Peptide biosynthesis is the biological formation and maturation of molecules containing amino-acid residues connected by peptide bonds. Ribosomal pathways translate an encoded precursor sequence, after which biosynthetic enzymes can modify the peptide to establish its mature chemical structure [1]. Leader regions within precursor peptides provide recognition elements that direct modifying enzymes toward the product-forming region [2]. Processing reactions can generate cyclic structures, altered side chains, and other chemical features within ribosomally produced natural peptides [3]. Multiple modifications may occur on a single precursor, including changes in amino-acid stereochemistry and the addition of methyl groups [4]. The mature product thus arises through an ordered relationship between precursor synthesis, enzyme recognition, chemical modification, and release of the processed peptide from any associated precursor regions [1].
- peptide biosynthesis
- precursor peptides
- peptide bonds
- natural products
Microbial Natural Products and Biosynthesis·Pharmacology·Medicine·Health Sciences
References
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