Malignant Pleural Mesothelioma: Comparison
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Mesothelioma is a malignancy of serosal membranes including the peritoneum, pleura, pericardium and the tunica vaginalis of the testes. Malignant mesothelioma (MM) is a rare disease with a global incidence in countries like Italy of about 1.15 per 100,000 inhabitants. Malignant Pleural Mesothelioma (MPM) is the most common form of mesothelioma, accounting for approximately 80% of disease. Although rare in the global population, mesothelioma is linked to industrial pollutants and mineral fiber exposure, with approximately 80% of cases linked to asbestos. Due to the persistent asbestos exposure in many countries, a worldwide progressive increase in MPM incidence is expected for the current and coming years. The tumor grows in a loco-regional pattern, spreading from the parietal to the visceral pleura and invading the surrounding structures that induce the clinical picture of pleural effusion, pain and dyspnea. Distant spreading and metastasis are rarely observed, and most patients die from the burden of the primary tumor. Currently, there are no effective treatments for MPM, and the prognosis is invariably poor. Some studies average the prognosis to be roughly one-year after diagnosis. The uniquely poor mutational landscape which characterizes MPM appears to derive from a selective pressure operated by the environment; thus, inflammation and immune response emerge as key players in driving MPM progression and represent promising therapeutic targets.

  • asbestos
  • genetics
  • inflammation
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References

  1. Robinson, B.M. Malignant pleural mesothelioma: an epidemiological perspective. Ann. Cardiothorac. Surg. 2012, 1, 491–496. doi:10.3978/j.issn.2225-319X.2012.11.04
  2. Gloyne, S. Roodhouse. Two Cases of Squamous Carcinoma of the Lung Occurring in Asbestosis. Tubercle 1935, 17, 5–10. doi:10.1016/s0041-3879(35)80795-2.
  3. Gilham, C.; Rake, C.; Burdett, G.; Nicholson, A.G.; Davison, L.; Franchini, A.; Carpenter, J.; Hodgson, J.; Darnton, A.; Peto, J. Pleural mesothelioma and lung cancer risks in relation to occupational history and asbestos lung burden. Occup. Environ. Med. 2016, 73, 290–299. doi:10.1136/oemed-2015-103074.
  4. Leigh, J.; Davidson, P.; Hendrie, L.; Berry, D. Malignant mesothelioma in Australia, 1945–2000. Am. J. Ind. Med. 2002, 41, 188–201. doi:10.1002/ajim.10047.
  5. Røe, O.D.; Stella, G.M. Malignant pleural mesothelioma: history, controversy and future of a manmade epidemic. Eur. Respir. Rev. 2015, 24, 115–131. doi:10.1183/09059180.00007014.
  6. Carbone, M.; Yang, H.; Pass, H.I.; Krausz, T.; Testa, J.R.; Gaudino, G. BAP1 and cancer. Nat. Rev. Cancer 2013, 13, 153–159. doi:10.1038/nrc3459.
  7. Panou, V.; Gadiraju, M.; Wolin, A.; Weipert, C.M.; Skarda, E.; Husain, A.N.; Patel, J.D.; Rose, B.; Zhang, S.R.; Weatherly, M.; et al. Frequency of Germline Mutations in Cancer Susceptibility Genes in Malignant Mesothelioma. J. Clin. Oncol. 2018; 36, 2863–2871. doi:10.1200/JCO.2018.78.5204.
  8. Attanoos, R.L.; Churg, A.; Galateau-Salle, F.; Gibbs, A.R.; Roggli, V.L. Malignant Mesothelioma and Its Non-Asbestos Causes. Arch. Pathol. Lab. Med. 2018, 142, 753–760. doi:10.5858/arpa.2017-0365-RA.
  9. Delgermaa, V.; Takahashi, K.; Park, E.K.; Le, G.V.; Hara, T.; Sorahan, T. Global mesothelioma deaths reported to the World Health Organization between 1994 and 2008. Bull. World Health Organ. 2011, 89, 716–724. doi:10.2471/BLT.11.086678.
  10. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Arsenic, metals, fibres, and dusts. IARC Monogr. Eval. Carcinog. Risks Hum. 2012, 100(Pt C), 11–465.
  11. Mensi, C.; Riboldi, L.; De Matteis, S.; Bertazzi, P.A.; Consonni, D. Impact of an asbestos cement factory on mesothelioma incidence: global assessment of effects of occupational, familial, and environmental exposure. Environ. Int. 2015, 74, 191–199.
  12. Ngamwong, Y.; Tangamornsuksan, W.; Lohitnavy, O.; Chaiyakunapruk, N.; Scholfield, C.N.; Reisfeld, B.; Lohitnavy, M. Additive Synergism between Asbestos and Smoking in Lung Cancer Risk: A Systematic Review and Meta-Analysis. PLoS ONE 2015, 10, e0135798. doi:10.1371/journal.pone.0135798.
  13. Carbone, M.; Baris, Y.I.; Bertino, P.; Brass, B.; Comertpay, S.; Dogan, A.U.; Gaudino, G.; Jube, S.; Kanodia, S.; Partridge, C.R.; et al. Erionite exposure in North Dakota and Turkish villages with mesothelioma. Proc. Natl. Acad. Sci. USA 2011, 108, 13618–13623. doi:10.1073/pnas.1105887108.
  14. Paoletti, L.; Batisti, D.; Bruno, C.; Di Paola, M.; Gianfagna, A.; Mastrantonio, M.; Nesti, M.; Comba, P. Unusually high incidence of malignant pleural mesothelioma in a town of eastern Sicily: an epidemiological and environmental study. Arch. Environ. Health 2000, 55, 392–398. doi:10.1080/00039890009604036.
