Please note this is a comparison between Version 4 by Lily Guo and Version 3 by Nicola Nasser.
Lung cancer is divided to Non-Small Cell Lung Cancer (NSCLC) comprising about 85% of lung cancer cases, and small cell lung cancer (15% of lung cancer cases). Non-small cell lung cancer (NSCLC) has several subtypes: a. Adenocarcinoma, b. Squamous cell carcinoma, c. Large cell carcinoma, or d. mixed histology. Treatment of localized NSCLC is surgical resection, stereotactic ablative radiation therapy, or combination of chemotherapy and radiation (chemoradiation). Treatment of advanced / metastatic disease includes targeted therapies, chemotherapy and immunotherapy.
Non-Small Cell Lung Cancer
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References
Siegel, R.L.; Miller, K.D.; Jemal, A. Cancer statistics, 2020. CA Cancer J. Clin. 2020, 70, 7–30, doi:10.3322/caac.21590.
Zappa, C.; Mousa, S.A. Non-small cell lung cancer: Current treatment and future advances. Transl. Lung Cancer Res. 2016, 5, 288–300, doi:10.21037/tlcr.2016.06.07.
Turnis, M.E.; Andrews, L.P.; Vignali, D.A.A. Inhibitory receptors as targets for cancer immunotherapy. Eur. J. Immunol. 2015, 45, 1892–1905, doi:10.1002/eji.201344413.
Wherry, E.J.; Kurachi, M. Molecular and cellular insights into T cell exhaustion. Nat. Rev. Immunol. 2015, 15, 486–499, doi:10.1038/nri3862.
Francisco, L.M.; Sage, P.T.; Sharpe, A.H. The PD-1 pathway in tolerance and autoimmunity. Immunol. Rev. 2010, 236, 219–242, doi:10.1111/j.1600-065X.2010.00923.x.
Paulsen, E.-E.; Kilvaer, T.K.; Khanehkenari, M.R.; Al-Saad, S.; Hald, S.M.; Andersen, S.; Richardsen, E.; Ness, N.; Busund, L.-T.; Bremnes, R.M.; et al. Assessing PDL-1 and PD-1 in Non–Small Cell Lung Cancer: A Novel Immunoscore Approach. Clin. Lung Cancer 2017, 18, 220–233.e8, doi:10.1016/j.cllc.2016.09.009.
Poole, R.M. Pembrolizumab: First Global Approval. Drugs 2014, 74, 1973–1981, doi:10.1007/s40265-014-0314-5.
Buchbinder, E.I.; Desai, A. CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition. Am. J. Clin. Oncol. 2016, 39, 98–106, doi:10.1097/COC.0000000000000239.
Genova, C.; Rijavec, E.; Barletta, G.; Sini, C.; Dal Bello, M.G.; Truini, M.; Murolo, C.; Pronzato, P.; Grossi, F. Ipilimumab (MDX-010) in the treatment of non-small cell lung cancer. Expert Opin. Biol. Ther. 2012, 12, 939–948, doi:10.1517/14712598.2012.681371.
Larkin, J.; Chiarion-Sileni, V.; Gonzalez, R.; Grob, J.J.; Cowey, C.L.; Lao, C.D.; Schadendorf, D.; Dummer, R.; Smylie, M.; Rutkowski, P.; et al. Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. N. Engl. J. Med. 2015, 373, 23–34, doi:10.1056/NEJMoa1504030.
Wei, S.C.; Anang, N.-A.A.S.; Sharma, R.; Andrews, M.C.; Reuben, A.; Levine, J.H.; Cogdill, A.P.; Mancuso, J.J.; Wargo, J.A.; Pe’er, D.; et al. Combination anti–CTLA-4 plus anti–PD-1 checkpoint blockade utilizes cellular mechanisms partially distinct from monotherapies. Proc. Natl. Acad. Sci. USA 2019, 116, 22699–22709, doi:10.1073/pnas.1821218116.
Soda, M.; Choi, Y.L.; Enomoto, M.; Takada, S.; Yamashita, Y.; Ishikawa, S.; Fujiwara, S.; Watanabe, H.; Kurashina, K.; Hatanaka, H.; et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007, 448, 561–566, doi:10.1038/nature05945.
Choi, Y.L.; Soda, M.; Yamashita, Y.; Ueno, T.; Takashima, J.; Nakajima, T.; Yatabe, Y.; Takeuchi, K.; Hamada, T.; Haruta, H.; et al. EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors. N. Engl. J. Med. 2010, 363, 1734–1739, doi:10.1056/NEJMoa1007478.
