References

1. Deanfield, J.E.; Halcox, J.P.; Rabelink, T.J; Endothelial Function and Dysfunction. Testing and Clinical Relevance. Circulation 2007, 115, 1285–1295.
2. Zecchin, A.; Borgers, G.; Carmeliet, P. Endothelial cells and cancer cells: Metabolic partners in crime? Curr. Opin. Hematol. 2015, 22, 234–242.
3. Robert F. Furchgott; John V. Zawadzki; The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980, 288, 373-376, 10.1038/288373a0.
4. Ryszard J. Gryglewski; Stuart Bunting; Salvador Moncada; Roderick J. Flower; John R. Vane; Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides. Prostaglandins 1976, 12, 685-713, 10.1016/0090-6980(76)90047-2.
5. D. Leung; G Cachianes; W. Kuang; D. Goeddel; N Ferrara; Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989, 246, 1306-1309, 10.1126/science.2479986.
6. Dudley, A.C; Tumor endothelial cells. Cold Spring Harb. Perspect. Med. 2012, 2, a006536.
7. Lin Xiao; Dae Joong Kim; Clayton L. Davis; James V. McCann; James M. Dunleavey; Alissa K. Vanderlinden; Nuo Xu; Samantha G. Pattenden; Stephen V. Frye; Xia Xu; et al.Mark OnaitisElizabeth Monaghan-BensonKeith BurridgeAndrew C. Dudley Tumor Endothelial Cells with Distinct Patterns of TGFβ-Driven Endothelial-to-Mesenchymal Transition. Cancer Research 2015, 75, 1244-54, 10.1158/0008-5472.CAN-14-1616.
8. Unterleuthner, D.; Neuhold, P.; Schwarz, K.; Janker, L.; Neuditschko, B.; Nivarthi, H.; Crncec, I.; Kramer, N.; Unger, C.; Hengstschläger, M.; et al. Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer. Angiogenesis 2019.
9. Takashi Aizawa; Hideaki Karasawa; Ryo Funayama; Matsuyuki Shirota; Takashi Suzuki; Shimpei Maeda; Hideyuki Suzuki; Akihiro Yamamura; Takeshi Naitoh; Keiko Nakayama; Michiaki Unno; Cancer-associated fibroblasts secrete Wnt2 to promote cancer progression in colorectal cancer.. Cancer Medicine 2019, 8, 6370-6382, 10.1002/cam4.2523.
10. N Kramer; J Schmöllerl; C Unger; H Nivarthi; A Rudisch; D Unterleuthner; M Scherzer; A Riedl; M Artaker; I Crncec; D Lenhardt; T Schwarz; B Prieler; Xiaonan Han; M Hengstschläger; J Schüler; Robert Eferl; Richard H Moriggl; W Sommergruber; Helmut Dolznig; Autocrine WNT2 signaling in fibroblasts promotes colorectal cancer progression. Oncogene 2017, 36, 5460-5472, 10.1038/onc.2017.144.
11. Erik Sahai; Igor Astsaturov; Edna Cukierman; David G. DeNardo; Mikala Egeblad; Ronald M. Evans; Douglas Fearon; Florian R. Greten; Sunil R. Hingorani; Tony Hunter; Richard O. Hynes; Rakesh K. Jain; Tobias Janowitz; Claus Jorgensen; Alec C. Kimmelman; Mikhail G. Kolonin; Robert G. Maki; R. Scott Powers; Ellen Puré; Daniel C. Ramirez; Ruth Scherz-Shouval; Mara H. Sherman; Sheila Stewart; Thea D. Tlsty; David A. Tuveson; Fiona M. Watt; Valerie Weaver; Ashani T. Weeraratna; Zena Werb; A framework for advancing our understanding of cancer-associated fibroblasts. Nature Reviews Cancer 2020, 20, 174-186, 10.1038/s41568-019-0238-1.
12. Xueman Chen; Erwei Song; Turning foes to friends: targeting cancer-associated fibroblasts. Nature Reviews Drug Discovery 2018, 18, 9-115, 10.1038/s41573-018-0004-1.
13. Michel Félétou; The Endothelium, Part I: Multiple Functions of the Endothelial Cells -- Focus on Endothelium-Derived Vasoactive Mediators. Colloquium Series on Integrated Systems Physiology: From Molecule to Function 2011, 3, 1-306, 10.4199/c00031ed1v01y201105isp019.
14. Kyoko Hida; Nako Maishi; Chisaho Torii; Yasuhiro Hida; Tumor angiogenesis—characteristics of tumor endothelial cells. International Journal of Clinical Oncology 2016, 21, 206-212, 10.1007/s10147-016-0957-1.
15. Francesco De Sanctis; Stefano Ugel; John Facciponte; Andrea Facciabene; The dark side of tumor-associated endothelial cells. Seminars in Immunology 2018, 35, 35-47, 10.1016/j.smim.2018.02.002.