  15. Comba, P.; Gianfagna, A.; Paoletti, L. Pleural mesothelioma cases in Biancavilla are related to a new fluoro-edenite fibrous amphibole. Arch. Environ. Health 2003, 58, 229–232. doi:10.3200/AEOH.58.4.229-232.
  16. Stella, G.M. Carbon nanotubes and pleural damage: perspectives of nanosafety in the light of asbestos experience. Biointerphases 2011, 6, P1–17. doi:10.1116/1.3582324.
  17. Farioli, A.; Ottone, M.; Morganti, A.G.; Compagnone, G.; Romani, F.; Cammelli, S.; Mattioli, S.; Violante, F.S. Radiation-induced mesothelioma among long-term solid cancer survivors: a longitudinal analysis of SEER database. Cancer Med. 2016, 5, 950–959. doi:10.1002/cam4.656.
  18. Jaurand, M.C.; Fleury-Feith, J. Pathogenesis of malignant pleural mesothelioma. Respirology 2005, 10, 2–8. doi:10.1111/j.1440-1843.2005.00694.x.
  19. Weiner, S.J.; Neragi-Miandoab, S. Pathogenesis of malignant pleural mesothelioma and the role of environmental and genetic factors. J. Cancer Res. Clin. Oncol. 2009, 135, 15–27. doi:10.1007/s00432-008-0444-9.
  20. Ordóñez, N.G. The immunohistochemical diagnosis of mesothelioma: a comparative study of epithelioid mesothelioma and lung adenocarcinoma. Am. J. Surg. Pathol. 2003, 27, 1031–1051. doi:10.1097/00000478-200308000-00001.
  21. Marchevsky, A.M. Application of Immunohistochemistry to the Diagnosis of Malignant Mesothelioma. Arch. Pathol. Lab. Med. 2008, 132, 397–401. doi:10.1043/1543-2165(2008)132.
  22. Panou, V.; Vyberg, M.; Weinreich, U.M.; Meristoudis, C.; Falkmer, U.G.; Røe, O.D. The established and future biomarkers of malignant pleural mesothelioma. Cancer Treat. Rev. 2015, 41, 486–495. doi:10.1016/j.ctrv.2015.05.001.
  23. Ascoli, V.; Minelli, G.; Cozzi, I.; Romeo, E.; Carnovale Scalzo, C.; Ancona, L.; Forastiere, F. Pathology reporting of malignant pleural mesothelioma first diagnosis: A population-based approach. Pathol. Res. Pract. 2016, 212, 886–892. doi:10.1016/j.prp.2016.07.010.
  24. Marchevsky, A.M.; LeStang, N.; Hiroshima, K.; Pelosi, G.; Attanoos, R.; Churg, A.; Chirieac, L.; Dacic, S.; Husain, A.; Khoor, A.; et al. The differential diagnosis between pleural sarcomatoid mesothelioma and spindle cell/pleomorphic (sarcomatoid) carcinomas of the lung: evidence-based guidelines from the International Mesothelioma Panel and the MESOPATH National Reference Center. Hum. Pathol. 2017, 67, 160–168. doi:10.1016/j.humpath.2017.07.015.
  25. Husain, A.N.; Colby, T.V.; Ordóñez, N.G.; Allen, T.C.; Attanoos, R.L.; Beasley, M.B.; Butnor, K.J.; Chirieac, L.R.; Churg, A.M.; Dacic, S.; et al. Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group. Arch. Pathol. Lab. Med. 2018, 142, 89–108. doi:10.5858/arpa.2017-0124-RA.
  26. Dacic, S.; Le Stang, N.; Husain, A.; Weynand, B.; Beasley, M.B.; Butnor, K.; Chapel, D.; Gibbs, A.; Klebe, S.; Lantuejoul, S.; et al. Interobserver variation in the assessment of the sarcomatoid and transitional components in biphasic mesotheliomas. Mod. Pathol. 2020, 33, 255–262. doi:10.1038/s41379-019-0320-y.
  27. Galateau Salle, F.; Le Stang, N.; Nicholson, A.G.; Pissaloux, D.; Churg, A.; Klebe, S.; Roggli, V.L.; Tazelaar, H.D.; Vignaud, J.M.; Attanoos, R.; et al. New Insights on Diagnostic Reproducibility of Biphasic Mesotheliomas: A Multi-Institutional Evaluation by the International Mesothelioma Panel From the MESOPATH Reference Center. J. Thorac. Oncol. 2018, 13, 1189–1203. doi:10.1016/j.jtho.2018.04.023.
  28. Galateau Salle, F.; Le Stang, N.; Tirode, F.; Courtiol, P.; Nicholson, A.G.; Tsao, M.S.; Tazelaar, H.D.; Churg, A.; Dacic, S.; Roggli, V.; et al. Comprehensive Molecular and Pathologic Evaluation of Transitional Mesothelioma Assisted by Deep Learning Approach: A Multi-Institutional Study of the International Mesothelioma Panel from the MESOPATH Reference Center. J. Thorac. Oncol. 2020, doi:10.1016/j.jtho.2020.01.025.
  29. Singh, A.S.; Heery, R.; Gray, S.G. In Silico and In Vitro Analyses of LncRNAs as Potential Regulators in the Transition from the Epithelioid to Sarcomatoid Histotype of Malignant Pleural Mesothelioma (MPM). Int. J. Mol. Sci. 2018, 19, 1297. doi:10.3390/ijms19051297.
  30. de Reyniès, A.; Jaurand, M.C.; Renier, A.; Couchy, G.; Hysi, I.; Elarouci, N.; Galateau-Sallé, F.; Copin, M.C.; Hofman, P.; Cazes, A.; et al. Molecular classification of malignant pleural mesothelioma: identification of a poor prognosis subgroup linked to the epithelial-to-mesenchymal transition. Clin. Cancer Res. 2014, 20, 1323–1334. doi:10.1158/1078-0432.CCR-13-2429.