Camidge, D.R.; Kim, H.R.; Ahn, M.-J.; Yang, J.C.-H.; Han, J.-Y.; Lee, J.-S.; Hochmair, M.J.; Li, J.Y.-C.; Chang, G.-C.; Lee, K.H.; et al. Brigatinib versus Crizotinib in ALK-Positive Non–Small-Cell Lung Cancer. N. Engl. J. Med. 2018, 379, 2027–2039, doi:10.1056/NEJMoa1810171.
Maemondo, M.; Inoue, A.; Kobayashi, K.; Sugawara, S.; Oizumi, S.; Isobe, H.; Gemma, A.; Harada, M.; Yoshizawa, H.; Kinoshita, I.; et al. Gefitinib or Chemotherapy for Non–Small-Cell Lung Cancer with Mutated EGFR. N. Engl. J. Med. 2010, 362, 2380–2388, doi:10.1056/NEJMoa0909530.
Soria, J.-C.; Ohe, Y.; Vansteenkiste, J.; Reungwetwattana, T.; Chewaskulyong, B.; Lee, K.H.; Dechaphunkul, A.; Imamura, F.; Nogami, N.; Kurata, T.; et al. Osimertinib in Untreated EGFR-Mutated Advanced Non–Small-Cell Lung Cancer. N. Engl. J. Med. 2017, 378, 113–125, doi:10.1056/NEJMoa1713137.
Pardoll, D.M. The blockade of immune checkpoints in cancer immunotherapy. Nat. Rev. Cancer 2012, 12, 252–264, doi:10.1038/nrc3239.
Bristol Myers Squibb. OPDIVO™ (Nivolumab) [Package Insert]. Available online: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/125554s083lbl.pdf (accessed on 9 May 2020).
Carbone, D.P.; Reck, M.; Paz-Ares, L.; Creelan, B.; Horn, L.; Steins, M.; Felip, E.; van den Heuvel, M.M.; Ciuleanu, T.E.; Badin, F.; et al. First-Line Nivolumab in Stage IV or Recurrent Non-Small-Cell Lung Cancer. N. Engl. J. Med. 2017, 376, 2415–2426, doi:10.1056/NEJMoa1613493.
Kobayashi, T.; Iwama, S.; Yasuda, Y.; Okada, N.; Tsunekawa, T.; Onoue, T.; Takagi, H.; Hagiwara, D.; Ito, Y.; Morishita, Y. Patients with antithyroid antibodies are prone to develop destructive thyroiditis by nivolumab: A prospective study. J. Endocr. Soc. 2018, 2, 241–251.
Yamauchi, I.; Sakane, Y.; Fukuda, Y.; Fujii, T.; Taura, D.; Hirata, M.; Hirota, K.; Ueda, Y.; Kanai, Y.; Yamashita, Y. Clinical features of nivolumab-induced thyroiditis: A case series study. Thyroid 2017, 27, 894–901.
Jotatsu, T.; Oda, K.; Yamaguchi, Y.; Noguchi, S.; Kawanami, T.; Kido, T.; Satoh, M.; Yatera, K. Immune-mediated thrombocytopenia and hypothyroidism in a lung cancer patient treated with nivolumab. Immunotherapy 2018, 10, 85–91.
Dudzińska, M.; Szczyrek, M.; Wojas-Krawczyk, K.; Świrska, J.; Chmielewska, I.; Zwolak, A. Endocrine Adverse Events of Nivolumab in Non-Small Cell Lung Cancer Patients—Literature Review. Cancers 2020, 12, 2314.
Yoshino, K.; Nakayama, T.; Ito, A.; Sato, E.; Kitano, S. Severe colitis after PD-1 blockade with nivolumab in advanced melanoma patients: Potential role of Th1-dominant immune response in immune-related adverse events: Two case reports. BMC Cancer 2019, 19, 1019.
Mathew Thomas, V.; Bindal, P.; Ann Alexander, S.; McDonald, K. Nivolumab-induced hepatitis: A rare side effect of an immune check point inhibitor. J. Oncol. Pharm. Pract. 2020, 26, 459–461.
Vandiver, J.W.; Singer, Z.; Harshberger, C. Severe hyponatremia and immune nephritis following an initial infusion of nivolumab. Target. Oncol. 2016, 11, 553–556.
Merck Sharp & Dohme Corp. KEYTRUDA® (Pembrolizumab) [Package Insert]. Available online: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/125514s084lbl.pdf (accessed on 9 June 2020).
