Malignant Acute Colonic Obstruction: Multidisciplinary Approach for Endoscopic Management

Malignant Acute Colonic Obstruction: Multidisciplinary Approach for Endoscopic Management: Comparison

Please note this is a comparison between Version 2 by Peter Tang and Version 1 by Aurelio Mauro.

Acute colonic obstruction is one of the most common manifestations of locally advanced colorectal cancer. Endoscopic stenting has become by far the minimally invasive treatment of choice for malignant colonic obstruction especially in the palliative setting.

acute colonic obstruction
colorectal cancer
endoscopic stent
bridge to surgery
antiangiogenic agents
self-expandable metal stent

1. Introduction

Colorectal cancer (CRC) is the third most frequently diagnosed malignancy in the world and the second leading cause of cancer-related mortality ^[1]. About 10–40% of colorectal cancer patients have bowel obstruction at the time of diagnosis, particularly on the left side ^[2], and large bowel obstruction (LBO) is a common condition that accounts for about 24% of admissions for acute mechanical bowel obstruction ^[3]. Acute colonic obstruction requires urgent management in order to avoid further complications such as perforation or ischemia. In the past, urgent surgery with colonic resection and/or stoma formation was the only available treatment. Endoscopic decompression with the application of self-expandable metal stents (SEMS) within the stricture has been proposed in the last decades as a less invasive option and has become the treatment of choice for patients who need palliative treatment ^[4].

The surgeon is usually the first specialist to evaluate patients with acute colonic obstruction in the emergency department; the consultation with the endoscopist aims to share the indication of endoscopic stenting, especially for resectable patients for whom there are still no clear indications for the bridge-to-surgery stenting ^[5]. When evaluating the patient for colonic stenting, the on-call endoscopist usually performs a virtual urgent multidisciplinary consultation with the main figures involved in the management of the patient. Radiological consultation is then essential before endoscopic stenting in order to confirm the malignant etiology of the acute obstruction, to better define the colonic anatomy and to identify urgent criteria for the timing of endoscopic decompression. Lastly, acute colonic obstruction may develop in patients with a known colon cancer under active chemotherapy treatment. Antiangiogenic therapy (e.g., bevacizumab) has been associated with an increased risk of perforation in patients treated with colonic stenting ^[6]. However, evidence is lacking and based on retrospective studies. Thus, multidisciplinary evaluation with an oncologist and surgeon is crucial in order to identify the correct management strategy and to discuss the risks and benefits of the endoscopic procedure.

Endoscopic colonic stenting is an interventional procedure that requires specific endoscopic skills and experience in the interpretation of intraprocedural radiological frames ^[7]. The placement of a colonic stent is usually easy in the case of short and linear strictures, whereas it could become particularly challenging in the case of difficult anatomic locations, including lesions close to the anal verge, in the right colon or colonic flexures.

Acute LBO remains a surgical urgency and initial evaluation should be performed by the general surgeon. Preliminary surgical evaluation is aimed at confirming the diagnosis of malignant etiology, excluding other benign causes of LBO that usually do not require endoscopic management except for specific cases (e.g., endoscopic decompression for sigmoid volvulus). Surgical consultation is also essential for the interpretation of CT scan images in order to exclude the presence of abdominal complications that require urgent surgical therapy such as bowel perforation and/or ischemia. Once a diagnosis of malignant LBO is confirmed, it is essential for the surgeon and endoscopist to collaboratively determine the indication for endoscopic stenting. Endoscopic treatment is sometimes contraindicated when there are signs of colonic ischemia or perforation and therefore emergency surgery (ES) is the only possible treatment ^[8]. ES contemplates the emergency resection of the primary lesion with an immediate colorectal anastomosis (possibly associated with a diverting loop ileostomy) or without a prompt recanalization and the creation of a colostomy (“Hartmann’s procedure”). When contraindications to stenting are excluded, it is important to evaluate the clinical context of the patient. Patients unsuitable for surgery due to advanced disease (e.g., metastatic CRC) or for the presence of multiple comorbidities should be referred for endoscopic palliative stenting. When the patient has a resectable CRC, it is possible to perform a two-step approach consisting of the endoscopic placement of a SEMS to resolve the obstruction and in the elective surgical resection a few weeks after (stent as a bridge to surgery). Acute colonic obstruction may also be caused by a non-primary colonic tumor such as pelvic tumors, advanced gastric or other metastatic cancers that cause extrinsic compression. Usually, patients with extrinsic obstruction have milder symptoms than patients with strictures caused by primary colonic cancer ^[5]. In this subgroup of patients, the aim of the treatment is usually palliative and endoscopic stenting, which demonstrates feasibility but with lower rate of clinical success ^[9]. Surgical treatment should be evaluated according to the performance status of the patients and to the resectability of the primary neoplasia.