  31. Turini, S.; Bergandi, L.; Gazzano, E.; Prato, M.; Aldieri, E. Epithelial to Mesenchymal Transition in Human Mesothelial Cells Exposed to Asbestos Fibers: Role of TGF-β as Mediator of Malignant Mesothelioma Development or Metastasis via EMT Event. Int. J. Mol. Sci. 2019, 20,150. doi: 10.3390/ijms20010150.
  32. Schelch, K.; Wagner, C.; Hager, S.; Pirker, C.; Siess, K.; Lang, E.; Lin, R.; Kirschner M.B.; Mohr, T.; Brcic, L.; et al. FGF2 and EGF induce epithelial-mesenchymal transition in malignant pleural mesothelioma cells via a MAPKinase/MMP1 signal. Carcinogenesis 2018, 39, 534–545. doi:10.1093/carcin/bgy018.
  33. Schramm, A.; Opitz, I.; Thies, S.; Seifert, B.; Moch, H.; Weder, W.; Soltermann, A. Prognostic significance of epithelial-mesenchymal transition in malignant pleural mesothelioma. Eur. J. Cardiothorac. Surg. 2010, 37, 566–572. doi:10.1016/j.ejcts.2009.08.027.
  34. Tamura, M.; Gu, J.; Tran, H.; Yamada, K.M. PTEN gene and integrin signaling in cancer. J. Natl. Cancer Inst. 1999; 91, 1820–1828. doi:10.1093/jnci/91.21.1820.
  35. Kim, M.C.; Cui, F.J.; Kim, Y. Hydrogen peroxide promotes epithelial to mesenchymal transition and stemness in human malignant mesothelioma cells. Asian Pac. J. Cancer Prev. 2013, 14, 3625–3630. doi:10.7314/apjcp.2013.14.6.3625.
  36. He, X.; Wang. L.; Riedel, H.; Wang, K.; Yang, Y.; Dinu, C.Z.; Rojanasakul, Y. Mesothelin promotes epithelial-to-mesenchymal transition and tumorigenicity of human lung cancer and mesothelioma cells. Mol Cancer. 2017, 16,63. doi:10.1186/s12943-017-0633-8.
  37. Wörthmüller, J.; Blum, W.; Pecze, L.; Salicio, V.; Schwaller, B. Calretinin promotes invasiveness and EMT in malignant mesothelioma cells involving the activation of the FAK signaling pathway. Oncotarget 2018, 9, 36256–36272. doi:10.18632/oncotarget.26332.
  38. Blum, W.; Pecze, L.; Rodriguez, J.W.; Steinauer, M.; Schwaller, B. Regulation of calretinin in malignant mesothelioma is mediated by septin 7 binding to the CALB2 promoter. BMC Cancer 2018, 18, 475. doi:10.1186/s12885-018-4385-7.
  39. Wörthmüller, J.; Salicio, V.; Oberson, A.; Blum, W.; Schwaller, B. Modulation of Calretinin Expression in Human Mesothelioma Cells Reveals the Implication of the FAK and Wnt Signaling Pathways in Conferring Chemoresistance towards Cisplatin. Int. J. Mol. Sci. 2019, 20, 5391. doi:10.3390/ijms20215391.
  40. Carbone, M.; Gaudino G, Yang H. Recent insights emerging from malignant mesothelioma genome sequencing. J. Thorac. Oncol. 2015, 10, 409–411. doi:10.1097/JTO.0000000000000466.
  41. Bueno, R.; Stawiski, E.W.; Goldstein, L.D.; Durinck, S.; De Rienzo, A.; Modrusan, Z.; Gnad, F.; Nguyen, T.T.; Jaiswal, B.S.; Chirieac, L.R.; et al. Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations. Nat. Genet. 2016, 48, 407–416. doi:10.1038/ng.3520.
  42. Kiyotani, K.; Park, J.-H.; Inoue, H.; Husain, A.; Olugbile, S.; Zewde, M.; Nakamura, Y.; Vigneswaran, W.T. Integrated analysis of somatic mutations and immune microenvironment in malignant pleural mesothelioma. OncoImmunology 2017, 6, e1278330. doi: 10.1080/2162402X.2016.1278330.
  43. Guo, G.; Chmielecki, J.; Goparaju, C.; Heguy, A.; Dolgalev, I.; Carbone, M.; Seepo, S.; Meyerson, M.; Pass, H.I. Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma. Cancer Res. 2014, 75, 264–269. doi:10.1158/0008-5472.CAN-14-1008.
  44. Mezzapelle, R.; Miglio, U.; Rena, O.; Paganotti, A.; Allegrini, S.; Antona, J.; Molinari, F.; Frattini, M.; Monga, G.; Alabiso, O.; et al. Mutation analysis of the EGFR gene and downstream signalling pathway in histologic samples of malignant pleural mesothelioma. Br. J. Cancer. 2013, 108, 1743−1749. doi:10.1038/bjc.2013.130.
  45. Kim, J.E.; Kim, D.; Hong, Y.S.; Kim, K.-P.; Yoon, Y.K.; Lee, D.H.; Kim, S.-W.; Chun, S.-M.; Jang, S.J.; Kim, T.W. Mutational Profiling of Malignant Mesothelioma Revealed Potential Therapeutic Targets in EGFR and NRAS. Transl. Oncol. 2018, 11, 268–274, doi:10.1016/j.tranon.2018.01.005.
