2. Physical Activity
There is a consensus that stroke survivors who participate in regular physical activity may have a reduced risk of subsequent stroke
[44,45][44][45]. For patients with a previous stroke, the identification and targeting of barriers to exercise delivery could lead to the more widespread implementation of exercise prescriptions in this population
[45]. Lifestyle risk factors are an essential consideration among stroke survivors. These risk factors can lead to worsening symptoms and disease recurrence
[45]. For successful risk reduction, communication between the physician and patient is necessary
[45]. The main lifestyle steps in reducing cardiovascular mortality in stroke patients are (1) a healthy diet and regular exercise and (2) the reduction in or cessation of unhealthy habits (such as smoking and alcohol consumption)
[12]. Only a tiny amount of research has assessed the effect of lifestyle changes on secondary stroke prevention. In routine practice, these necessary lifestyle changes are not made after a stroke
[7]. Recurrent stroke occurs in about one-third of patients
[21], and these patients are also at higher risk of other cardiovascular events
[21]. Physical activity is a known preventive measure against primary and secondary stroke. The dose–effect relation is controversial, however; thus, it is not clear whether maximal physical activity also leads to maximal stroke reduction
[38]. Regular physical activity has well-established benefits for reducing the risk of premature death and cardiovascular disease
[46]. Physical activity has also been found to reduce the risk of coronary heart disease compared to a sedentary lifestyle. Additionally, there is no evidence that heavy physical activity confers any greater benefit than moderate levels. In recent years, accumulating evidence has supported the protective effect of moderate physical activity on stroke incidence in men and women. For stroke, the benefits are apparent even for light-to-moderate activities, such as walking, and the data support additional benefits from increasing the level and duration of one’s recreational activity
[18]. Particular attention should be focused on overcoming possible barriers
[45]. The further education of health professionals in this field is necessary. Exercise has proven benefits in terms of balance, walking speed, endurance, disability improvement, and metabolic function
[38]. Healthy adults engage more in non-sedentary activities (57% to 72% sedentary activities) than do stroke survivors (86% to 88% sedentary)
[7]. Patients who have had a stroke are particularly susceptible to sedentary and prolonged sitting behaviors. Encouraging them to engage in physical activity in a supervised and safe manner is essential. Changing their behaviors, such as diet, exercise, and medication compliance, requires more than simply providing advice or a brochure. Exercise training can be highly beneficial for people who have suffered a stroke as it can improve hypertension, lipid profiles, glucose metabolism, and insulin sensitivity. These improvements are significant, considering that up to 80% of stroke patients experience abnormal glucose metabolism. In addition to these benefits, exercise training after a stroke can improve balance, gait speed, and endurance and reduce disability
[24]. The recommendations state that a sedentary lifestyle should be avoided, aside from increasing exercise
[24]. However, stroke survivors often lose their exercise capacity. They need twice as much oxygen for routine walking compared to healthy individuals. The same is true with dressing, bathing, and other self-care activities; these routine activities, after stroke, take up to two-thirds of the patient’s exercise capacity. Standing and walking are good examples of non-exercise, light-intensity training. A lack of physical readiness, depressive symptoms, inaccessible environments, and physical impairment may discourage an individual from exercising, but keeping physically active has an enormous positive benefit on modifiable risk factors
[7,47,48][7][47][48]. Exercise positively impacts the atrial fibrillation (AF) burden by reducing body weight
[40,41,42,43,45][40][41][42][43][45]. It is still unclear whether high-intensity exercise reduces stroke occurrence, since it might increase the risk of developing AF
[38]. There is increasing evidence that inactivity represents an independent AF risk factor
[40,41,42][40][41][42]. However, it is more beneficial to influence lifestyle changes than it is to treat one single risk factor
[38]. Quality of life after a stroke depends on exercise and support to perform regular training
[47]. Even more significant impacts can be achieved with population-level interventions for physical activity, including investments in health-promoting infrastructure (e.g., sidewalks, walking paths, bike lanes)
[23]. Additional barriers to physical activity after stroke include deconditioning, depression, inaccessible environments (e.g., wheelchair-friendly transportation and gym equipment), low motivation, poor social support, and physical impairment
