Aerobic fermentation is fermentative metabolism that occurs while oxygen is available to the cells. In Crabtree-positive yeasts, sugar consumption can generate ethanol even under oxygen-rich conditions, producing a physiological state in which fermentation and respiration coexist [1]. Carbon flow is distributed between these routes through the organization of the metabolic network and constraints on cellular resources. Compartment-specific limits on mitochondrial capacity and cytosolic protein allocation can contribute to the onset of overflow metabolism [2]. Reorganization of pyruvate metabolism and global transcriptional control can alter this respiro-fermentative state [3]. Increased glycolytic gene expression and glucose uptake can promote fermentative overflow despite continued oxygen availability. The defining biochemical feature is therefore the formation of fermentation products under aerobic conditions, with respiratory and fermentative reactions carrying parallel portions of the carbon flux [4][5].
- aerobic fermentation
- Crabtree effect
- ethanol
- carbon flux
Metabolic Engineering and Synthetic Biology·Molecular Biology·Biochemistry, Genetics and Molecular Biology·Life Sciences
References
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