  46. Kang, H.C.; Kim, H.K.; Lee, S.; Mendez, P.; Kim, J.W.; Woodard, G.; Yoon, J.H.; Jen, K.Y.; Fang, L.T.; Jones, K.; et al. Whole exome and targeted deep sequencing identify genome-wide allelic loss and frequent SETDB1 mutations in malignant pleural mesotheliomas. Oncotarget 2016, 7, 8321–8331. doi:10.18632/oncotarget.7032.
  47. Solbes, E.; Harper, R.W. Biological responses to asbestos inhalation and pathogenesis of asbestos-related benign and malignant disease. J. Investig. Med. 2018, 66, 721–727. doi:10.1136/jim-2017-000628.
  48. Xu, A.; Smilenov, L.B.; He, P.; Masumura, K.; Nohmi, T.; Yu, Z.; Hei, T.K. New insight into intrachromosomal deletions induced by chrysotile in the gpt delta transgenic mutation assay. Environ. Health Perspect. 2007, 115, 87–92. doi:10.1289/ehp.9425.
  49. Thurneysen, C.; Opitz, I.; Kurtz, S.; Weder, W.; Stahel, R.A.; Felley-Bosco, E. Functional inactivation of NF2/merlin in human mesothelioma. Lung Cancer 2009, 64, 140–147. doi:10.1016/j.lungcan.2008.08.014.
  50. Cheng, J.Q.; Lee, W.C.; A Klein, M.; Cheng, G.Z.; Jhanwar, S.C.; Testa, J.R. Frequent mutations of NF2 and allelic loss from chromosome band 22q12 in malignant mesothelioma: evidence for a two-hit mechanism of NF2 inactivation. Genes, Chromosom. Cancer 1999, 24, 238–242.
  51. Felley-Bosco, E. Special Issue on Mechanisms of Mesothelioma Heterogeneity: Highlights and Open Questions. Int. J. Mol. Sci. 2018, 19, 3560. doi:10.3390/ijms19113560.
  52. Sekido, Y. Targeting the Hippo Pathway Is a New Potential Therapeutic Modality for Malignant Mesothelioma. Cancers (Basel). 2018, 10, 90. doi:10.3390/cancers10040090.
  53. Yoshikawa, Y.; Emi, M.; Hashimoto-Tamaoki, T.; Ohmuraya, M.; Sato, A.; Tsujimura, T.; Hasegawa, S.; Nakano, T.; Nasu, M.; Pastorino, S.; et al. High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma. Proc. Natl. Acad. Sci. USA. 2016, 113, 13432–13437. doi:10.1073/pnas.1612074113.
  54. Tubio, J.M.C.; Estivill, X. Cancer: When catastrophe strikes a cell. Nature 2011, 470, 476–477. doi:10.1038/470476a.
  55. Sekido, Y.; I Pass, H.; Bader, S.; Mew, D.J.; Christman, M.F.; Gazdar, A.F.; Minna, J.D. Neurofibromatosis type 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancer. Cancer Res. 1995, 55, 1227–1231.
  56. Pulito, C.; Korita, E.; Sacconi, A.; Valerio, M.; Casadei, L.; Sardo, F.L.; Mori, F.; Ferraiuolo, M.; Grasso, G.; Maidecchi, A.; et al. Dropwort-induced metabolic reprogramming restrains YAP/TAZ/TEAD oncogenic axis in mesothelioma. J Exp Clin Cancer Res. J. Exp. Clin. Cancer Res. 2019, 38, 349. doi:10.1186/s13046-019-1352-3.
  57. Walpole, S.; Pritchard, A.; Cebulla, C.; Pilarski, R.; Stautberg, M.; Davidorf, F.H.; De La Fouchardière, A.; Cabaret, O.; Golmard, L.; Stoppa-Lyonnet, D.; et al. Comprehensive Study of the Clinical Phenotype of Germline BAP1 Variant-Carrying Families Worldwide. J. Natl. Cancer Inst. 2018, 110, 1328–1341. doi:10.1093/jnci/djy171.
  58. Cheung, M.; Testa, J.R. BAP1, a tumor suppressor gene driving malignant mesothelioma. Transl. Lung Cancer Res. 2017, 6, 270–278. doi:10.21037/tlcr.2017.05.03.
  59. Pignochino, Y.; Dell’Aglio, C.; Inghilleri, S.; Zorzetto, M.; Basiricò, M.; Capozzi, F.; Canta, M.; Piloni, D.; Cemmi, F.; Sangiolo, D.; et al. The combination of sorafenib and everolimus shows antitumor activity in preclinical models of malignant pleural mesothelioma. BMC Cancer 2015, 15, 374. doi:10.1186/s12885-015-1363-1.
  60. Bitanihirwe, B.K.; Meerang, M.; Friess, M.; Soltermann, A.; Frischknecht, L.; Thies, S.; Felley-Bosco, E.; Tsao, M.-S.; Allo, G.; De Perrot, M.; et al. PI3K/mTOR signaling in mesothelioma patients treated with induction chemotherapy followed by extrapleural pneumonectomy. J. Thorac. Oncol. 2014, 9, 239–247. doi:10.1097/JTO.0000000000000055.
  61. Kanteti, R.; Riehm, J.J.; Dhanasingh, I.; Lennon, F.E.; Mirzapoiazova, T.; Mambetsariev, B.; Kindler, H.L.; Salgia, R. PI3 Kinase Pathway and MET Inhibition is Efficacious in Malignant Pleural Mesothelioma. Sci. Rep. 2016, 6, 32992. doi:10.1038/srep32992.