Mok, T.S.K.; Wu, Y.L.; Kudaba, I.; Kowalski, D.M.; Cho, B.C.; Turna, H.Z.; Castro, G., Jr.; Srimuninnimit, V.; Laktionov, K.K.; Bondarenko, I.; et al. Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): A randomised, open-label, controlled, phase 3 trial. Lancet Lond. Engl. 2019, 393, 1819–1830, doi:10.1016/s0140-6736(18)32409-7.
Reck, M.; Rodríguez-Abreu, D.; Robinson, A.G.; Hui, R.; Csőszi, T.; Fülöp, A.; Gottfried, M.; Peled, N.; Tafreshi, A.; Cuffe, S.; et al. Updated Analysis of KEYNOTE-024: Pembrolizumab Versus Platinum-Based Chemotherapy for Advanced Non-Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score of 50% or Greater. J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol. 2019, 37, 537–546, doi:10.1200/jco.18.00149.
Reck, M.; Rodríguez-Abreu, D.; Robinson, A.G.; Hui, R.; Csőszi, T.; Fülöp, A.; Gottfried, M.; Peled, N.; Tafreshi, A.; Cuffe, S.; et al. Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer. N. Engl. J. Med. 2016, 375, 1823–1833, doi:10.1056/NEJMoa1606774.
Zhou, C.; Klionsky, Y.; Treasure, M.E.; Bruno, D.S. Pembrolizumab-induced immune-mediated colitis in a patient with concurrent Clostridium difficile infection. Case Rep. Oncol. 2019, 12, 164–170.
Ahmed, M.; Francis, G. Pembrolizumab-Induced Microscopic Colitis. Am. J. Gastroenterol. 2018, 113, 629–630.
Aivazian, K.; Long, G.V.; Sinclair, E.C.; Kench, J.G.; McKenzie, C.A. Histopathology of pembrolizumab-induced hepatitis: A case report. Pathology 2017, 49, 789–792.
Kobayashi, K.; Nakachi, I.; Mitsuishi, A.; Arai, D.; Sakurai, K.; Masaki, K.; Chiyotani, A.; Takahashi, H.; Tahara, T.; Soejima, K. Successful Retreatment Using Pembrolizumab for Non-small-cell Lung Cancer After Severe Immune-related Hepatitis: A Case Report. Clin. Lung Cancer 2020, 21, e30.
Kawaji, L.D.R.; Villanueva, M.G.M.; Villa, M.L. SUN-276 Pembrolizumab-Induced Secondary Adrenal Insufficiency Presenting as Severe Hyponatremia in an 80-Year-Old Male. J. Endocr. Soc. 2020, 4, SUN–276.
Oristrell, G.; Bañeras, J.; Ros, J.; Muñoz, E. Cardiac tamponade and adrenal insufficiency due to pembrolizumab: A case report. Eur. Heart J. Case Rep. 2018, 2, yty038.
Garon, E.B.; Rizvi, N.A.; Hui, R.; Leighl, N.; Balmanoukian, A.S.; Eder, J.P.; Patnaik, A.; Aggarwal, C.; Gubens, M.; Horn, L.; et al. Pembrolizumab for the Treatment of Non–Small-Cell Lung Cancer. N. Engl. J. Med. 2015, 372, 2018–2028, doi:10.1056/NEJMoa1501824.
Maamari, J.; Yeung, S.-C.J.; Chaftari, P.S. Diabetic ketoacidosis induced by a single dose of pembrolizumab. Am. J. Emerg. Med. 2019, 37, 376.e1–376.e2.
Chae, Y.K.; Chiec, L.; Mohindra, N.; Gentzler, R.; Patel, J.; Giles, F. A case of pembrolizumab-induced type-1 diabetes mellitus and discussion of immune checkpoint inhibitor-induced type 1 diabetes. Cancer Immunol. Immunother. 2017, 66, 25–32.
Shirali, A.C.; Perazella, M.A.; Gettinger, S. Association of Acute Interstitial Nephritis With Programmed Cell Death 1 Inhibitor Therapy in Lung Cancer Patients. Am. J. Kidney Dis. 2016, 68, 287–291, doi:10.1053/j.ajkd.2016.02.057.
Taki, T.; Oda, N.; Fujioka, Y.; Mitani, R.; Tokura, T.; Takata, I.; Oshiro, Y.; Takigawa, N. Successful Treatment of Non-small-cell Lung Cancer with Atezolizumab following Tubulointerstitial Nephritis due to Pembrolizumab. Intern. Med. 2020, 29, 1639–1642.
