Modulation of Brain Hyperexcitability: Comparison
Please note this is a comparison between Version 1 by Sofia Toniolo and Version 2 by Vivi Li.

People with Alzheimer’s disease (AD) have significantly higher rates of subclinical and overt epileptiform activity. In animal models, oligomeric Aβ amyloid is able to induce neuronal hyperexcitability even in the early phases of the disease. Such aberrant activity subsequently leads to downstream accumulation of toxic proteins, and ultimately to further neurodegeneration and neuronal silencing mediated by concomitant tau accumulation. Several neurotransmitters participate in the initial hyperexcitable state, with increased synaptic glutamatergic tone and decreased GABAergic inhibition. These changes appear to activate excitotoxic pathways and, ultimately, cause reduced long-term potentiation, increased long-term depression, and increased GABAergic inhibitory remodelling at the network level. Brain hyperexcitability has therefore been identified as a potential target for therapeutic interventions aimed at enhancing cognition, and, possibly, disease modification in the longer term. Clinical trials are ongoing to evaluate the potential efficacy in targeting hyperexcitability in AD, with levetiracetam showing some encouraging effects. Newer compounds and techniques, such as gene editing via viral vectors or brain stimulation, also show promise. Diagnostic challenges include identifying best biomarkers for measuring sub-clinical epileptiform discharges. Determining the timing of any intervention is critical and future trials will need to carefully stratify participants with respect to the phase of disease pathology.

  • Alzheimer’s disease
  • epilepsy
  • hyperexcitability
  • neurodegeneration
  • Alzheimer’s disease,epilepsy,hyperexcitability,neurodegeneration

1. Introduction

Recent clinical and preclinical research has led to a growing realization of the strong association between brain hyperexcitability, manifest in its extreme form as epilepsy, and Alzheimer’s disease (AD)


. Epileptiform activity in AD might arise as a bystander effect, encountered as consequence of neurodegeneration as the disease progresses. On the other hand, it might be a constituent component of the AD phenotype


. It is now, for example, established that AD patients have higher rates of subclinical and overt epileptiform activity


. The prevalence of subclinical epileptiform activity is still largely unknown


, with some evidence suggesting it could be present in up to 42.4% of AD cases


. Clinically overt seizures among AD patients have been reported to be from 6 to 17 times higher compared to age-matched controls


, while the lifetime prevalence of seizures in AD populations ranges from 1.5 to 64%, partly owing to the pleomorphic clinical representations of epileptic discharges


. Most seizures are subtle and non-convulsive in AD; they could easily be missed, and confusional or amnestic episodes overlap with typical AD symptoms



Preclinical data in both AD and epilepsy models show that covert epileptic discharges can have an adverse impact on cognition


. Murine models of epilepsy frequently report behavioural impairment in standard tests of spatial cognition such as the Morris water maze task


, with a disruption of precise temporal organization of neuronal firing that is essential for normal cognitive processing


. Epileptiform discharges are also associated with impaired performance in cognitive tasks, usually involving memory and spatial processing in mouse models of AD


. Similarly, subclinical epileptiform activity in AD patients associates with an earlier and more rapid cognitive decline, in both memory and executive function



2. Who, When, and How to Treat Brain Hyperexcitability: Diagnostic and Therapeutic Challenges

Preclinical and human studies show that seizure susceptibility is higher if a genetic risk factor for early or late onset AD is present


. Young patients who carry APP, PSEN1, or PSEN2 mutations show an increased prevalence of seizures compared to sporadic AD patients


, which could be as high as 87 fold


. ApoE4+ mice show increased hyperexcitability, especially in the entorhinal cortex, even independently of Aβ and tau pathology


, implying that ApoE4 genotype might be a distinct risk factor for hyperexcitability. Young healthy humans who are ApoE4 carriers also show fMRI hyperactivity of the hippocampus


. Adeno-associated virus (AAV) vectors, and specifically the AAVrh.10-APOE2 vector, have shown promising results in mice and non-human primates in shifting the more detrimental ApoE4 genotype expression to ApoE2, with a single intracerebral injection resulting in decreased Aβ levels and amyloid plaque formation


. A pioneering phase 1 study with AAVrh.10-APOE2 vector is currently ongoing in ApoE4+ MCI and AD patients. One possible implication therefore is that ApoE4+ individuals might be an important group to target for initial attempts to reduce brain hyperexcitability, but further data in humans are needed to confirm these promising preclinical data.