2. Palliative Colonic Stenting

In patients with LBO due to colorectal cancer and advanced/metastatic disease that are not eligible for curative treatment, surgical or non-surgical palliation should be considered. Resection, bypass, and colostomy are the available surgical options, but the European Society of Gastrointestinal Endoscopy (ESGE) Guideline ^[10] strongly recommends colonic stenting as the preferred treatment for the palliation of malignant colonic obstruction. Some studies comparing colonic stenting and ES for palliation [11,12,13,14,15,16,17,18]^{[11][12][13][14][15][16][17][18]} showed a that technical success of stent placement ranged from 88% to 100%, while the initial clinical relief of obstruction was significantly higher after palliative surgery compared to colonic stenting ^[12]. Conflicting results have been reported regarding short-term mortality and overall morbidity [11^{[11][12][13][14][15]},12,13,14,15], but colonic stenting was associated with a shorter length of stay, lower costs, a lower intensive care unit admission rate and a shorter time to the initiation of chemotherapy [11,12,13,14,15,17,18]^{[11][12][13][14][15][17][18]}. Furthermore, patients treated with endoscopic stenting had better quality of life if compared to patients treated with palliative surgery until 12 months after the procedure ^[18]. However, some observational studies [9,19,20]^[9][19][20] showed lower technical success and an increased complication rate for colonic stenting in patients with peritoneal metastases, because the main limitations to the success of bowel stenting are the presence of multiple sites of obstruction. In this situation, a surgical approach could be considered.

3. SEMS Role as Bridge to Surgery

Placement of an SEMS before elective surgery has the rationale to allow resolution of the obstruction and consequently to obtain patients’ stabilization, improvement of general conditions and nutritional status, accurate staging and definition of a tailored treatment for the patients ^[21]. As a result, higher quality oncologic resections could be performed using minimally invasive approaches and without the need for permanent stoma ^[22]. However, some controversies have emerged regarding the oncological safety of SEMS. It has been speculated that the increased interstitial pressure in the neoplastic mass can cause cell dissemination, cell shedding and tumor embolization into lymphatic vessels, as a consequence of a higher rate of recurrence observed in patients with SEMS [23,24]^[23][24]. For these reasons, choosing the most appropriate decompression method can be challenging given the need to balance short- and long-term outcomes. Moreover, guidelines on this topic are inconsistent about the optimal treatment to choose [10,25,26]^[10][25][26]. Several randomized trials investigated this issue and were summarized in several meta-analyses [21,27,28,29,30,31,32,33^{[21][27][28][29][30][31][32][33][34][35]},34,35], which compared short- and long-term outcomes of ES and stenting as a bridge to surgery in malignant LBO (Table 1). Considering short-term outcomes, multiple studies demonstrated that post-operative morbidity, such as the rate of anastomotic leak and wound infection, was significantly lower in patients who underwent stenting as a bridge to surgery [27,29,31,32,33,35]^{[27][29][31][32][33][35]}; among these, only one study also showed a significantly lower post-operative mortality ^[33] in this group of patients. Other short-term surgical outcomes that have a significant impact on patients’ quality of life, such as the rate of temporary [27,29,32,33]^{[27][29][32][33]} or permanent [27,29,35]^[27][29][35] stoma, were significantly lower in the group of stenting as a bridge to surgery with an odds ratio (OR) of 0.39 ^[33]. Finally, two meta-analyses [32,33]^[32][33] compared the rate of laparoscopic versus open resection in the two groups, finding a significantly higher rate of laparoscopic resection in the endoscopic stenting group. On the other hand, the implantation of an endoscopic stent may increase the length of stay in order to wait for the time for recanalization and optimal timing for surgery [29,32]^[29][32]; however, this hospitalization time is usually exploited for the correct clinical staging, for patients’ stabilization and restarting of enteral nutrition.