Genentech Inc. TECENTRIQ® (Atezolizumab) [Package Insert]. Available online: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/761034s028lbl.pdf (accessed on 9 June 2020).
Li, J.; Deng, X.; Wang, B.; Li, W. Fatal outcome of atezolizumab in a patient with immune-mediated pneumonitis, thrombocytopenia, and cardiac dysfunction: A case report. Int. J. Clin. Pharmacol. Ther. 2019, 57, 607–611.
Hsu, P.-C.; Li, S.-H.; Yang, C.-T. Recurrent Pneumonitis Induced by Atezolizumab (Anti–Programmed Death Ligand 1) in NSCLC Patients Who Previously Experienced Anti-Programmed Death 1 Immunotherapy-Related Pneumonitis. J. Thorac. Oncol. 2018, 13, e227–e230.
Ikeda, S.; Kato, T.; Kenmotsu, H.; Ogura, T.; Iwasawa, S.; Sato, Y.; Harada, T.; Kubota, K.; Tokito, T.; Okamoto, I. A phase II study of atezolizumab for pretreated non-small cell lung cancer with idiopathic interstitial pneumonias. J. Thorac. Oncol. 2020, doi:10.1016/j.jtho.2020.08.018.
Fehrenbacher, L.; Spira, A.; Ballinger, M.; Kowanetz, M.; Vansteenkiste, J.; Mazieres, J.; Park, K.; Smith, D.; Artal-Cortes, A.; Lewanski, C.; et al. Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): A multicentre, open-label, phase 2 randomised controlled trial. Lancet 2016, 387, 1837–1846, doi:10.1016/S0140-6736(16)00587-0.
Schmid, P.; Rugo, H.S.; Adams, S.; Schneeweiss, A.; Barrios, C.H.; Iwata, H.; Diéras, V.; Henschel, V.; Molinero, L.; Chui, S.Y.; et al. Atezolizumab plus nab-paclitaxel as first-line treatment for unresectable, locally advanced or metastatic triple-negative breast cancer (IMpassion130): Updated efficacy results from a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. 2020, 21, 44–59, doi:10.1016/S1470-2045(19)30689-8.
Kanie, K.; Iguchi, G.; Bando, H.; Fujita, Y.; Odake, Y.; Yoshida, K.; Matsumoto, R.; Fukuoka, H.; Ogawa, W.; Takahashi, Y. Two cases of atezolizumab-induced hypophysitis. J. Endocr. Soc. 2018, 2, 91–95.
Socinski, M.A.; Jotte, R.M.; Cappuzzo, F.; Orlandi, F.; Stroyakovskiy, D.; Nogami, N.; Rodríguez-Abreu, D.; Moro-Sibilot, D.; Thomas, C.A.; Barlesi, F.; et al. Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC. New Engl. J. Med. 2018, 378, 2288–2301, doi:10.1056/NEJMoa1716948.
West, H.; McCleod, M.; Hussein, M.; Morabito, A.; Rittmeyer, A.; Conter, H.J.; Kopp, H.-G.; Daniel, D.; McCune, S.; Mekhail, T.; et al. Atezolizumab in combination with carboplatin plus nab-paclitaxel chemotherapy compared with chemotherapy alone as first-line treatment for metastatic non-squamous non-small-cell lung cancer (IMpower130): A multicentre, randomised, open-label, phase 3 trial. Lancet Oncol. 2019, 20, 924–937, doi:10.1016/S1470-2045(19)30167-6.
Reuben, A.; Petaccia de Macedo, M.; McQuade, J.; Joon, A.; Ren, Z.; Calderone, T.; Conner, B.; Wani, K.; Cooper, Z.A.; Tawbi, H. Comparative immunologic characterization of autoimmune giant cell myocarditis with ipilimumab. Oncoimmunology 2017, 6, e1361097.
BRISTOL MYERS SQUIBB. YERVOY® (Ipilimumab) [Packzage Insert]. Available online: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/125377s111lbl.pdf (accessed on 9 June 2020).
Lai, K.; Shannon, V.; Bashoura, L.; Faiz, S. Ipilimumab Pneumonitis Treated with Infliximab. In A39. Drug Related Case Reports; American Thoracic Society: New York, NY, USA, 2019; p. A1505.
