Cationic Antibacterial Dendrimers: Comparison
Please note this is a comparison between Version 1 by Silvana Alfei and Version 6 by Catherine Yang.

The alarming increase in antimicrobial resistance, based on the built-in abilities of bacteria to nullify the activity of current antibiotics, leaves a growing number of bacterial infections untreatable. An appealing approach, advanced in recent decades, concerns the development of novel agents able to interact with the external layers of bacteria, causing irreparable damage. Regarding this, some natural cationic antimicrobial peptides (CAMPs) have been reconsidered, and synthetic cationic polymers, mimicking CAMPs and able to kill bacteria by non-specific detrimental interaction with the negative bacterial membranes, have been proposed as promising solutions. Lately, also dendrimers were considered suitable macromolecules for the preparation of more advanced cationic biomimetic nanoparticles, able to harmonize the typical properties of dendrimers, including nanosize, mono-dispersion, long-term stability, high functionality, and the non-specific mechanism of action of CAMPs. Although cationic dendrimers are extensively applied in nanomedicine for drug or gene delivery, their application as antimicrobial agents is still in its infancy. In this first part of our overview on the main types of cationic antibacterial dendrimers, the state of the art of the potential applications of PAMAM and PPI-based agents has therefore been reviewed here, with particular attention to the innovative case studies in reported in the literature 

  • antibiotic resistance
  • novel antimicrobial agents
  • cationic antimicrobial polymers
  • non-specific membrane disruption
  • biomimetic cationic dendrimer nanoparticles
  • PAMAM and PPI antibacterial dendrimers
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