16. Hida, K.; Maishi, N; Abnormalities of tumor endothelial cells and cancer progression. Oral Sci. Int. 2018, 15, 1-6.
17. Kohei Matsuda; Noritaka Ohga; Yasuhiro Hida; Chikara Muraki; Kunihiko Tsuchiya; Takuro Kurosu; Tomoshige Akino; Shou-Ching Shih; Yasunori Totsuka; Michael Klagsbrun; Masanobu Shindoh; Kyoko Hida; Isolated tumor endothelial cells maintain specific character during long-term culture. Biochemical and Biophysical Research Communications 2010, 394, 947-954, 10.1016/j.bbrc.2010.03.089.
18. Hitomi Ohmura-Kakutani; Kosuke Akiyama; Nako Maishi; Noritaka Ohga; Yasuhiro Hida; Taisuke Kawamoto; Junichiro Iida; Masanobu Shindoh; Kunihiko Tsuchiya; Nobuo Shinohara; Kyoko Hida; Identification of Tumor Endothelial Cells with High Aldehyde Dehydrogenase Activity and a Highly Angiogenic Phenotype. PLOS ONE 2014, 9, e113910, 10.1371/journal.pone.0113910.
19. Valentina Fonsato; Stefano Buttiglieri; Maria Chiara Deregibus; Valeria Puntorieri; Benedetta Bussolati; Giovanni Camussi; Expression of Pax2 in Human Renal Tumor-Derived Endothelial Cells Sustains Apoptosis Resistance and Angiogenesis. The American Journal of Pathology 2006, 168, 706-713, 10.2353/ajpath.2006.050776.
20. K. Hida; Tumor-Associated Endothelial Cells with Cytogenetic Abnormalities. Cancer Research 2004, 64, 8249-8255, 10.1158/0008-5472.can-04-1567.
21. Tomoshige Akino; Kyoko Hida; Yasuhiro Hida; Kunihiko Tsuchiya; Deborah Freedman; Chikara Muraki; Noritaka Ohga; Kouhei Matsuda; Kousuke Akiyama; Toru Harabayashi; et al.Nobuo ShinoharaKatsuya NonomuraMichael KlagsbrunMasanobu Shindoh Cytogenetic Abnormalities of Tumor-Associated Endothelial Cells in Human Malignant Tumors. The American Journal of Pathology 2009, 175, 2657-2667, 10.2353/ajpath.2009.090202.
22. Kyoko Hida; Nako Maishi; Dorcas A. Annan; Yasuhiro Hida; Contribution of Tumor Endothelial Cells in Cancer Progression. International Journal of Molecular Sciences 2018, 19, 1272, 10.3390/ijms19051272.
23. Hisamichi Naito; Taku Wakabayashi; Hiroyasu Kidoya; Fumitaka Muramatsu; Kazuhiro Takara; Daisuke Eino; Keitaro Yamane; Tomohiro Iba; Nobuyuki Takakura; Endothelial side population cells contribute to tumor angiogenesis and anti-angiogenic drug resistance. Cancer Research 2016, 76, 3200-3210, 10.1158/0008-5472.can-15-2998.
24. Aird, W.C.; Phenotypic Heterogeneity of the Endothelium. Circ. Res. 2007, 100, 158–173, 10.1161/01.res.0000255690.03436.ae.
25. Yong S. Chang; Emmanuelle Di Tomaso; Nald M. McDonald; Rosemary Jones; Rakesh K. Jain; L.L. Munn; Mosaic blood vessels in tumors: Frequency of cancer cells in contact with flowing blood. Proceedings of the National Academy of Sciences 2000, 97, 14608-14613, 10.1073/pnas.97.26.14608.
26. Hiroya Hashizume; Peter Baluk; Shunichi Morikawa; John W. McLean; Gavin Thurston; Sylvie Roberge; Rakesh K. Jain; Donald M. McDonald; Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness. The American Journal of Pathology 2000, 156, 1363-1380, 10.1016/s0002-9440(10)65006-7.
27. J. Denekamp; B. Hobson; Endothelial-cell proliferation in experimental tumours.. British Journal of Cancer 1982, 46, 711-720.
28. Nako Maishi; Hiroshi Kikuchi; Masumi Sato; Hiroko Nagao-Kitamoto; Dorcas A. Annan; Shogo Baba; Takayuki Hojo; Misa Yanagiya; Yusuke Ohba; Genichiro Ishii; Kenkichi Masutomi; Nobuo Shinohara; Yasuhiro Hida; Kyoko Hida; Development of Immortalized Human Tumor Endothelial Cells from Renal Cancer. International Journal of Molecular Sciences 2019, 20, 4595, 10.3390/ijms20184595.