2.1. Diagnostic Tools

Whereas counteracting 


excitability might be the optimal strategy in early phases of AD, preventing neuronal 


excitability might be crucial in later phases


. Therefore, the timing of therapeutic strategies in different stages of AD (preclinical, prodromal, moderate, severe pathology) might need to be accounted for when designing clinical trials addressing neuronal hyperexcitability.

How would it be possible to stage a patient in vivo (Figure 1)?

Figure 1.

Proposed model of biomarker dynamics of hyperexcitability in humans. Amyloid load, measured by either cerebrospinal fluid (CSF) or Pittsburgh B compound amyloid ligand (PiB) positron emission tomography (), is the first to increase. Functional magnetic resonance imaging (fMRI) hippocampal activation is elevated in the preclinical and early prodromal Alzheimer’s disease (AD) phases, and subsequently decreases, with final hypoactivation in AD dementia stage. Tau load elevation, at CSF analysis or tau imaging, subsequently follows. Higher rates of MRI atrophy appear after fMRI hyperactivation and tau increase. Electroencephalogram (EEG) abnormalities increase longitudinally as disease progress, with suboptimal detection rates. The combined effect of Aβ amyloid and tau induces hyperexcitability in early and hypoexcitability in late disease stages, as depicted by fMRI hippocampal activation. Made in ©BioRender -

Hippocampal fMRI activation has gained attention as a marker of hyperexcitability, as it is increased in MCI patients compared to controls, and in early MCI compared to late MCIs, while AD patients typically show an hypoactivation pattern, thus suggesting this might reflect a temporal dynamic shift from hyper to hypoexcitability


, (

Figure 1

). Notably, hippocampal fMRI hyperactivation has been found also in young, cognitively-intact presymptomatic individuals with the E280A PSEN1 mutation


, in ApoE4+ individuals


, and controls with a family history of AD


, suggesting that it might be a possible signature of early preclinical neuronal dysfunction. It is also correlated with cortical thinning in brain regions typically associated with AD pathology


, to longitudinal increased amyloid accumulation measured by PiB-PET and higher rates of cognitive decline


, (

Figure 1

). “When” to treat seems, therefore, as soon as possible, given also that when hypoactivity is present, as shown by preclinical models, tau-related damage might already be irreversible



Nevertheless, task-related fMRI hyperactivity is not a direct measure of epileptiform activity, so its interpretation as marker of epileptiform activity is still speculative. One key piece of evidence strengthening this link, however, is the finding that levetiracetam is able to counteract the hippocampal hyperactivation in MCI patients


, implying that it is indeed reflecting underlying epileptiform activity.

What is the role of the most used tool to assess hyperexcitability in clinical practice, which is standard EEG? Areas of hyperexcitability might be limited to a small region such as the entorhinal cortex


, and could coexist with hypoactive circuits, even in adjacent regions


, making any changes difficult to detect by large scale surface EEG recordings


. Therefore, non-invasive scalp recording as provided by standard EEG might substantially underestimate brain hyperexcitability


. Moreover, epileptiform activity could be more prevalent during sleep


, and therefore missed in routine clinical evaluations. Even if standard EEG abnormalities, as increased theta and delta activities, have shown a potential in tracking AD progression, longitudinal EEGs as are rarely used in clinical practice for AD staging



Figure 1

). A 24 h long-term monitoring by video-electroencephalography (LTM-EEG) telemetry has proven to increase the chances of uncovering subclinical epileptiform activity in AD patients


. Quantitative EEG (qEEG) analysis has also shown promise in detecting early neuronal dysfunction and to correlate with molecular and imaging biomarkers of the disease


. Another emerging technique to measure the disruption of neuronal fine tuning in AD is magnetoencephalography (MEG), which has several advantages over fMRI and EEG, combining high spatial and sub-millisecond temporal resolution


. MEG has been shown to outperform standard and prolonged EEG in detecting subclinical epileptiform activity in AD patients and controls


. It is able not only to detect localized patterns of reduced connectivity in AD patients


, but also to predict future conversion from MCI to AD


. MEG can detect deficits of functional connectivity even in patients with subjective cognitive impairment, possibly providing a very early maker of the disease