Witges, K.; Shafer, L.A.; Zarychanski, R.; Abou-Setta, A.M.; Rabbani, R.; Dingwall, O.; Bernstein, C.N. Ipilimumab-Induced Enterocolitis: A Systematic Review and Meta-Analysis. Drug Saf. 2020, 1–12, doi:10.1007/s40264-020-00979-4
Pagès, C.; Gornet, J.M.; Monsel, G.; Allez, M.; Bertheau, P.; Bagot, M.; Lebbé, C.; Viguier, M. Ipilimumab-induced acute severe colitis treated by infliximab. Melanoma Res. 2013, 23, 227–230.
Izzedine, H.; Gueutin, V.; Gharbi, C.; Mateus, C.; Robert, C.; Routier, E.; Thomas, M.; Baumelou, A.; Rouvier, P. Kidney injuries related to ipilimumab. Investig. New Drugs 2014, 32, 769–773.
Gaballa, S.; Hlaing, K.M.; Mahler, N.; Moursy, S.; Ahmed, A. A Rare Case of Immune-Mediated Primary Adrenal Insufficiency With Cytotoxic T-Lymphocyte Antigen-4 Inhibitor Ipilimumab in Metastatic Melanoma of Lung and Neck of Unknown Primary. Cureus 2020, 12, e8602.
Shiba, M.; Inaba, H.; Ariyasu, H.; Kawai, S.; Inagaki, Y.; Matsuno, S.; Iwakura, H.; Yamamoto, Y.; Nishi, M.; Akamizu, T. Fulminant type 1 diabetes mellitus accompanied by positive conversion of anti-insulin antibody after the administration of anti-CTLA-4 antibody following the discontinuation of anti-PD-1 antibody. Intern. Med. 2018, 57, 2029–2034.
Tsiogka, A.; Jansky, G.L.; Bauer, J.W.; Koelblinger, P. Fulminant type 1 diabetes after adjuvant ipilimumab therapy in cutaneous melanoma. Melanoma Res. 2017, 27, 524–525.
AstraZeneca Pharmaceuticals LP. IMFINZI® (Durvalumab) [Package Insert]. Available online: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/761069s020lbl.pdf (accessed on 9 July 2020).
Garassino, M.C.; Cho, B.-C.; Kim, J.-H.; Mazières, J.; Vansteenkiste, J.; Lena, H.; Corral Jaime, J.; Gray, J.E.; Powderly, J.; Chouaid, C.; et al. Durvalumab as third-line or later treatment for advanced non-small-cell lung cancer (ATLANTIC): An open-label, single-arm, phase 2 study. Lancet Oncol. 2018, 19, 521–536, doi:10.1016/S1470-2045(18)30144-X.
Tonk, E.H.J.; van Lindert, A.S.R.; Verhoeff, J.J.C.; Suijkerbuijk, K.P.M. Acute-Onset Pneumonitis while Administering the First Dose of Durvalumab. Case Rep. Oncol. 2019, 12, 621–624, doi:10.1159/000502202.
Nakamura, M.; Otsuka, T.; Hayashi, R.; Horita, T.; Ota, M.; Sakurai, N.; Takano, H.; Hayashi, T.; Kumagai, M.; Yamada, S. Durvalumab-Induced Immune-Related Hepatitis in a Patient with Non-small Cell Lung Cancer. Intern. Med. 2020, 4699-4620.
Yang, H.; Shen, K.; Zhu, C.; Li, Q.; Zhao, Y.; Ma, X. Safety and efficacy of durvalumab (MEDI4736) in various solid tumors. Drug Des. Dev. Ther. 2018, 12, 2085.
Coleman, E.; Ko, C.; Dai, F.; Tomayko, M.M.; Kluger, H.; Leventhal, J.S. Inflammatory eruptions associated with immune checkpoint inhibitor therapy: A single-institution retrospective analysis with stratification of reactions by toxicity and implications for management. J. Am. Acad. Dermatol. 2019, 80, 990–997, doi:10.1016/j.jaad.2018.10.062.
Lin, W.-H.; Lee, K.-Y.; Lee, W.-R.; Shih, Y.-H. Durvalumab-induced de novo annular psoriasiform drug eruption successfully treated with a combination of narrowband ultraviolet B phototherapy and topical treatment. J. Dermatol. 2020, 47, 1041–1045, doi:10.1111/1346-8138.15371.
Gorantla, Y.; Amblee, A.; Lee, Y.L.; Yap, S.E.T. SAT-506 Rare Case of Durvalumab-Induced Thyroiditis, Transient Secondary Adrenal Insufficiency and Autoimmune Diabetes. J. Endocr. Soc. 2020, 4, SAT–506.