29. Dhara N. Amin; Kyoko Hida; Diane R Bielenberg; Michael Klagsbrun; Tumor Endothelial Cells Express Epidermal Growth Factor Receptor (EGFR) but not ErbB3 and Are Responsive to EGF and to EGFR Kinase Inhibitors. Cancer Research 2006, 66, 2173-2180, 10.1158/0008-5472.can-05-3387.
30. Yasufumi Sato; Persistent vascular normalization as an alternative goal of anti?angiogenic cancer therapy. Cancer Science 2011, 102, 1253-1256, 10.1111/j.1349-7006.2011.01929.x.
31. Helfrich, I.; Scheffrahn, I.; Bartling, S.; Weis, J.; Felbert, V.V.; Middleton, M.; Kato, M.; Ergün, S.; Augustin, H.G.; Schadendorf, D; et al. Resistance to antiangiogenic therapy is directed by vascular phenotype, vessel stabilization, and maturation in malignant melanoma. J. Exp. Med. 2010, 207, 491–503.
32. Sarah M. Taylor; Kathleen R. Nevis; Hannah L. Park; Gregory C. Rogers; Stephen L. Rogers; Jean Cook; Victoria L. Bautch; Angiogenic factor signaling regulates centrosome duplication in endothelial cells of developing blood vessels. Blood 2010, 116, 3108-3117, 10.1182/blood-2010-01-266197.
33. Ohga, N.; Ishikawa, S.; Maishi, N.; Akiyama, K.; Hida, Y.; Kawamoto, T.; Sadamoto, Y.; Osawa, T.; Yamamoto, K.; Kondoh, M.; et al.et al Heterogeneity of Tumor Endothelial Cells. Am. J. Pathol. 2012, 180, 1294–1307.
34. Lyssiotis, C.A.; Kimmelman, A.C; Metabolic Interactions in the Tumor Microenvironment. Trends Cell Biol. 2017, 27, 863–875.
35. Annalisa Zecchin; Joanna Kalucka; Charlotte Dubois; Peter Carmeliet; How Endothelial Cells Adapt Their Metabolism to Form Vessels in Tumors. Frontiers in Immunology 2017, 8, 1750, 10.3389/fimmu.2017.01750.
36. Cantelmo, A.R.; Conradi, L.C.; Brajic, A.; Goveia, J.; Kalucka, J.; Pircher, A.; Chaturvedi, P.; Hol, J.; Thienpont, B.; Teuwen, L.A.; et al.et al Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy. Cancer Cell 2016, 30, 968-985, 10.1016/j.ccell.2016.10.006.
37. Annan, D.A.; Maishi, N.; Soga, T.; Dawood, R.; Li, C.; Kikuchi, H.; Hojo, T.; Morimoto, M.; Kitamura, T.; Alam, M.T.; et al.et al Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment. Cell Communication and Signaling 2019, 17, 169, 10.1186/s12964-019-0478-4.
38. De Bock, K.; Georgiadou, M.; Schoors, S.; Kuchnio, A.; Wong, B.W.; Cantelmo, A.R.; Quaegebeur, A.; Ghesquière, B.; Cauwenberghs, S.; Eelen, G.; et al.et al Role of PFKFB3-Driven Glycolysis in Vessel Sprouting. Cell 2013, 154, 651-663, 10.1016/j.cell.2013.06.037.
39. Longhou Fang; Soo-Ho Choi; Ji Sun Baek; Chao Liu; Felicidad Almazan; Florian Ulrich; Philipp Wiesner; Adam Taleb; Elena Deer; Jennifer Pattison; Jesús Torres-Vázquez; Andrew C. Li; Yury I. Miller; Control of angiogenesis by AIBP-mediated cholesterol efflux. Nature 2013, 498, 118-122, 10.1038/nature12166.
40. Elmasri, H.; Karaaslan, C.; Teper, Y.; Ghelfi, E.; Weng, M.; Ince, T.A.; Kozakewich, H.; Bischoff, J.; Cataltepe, S; Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells. FASEB J. 2009, 23, 3865–3873.
41. Schoors, S.; Bruning, U.; Missiaen, R.; Queiroz, K.C.S.; Borgers, G.; Elia, I.; Zecchin, A.; Cantelmo, A.R.; Christen, S.; Goveia, J.; et al.et al Fatty acid carbon is essential for dNTP synthesis in endothelial cells. Nature 2015, 520, 192–197.
42. Kimberly Krautkramer; Julia H. Kreznar; Kymberleigh A. Romano; Eugenio I. Vivas; Gregory A. Barrett-Wilt; Mary E. Rabaglia; Mark P. Keller; Alan D. Attie; Federico E Rey; John M. Denu; et al. Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues. Molecular Cell 2016, 64, 982-992, 10.1016/j.molcel.2016.10.025.
43. Anaïs Alves; Arthur Bassot; Anne-Laure Bulteau; Luciano Pirola; Béatrice Morio; Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases. Nutrients 2019, 11, 1356, 10.3390/nu11061356.
