parisi, V.; Petretta, M.; Cavallo, C.; Desando, G.; Bartolotti, I.; Grigolo, B. Scaffolds for bone tissue engineering: State of the art and new perspectives. Mater. Sci. Eng. C 2017, 78, 1246–1262.
  62. Nikolova, M.P.; Chavali, M.S. Recent Adv. biomaterials for 3D scaffolds: A review. Bioact. Mater. 2019, 4, 271–292.
  63. Agrawal, S.; Srivastava, R. Osteoinductive and Osteoconductive Biomaterials; Springer: Berlin/Heidelberg, Germany, 2020; pp. 355–395.
  64. Gao, C.; Peng, S.; Feng, P.; Shuai, C. Bone Biomaterials and Interactions with Stem Cells. Bone Res. 2017, 5, 1–33.
  65. Shuai, C.; Yang, W.; He, C.; Peng, S.; Gao, C.; Yang, Y.; Qi, F.; Feng, P. A magnetic micro-environment in scaffolds for stimulating bone regeneration. Mater. Des. 2020, 185, 108275.
  66. Eivazzadeh-Keihan, R.; Bahojb Noruzi, E.; Khanmohammadi Chenab, K.; Jafari, A.; Radinekiyan, F.; Hashemi, S.M.; Ahmadpour, F.; Behboudi, A.; Mosafer, J.; Mokhtarzadeh, A.; et al. Metal-based nanoparticles for bone tissue engineering. J. Tissue Eng. Regen. Med. 2020, 14, 1687–1714.
  67. Fan, B.; Guo, Z.; Li, X.; Li, S.; Gao, P.; Xiao, X.; Wu, J.; Shen, C.; Jiao, Y.; Hou, W. Electroactive barium titanate coated titanium scaffold improves osteogenesis and osseointegration with low-intensity pulsed ultrasound for large segmental bone defects. Bioact. Mater. 2020, 5, 1087–1101.
  68. Lv, J.; Xiu, P.; Tan, J.; Jia, Z.; Cai, H.; Liu, Z. Enhanced angiogenesis and osteogenesis in critical bone defects by the controlled release of BMP-2 and VEGF: Implantation of electron beam melting-fabricated porous Ti 6 Al 4 V scaffolds incorporating growth factor-doped fibrin glue. Biomed. Mate. 2015, 10, 035013.
  69. Vehof, J.W.; Haus, M.T.; de Ruijter, A.E.; Spauwen, P.H.; Jansen, J.A. Bone formation in transforming growth factor beta-I-loaded titanium fiber mesh implants. Clin. Oral Implants Res. 2002, 13, 94–102.
  70. Comesaña, R.; Lusquiños, F.; Del Val, J.; Quintero, F.; Riveiro, A.; Boutinguiza, M.; Jones, J.R.; Hill, R.G.; Pou, J. Toward smart implant synthesis: Bonding bioceramics of different resorbability to match bone growth rates. Sci. Rep. 2015, 5, 10677.
  71. Blackwood, K.A.; Bock, N.; Dargaville, T.R.; Ann Woodruff, M. Scaffolds for growth factor delivery as applied to bone tissue engineering. Int. J. Polym. Sci. 2012, 2012, 174942.
  72. Geiger, M.; Li, R.H.; Friess, W. Collagen sponges for bone regeneration with rhBMP-2. Adv. Drug Deliv. Rev. 2003, 55, 1613–1629.
  73. Lin, X.; Patil, S.; Gao, Y.G.; Qian, A. The Bone Extracellular Matrix in Bone Formation and Regeneration. Front. Pharmacol. 2020, 11, 757.
  74. Gu, L.; Shan, T.; Ma, Y.x.; Tay, F.R.; Niu, L. Novel biomedical applications of crosslinked collagen. Trends Biotechnol. 2019, 37, 464–491.
  75. Wang, Q.; Zhang, Y.; Li, B.; Chen, L. Controlled dual delivery of low doses of BMP-2 and VEGF in a silk fibroin–nanohydroxyapatite scaffold for vascularized bone regeneration. J. Mater. Chem. B 2017, 5, 6963–6972.
  76. Lee, J.H.; Luo, X.; Ren, X.; Tan, T.C.; Smith, R.A.A.; Swaminathan, K.; Sekar, S.; Bhakoo, K.; Nurcombe, V.; Hui, J.H.; et al. A Heparan Sulfate Device for the Regeneration of Osteochondral Defects. Tissue Eng. Part A 2019, 25, 352–363.
  77. Choi, J.H.; Kim, D.K.; Song, J.E.; Oliveira, J.M.; Reis, R.L.; Khang, G. Silk Fibroin-Based Scaffold for Bone Tissue Engineering; Springer: New York, NY, USA, 2018; Volume 1077, pp. 371–387.
