Regulatory RNAs in Communication: Comparison
Please note this is a comparison between Version 2 by Peter Tang and Version 1 by Emma Layton.

In eukaryotes, microRNAs (miRNAs) have roles in development, homeostasis, disease and the immune response. Recent work has shown that plant and mammalian miRNAs also mediate cross-kingdom and cross-domain communications, but these studies remain controversial and are lacking critical mechanistic explanations. However, there are several conserved features and homologous components in the distinct Regulatory RNA pathways in eukaryotes and bacteria that could explain how eukaryotic miRNAs could function in such cross-domain communications.

  • RNA
  • miRNA
  • microbiota
  • commuincation
  • extracellular vesicles
  • hfq
  • msRNA
  • ELNs
  • asRNA

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1. Introduction 

The expansive non-coding regions of eukaryotic genomes are now known to encode many important regulatory elements such as promoters, enhancers and long non-coding RNAs (lncRNAs) that influence the transcription of both protein-coding and non-coding regions [1,2][1][2]. Some regions function as post-transcriptional gene expression regulators, such as microRNAs (miRNAs), small interfering RNAs (siRNAs) and P-element-induced wimpy testis (PIWI)-interacting RNAs (piRNAs) that bind to their targets through complementary base pairing (Table 1).

Table 1.

Illustrating the similarities between eukaryotic and bacterial antisense RNA-mediated regulatory pathways.


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