44. Loscalzo, J.; Handy, D.E. Epigenetic Modifications: Basic Mechanisms and Role in Cardiovascular Disease (2013 Grover Conference Series). Pulm. Circ. 2014, 4, 169–174.
45. Cathérine Dupont; D. Randall Armant; C. A. Brenner; Epigenetics: definition, mechanisms and clinical perspective.. Seminars in Reproductive Medicine 2009, 27, 351-357, 10.1055/s-0029-1237423.
46. Luciano Pirola; Oskar Ciesielski; Aneta Balcerczyk; The Methylation Status of the Epigenome: Its Emerging Role in the Regulation of Tumor Angiogenesis and Tumor Growth, and Potential for Drug Targeting. Cancers 2018, 10, 268, 10.3390/cancers10080268.
47. Søreide, K. Cancer Epigenetics. In Handbook of Epigenetics; Elsevier: Amsterdam, The Netherlands, 2017; pp. 519–534.
48. Aditi Mehta; Stephanie Dobersch; Addi J. Romero-Olmedo; Guillermo Barreto; Epigenetics in lung cancer diagnosis and therapy. Cancer and Metastasis Reviews 2015, 34, 229-241, 10.1007/s10555-015-9563-3.
49. Ewa Michalak; Marian L. Burr; Andrew J. Bannister; Mark A. Dawson; The roles of DNA, RNA and histone methylation in ageing and cancer. Nature Reviews Molecular Cell Biology 2019, 20, 573-589, 10.1038/s41580-019-0143-1.
50. A. E. Morgan; T. J. Davies; Mark T. Mc Auley; The role of DNA methylation in ageing and cancer. Proceedings of the Nutrition Society 2018, 77, 412-422, 10.1017/s0029665118000150.
51. Siavash K. Kurdistani; Histone Modifications in Cancer Biology and Prognosis. Epigenetics and Disease 2010, 67, 91-106, 10.1007/978-3-7643-8989-5_5.
52. Yan, M.S.; Marsden, P.A; Epigenetics in the Vascular Endothelium. Arterioscler. Thromb. Vasc. Biol. 2015, 35, 2297–2306.
53. Majerski, A.A.; Quinton, A.C.; Marsden, P.A. Epigenetic Mechanisms of the Vascular Endothelium. Epigenet. Epigenom. 2014.
54. Jessilyn Dunn; Salim Thabet; Hanjoong Jo; Flow-Dependent Epigenetic DNA Methylation in Endothelial Gene Expression and Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 2015, 35, 1562-1569, 10.1161/ATVBAHA.115.305042.
55. Jason E. Fish; Charles C. Matouk; Alisa Rachlis; Steve Lin; Sharon C. Tai; Cheryl D'abreo; Philip A. Marsden; The Expression of Endothelial Nitric-oxide Synthase Is Controlled by a Cell-specific Histone Code. Journal of Biological Chemistry 2005, 280, 24824-24838, 10.1074/jbc.m502115200.
56. Sarah Costantino; Epigenetic mechanisms of vascular dysfunction in obesity and type 2 diabetes. Cardiovascular Medicine 2019, 22, w02066, 10.4414/cvm.2019.02064.
57. Ding-Yu Lee; Jeng-Jiann Chiu; Atherosclerosis and flow: roles of epigenetic modulation in vascular endothelium.. Journal of Biomedical Science 2019, 26, 56, 10.1186/s12929-019-0551-8.
58. Peter A. Jones; Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nature Reviews Microbiology 2012, 13, 484-492, 10.1038/nrg3230.
59. Chan, Y.; Fish, J.E.; Dabreo, C.; Lin, S.; Robb, G.B.; Teichert, A.-M.; Karantzoulis-Fegaras, F.; Keightley, A.; Steer, B.M.; Marsden, P.A; et al. The Cell-specific Expression of Endothelial Nitric-oxide Synthase. J. Biol. Chem. 2004, 279, 35087–35100.
60. Shirodkar, A.V.; Bernard, R.S.; Gavryushova, A.; Kop, A.; Knight, B.J.; Yan, M.S.-C.; Man, H.-S.J.; Sud, M.; Hebbel, R.P.; Oettgen, P.; et al. A mechanistic role for DNA methylation in endothelial cell (EC)-enriched gene expression: Relationship with DNA replication timing. Blood 2013, 121, 3531–3540.
61. Debby M.E.I. Hellebrekers; Veerle Melotte; Emmanuelle Viré; Elise Langenkamp; Grietje Molema; François Fuks; James G. Herman; Wim Van Criekinge; Arjan W. Griffioen; Manon Van Engeland; Identification of Epigenetically Silenced Genes in Tumor Endothelial Cells. Cancer Research 2007, 67, 4138-4148, 10.1158/0008-5472.can-06-3032.