  78. Walsh, D.P.; Raftery, R.M.; Chen, G.; Heise, A.; O’Brien, F.J.; Cryan, S.A. Rapid healing of a critical-sized bone defect using a collagen-hydroxyapatite scaffold to facilitate low dose, combinatorial growth factor delivery. J. Tissue Eng. Regen. Med. 2019, 13, 1843–1853.
  79. Shen, X.; Zhang, Y.; Gu, Y.; Xu, Y.; Liu, Y.; Li, B.; Chen, L. Sequential and sustained release of SDF-1 and BMP-2 from silk fibroin-nanohydroxyapatite scaffold for the enhancement of bone regeneration. Biomaterials 2016, 106, 205–216.
  80. Naskar, D.; Ghosh, A.K.; Mandal, M.; Das, P.; Nandi, S.K.; Kundu, S.C. Dual growth factor loaded nonmulberry silk fibroin/carbon nanofiber composite 3D scaffolds for in vitro and in vivo bone regeneration. Biomaterials 2017, 136, 67–85.
  81. Bhattacharjee, P.; Naskar, D.; Maiti, T.K.; Bhattacharya, D.; Kundu, S.C. Investigating the potential of combined growth factors delivery, from non-mulberry silk fibroin grafted poly(ε-caprolactone)/hydroxyapatite nanofibrous scaffold, in bone tissue engineering. Appl. Mater. Today 2016, 5, 52–67.
  82. Lee, K.Y.; Mooney, D.J. Alginate: Properties and Biomedical Applications. Progr. Polym. Sci. 2012, 37, 106–126.
  83. Tohamy, K.M.; Mabrouk, M.; Soliman, I.E.; Beherei, H.H.; Aboelnasr, M.A. Novel alginate/hydroxyethyl cellulose/hydroxyapatite composite scaffold for bone regeneration: In vitro cell viability and proliferation of human mesenchymal stem cells. Int. J. Biol. Macromol. 2018, 112, 448–460.
  84. Hecht, H.; Srebnik, S. Structural characterization of sodium alginate and calcium alginate. Biomacromolecules 2016, 17, 2160–2167.
  85. Nataraj, D.; Narendra, R. Chemical modifications of alginate and its derivatives. Int. J. Chem. Res. 2019, 1–17.
  86. Abouzeid, R.E.; Khiari, R.; Beneventi, D.; Dufresne, A. Biomimetic mineralization of three-dimensional printed alginate/TEMPO-oxidized cellulose nanofibril scaffolds for bone tissue engineering. Biomacromolecules 2018, 19, 4442–4452.
  87. Bayer, E.A.; Jordan, J.; Roy, A.; Gottardi, R.; Fedorchak, M.V.; Kumta, P.N.; Little, S.R. Programmed platelet-derived growth factor-BB and bone morphogenetic protein-2 delivery from a hybrid calcium phosphate/alginate scaffold. Tissue Eng. Part A 2017, 23, 1382–1393.
  88. Coelho, F.; Cavicchioli, M.; Specian, S.S.; Scarel-Caminaga, R.M.; Penteado, L.D.A.; Medeiros, A.I.D.; Ribeiro, S.J.D.L.; Capote, T.S.D.O. Bacterial cellulose membrane functionalized with hydroxiapatite and anti-bone morphogenetic protein 2: A promising material for bone regeneration. PLoS ONE 2019, 14, e0221286.
  89. Dutta, S.D.; Patel, D.K.; Lim, K.T. Functional Cellulose-Based Hydrogels as Extracellular Matrices for Tissue Engineering. J. Biol. Eng. 2019, 13, 1–19.
  90. Zhang, X.; Wang, C.; Liao, M.; Dai, L.; Tang, Y.; Zhang, H.; Coates, P.; Sefat, F.; Zheng, L.; Song, J.; et al. Aligned electrospun cellulose scaffolds coated with rhBMP-2 for both in vitro and in vivo bone tissue engineering. Carbohydr. Polym. 2019, 213.
  91. Deepthi, S.; Venkatesan, J.; Kim, S.K.; Bumgardner, J.D.; Jayakumar, R. An overview of chitin or chitosan/nano ceramic composite scaffolds for bone tissue engineering. Int. J. Biol. Macromol. 2016, 93, 1338–1353.
  92. Tao, J.; Zhang, Y.; Shen, A.; Yang, Y.; Diao, L.; Wang, L.; Cai, D.; Hu, Y. Injectable chitosan-based thermosensitive hydrogel/nanoparticle-loaded system for local delivery of vancomycin in the treatment of osteomyelitis. Int. J. Nanomed. 2020, 15, 5855–5871.