. Intriguingly, metrics such as Synchronization Likelihood (SL), a measure of functional connectivity, could be increased in MCI patients and reduced in AD, possibly mirroring fMRI dynamics of initial hyper and subsequent hypoactivation



Whether, however, these changes reflect an underlying hyperexcitable state, remains to be ascertained. Multiple MEG metrics show different trajectories alongside disease progression and MEG availability is still limited to a relatively smaller number of research centres


. One study supported the detection of Aβ-induced hyperexcitability in MCI patients, showing that Aβ-positive MCIs had increased alpha band power in medial frontal areas and increased delta band power, which correlated with disease progression within the AD continuum


. Even if some data suggest that MEG is able to record signal coming from the hippocampus, the decrease in MEG signal-to-noise ratio as a function of source depth implies that, as for surface EEG, its detection of subtle abnormalities in deep brain structures might be suboptimal


. A phase 2 clinical trial is ongoing to test the effect of levetiracetam on MEG signal changes in patients with MCI and AD. Another clinical trial (NCT04131491) is currently recruiting to quantify subclinical epileptiform discharges and hippocampal hyperactivity with MEG, prolonged EEG and their impact on CSF biomarkers of AD.

2.2. Therapeutic Tools

Different non-pharmacological brain stimulation techniques such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), either alone or combined with EEG have been used either to diagnose or to treat brain hyperexcitability in AD through detection and modulation of LTP and LTD changes. Given the modulatory properties of TMS, and the possibility of detecting its impact at a granular temporal scale with EEG, these techniques have also been proposed as therapeutic tools to tune the brain’s excitatory state


. TMS protocols have been extensively used in AD for diagnostic and therapeutic purposes


, particularly Theta burst Stimulation (TBS), which resembles the methods used for investigation of hippocampal plasticity


, and its metrics of LTP reduction correlate with hippocampal-type cognitive impairment in AD


. Short latency afferent inhibition (SAI), which is a measure of cholinergic pathways’ integrity, shows that AD patients have impaired LTP-like cortical plasticity, with preservation of LTD


. TMS and TMS-EEG have been able to detect hyperexcitability in early stages of AD


. TMS-EEG with stimulation of the precuneus has been reported to ameliorate memory deficits and enhance beta oscillations in prodromal AD


, and several trials in MCI or AD are currently ongoing.

Several small studies with tDCS have shown some efficacy in enhancing memory function in AD patients, even if with conflicting results


. tACS, with its ability to entrain or synchronize brain network oscillations, especially in the 40 Hz gamma frequency, is being explored as a therapeutic tool in AD disease


. GammaSense stimulation, which delivers a LED light flashing at 40 Hz and auditory stimuli, has shown promise in different mouse models, including 5XFAD, APP/PS1, and wild type mice, with reduction of Aβ and tau levels and positive effect on microglia


. Positive effects in reducing amyloid load in auditory cortex and hippocampus, as well as a more widespread reduction of Aβ load, and improved spatial and recognition memory of 5XFAD mice, have been reported


. Moreover, reduced tau phosphorylation has been found in the P301S tauopathy model after GammaSense treatment


. Human studies applying GammaSense stimulation in MCI or AD are currently ongoing, though a small pilot study in 10 patients on 40 Hz light therapy had no effects on Aβ load


. Some groups have also coupled TMS or tDCS with cognitive stimulation




. Other devices, such as NeuroEM, based on Transcranial Electromagnetic Treatment (TEMT), seem to show promising results


, and clinical trials to assess its efficacy are currently ongoing. Alternative approaches are also being studied, such as temporal interference stimulation (TI), which can selectively modulate neurons in the deep brain structures in animal models and human prototypes


. Intranasal delivery of near infrared (NIR) light via light emitting diodes, or photobiomodulation is also being tested in AD for its possible beneficial impact of mitochondrial function, and improvements in cognition, increased cerebral perfusion, and enhanced connectivity between the posterior cingulate cortex and lateral parietal nodes of the default-mode network after 12 weeks of treatment have been reported in a small pilot study



All of these non-pharmacological brain stimulation techniques have their limitations. Some of these stimulation protocols have “history of seizure” as exclusion criterion, as they can lower seizure threshold


, which might be extremely important in the context of increased hyperexcitability in AD patients. Moreover, the reported positive effects on cognition usually last only for few weeks after stimulation, and there is still little evidence for long-term cognitive benefit


. Besides these new approaches, which are available in the context of research, different pharmacological compounds such as anti-seizure medications (ASMs) have been used to address the question of “How” to treat brain hyperexcitability, targeting different steps of the excitotoxic cascade (

Figure 2

), and they remain at the moment the most reliable option.