Mengíbar, J.L.; Capel, I.; Bonfill, T.; Mazarico, I.; Espuña, L.C.; Caixàs, A.; Rigla, M. Simultaneous onset of type 1 diabetes mellitus and silent thyroiditis under durvalumab treatment. Endocrinol. Diabetes Metab. Case Rep. 2019, 2019, doi:10.1530/EDM-19-0045.
Patel, S.; Chin, V.; Greenfield, J.R. Durvalumab-induced diabetic ketoacidosis followed by hypothyroidism. Endocrinol. Diabetes Metab. Case Rep. 2019, 2019, 98.
Schiller, J.H.; Harrington, D.; Belani, C.P.; Langer, C.; Sandler, A.; Krook, J.; Zhu, J.; Johnson, D.H. Comparison of Four Chemotherapy Regimens for Advanced Non–Small-Cell Lung Cancer. N. Engl. J. Med. 2002, 346, 92–98, doi:10.1056/NEJMoa011954.
Scagliotti, G.V.; Parikh, P.; von Pawel, J.; Biesma, B.; Vansteenkiste, J.; Manegold, C.; Serwatowski, P.; Gatzemeier, U.; Digumarti, R.; Zukin, M.; et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol. 2008, 26, 3543–3551, doi:10.1200/jco.2007.15.0375.
Rowinsky, E.K.; Donehower, R.C. Paclitaxel (Taxol). N. Engl. J. Med. 1995, 332, 1004–1014, doi:10.1056/nejm199504133321507.
Verweij, J.; Clavel, M.; Chevalier, B. Paclitaxel (Taxol) and docetaxel (Taxotere): Not simply two of a kind. Ann. Oncol. Off. J. Eur. Soc. Med Oncol. 1994, 5, 495–505, doi:10.1093/oxfordjournals.annonc.a058903.
Vu, T.; Ellard, S.; Speers, C.H.; Taylor, S.C.M.; de Lemos, M.L.; Hu, F.; Kuik, K.; Olivotto, I.A. Survival outcome and cost-effectiveness with docetaxel and paclitaxel in patients with metastatic breast cancer: A population-based evaluation. Ann. Oncol. 2008, 19, 461–464, doi:10.1093/annonc/mdm527.
Jones, S.E.; Erban, J.; Overmoyer, B.; Budd, G.T.; Hutchins, L.; Lower, E.; Laufman, L.; Sundaram, S.; Urba, W.J.; Pritchard, K.I.; et al. Randomized Phase III Study of Docetaxel Compared With Paclitaxel in Metastatic Breast Cancer. J. Clin. Oncol. 2005, 23, 5542–5551, doi:10.1200/jco.2005.02.027.
Scotté, F.; Tourani, J.-M.; Banu, E.; Peyromaure, M.; Levy, E.; Marsan, S.; Magherini, E.; Fabre-Guillevin, E.; Andrieu, J.-M.; Oudard, S. Multicenter Study of a Frozen Glove to Prevent Docetaxel-Induced Onycholysis and Cutaneous Toxicity of the Hand. J. Clin. Oncol. 2005, 23, 4424–4429, doi:10.1200/jco.2005.15.651.
Martín, M.; Seguí, M.A.; Antón, A.; Ruiz, A.; Ramos, M.; Adrover, E.; Aranda, I.; Rodríguez-Lescure, A.; Große, R.; Calvo, L.; et al. Adjuvant Docetaxel for High-Risk, Node-Negative Breast Cancer. N. Engl. J. Med. 2010, 363, 2200–2210, doi:10.1056/NEJMoa0910320.
Lee, H.; Park, S.; Kang, J.E.; Lee, H.M.; Kim, S.A.; Rhie, S.J. Efficacy and safety of nanoparticle-albumin-bound paclitaxel compared with solvent-based taxanes for metastatic breast cancer: A meta-analysis. Sci. Rep. 2020, 10, 530, doi:10.1038/s41598-019-57380-0.
Schmid, P.; Adams, S.; Rugo, H.S.; Schneeweiss, A.; Barrios, C.H.; Iwata, H.; Diéras, V.; Hegg, R.; Im, S.-A.; Shaw Wright, G.; et al. Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer. N. Engl. J. Med. 2018, 379, 2108–2121, doi:10.1056/NEJMoa1809615.
Eli, L. GEMZAR (Gemcitabine) [Package Insert]. Available online: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/020509s082lbl.pdf (accessed on 9 October 2020).
Conroy, T.; Desseigne, F.; Ychou, M.; Bouché, O.; Guimbaud, R.; Bécouarn, Y.; Adenis, A.; Raoul, J.-L.; Gourgou-Bourgade, S.; de la Fouchardière, C.; et al. FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer. N. Engl. J. Med. 2011, 364, 1817–1825, doi:10.1056/NEJMoa1011923.