Table 1. Short- and long-term outcomes of Emergency Surgery and Stent as Bridge to Surgery (SBTS) in malignant bowel obstruction reported in the most recent meta-analyses. Green color: outcomes in favor of SBTS; red color: outcomes in favor of ES; yellow color: outcomes in which ES and SBTS are not significantly different.

Meta-Analyses		Short-Term Outcomes						Long-Term Outcomes
	Included Studies	Morbidity	Mortality	Stoma Rate	Permanent Stoma	VLS	LOS	OS	DFS	Local Recurrence
Allievi 2017, ^[27]	7 RCTs (448 pts)	ES 54.8% vs. SBTS 37.8% (p = 0.02)	ns	ES 46.0% vs. SBTS 28.9% (p < 0.0001)	ES 35.2% vs. SBTS 24.5% (p < 0.02)	/	/	/	/	/
Amelung 2018, ^[28]	5 RCTs, 4 prospective, 12 retrospective (1919 pts)	/	/	/	/	/	/	3 years and 5 years: ns	3 years and 5 years: ns	ns
Arezzo 2017, ^[29]	8 RCTs (497 pts)	ES 51.2% vs. SBTS 33.9% (p = 0.023)	ns	ES 51.4% vs. SBTS 33.9% (p < 0.001)	ES 35.2% vs. SBTS 22.2% (p = 0.003)	/	ES 14.5 d vs. SBTS 15.5 (p = 0.039)	/	/	ES 26.6% vs. SBTS 40.5% (p = 0.09)
Cao 2019, ^[30]	5 RCTs, 3 prospective, 16 retrospective (2508 pts)	/	/	/	/	/	/	3 years and 5 years: ns	3 years and 5 years: ns	ns
Ceresoli 2017, ^[21]	5 RCTs, 3 prospective, 9 retrospective	/	/	/	/	/	/	ns	Ns	ns
Foo 2019, ^[31]	7 RCTs (448 pts)	Reduced in SBTS (RR 0.6, p = 0.032)	ns	/	/	/	/	3 years: ns	3 years: ns	ns
Jain 2020, ^[32]	8 RCTs, 25 observational (15,224 pts)	SBTS vs. ES: anastomotic leak OR 0.59 (p = 0.006), wound infection OR 0.64 (p = 0.004)	SBTS vs. ES: OR 0.69 (p = 0.010)	SBTS vs. ES: OR 0.39 (p < 0.001)	ns	SBTS vs. ES: OR 5.9 (p < 0.001)	SBTS vs. ES: Reduction in ES (<0.001)	ns	Ns	ns
Kanaka 2022, ^[33]	Right-sided MLBO:#break#7 observational studies (5136 pts)	SBTS vs. ES: OR 0.78 (p = 0.003)	SBTS vs. ES: OR 0.51 (p = 0.03)	SBTS 2.0% vs. ES 11.0% (p < 0.01))	/	SBTS 48.5% vs. ES 15.7% (p < 0.01)	/	/	/	/
Matsuda 2015, ^[34]	2 RCTs, 9 observational studies (1136 pts)	/	/	/	/	/	/	3 y and 5 y: ns	3 y and 5 y: ns	/
McKechnie 2023, ^[35]	Network meta-analysis: 53 studies	ES vs. SBTS: OR 2.14 (p < 0.0019	ns	/	ES vs. SBTS: OR 2.91 (p < 0.001)	/	/	3 y and 5 y: ns	/	/