[23]. After an ischemic stroke or transient ischemic attack, eligible patients should exercise for half an hour (physical exercise of moderate intensity) up to five times weekly
[47]. For patients with ischemic stroke or transient ischemic attack (TIA) who are capable of engaging in physical activity, at least 30 min of moderate-intensity physical exercise, typically defined as vigorous activity sufficient to break a sweat or noticeably raise heart rate, one to three times a week (e.g., walking briskly, using an exercise bicycle) may be considered to reduce the risk factors and comorbid conditions that increase the likelihood of recurrent stroke. For those individuals with a disability after ischemic stroke, supervision by a healthcare professional, such as a physical therapist or cardiac rehabilitation professional, at least on initiation of an exercise regimen, may be considered
[24,47][24][47]. At a slightly higher prevalence, an estimated 57% of adults with stroke do not meet the weekly aerobic physical activity recommendations of approximately 150 min/week of moderate physical activity. This prevalence of insufficient physical activity is similar to the 62% reported among adults with disability
[12]. Higher proportions of patients with TIA were noted to meet the physical activity recommendations. Insufficient levels of moderate–vigorous physical activity (typically <10 MET-hours/week) have been identified as predictive of recurrent ischemic stroke. Cardiovascular fitness is the most helpful determinant of physical activity participation and combined health behaviors after stroke, presenting a legitimate target in stroke secondary prevention. A previous systematic review also identified that cardiorespiratory fitness is highly associated with post-stroke physical activity levels. This study further showed that for every incremental increase in L/min of VO
2peak, a stroke patient is 7.5 times more likely to meet the recommended levels of moderate–vigorous physical activity. The need for aerobic training interventions after stroke is clear, as the cardiorespiratory fitness levels of stroke patients are roughly half those of age-matched sedentary counterparts and are often insufficient to meet the threshold level required for basic activities of daily living
[26]. Patients do not benefit more from intense physical activity than from moderate physical activity
[18]. Further, exercise has many biological benefits related to coagulation and lipid metabolism
[49]. Most stroke patients were found to have at least three modifiable unhealthy habits and two health conditions, and about one-half also had a third health condition
[12]. Further, more than one-half of stroke patients did not meet weekly exercise recommendations
[12]. Stroke rehabilitation starts soon after the incident and is a long-term assignment. A quick improvement in strength and mobility occurs in the first month, but the most significant improvement is reached around the fourth month. Brain remodeling continues long after this initial improvement. It is essential to remember that cognitive rehabilitation is also needed. Patients after stroke need rehabilitation regarding speech and language, dysphagia, incontinence, etc.
Aerobic exercise is essential, regardless of the patient’s specific rehabilitation needs. Enrolling patients in community exercise programs has shown particular effectiveness
[50]. Recent meta-analyses suggest that office-based practices can help patients increase their levels of physical activity by 20% to 40%
[51]. During the first recovery year, patients often visit their physician for concerns other than stroke. When stoke is a concern, recommended actions are often neglected
[51]. Restoration of the ability to engage in physical activities stretches beyond this time; however, because of brain remodeling (i.e., healthy brain taking over the functions of the infarcted brain), the adaptation of compensating strategies, restoration of confidence, and use of adaptive equipment may be required. Effective rehabilitation therapies exist for motor recovery, cognition (i.e., memory, orientation, attention, and language), communication, incontinence, pain, dysphagia, sensory impairment (i.e., vision, neglect), spasticity, balance, and mobility. Improvements in these domains follow the same course as motor improvement, with rapid early recovery followed by a longer time to the maximum restoration of function
[50]. The protective effect of physical activity may be partly mediated through its role in controlling various known risk factors for stroke. Other biological mechanisms are associated with physical activity, including reductions in plasma fibrinogen and platelet activity and elevations in plasma tissue plasminogen activator activity and high-density lipoprotein (HDL) concentrations. Thus, physical activity is a modifiable behavior that requires greater emphasis in stroke prevention campaigns
[49].