  62. Bois, M.C.; Mansfield, A.; Sukov, W.R.; Jenkins, S.M.; Moser, J.C.; Sattler, C.A.; Smith, C.; Molina, J.R.; Peikert, T.; Roden, A.C. c-Met expression and MET amplification in malignant pleural mesothelioma. Ann. Diagn. Pathol. 2016, 23, 1–7. doi:10.1016/j.anndiagpath.2016.04.007.
  63. Hylebos, M.; Van Camp, G.; Vandeweyer, G.; Fransen, E.; Beyens, M.; Cornelissen, R.; Suls, A.; Pauwels, P.; Van Meerbeeck, J.P.; De Beeck, K.O. Large-scale copy number analysis reveals variations in genes not previously associated with malignant pleural mesothelioma. Oncotarget 2017, 8, 113673–113686. doi:10.18632/oncotarget.22817.
  64. Kukuyan, A.-M.; Sementino, E.; Kadariya, Y.; Menges, C.W.; Cheung, M.; Tan, Y.; Cai, K.Q.; Slifker, M.; Peri, S.; Klein-Szanto, A.J.; et al. Inactivation of Bap1 Cooperates with Losses of Nf2 and Cdkn2a to Drive the Development of Pleural Malignant Mesothelioma in Conditional Mouse Models. Cancer Res. 2019, 79, 4113–4123. doi:10.1158/0008-5472.CAN-18-4093.
  65. Hylebos, M.; Van Camp, G.; Van Meerbeeck, J.P.; De Beeck, K.O. The Genetic Landscape of Malignant Pleural Mesothelioma: Results from Massively Parallel Sequencing. J. Thorac. Oncol. 2016, 11, 1615–1626. doi:10.1016/j.jtho.2016.05.020.
  66. Dong, L.; De Rienzo, A.; Maulik, G.; Glickman, J.N.; Chirieac , L.R.; Hartman, M.L.; Taillon, B.E.; Du, L.; Bouffard, P.; Kingsmore, S.F.; et al. Transcriptome sequencing of malignant pleural mesothelioma tumors. Proc. Natl. Acad. Sci. USA 2008, 105, 3521–3526. doi:10.1073/pnas.0712399105.
  67. Dong, L.; Jensen, R.V.; De Rienzo, A.; Gordon, G.J.; Xu, Y.; Sugarbaker, D.J.; Bueno, R. Differentially expressed alternatively spliced genes in malignant pleural mesothelioma identified using massively parallel transcriptome sequencing. BMC Med. Genet. 2009, 10, 149. doi:10.1186/1471-2350-10-149.
  68. Taniguchi, T.; Karnan, S.; Fukui, T.; Yokoyama, T.; Tagawa, H.; Yokoi, K.; Ueda, Y.; Mitsudomi, T.; Horio, Y.; Hida, T.; et al. Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32. Cancer Sci. 2007, 98, 438–446. doi:10.1111/j.1349-7006.2006.00386.x.
  69. Sage, A.P.; Martinez, V.; Minatel, B.; Pewarchuk, M.; Marshall, E.A.; Macaulay, G.M.; Hubaux, R.; Pearson, D.D.; Goodarzi, A.A.; Dellaire, G.; et al. Genomics and Epigenetics of Malignant Mesothelioma. High Throughput 2018, 7, 20. doi:10.3390/ht7030020.
  70. Blum, Y.; Jaurand, M.-C.; De Reyniès, A.; Jean, D. Unraveling the cellular heterogeneity of malignant pleural mesothelioma through a deconvolution approach. Mol. Cell. Oncol. 2019, 6, 1610322. doi:10.1080/23723556.2019.1610322.
  71. Mutsaers, S.; Birnie, K.; Lansley, S.; Herrick, S.E.; Lim, C.B.; Prêle, C.M. Mesothelial cells in tissue repair and fibrosis. Front. Pharmacol. 2015, 6, 113. doi:10.3389/fphar.2015.00113.
  72. Rouka, E.; Beltsios, E.; Goundaroulis, D.; Vavougios, G.D.; Solenov, E.; Hatzoglou, C.; Gourgoulianis, K.I.; Zarogiannis, S.G. In Silico Transcriptomic Analysis of Wound-Healing-Associated Genes in Malignant Pleural Mesothelioma. Medicina (Kaunas) 2019, 55, 267. doi:10.3390/medicina55060267.
  73. Hmeljak, J.; Sanchez-Vega, F.; Hoadley, K.A.; Shih, J.; Stewart, C.; Heiman, D.; Tarpey, P.; Danilova, L.V.; Drill, E.; Gibb, E.A.; et al. Integrative Molecular Characterization of Malignant Pleural Mesothelioma. Cancer Discov. 2018, 8, 1548–1565. doi:10.1158/2159-8290.CD-18-0804.
  74. Tan, K.; Kajino, K.; Momose, S.; Masaoka, A.; Sasahara, K.; Shiomi, K.; Izumi, H.; Abe, M.; Ohtsuji, N.; Wang, T.; et al. Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter. Hum. Pathol. 2010, 41, 1330–1338. doi:10.1016/j.humpath.2010.03.002.
  75. Nowak, E.C.; Lines, J.L.; Varn, F.S.; Deng, J.; Sarde, A.; Mabaera, R.; Kuta, A.; Le Mercier, I.; Cheng, C.; Noelle, R.J. Immunoregulatory functions of VISTA. Immunol. Rev. 2017, 276, 66–79. doi:10.1111/imr.12525.
  76. Alcala, N.; Mangiante, L.; Le Stang, N.; Gustafson, C.E.; Boyault, S.; Damiola, F.; Alcala, K.; Brevet, M.; Thivolet-Bejui, F.; Blanc-Fournier, C.; et al. Redefining malignant pleural mesothelioma types as a continuum uncovers immune-vascular interactions. EBioMedicine 2019, 48, 191–202. doi:10.1016/j.ebiom.2019.09.003.