  93. Gohil, S.V.; Padmanabhan, A.; Deschamps, J.; Nair, L.S. Chitosan-Based Scaffolds for Growth Factor Delivery. Tissue Eng. Ther. 2017, 2, 175–207.
  94. Bastami, F.; Paknejad, Z.; Jafari, M.; Salehi, M.; Rezai Rad, M.; Khojasteh, A. Fabrication of a three-dimensional β-tricalcium-phosphate/gelatin containing chitosan-based nanoparticles for sustained release of bone morphogenetic protein-2: Implication for bone tissue engineering. Mater. Sci. Eng. C 2017, 72, 481–491.
  95. Xia, Y.J.; Xia, H.; Chen, L.; Ying, Q.S.; Yu, X.; Li, L.H.; Wang, J.H.; Zhang, Y. Efficient delivery of recombinant human bone morphogenetic protein (rhBMP-2) with dextran sulfate-chitosan microspheres. Exp. Ther. Med. 2018, 15, 3265–3272.
  96. Celikkin, N.; Rinoldi, C.; Costantini, M.; Trombetta, M.; Rainer, A.; Święszkowski, W. Naturally Derived Proteins and Glycosaminoglycan Scaffolds for Tissue Engineering Applications. Mater. Sci. Eng. C 2017, 78, 1277–1299.
  97. Hachim, D.; Whittaker, T.E.; Kim, H.; Stevens, M.M. Glycosaminoglycan-based biomaterials for growth factor and cytokine delivery: Making the right choices. J. Control. Release 2019, 313, 131–147.
  98. Dinoro, J.; Maher, M.; Talebian, S.; Jafarkhani, M.; Mehrali, M.; Orive, G.; Foroughi, J.; Lord, M.S.; Dolatshahi-Pirouz, A. Sulfated Polysaccharide-Based Scaffolds for Orthopaedic Tissue Engineering. Biomaterials 2019, 214, 119214.
  99. Thanyaphoo, S.; Kaewsrichan, J. A new biocompatible delivery scaffold containing heparin and bone morphogenetic protein 2. Acta Pharm. 2016, 66, 373–385.
  100. Hettiaratchi, M.H.; Krishnan, L.; Rouse, T.; Chou, C.; McDevitt, T.C.; Guldberg, R.E. Heparin-mediated delivery of bone morphogenetic protein-2 improves spatial localization of bone regeneration. Sci. Adv. 2020, 6, eaay1240.
  101. Ma, C.; Jing, Y.; Sun, H.; Liu, X. Hierarchical nanofibrous microspheres with controlled growth factor delivery for bone regeneration. Adv. Healthc. Mater. 2015, 4, 2699–2708.
  102. Liu, Y.; Gu, J.; Fan, D. Fabrication of high-strength and porous hybrid scaffolds based on nano-hydroxyapatite and human-like collagen for bone tissue regeneration. Polymers 2020, 12, 61.
  103. Andrews, S.; Cheng, A.; Stevens, H.; Logun, M.T.; Webb, R.; Jordan, E.; Xia, B.; Karumbaiah, L.; Guldberg, R.E.; Stice, S. Chondroitin sulfate glycosaminoglycan scaffolds for cell and recombinant protein-based bone regeneration. Stem Cells Transl. Med. 2019, 8, 575–585.
  104. Fenbo, M.; Sijing, L.; Ruiz-Ortega, L.I.; Yuanjun, Z.; Lei, X.; Kui, W.; Lijun, L.; Bin, T. Effects of alginate/chondroitin sulfate-based hydrogels on bone defects healing. Mater. Sci. Eng. C 2020, 116, 111217.
  105. Caterson, B.; Melrose, J. Keratan Sulfate, a Complex Glycosaminoglycan with Unique Functional Capability. Glycobiology 2018, 28, 182–206.
  106. Li, M.; Zhang, X.; Jia, W.; Wang, Q.; Liu, Y.; Wang, X.; Wang, C.; Jiang, J.; Gu, G.; Guo, Z.; et al. Improving in vitro biocompatibility on biomimetic mineralized collagen bone materials modified with hyaluronic acid oligosaccharide. Mater. Sci. Eng. C 2019, 104, 110008.
  107. Makvandi, P.; Ali, G.W.; Della Sala, F.; Abdel-Fattah, W.I.; Borzacchiello, A. Hyaluronic acid/corn silk extract based injectable nanocomposite: A biomimetic antibacterial scaffold for bone tissue regeneration. Mater. Sci. Eng. C 2020, 107, 110195.
More
© Text is available under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)
ScholarVision Creations
Feedback