Sabria-Trias, J.; Bonnaud, F.; Sioniac, M. Severe interstitial pneumonitis related to gemcitabine. Rev. Des Mal. Respir. 2002, 19, 645–647.
Pavlakis, N.; Bell, D.R.; Millward, M.J.; Levi, J.A. Fatal pulmonary toxicity resulting from treatment with gemcitabine. Cancer Interdiscip. Int. J. Am. Cancer Soc. 1997, 80, 286–291.
De Pas, T.; Curigliano, G.; Franceschelli, L.; Catania, C.; Spaggiari, L.; De Braud, F. Gemcitabine-induced systemic capillary leak syndrome. Ann. Oncol. 2001, 12, 1651–1652.
Pulkkanen, K.; Kataja, V.; Johansson, R. Systemic capillary leak syndrome resulting from gemcitabine treatment in renal cell carcinoma: A case report. J. Chemother. 2003, 15, 287–289.
Els, N.J.V.; Miller, V. Successful treatment of gemcitabine toxicity with a brief course of oral corticosteroid therapy. Chest 1998, 114, 1779–1781.
Kwon, E.J.; Kim, S.W.; Kim, K.K.; Seo, H.S.; Kim, D.Y. A case of gemcitabine and cisplatin associated posterior reversible encephalopathy syndrome. Cancer Res. Treat. Off. J. Korean Cancer Assoc. 2009, 41, 53.
Lilly USA LLC. ALIMTA (Pemetrexed) [Package Insert]. Available online: https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/021462s053lbl.pdf (accessed on 13 September 2020).
Huang, J.-J.; Ma, S.-X.; Hou, X.; Wang, Z.; Zeng, Y.-D.; Qin, T.; Dinglin, X.-X.; Chen, L.-K. Toxic epidermal necrolysis related to AP (pemetrexed plus cisplatin) and gefitinib combination therapy in a patient with metastatic non-small cell lung cancer. Chin. J. Cancer 2015, 34, 94–98.
Scheinpflug, K.; Menzel, C.; Koch, A.; Kahl, C.; Achenbach, H.J. Toxic epidermal necrolysis related to cisplatin and pemetrexed for metastatic non-small cell lung cancer. Oncol. Res. Treat. 2012, 35, 600–603.
Paz-Ares, L.; Luft, A.; Vicente, D.; Tafreshi, A.; Gümüş, M.; Mazières, J.; Hermes, B.; Çay Şenler, F.; Csőszi, T.; Fülöp, A.; et al. Pembrolizumab plus Chemotherapy for Squamous Non-Small-Cell Lung Cancer. N. Engl. J. Med. 2018, 379, 2040–2051, doi:10.1056/NEJMoa1810865.
Gadgeel, S.; Rodríguez-Abreu, D.; Speranza, G.; Esteban, E.; Felip, E.; Dómine, M.; Hui, R.; Hochmair, M.J.; Clingan, P.; Powell, S.F.; et al. Updated Analysis From KEYNOTE-189: Pembrolizumab or Placebo Plus Pemetrexed and Platinum for Previously Untreated Metastatic Nonsquamous Non-Small-Cell Lung Cancer. J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol. 2020, 38, 1505–1517, doi:10.1200/jco.19.03136.
Gandhi, L.; Rodríguez-Abreu, D.; Gadgeel, S.; Esteban, E.; Felip, E.; De Angelis, F.; Domine, M.; Clingan, P.; Hochmair, M.J.; Powell, S.F.; et al. Pembrolizumab plus Chemotherapy in Metastatic Non-Small-Cell Lung Cancer. N. Engl. J. Med. 2018, 378, 2078–2092, doi:10.1056/NEJMoa1801005.
Jassem, J.; Herbst, R.S.; de Marinis, F.; Cadranel, J.; Csőszi, T.; Isla, D.; Chen, G.; Syrigos, K.N.; Cortinovis, D.; Hida, T. IMpower110: Clinical Safety in a Phase III Study of Atezolizumab (Atezo) Monotherapy (Mono) vs Platinum-Based Chemotherapy (Chemo) in First-Line Non-Small Cell Lung Cancer (NSCLC); American Society of Clinical Oncology: Alexandria, VA, USA, 2020.