  77. Benedetti, S.; Nuvoli, B.; Catalani, S.; Galati, R. Reactive oxygen species a double-edged sword for mesothelioma. Oncotarget 2015, 6, 16848–16865. doi:10.18632/oncotarget.4253.
  78. Valinluck, V.; Sowers, L.C. Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. Cancer Res. 2007, 67, 946–950. doi:10.1158/0008-5472.CAN-06-3123.
  79. De Vos, M.; El Ramy, R.; Quénet, D.; Wolf, P.; Spada, F.; Magroun, N.; Babbio, F.; Schreiber, V.; Leonhardt, H.; Bonapace, I.M.; et al. Poly(ADP-ribose) polymerase 1 (PARP1) associates with E3 ubiquitin-protein ligase UHRF1 and modulates UHRF1 biological functions. J. Boil. Chem. 2014, 289, 16223–16238. doi:10.1074/jbc.M113.527424.
  80. Zampieri, M.; Passananti, C.; Calabrese, R.; Perilli, M.; Corbi, N.; De Cave, F.; Guastafierro, T.; Bacalini, M.G.; Reale, A.; Amicosante, G.; et al. Parp1 Localizes within the Dnmt1 Promoter and Protects Its Unmethylated State by Its Enzymatic Activity. PLoS ONE 2009, 4, e4717. doi:10.1371/journal.pone.0004717.
  81. Tomasetti, M.; Gaetani, S.; Monaco, F.; Neuzil, J.; Santarelli, L. Epigenetic Regulation of miRNA Expression in Malignant Mesothelioma: miRNAs as Biomarkers of Early Diagnosis and Therapy. Front. Oncol. 2019, 9, 1293. doi:10.3389/fonc.2019.01293.
  82. Weber, D.G.; Johnen, G.; Bryk, O.; Jockel, K.-H.; Brüning, T. Identification of miRNA-103 in the cellular fraction of human peripheral blood as a potential biomarker for malignant mesothelioma--a pilot study. PLoS ONE 2012, 7, e30221. doi:10.1371/journal.pone.0030221.
  83. Kirschner, M.B.; Cheng, Y.Y.; Badrian, B.; Kao, S.C.; Creaney, J.; Edelman, J.J.B.; Armstrong, N.J.; Vallely, M.P.; Musk, A.W.; Robinson, B.W.; et al. Increased Circulating miR-625-3p: A Potential Biomarker for Patients With Malignant Pleural Mesothelioma. J. Thorac. Oncol. 2012, 7, 1184–1191. doi:10.1097/JTO.0b013e3182572e83.
  84. Matboli, M.; Shafei, A.E.; Ali, M.A.; Gaber, A.I.; Galal, A.; Tarek, O.; Marei, M.; Khairy, E.; El-Khazragy, N.; Anber, N.; et al. Clinical significance of serum DRAM1 mRNA, ARSA mRNA, hsa‐miR‐2053 and lncRNA‐RP1‐86D1.3 axis expression in malignant pleural mesothelioma. J. Cell. Biochem. 2018, 120, 3203–3211. doi:10.1002/jcb.27586.
  85. Ferrari, L.; Carugno, M.; Mensi, C.; Pesatori, A.C. Circulating Epigenetic Biomarkers in Malignant Pleural Mesothelioma: State of the Art and critical Evaluation. Front. Oncol. 2020, 10, 445. doi:10.3389/fonc.2020.00445.
  86. Blum, Y.; Meiller, C.; Quetel, L.; Elarouci, N.; Ayadi, M.; Tashtanbaeva, D.; Armenoult, L.; Montagne, F.; Tranchant, R.; Renier, A.; et al. Dissecting heterogeneity in malignant pleural mesothelioma through histo-molecular gradients for clinical applications. Nat. Commun. 2019, 10, 1333. doi:10.1038/s41467-019-09307-6.
  87. Miserocchi, G.; Sancini, G.; Mantegazza, F.; Chiappino, G. Translocation pathways for inhaled asbestos fibers. Environ. Health 2008, 7, 4. doi:10.1186/1476-069X-7-4.
  88. Krismann, M.; Muller, K.M.; Jaworska, M.; Johnen, G. Severe chromosomal aberrations in pleural mesotheliomas with unusual mesodermal features. Comparative genomic hybridization evidence for a mesothelioma subgroup. J. Mol. Diagn. 2000, 2, 209–216. doi:10.1016/S1525-1578(10)60639-3.
  89. Scattone, A.; Pennella, A.; Gentile, M.; Musti, M.; Nazzaro, P.; Buonadonna, A.L.; Marzullo, A.; Cavone, D.; Pollice, L.; Serio, G. Comparative genomic hybridisation in malignant deciduoid mesothelioma. J. Clin. Pathol. 2006, 59, 764–769. doi:10.1136/jcp.2005.026435.
  90. Arulananda, S.; Thapa, B.; Walkiewicz, M.; Zapparoli, G.V.; Williams, D.S.; Dobrovic, A.; John, T. Mismatch Repair Protein Defects and Microsatellite Instability in Malignant Pleural Mesothelioma. J. Thorac. Oncol. 2018, 13, 1588–1594. doi:10.1016/j.jtho.2018.07.015.
  91. Betti, M.; Ferrante, D.; Padoan, M.; Guarrera, S.; Giordano, M.; Aspesi, A.; Mirabelli, D.; Casadio, C.; Ardissone, F.; Ruffini, E.; et al. XRCC1 and ERCC1 variants modify malignant mesothelioma risk: a case-control study. Mutat. Res. Mol. Mech. Mutagen. 2011, 708, 11–20. doi:10.1016/j.mrfmmm.2011.01.001.