Figure 2. Overview of mechanisms and therapeutic targets of hyperexcitability in AD. Aβ dimers block glutamate reuptake by astrocytes through glutamate transporter-1 (GLT-1) receptors. This causes increased glutamate levels in the synaptic cleft, activation of perisynaptic N-methyl-D-aspartate (NMDA) 2B receptors, increased Ca++ influx, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors internalization and activation of glycogen synthase kinase 3 beta (GSK-3β) and p38 mitogen-activated protein kinase (p38-MAPK) pathways. These pathologic cascades lead to abnormal tau phosphorylation and neurodegeneration. Long-term potentiation (LTP) is reduced and long-term depression (LTD) increases. Aβ oligomers interact pre- and postsynaptically with alpha-7 nicotinic receptors (alpha7-nAChRs), metabotropic glutamate receptors 5 (mGluR5s), and NMDA receptors. mGluR5 activates Fyn-mediated neurodegenerative changes. Increased excitation can also be driven by presynaptic changes in synaptic vesicle glycoprotein (SV2A) and Na+ channels. Decrease of GABAergic transmission or impaired glycine levels are also implicated in increasing hyperexcitability. Several therapeutic compounds are able to counteract specific molecular targets implicated in hyperexcitability. Made in ©BioRender -  

3. Conclusions

Hyperexcitability, especially localized to the hippocampus, seems to be an early signature of neuronal and cognitive dysfunction in patients who are at risk of developing AD


. Preclinical models and human studies suggest that these changes reflect an early aberrant E > I (excitatory > inhibitory) imbalance, which is associated with Aβ synaptopathy, and fosters further reactive release of toxic compounds such as Aβ amyloid and tau


. These alterations might decrease during disease progression, as shown by the progressive tau induced neuronal silencing, i.e., E < I, and subsequent neurodegeneration in the later phases of the disease


. Therefore, there might be a very narrow window of opportunity to target brain hyperexcitability, which might need to be taken into account when designing clinical trials tackling hyperexcitability in AD.

Several ASMs have been proposed as a means of counteracting brain hyperexcitability in preclinical models of AD, as well as in patients


, with levetiracetam showing promising results


. GABAergic modulation is also being explored, through repurposing of licensed medications; new GABA


 agonists and GABA


antagonists; and innovative techniques such as gene and stem cell therapies



Targeting cardiovascular risk factors, such as hypertension and diabetes, has been proposed to counteract the development of additional vascular lesions in AD patients, but also to help reduce brain hyperexcitability


. Clinical trials to tackle neuroinflammation, rather than systemic inflammation, through more tailored approaches are ongoing, as is work on gene editing via viral vectors to reduce the detrimental and pro-excitatory effects of ApoE4 genotype



Non-pharmacological stimulation techniques have also been shown to enhance cognition in AD patients, at least in the short-term, by modulating brain hyperexcitability, and are being trialed for their possible long-term effects on AD pathological cascades.

One of the critical questions is what defines the best in vivo marker for hyperexcitability, as this would help stratify people with AD for clinical trials. In humans, fMRI has shown promising results in detecting early hippocampal alterations


, but other approaches such as MEG or TMS-EEG might also be considered to measure brain hyperexcitability owing to their good temporal resolution and modulation potential



Clinical trials targeting different molecular pathways that contribute to the genesis of such aberrant cortical function, as well as being of therapeutic relevance, offer insights on AD progression and how to potentially prevent the development of dementia in susceptible populations. Nevertheless, several clinical trials have failed so far in halting AD progression through modulation of possible targets of brain hyperexcitability, and multiple diagnostic and therapeutic challenges have yet to be overcome. Licensed drugs, as well as new strategies are being tested in cognitively healthy people at risk of developing AD, as well as in MCI and AD patients, mostly in early-prodromal phases. These upcoming trials could cast a light on the potential of brain fine-tuning, and possible disease modifying effects in AD.


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