62. Debby M.E.I. Hellebrekers; Karolien Castermans; Ruud Dings; Nicole T.H. Hoebers; Kevin H. Mayo; Mirjam G. A. Oude Egbrink; Grietje Molema; François Fuks; Manon Van Engeland; Arjan W. Griffioen; Emmanuelle Viré; Epigenetic Regulation of Tumor Endothelial Cell Anergy: Silencing of Intercellular Adhesion Molecule-1 by Histone Modifications. Cancer Research 2006, 66, 10770-10777, 10.1158/0008-5472.can-06-1609.
63. Wei Luo; Qiang Hu; Dan Wang; Kristin K. Deeb; Yingyu Ma; Carl D. Morrison; Song Liu; Candace S. Johnson; Donald L. Trump; Isolation and genome-wide expression and methylation characterization of CD31+ cells from normal and malignant human prostate tissue. Oncotarget 2013, 4, 1472-1483, 10.18632/oncotarget.1269.
64. Kristin K. Deeb; Wei Luo; Adam R. Karpf; Angela R. Omilian; Wiam Bshara; Lili Tian; Michael A. Tangrea; Carl D. Morrison; Candace S. Johnson; Donald L. Trump; Differential vitamin D 24-hydroxylase/CYP24A1 gene promoter methylation in endothelium from benign and malignant human prostate. Epigenetics 2011, 6, 994-1000, 10.4161/epi.6.8.16536.
65. B. St. Croix; Joel Bourne; Genes Expressed in Human Tumor Endothelium. Science 2000, 289, 1197-1202, 10.1126/science.289.5482.1197.
66. Dylan T. Jones; Tanguy Lechertier; Richard Mitter; John M. J. Herbert; Roy Bicknell; J. Louise Jones; Ji-Liang Li; Francesca M. Buffa; Adrian L. Harris; Kairbaan Hodivala-Dilke; Gene Expression Analysis in Human Breast Cancer Associated Blood Vessels. PLOS ONE 2012, 7, e44294, 10.1371/journal.pone.0044294.
67. Ivy Chung; Adam R. Karpf; Josephia R. Muindi; Jeffrey M. Conroy; Norma J. Nowak; Candace S. Johnson; Nald L. Trump; Epigenetic Silencing of CYP24 in Tumor-derived Endothelial Cells Contributes to Selective Growth Inhibition by Calcitriol. Journal of Biological Chemistry 2007, 282, 8704-8714, 10.1074/jbc.m608894200.
68. Bin Liu; Tonghong Xu; Xinning Xu; Yuzhu Cui; Xiaojing Xing; Biglycan promotes the chemotherapy resistance of colon cancer by activating NF-κB signal transduction. Molecular and Cellular Biochemistry 2018, 449, 285-294, 10.1007/s11010-018-3365-1.
69. Nako Maishi; Yusuke Ohba; Kosuke Akiyama; Noritaka Ohga; Jun-Ichi Hamada; Hiroko Nagao-Kitamoto; Mohammad Towfik Alam; Kazuyuki Yamamoto; Taisuke Kawamoto; Nobuo Inoue; Akinobu Taketomi; Masanobu Shindoh; Yasuhiro Hida; Kyoko Hida; Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan. Scientific Reports 2016, 6, 28039, 10.1038/srep28039.
70. Andrew J. Bannister; Tony Kouzarides; Regulation of chromatin by histone modifications. Cell Research 2011, 21, 381-395, 10.1038/cr.2011.22.
71. Anton Eberharter; Peter B Becker; Histone acetylation: a switch between repressive and permissive chromatin. EMBO reports 2002, 3, 224-229, 10.1093/embo-reports/kvf053.
72. Philip Gregory; Klaus Wagner; Wolfram Hörz; Histone Acetylation and Chromatin Remodeling. Experimental Cell Research 2001, 265, 195-202, 10.1006/excr.2001.5187.
73. Andrew J. Bannister; Robert Schneider; Tony Kouzarides; Histone Methylation. Cell 2002, 109, 801-806, 10.1016/s0092-8674(02)00798-5.
74. Howe, F.S.; Fischl, H.; Murray, S.C.; Mellor, J. Is H3K4me3 instructive for transcription activation? BioEssays 2016, 39, 1–12.
75. Wei Chen; Methode Bacanamwo; David G. Harrison; Activation of p300 histone acetyltransferase activity is an early endothelial response to laminar shear stress and is essential for stimulation of endothelial nitric-oxide synthase mRNA transcription. Journal of Biological Chemistry 2008, 283, 16293-16298, 10.1074/jbc.M801803200.
76. Carmen Urbich; Lothar Rössig; David Kaluza; Michael Potente; Jes-Niels Boeckel; Andrea Knau; Florian Diehl; Jian-Guo Geng; Wolf-Karsten Hofmann; Andreas M. Zeiher; Stefanie Dimmeler; HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells. Blood 2009, 113, 5669-5679, 10.1182/blood-2009-01-196485.