  92. Dianzani, I.; Gibello, L.; Biava, A.; Giordano, M.; Bertolotti, M.; Betti, M.; Ferrante, D.; Guarrera, S.; Betta, G.; Mirabelli, D.; et al. Polymorphisms in DNA repair genes as risk factors for asbestos-related malignant mesothelioma in a general population study. Mutat. Res. Mol. Mech. Mutagen. 2006, 599, 124–134. doi:10.1016/j.mrfmmm.2006.02.005.
  93. Hillegass, J.M.; Shukla, A.; Lathrop, S.A.; MacPherson, M.B.; Beuschel, S.L.; Butnor, K.J.; Testa, J.R.; Pass, H.I.; Carbone, M.; Steele, C.; et al. Inflammation precedes the development of human malignant mesotheliomas in a SCID mouse xenograft model. Ann. N. Y. Acad. Sci. 2010, 1203, 7–14.
  94. ube, S.; Rivera, Z.S.; Bianchi, M.E.; Powers, A.; Wang, E.; Pagano, I.; Pass, H.I.; Gaudino, G.; Carbone, M.; Yang, H. Cancer cell secretion of the DAMP protein HMGB1 supports progression in malignant mesothelioma. Cancer Res. 2012, 72, 3290–3301. doi:10.1158/0008-5472.CAN-11-3481.
  95. Bianchi, M.E.; Crippa, M.; Manfredi, A.A.; Mezzapelle, R.; Rovere Querini, P.; Venereau, E. High-mobility group box 1 protein orchestrates responses to tissue damage via inflammation, innate and adaptive immunity, and tissue repair. Immunol. Rev. 2017, 280, 74–82. doi:10.1111/imr.12601.
  96. Mukherjee, A.; Vasquez, K.M. Targeting chromosomal architectural HMGB proteins could be the next frontier in cancer therapy Cancer Res. 2020,doi:10.1158/0008-5472.CAN-19-3066.
  97. Yang, H.; Rivera, Z.; Jube, S.; Nasu, M.; Bertino, P.; Goparaju, C.; Franzoso, G.; Lotze, M.T.; Krausz, T.; Pass, H.I.; et al. Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation. Proc. Natl. Acad. Sci. USA 2010, 107, 12611–12616. doi:10.1073/pnas.100654210.
  98. Qi, F.; Okimoto, G.; Jube, S.; Napolitano, A.; Pass, H.I.; Laczko, R.; DeMay, R.M.; Khan, G.; I Tiirikainen, M.; Rinaudo, C.; et al. Continuous exposure to chrysotile asbestos can cause transformation of human mesothelial cells via HMGB1 and TNF-α signaling. Am. J. Pathol. 2013, 183, 1654–1666. doi:10.1016/j.ajpath.2013.07.029.
  99. Napolitano, A.; Antoine, D.J.; Pellegrini, L.; Baumann, F.; Pagano, I.S.; Pastorino, S.; Goparaju, C.M.; Prokrym, K.; Canino, C.; Pass, H.I.; et al. HMGB1 and Its Hyperacetylated Isoform are Sensitive and Specific Serum Biomarkers to Detect Asbestos Exposure and to Identify Mesothelioma Patients. Version 2. Clin. Cancer Res. 2016, 22, 3087–3096. doi:10.1158/1078-0432.CCR-15-1130.
  100. Tabata, C.; Shibata, E.; Tabata, R.; Kanemura, S.; Mikami, K.; Nogi, Y.; Masachika, E.; Nishizaki, T.; Nakano, T. Serum HMGB1 as a prognostic marker for malignant pleural mesothelioma. BMC Cancer 2013, 13, 205. doi:10.1186/1471-2407-13-205.
  101. Yang, H.; Pellegrini, L.; Napolitano, A.; Giorgi, C.; Jube, S.; Preti, A.; Jennings, C.J.; De Marchis, F.; Flores, E.G.; Larson, D.; et al. Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression. Cell Death Dis. 2015, 6, e1786. doi:10.1038/cddis.2015.153.
  102. Wang, Y.; Jiang, Z.; Yan, J.; Ying, S. HMGB1 as a Potential Biomarker and Therapeutic Target for Malignant Mesothelioma. Dis. Markers 2019, 2019, 4183157. doi:10.1155/2019/4183157.
  103. Minnema-Luiting, J.; Vroman, H.; Aerts, J.; Cornelissen, R. Heterogeneity in Immune Cell Content in Malignant Pleural Mesothelioma. Int. J. Mol. Sci. 2018, 19, 1041. doi:10.3390/ijms19041041.
  104. Cornelissen, R.; Lievense, L.A.; Maat, A.P.; Hendriks, R.W.; Hoogsteden, H.C.; Bogers, A.J.; Hegmans, J.P.; Aerts, J.G. Ratio of intratumoral macrophage phenotypes is a prognostic factor in epithelioid malignant pleural mesothelioma. PLoS ONE 2014, 9, e106742.
  105. Yap, T.A.; Aerts, J.G.; Popat, S.; Fennell, D.A. Novel insights into mesothelioma biology and implications for therapy. Nat. Rev. Cancer 2017, 17, 475–488.
  106. Burt, B.M.; Rodig, S.J.; Tilleman, T.R.; Elbardissi, A.W.; Bueno, R.; Sugarbaker, D.J. Circulating and tumor-infiltrating myeloid cells predict survival in human pleural mesothelioma. Cancer 2011; 117, 5234–5244.
  107. Suzuki, K.; Kadota, K.; Sima, C.S.; Sadelain, M.; Rusch, V.W.; Travis, W.D.; Adusumilli, P.S. Chronic inflammation in tumor stroma is an independent predictor of prolonged survival in epithelioid malignant pleural mesothelioma patients. Cancer Immunol. Immunother. 2011; 60, 1721–1728.