ES, emergency surgery; SBTS, stent as a bridge to surgery; VLS, videolaparoscopy; LOS, length of stay; OS, overall survival; DFS, disease-free survival; RCT, randomized controlled trials; pts, patients; OR, odd ratio. While short-term outcomes are globally in favor of the bridge-to-surgery approach, less evidence supports this kind of approach for long-term outcomes. Different meta-analyses failed to find any differences between ES and stenting as a bridge to surgery in terms of overall survival [21,28,30,31,32,34,35]^{[21][28][30][31][32][34][35]} or disease-free survival [21,28,30,31,32,34]^{[21][28][30][31][32][34]} at three or five years. Moreover, the meta-analysis by Arezzo et al. found a higher local recurrence rate in the stent as a bridge to surgery group that was not even statistically significant (40.5% vs. 26.6%, p = 0.09) ^[29]. However, several other meta-analyses did not confirm this finding [21,28,30,31,32]^{[21][28][30][31][32]}. In conclusion, the current available evidence on the role of endoscopic stenting as a bridge to surgery are globally weak. However, short-term outcomes such as the rate of permanent or temporary stoma, which significantly affect patients’ quality of life, are significantly improved with the endoscopic stenting. It is therefore recommended to propose the endoscopic stenting as a first line of treatment in this situation only if the global organization of the Institution (i.e., on-call endoscopist with expertise in radiological procedure availability 24 h a day) and an agreed pathway with surgeons allow this kind of approach. As an alternative, ES remains a valid option for the treatment of resectable patients with acute malignant colonic obstruction.