77. Deokbum Park; Hyunmi Park; Youngmi Kim; Hyuna Kim; Dooil Jeoung; HDAC3 acts as a negative regulator of angiogenesis. BMB Reports 2014, 47, 227–232.
78. Roshana Thambyrajah; Muhammad Z.H. Fadlullah; Martin Proffitt; Rahima Patel; Shaun Cowley; Valerie Kouskoff; Georges Lacaud; HDAC1 and HDAC2 Modulate TGF-β Signaling during Endothelial-to-Hematopoietic Transition. Stem Cell Reports 2018, 10, 1369-1383, 10.1016/j.stemcr.2018.03.011.
79. Andriana Margariti; Anna Zampetaki; Qingzhong Xiao; Boda Zhou; Eirini Karamariti; Daniel Martin; Xiaoke Yin; Manuel Mayr; Hongling Li; Zhongyi Zhang; Elena De Falco; Yanhua Hu; Gillian Cockerill; Qingbo Xu; Lingfang Zeng; Histone Deacetylase 7 Controls Endothelial Cell Growth Through Modulation of -Catenin. Circulation Research 2010, 106, 1202-1211, 10.1161/circresaha.109.213165.
80. Madalena Barroso; Derrick Kao; Henk J. Blom; Isabel Tavares De Almeida; Maria Rita Azevedo E Castro; Joseph Loscalzo; Diane Handy; S-adenosylhomocysteine induces inflammation through NFkB: A possible role for EZH2 in endothelial cell activation.. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2015, 1862, 82-92, 10.1016/j.bbadis.2015.10.019.
81. Aneta Balcerczyk; Dorota Rybaczek; Martyna Wojtala; Luciano Pirola; Jun Okabe; Assam El-Osta; Pharmacological inhibition of arginine and lysine methyltransferases induces nuclear abnormalities and suppresses angiogenesis in human endothelial cells. Biochemical Pharmacology 2016, 121, 18-32, 10.1016/j.bcp.2016.09.013.
82. Martyna Wojtala; Ewa Macierzyńska-Piotrowska; Dorota Rybaczek; Luciano Pirola; Aneta Balcerczyk; Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells. Pharmacological Research 2018, 128, 252-263, 10.1016/j.phrs.2017.10.014.
83. Yang Duan; Xue Wu; Qiang Zhao; Jie Gao; Dawei Huo; Xinhua Liu; Zheng Ye; Xu Dong; Zheng Fu; Yongfeng Shang; Chenghao Xuan; DOT1L promotes angiogenesis through cooperative regulation of VEGFR2 with ETS-1. Oncotarget 2016, 7, 69674-69687, 10.18632/oncotarget.11939.
84. Hai-Na Zhang; Qiao Xu; Abhimanyu Thakur; Martin Omondi Alfred; Manas Chakraborty; Arunima Ghosh; Xu-Ben Yu; Endothelial dysfunction in diabetes and hypertension: Role of microRNAs and long non-coding RNAs. Life Sciences 2018, 213, 258-268, 10.1016/j.lfs.2018.10.028.
85. Francesca Orso; Lorena Quirico; Daniela Dettori; Roberto Coppo; Federico Virga; Livia C Ferreira; Camilla Paoletti; Désirée Baruffaldi; Elisa Penna; Daniela Taverna; Role of miRNAs in tumor and endothelial cell interactions during tumor progression. Seminars in Cancer Biology 2020, 60, 214-224, 10.1016/j.semcancer.2019.07.024.
86. Shusheng Wang; Arin B. Aurora; Brett A. Johnson; Xiaoxia Qi; John McAnally; Joseph A. Hill; James A. Richardson; Rhonda Bassel-Duby; Eric Olson; The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis. Developmental Cell 2008, 15, 261-271, 10.1016/j.devcel.2008.07.002.
87. Jason E. Fish; Massimo Mattia Santoro; Sarah U. Morton; Sangho Yu; Ru-Fang Yeh; Joshua Wythe; Kathryn N Ivey; Benoit G. Bruneau; Didier Yr Stainier; Deepak Srivastava; et al. miR-126 Regulates Angiogenic Signaling and Vascular Integrity. Developmental Cell 2008, 15, 272-284, 10.1016/j.devcel.2008.07.008.
88. Roberto Sessa; Giorgio Seano; Laura Di Blasio; Paolo Armando Gagliardi; Claudio Isella; Enzo Medico; Franco Cotelli; F. Bussolino; Luca Primo; The miR-126 regulates Angiopoietin-1 signaling and vessel maturation by targeting p85β. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 2012, 1823, 1925-1935, 10.1016/j.bbamcr.2012.07.011.