3. Diet
Consuming a healthy diet is essential for cardiovascular health and stroke prevention. Reducing the daily caloric intake by 20% to 25% for three months or longer in obese and non-obese individuals improves blood pressure, low-density lipoprotein (LDL) cholesterol and triglycerides, insulin resistance, and glycemic control
[7]. These dietary recommendations are consistent with the Dietary Approaches to Stop Hypertension (DASH) and Mediterranean-style dietary patterns, effectively reducing the risk of stroke. Adopting a Mediterranean diet, which is high in olive oil, whole grains, fruits, vegetables, and legumes and low in cholesterol/saturated fat, is advised to prevent stroke. These diets can reduce the stroke rate by 40% or more in high-risk patients
[52,53][52][53]. However, supplementation with antioxidant vitamins A, C, and E or beta-carotene does not reduce the risk of stroke
[54]. Several studies have indicated that a higher potassium intake reduces stroke risk by 21% (relative risk 0.79, 95% CI 0.60–0.90). This effect seems to be dose-dependent: every 1 g per day increase in potassium intake was found to reduce stroke risk by 11%. The mechanism is probably partially mediated by a reduction in blood pressure
[55]. Calcium supplementation (>500 mg daily) is associated with a significant risk of myocardial infarction and a trend toward an increase in stroke
[38]. Therefore, minding what we eat is a great preventive health action, and following dietary recommendations is effective in stroke reduction
[7]. The Mediterranean diet has proven beneficial in stroke prevention
[38], but in Western diets, salt consumption is very high at about 10 g per day. In East Europe and Asia, the amount is higher still. The amount of salt taken daily should not exceed five to six grams. Increased salt consumption raises the risk of stroke and is associated with one-fifth of all intracerebral hemorrhages. The greatest preventive impact of salt reduction comes from blood pressure reduction
[38]. The consumption of all types of fat (animal, vegetable, saturated, non-saturated) does not seem to significantly influence stroke, but foods containing omega-3 fatty acids from vegetable oils decrease stroke recurrence. The consumption of industrially produced trans fats or saturated fatty acids, however, has been shown to increase the risk of coronary heart disease
[56]. Protein intake, whether from animal or plant sources, may also decrease stroke recurrence. Regular consumption of fish reduces the risk of stroke, while eating meat can increase it. A diet that includes fruits and vegetables decreases the possibility of stroke recurrence. Eating only vegetables, without fruits, does not seem to be protective. A high concentration of lycopene halves the stroke risk
[38].
Plant-based diets, used by vegetarians and vegans, are associated with lower body mass index and lower levels of LDL-cholesterol and blood pressure, which leads to a reduced risk of ischemic heart disease and ischemic stroke
[57,58][57][58]. Interestingly, some studies show that plant-based diets might increase the risk of stroke (particularly hemorrhagic stroke), with lower levels of vitamin D, B12, calcium, and iodine
[57,59][57][59]. Several meta-analyses showed that low vitamin D levels are related to an increased risk of ischemic stroke
[60,61][60][61]. Moreover, low vitamin D levels are an independent factor in mortality and cardiovascular events in the general population
[62]. Paradoxically, vitamin D supplementation is not associated with decreased cardiovascular events
[63,64,65][63][64][65]. Consuming up to four cups of coffee or tea per day has a stroke-protective effect compared to no consumption, probably due to antioxidative effects and their impact on endothelial function
[66]. Chocolate, with the anti-inflammatory and anti-thrombotic effects of cocoa, also has protective effects
[67]. The consumption of foods and liquids with added sugars and high dietary glycemic indices increases the risk of overweight, diabetes mellitus, and coronary heart disease
[68]. Dietary changes considering all the abovementioned effects may lead to a stroke risk reduction of forty percent or more in patients with high risk
[69]. Family members and caregivers have a crucial role in sustaining the healthy life habits of stroke survivors
[26,39][26][39]. Culture and ethnicity may play a role in this health behavior. The influence of environment, social norms, and family members on health behaviors, including fruit and vegetable intake, is well established. Studies addressing lifestyle after stroke have identified the ability of family and carers to exert both positive and negative influences on behavioral patterns, and a focus group study examining barriers to a healthy lifestyle after stroke identified that, particularly in men, the person with stroke often did not buy or prepare their own food/meals. The inclusion of family members/carers in dietary changes after stroke may be necessary to achieve sustainable behavior change, and future models of care should explore this aspect in greater depth
[26].
Table 1 presents a summary of lifestyle modification recommendations.
Table 1.
Summary of recommendations regarding personal lifestyle modifications.