  108. Marcq, E.; Siozopoulou, V.; De Waele, J.; Van Audenaerde, J.; Zwaenepoel, K.; Santermans, E.; Hens, N.; Pauwels, P.; van Meerbeeck, J.P.; Smits, E.L. Prognostic and predictive aspects of the tumor immune microenvironment and immune checkpoints in malignant pleural mesothelioma. OncoImmunology 2016, 6, e1261241.
  109. Nishikawa, H.; Sakaguchi, S. Regulatory T cells in cancer immunotherapy. Curr. Opin. Immunol. 2014, 27, 1–7.
  110. Khanna, S.; Thomas, A.; Abate-Daga, D.; Zhang, J.; Morrow, B.; Steinberg, S.M.; Orlandi, A.; Ferroni, P.; Schlom, J.; Ferroni, P.; et al. Malignant Mesothelioma Effusions Are Infiltrated by CD3+ T Cells Highly Expressing PD-L1 and the PD-L1+ Tumor Cells within These Effusions Are Susceptible to ADCC by the Anti-PD-L1 Antibody Avelumab. J. Thorac. Oncol. 2016, 11, 1993–2005. doi:10.1016/j.jtho.2016.07.033.
  111. Awad, M.M.; Jones, R.E.; Liu, H.; Lizotte, P.H.; Ivanova, E.V.; Kulkarni, M.; Herter-Sprie, G.S.; Liao, X.; Santos, A.A.; Bittinger, M.A.; et al. Cytotoxic T Cells in PD-L1-Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors. Cancer Immunol. Res. 2016, 4, 1038–1048. doi:10.1158/2326-6066.CIR-16-0171.
  112. Sakuishi, K.; Apetoh, L.; Sullivan, J.M.; Blazar, B.R.; Kuchroo, V.K.; Anderson, A.C. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J. Exp. Med. 2010, 207, 2187–2194; Erratum in: J Exp Med. 2011, 208, 1331. doi:10.1084/jem.20100643.
  113. Klampatsa, A.; O’Brien, S.M.; Thompson, J.C.; Rao, A.S.; Stadanlick, J.E.; Martinez, M.; Liousia, M.; Cantu, E.; Cengel, K.; Moon, E.K.; et al. Phenotypic and functional analysis of malignant mesothelioma tumor-infiltrating lymphocytes. OncoImmunology 2019, 8, e1638211. doi:10.1080/2162402X.2019.1638211.
  114. Forde, P.M.; Scherpereel, A.; Tsao, A.S. Use of Immune Checkpoint Inhibitors in Mesothelioma. Curr. Treat. Options Oncol. 2019, 20, 18. doi:10.1007/s11864-019-0613-x.
  115. Marvel, D.; Gabrilovich, D.I. Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. J. Clin. Invest. 2015, 125, 3356–3364. doi:10.1172/JCI80005.
  116. Cristaudo, A.; Bonotti, A.; Guglielmi, G.; Fallahi, P.; Foddis, R. Serum mesothelin and other biomarkers: what have we learned in the last decade? J. Thorac. Dis. 2018, 10(Suppl. 2), S353–S359. doi:10.21037/jtd.2017.10.132.
  117. Creaney, J.; Dick, I.M.; Meniawy, T.; Leong, S.L.; Leon, J.S.; Demelker, Y.; Segal, A.; Musk, A.W.; Lee, Y.C.G.; Skates, S.J.; et al. Comparison of fibulin-3 and mesothelin as markers in malignant mesothelioma. Thorax 2014, 69, 895–902. doi:10.1136/thoraxjnl-2014-205205.
  118. Arnold, D.T.; De Fonseka, D.; Hamilton, F.W.; Rahman, N.M.; Maskell, N.A. Prognostication and monitoring of mesothelioma using biomarkers: a systematic review. Br. J. Cancer 2017, 116, 731–741. doi:10.1038/bjc.2017.22.
  119. Ostroff, R.; Mehan, M.R.; Stewart, A.; Ayers, D.; Brody, E.N.; Williams, S.A.; Levin, S.; Black, B.; Harbut, M.; Carbone, M.; et al. Early detection of malignant pleural mesothelioma in asbestos-exposed individuals with a noninvasive proteomics-based surveillance tool. PLoS ONE. 2012, 7, e46091. doi:10.1371/journal.pone.0046091.
  120. Pei, D.; Li, Y.; Liu, X.; Yan, S.; Guo, X.; Xu, X.; Guo, X. Diagnostic and prognostic utilities of humoral fibulin-3 in malignant pleural mesothelioma: Evidence from a meta-analysis.Oncotarget. Oncotarget 2017, 8, 13030–13038. doi:10.18632/oncotarget.14712.
  121. Bonotti, A.; Simonini, S.; Pantani, E.; Giusti, L.; Donadio, E.; Mazzoni, M.R.; Chella, A.; Marconi, L.; Ambrosino, N.; Lucchi, M.; et al. Serum mesothelin, osteopontin and vimentin: useful markers for clinical monitoring of malignant pleural mesothelioma. Int. J. Boil. Markers 2017, 32, e126–e131. doi:10.5301/jbm.5000229.
  122. Smeele, P.; d'Almeida, S.M.; Meiller, C.; Chéné, A.L.; Liddell, C.; Cellerin, L.; Montagne, F.; Deshayes, S.; Benziane, S.; Copin, M.C.; et al. Brain-derived neurotrophic factor, a new soluble biomarker for malignant pleural mesothelioma involved in angiogenesis. Mol. Cancer 2018, 17, 148. doi:10.1186/s12943-018-0891-0.
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