89. Coen Van Solingen; Leonard Seghers; Roel Bijkerk; Jacques M.G.J. Duijs; Marko K. Roeten; Annemarie M. Van Oeveren‐Rietdijk; Hans J. Baelde; Matthieu Monge; Joost Vos; Hetty C. De Boer; Paul H. A. Quax; Ton J. Rabelink; Anton Jan Van Zonneveld; Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis. Journal of Cellular and Molecular Medicine 2008, 13, 1577-1585, 10.1111/j.1582-4934.2008.00613.x.
90. Hai-Xiang Sun; D.-Y. Zeng; Ruo-Tian Li; Rui-Ping Pang; Hui Yang; Y.-L. Hu; Qun Zhang; Yue Jiang; Lin-Yan Huang; Yong-Bo Tang; Gui-Jun Yan; Jia-Guo Zhou; Essential Role of MicroRNA-155 in Regulating Endothelium-Dependent Vasorelaxation by Targeting Endothelial Nitric Oxide Synthase. Hypertension 2012, 60, 1407-1414, 10.1161/hypertensionaha.112.197301.
91. F Muramatsu; Hiroyasu Kidoya; Hisamichi Naito; S Sakimoto; N Takakura; microRNA-125b inhibits tube formation of blood vessels through translational suppression of VE-cadherin. Oncogene 2012, 32, 414-421, 10.1038/onc.2012.68.
92. John Hung; Vladislav Miscianinov; Judith C. Sluimer; David E. Newby; Andrew H. Baker; Targeting Non-coding RNA in Vascular Biology and Disease. Frontiers in Physiology 2018, 9, 1655, 10.3389/fphys.2018.01655.
93. Amankeldi Salybekov; Ainur K. Salybekova; Roberto Pola; Takayuki Asahara; Sonic Hedgehog Signaling Pathway in Endothelial Progenitor Cell Biology for Vascular Medicine. International Journal of Molecular Sciences 2018, 19, 3040, 10.3390/ijms19103040.
94. Pan, Z.; Tian, Y.; Niu, G.; Cao, C. Role of microRNAs in remodeling the tumor microenvironment (Review). Int. J. Oncol. 2019.
95. Kai Zhu; Qi Pan; Xin Zhang; Ling-Qun Kong; Jia Fan; Zhi Dai; Lu Wang; Xin-Rong Yang; Jie Hu; Jin-Liang Wan; Yi-Ming Zhao; Zhong-Hua Tao; Zong-Tao Chai; Hai-Ying Zeng; Zhao-You Tang; H. C. Sun; Jian Zhou; Patric Jansson; Fei Yue; Jing Sun; Daohai Zhang; Dong-Hun Bae; Sumit Sahni; Ying Zheng; Qian Zhao; Zaklina Kovacevic; Des R. Richardson; MiR-146a enhances angiogenic activity of endothelial cells in hepatocellular carcinoma by promoting PDGFRA expression. Carcinogenesis 2013, 34, 2071-2079, 10.1093/carcin/bgt160.
96. Thomas Wurdinger; Bakhos A. Tannous; Okay Saydam; Johan Skog; Stephan Grau; Jürgen Soutschek; Ralph Weissleder; Xandra O. Breakefield; Anna M. Krichevsky; miR-296 Regulates Growth Factor Receptor Overexpression in Angiogenic Endothelial Cells. Cancer Cell 2008, 14, 382-393, 10.1016/j.ccr.2008.10.005.
97. Dominique Thuringer; Jonathan Boucher; Gaetan Jego; Nicolas Pernet; Laurent Cronier; Arlette Hammann; E. Solary; Carmen Garrido; Transfer of functional microRNAs between glioblastoma and microvascular endothelial cells through gap junctions. Oncotarget 2016, 7, 73925-73934, 10.18632/oncotarget.12136.
98. Zhicheng Zeng; Yuling Li; Yangjian Pan; Xiaoliang Lan; Fuyao Song; Jingbo Sun; Kun Zhou; Xiaolong Liu; Xiaoli Ren; Feifei Wang; Jinlong Hu; Xiaohui Zhu; Wei Yang; Wenting Liao; Guoxin Li; Yanqing Ding; L. Liang; Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis. Nature Communications 2018, 9, 5395, 10.1038/s41467-018-07810-w.
99. Kosaka, N.; Iguchi, H.; Hagiwara, K.; Yoshioka, Y.; Takeshita, F.; Ochiya, T. Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis. J. Biol. Chem. 2013, 288, 10849–10859.
100. Yue-Chao Fan; Peng-Jin Mei; Chen Chen; Fa-An Miao; Hui Zhang; Zhong-Lin Li; MiR-29c inhibits glioma cell proliferation, migration, invasion and angiogenesis. Journal of Neuro-Oncology 2013, 115, 179-188, 10.1007/s11060-013-1223-2.