References

Sung, H.; Ferlay, J.; Siegel, R.L.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J. Clin. 2021, 71, 209–249.
Seoane Urgorri, A.; Saperas, E.; O’Callaghan Castella, E.; Pera Román, M.; Raga Gil, A.; Riu Pons, F.; Barranco Priego, L.; Dedeu Cusco, J.M.; Pantaleón Sánchez, M.; Alvarez, M.A.; et al. Colonic stent vs surgical resection of the primary tumor. Effect on survival from stage-IV obstructive colorectal cancer. Rev. Esp. Enferm. Dig. 2020, 112, 694–700.
Sarani, B.; Paspulati, R.M.; Hambley, J.; Efron, D.; Martinez, J.; Perez, A.; Bowles-Cintron, R.; Yi, F.; Hill, S.; Meyer, D.; et al. A multidisciplinary approach to diagnosis and management of bowel obstruction. Curr. Probl. Surg. 2018, 55, 394–438.
Davids, P.H.; Groen, A.K.; Rauws, E.A.; Tytgat, G.N.; Huibregtse, K. Randomised trial of self-expanding metal stents versus polyethylene stents for distal malignant biliary obstruction. Lancet 1992, 340, 1488–1492.
Ormando, V.M.; Palma, R.; Fugazza, A.; Repici, A. Colonic stents for malignant bowel obstruction: Current status and future prospects. Expert. Rev. Med. Devices 2019, 16, 1053–1061.
Botrel, T.E.A.; Clark, L.G.O.; Paladini, L.; Clark, O.A.C. Efficacy and safety of bevacizumab plus chemotherapy compared to chemotherapy alone in previously untreated advanced or metastatic colorectal cancer: A systematic review and meta-analysis. BMC Cancer 2016, 16, 677.
Baron, T.H. Technique of colonic stenting. Tech. Gastrointest. Endosc. 2014, 16, 108–111.
Trompetas, V.; Saunders, M.; Gossage, J.; Anderson, H. Shortcomings in colonic stenting to palliate large bowel obstruction from extracolonic malignancies. Int. J. Color. Dis. 2010, 25, 851–854.
Faraz, S.; Salem, S.B.; Schattner, M.; Mendelsohn, R.; Markowitz, A.; Ludwig, E.; Zheng, J.; Gerdes, H.; Shah, P.M. Predictors of clinical outcome of colonic stents in patients with malignant large-bowel obstruction because of extracolonic malignancy. Gastrointest. Endosc. 2018, 87, 1310–1317.
van Hooft, J.E.; Bemelman, W.A.; Oldenburg, B.; Marinelli, A.W.; Lutke Holzik, M.F.; Grubben, M.J.; Sprangers, M.A.; Dijkgraaf, M.G.; Fockens, P. Self-expandable metal stents for obstructing colonic and extracolonic cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline—Update 2020. Endoscopy 2020, 52, 389–407.
Liang, T.W.; Sun, Y.; Wei, Y.C.; Yang, D.X. Palliative treatment of malignant colorectal obstruction caused by advanced malignancy: A self-expanding metallic stent or surgery? A system review and meta-analysis. Surg. Today 2014, 44, 22–33.
Ribeiro, I.B.; Bernardo, W.M.; Martins, B.D.C.; de Moura, D.T.H.; Baba, E.R.; Josino, I.R.; Miyahima, N.T.; Coronel Cordero, M.A.; Visconti, T.A.C.; Ide, E.; et al. Colonic stent versus emergency surgery as treatment of malignant colonic obstruction in the palliative setting: A systematic review and meta-analysis. Endosc. Int. Open 2018, 6, E558–E567.
Takahashi, H.; Okabayashi, K.; Tsuruta, M.; Hasegawa, H.; Yahagi, M.; Kitagawa, Y. Self-Expanding Metallic Stents Versus Surgical Intervention as Palliative Therapy for Obstructive Colorectal Cancer: A Meta-analysis. World J. Surg. 2015, 39, 2037–2044.
Zhao, X.D.; Cai, B.B.; Cao, R.S.; Shi, R.H. Palliative treatment for incurable malignant colorectal obstructions: A meta-analysis. World J. Gastroenterol. 2013, 19, 5565–5574.
Abelson, J.S.; Yeo, H.L.; Mao, J.; Milsom, J.W.; Sedrakyan, A. Long-term Postprocedural Outcomes of Palliative Emergency Stenting vs Stoma in Malignant Large-Bowel Obstruction. JAMA Surg. 2017, 152, 429–435.
Young, C.J.; Zahid, A. Randomized controlled trial of colonic stent insertion in non-curable large bowel obstruction: A post hoc cost analysis. Color. Dis. 2018, 20, 288–295.