Administration, U.S.F.D. FDA Approves Atezolizumab for First-Line Treatment of Metastatic NSCLC with High PD-L1 Expression. Available online: https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-atezolizumab-first-line-treatment-metastatic-nsclc-high-pd-l1-expression (accessed on 31 May 2020).
Herbst, R.S.; Giaccone, G.; de Marinis, F.; Reinmuth, N.; Vergnenegre, A.; Barrios, C.H.; Morise, M.; Felip, E.; Andric, Z.; Geater, S.; et al. Atezolizumab for First-Line Treatment of PD-L1–Selected Patients with NSCLC. N. Engl. J. Med. 2020, 383, 1328–1339, doi:10.1056/NEJMoa1917346.
Reck, M.; Mok, T.S.K.; Nishio, M.; Jotte, R.M.; Cappuzzo, F.; Orlandi, F.; Stroyakovskiy, D.; Nogami, N.; Rodríguez-Abreu, D.; Moro-Sibilot, D.; et al. Atezolizumab plus bevacizumab and chemotherapy in non-small-cell lung cancer (IMpower150): Key subgroup analyses of patients with EGFR mutations or baseline liver metastases in a randomised, open-label phase 3 trial. Lancet. Respir. Med. 2019, 7, 387–401, doi:10.1016/s2213-2600(19)30084-0.
Reck, M.; Wehler, T.; Orlandi, F.; Nogami, N.; Barone, C.; Moro-Sibilot, D.; Shtivelband, M.; González Larriba, J.L.; Rothenstein, J.; Früh, M.; et al. Safety and Patient-Reported Outcomes of Atezolizumab Plus Chemotherapy With or Without Bevacizumab Versus Bevacizumab Plus Chemotherapy in Non-Small-Cell Lung Cancer. J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol. 2020, doi:10.1200/jco.19.03158.
Hellmann, M.D.; Paz-Ares, L.; Bernabe Caro, R.; Zurawski, B.; Kim, S.-W.; Carcereny Costa, E.; Park, K.; Alexandru, A.; Lupinacci, L.; de la Mora Jimenez, E.; et al. Nivolumab plus Ipilimumab in Advanced Non–Small-Cell Lung Cancer. N. Engl. J. Med. 2019, 381, 2020–2031, doi:10.1056/NEJMoa1910231.
Wolchok, J.D.; Chiarion-Sileni, V.; Gonzalez, R.; Rutkowski, P.; Grob, J.J.; Cowey, C.L.; Lao, C.D.; Wagstaff, J.; Schadendorf, D.; Ferrucci, P.F.; et al. Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma. N. Engl. J. Med. 2017, 377, 1345–1356, doi:10.1056/NEJMoa1709684.
Reck, M.; Ciuleanu, T.-E.; Dols, M.C.; Schenker, M.; Zurawski, B.; Menezes, J.; Richardet, E.; Bennouna, J.; Felip, E.; Juan-Vidal, O. Nivolumab (NIVO)+ Ipilimumab (IPI)+ 2 Cycles of Platinum-Doublet Chemotherapy (Chemo) vs 4 Cycles Chemo as First-Line (1L) Treatment (tx) for Stage IV/Recurrent Non-Small Cell Lung Cancer (NSCLC): CheckMate 9LA; American Society of Clinical Oncology: Alexandria, VA, USA, 2020.
Howlader, N.; Forjaz, G.; Mooradian, M.J.; Meza, R.; Kong, C.Y.; Cronin, K.A.; Mariotto, A.B.; Lowy, D.R.; Feuer, E.J. The Effect of Advances in Lung-Cancer Treatment on Population Mortality. N. Engl. J. Med. 2020, 383, 640–649, doi:10.1056/NEJMoa1916623.
Reck, M.; Kerr, K.M.; Grohé, C.; Manegold, C.; Pavlakis, N.; Paz-Ares, L.; Huber, R.M.; Popat, S.; Thatcher, N.; Park, K.; et al. Defining aggressive or early progressing nononcogene-addicted non-small-cell lung cancer: A separate disease entity? Future Oncol. Lond. Engl. 2019, 15, 1363–1383, doi:10.2217/fon-2018-0948.
Seliger, B. Basis of PD1/PD-L1 Therapies. J. Clin. Med. 2019, 8, 2168, doi:10.3390/jcm8122168.
Alvarez-Argote, J.; Dasanu, C.A. Durvalumab in cancer medicine: a comprehensive review. Expert Opin. Biol. Ther. 2019, 19, 927–935
Picardo, S.L.; Doi, J.; Hansen, A.R. Structure and Optimization of Checkpoint Inhibitors. Cancers 2020, 12, 38.
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