101. Jong-Kuen Lee; Sae-Ra Park; Bong-Kwang Jung; Yoon-Kyung Jeon; Yeong-Shin Lee; Min-Kyoung Kim; Yong-Goo Kim; Ji-Young Jang; Chul-Woo Kim; Exosomes Derived from Mesenchymal Stem Cells Suppress Angiogenesis by Down-Regulating VEGF Expression in Breast Cancer Cells. PLOS ONE 2013, 8, e84256, 10.1371/journal.pone.0084256.
102. Guanglei Zhuang; Xiumin Wu; Zhaoshi Jiang; Ian Kasman; Jenny Yao; Yinghui Guan; Jason Oeh; Zora Modrusan; Carlos Bais; Deepak Sampath; Napoleone Ferrara; Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway. The EMBO Journal 2012, 31, 3513-3523, 10.1038/emboj.2012.183.
103. Xu Chen; Fan Yang; Tianze Zhang; Wei Wang; Wenjin Xi; Yufang Li; Dan Zhang; Yi Huo; Jianning Zhang; Angang Yang; Tao Wang; MiR-9 promotes tumorigenesis and angiogenesis and is activated by MYC and OCT4 in human glioma. Journal of Experimental & Clinical Cancer Research 2019, 38, 99, 10.1186/s13046-019-1078-2.
104. Haiou Yang; Haiyang Zhang; Shaohua Ge; Tao Ning; Ming Bai; Jialu Li; Shuang Li; Wu Sun; Ting Deng; Le Zhang; et al.Guoguang YingYi Ba Exosome-Derived miR-130a Activates Angiogenesis in Gastric Cancer by Targeting C-MYB in Vascular Endothelial Cells. Molecular Therapy 2018, 26, 2466-2475, 10.1016/j.ymthe.2018.07.023.
105. Liang Liang; Lei Zhao; Ying Zan; Qing Zhu; Juan Ren; Xinhan Zhao; MiR-93-5p enhances growth and angiogenesis capacity of HUVECs by down-regulating EPLIN. Oncotarget 2017, 8, 107033-107043, 10.18632/oncotarget.22300.
106. L Fang; Z Deng; T Shatseva; J Yang; C Peng; W W Du; A J Yee; L C Ang; C He; S W Shan; Burton B. Yang; MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8. Oncogene 2010, 30, 806-821, 10.1038/onc.2010.465.
107. W Kong; L He; E J Richards; Sridevi Challa; C-X Xu; J Permuth-Wey; J M Lancaster; D Coppola; T A Sellers; J Y Djeu; et al.George Cheng Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer. Oncogene 2013, 33, 679-89, 10.1038/onc.2012.636.
108. Guangmei Mao; Yan Liu; Xi Fang; Yahan Liu; Li Fang; Lianjun Lin; Xinmin Liu; Nanping Wang; Tumor-derived microRNA-494 promotes angiogenesis in non-small cell lung cancer. Angiogenesis 2015, 18, 373-382, 10.1007/s10456-015-9474-5.
109. Xiangdong Liu; Xiang Gao; Wentao Zhang; Tianyi Zhu; Wei Bi; Yanrong Zhang; MicroRNA-204 deregulation in lung adenocarcinoma controls the biological behaviors of endothelial cells potentially by modulating Janus kinase 2-signal transducer and activator of transcription 3 pathway. IUBMB Life 2017, 70, 81-91, 10.1002/iub.1706.
110. Zhang, L.; Lv, Z.; Xu, J.; Chen, C.; Ge, Q.; Li, P.; Wei, D.; Wu, Z.; Sun, X. Micro RNA -134 inhibits osteosarcoma angiogenesis and proliferation by targeting the VEGFA / VEGFR 1 pathway. FEBS J. 2018, 285, 1359–1371.
111. Li-Hong Wang; Hsiao-Chi Tsai; Yu-Che Cheng; Chih-Yang Lin; Yuan-Li Huang; Chun-Hao Tsai; Guo-Hong Xu; Shih-Wei Wang; Yi-Chin Fong; Chih-Hsin Tang; CTGF promotes osteosarcoma angiogenesis by regulating miR-543/angiopoietin 2 signaling. Cancer Letters 2017, 391, 28-37, 10.1016/j.canlet.2017.01.013.
112. Munekazu Yamakuchi; Craig D. Lotterman; Clare Bao; Ralph H. Hruban; Baktiar Karim; Joshua T. Mendell; David Huso; Charles J. Lowenstein; P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis. Proceedings of the National Academy of Sciences 2010, 107, 6334-6339, 10.1073/pnas.0911082107.
113. Jing-Jun Yan; Yu-Nan Zhang; Jia-Zhi Liao; Kun-Peng Ke; Ying Chang; Pei-Yuan Li; Min Wang; Ju-Sheng Lin; Xingxing He; MiR-497 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting VEGFA and AEG-1. Oncotarget 2015, 6, 29527-29542, 10.18632/oncotarget.5012.