Karoui, M.; Charachon, A.; Delbaldo, C.; Loriau, J.; Laurent, A.; Sobhani, I.; Tran Van Nhieu, J.; Delchier, J.C.; Fagniez, P.L.; Piedbois, P.; et al. Stents for palliation of obstructive metastatic colon cancer: Impact on management and chemotherapy administration. Arch. Surg. 2007, 142, 619–623.
Young, C.J.; De-Loyde, K.J.; Young, J.M.; Solomon, M.J.; Chew, E.H.; Byrne, C.M.; Salkeld, G. and Faragher, I.G. Improving Quality of Life for People with Incurable Large-Bowel Obstruction: Randomized Control Trial of Colonic Stent Insertion. Dis. Colon. Rectum. 2015, 58, 838–849.
Park, Y.E.; Park, Y.; Park, S.J.; Cheon, J.H.; Kim, W.H.; Kim, T.I. Outcomes of stent insertion and mortality in obstructive stage IV colorectal cancer patients through 10 year duration. Surg. Endosc. 2019, 33, 1225–1234.
Park, J.J.; Rhee, K.; Yoon, J.Y.; Park, S.J.; Kim, J.H.; Youn, Y.H.; Kim, T.I.; Park, H.; Kim, W.H.; Cheon, J.H. Impact of peritoneal carcinomatosis on clinical outcomes of patients receiving self-expandable metal stents for malignant colorectal obstruction. Endoscopy 2018, 50, 1163–1174.
Ceresoli, M.; Allievi, N.; Coccolini, F.; Montori, G.; Fugazzola, P.; Pisano, M.; Sartelli, M.; Catena, F.; Ansaloni, L. Long-term oncologic outcomes of stent as a bridge to surgery versus emergency surgery in malignant left side colonic obstructions: A meta-analysis. J. Gastrointest. Oncol. 2017, 8, 867–876.
Shin, S.J.; Kim, T.I.; Kim, B.C.; Lee, Y.C.; Song, S.Y.; Kim, W.H. Clinical application of self-expandable metallic stent for treatment of colorectal obstruction caused by extrinsic invasive tumors. Dis. Colon. Rectum. 2008, 51, 578–583.
Lemoine, L.; Sugarbaker, P.; Van der Speeten, K. Pathophysiology of colorectal peritoneal carcinomatosis: Role of the peritoneum. World J. Gastroenterol. 2016, 22, 7692–7707.
Hayashi, K.; Jiang, P.; Yamauchi, K.; Yamamoto, N.; Tsuchiya, H.; Tomita, K.; Moossa, A.R.; Bouvet, M. and Hoffman, R.M. Real-time imaging of tumor-cell shedding and trafficking in lymphatic channels. Cancer Res. 2007, 67, 8223–8228.
Pisano, M.; Zorcolo, L.; Merli, C.; Cimbanassi, S.; Poiasina, E.; Ceresoli, M.; Agresta, F.; Allievi, N.; Bellanova, G.; Coccolini, F.; et al. 2017 WSES guidelines on colon and rectal cancer emergencies: Obstruction and perforation. World J. Emerg. Surg. 2018, 13, 36.
Ferrada, P.; Patel, M.B.; Poylin, V.; Bruns, B.R.; Leichtle, S.W.; Wydo, S.; Sultan, S.; Haut, E.R.; Robinson, B. Surgery or stenting for colonic obstruction: A practice management guideline from the Eastern Association for the Surgery of Trauma. J. Trauma. Acute Care Surg. 2016, 80, 659–664.
Allievi, N.; Ceresoli, M.; Fugazzola, P.; Montori, G.; Coccolini, F.; Ansaloni, L. Endoscopic Stenting as Bridge to Surgery versus Emergency Resection for Left-Sided Malignant Colorectal Obstruction: An Updated Meta-Analysis. Int. J. Surg. Oncol. 2017, 2017, 2863272.
Amelung, F.J.; Burghgraef, T.A.; Tanis, P.J.; van Hooft, J.E.; Ter Borg, F.; Siersema, P.D.; Bemelman, W.A.; Consten, E.C.J. Critical appraisal of oncological safety of stent as bridge to surgery in left-sided obstructing colon cancer: A systematic review and meta-analysis. Crit. Rev. Oncol. Hematol. 2018, 131, 66–75.
Arezzo, A.; Passera, R.; Lo Secco, G.; Verra, M.; Bonino, M.A.; Targarona, E.; Morino, M. Stent as bridge to surgery for left-sided malignant colonic obstruction reduces adverse events and stoma rate compared with emergency surgery: Results of a systematic review and meta-analysis of randomized controlled trials. Gastrointest. Endosc. 2017, 86, 416–426.
Cao, Y.; Gu, J.; Deng, S.; Li, J.; Wu, K.; Cai, K. Long-term tumour outcomes of self-expanding metal stents as ‘bridge to surgery’ for the treatment of colorectal cancer with malignant obstruction: A systematic review and meta-analysis. Int. J. Color. Dis. 2019, 34, 1827–1838.
Foo, C.C.; Poon, S.H.T.; Chiu, R.H.Y.; Lam, W.Y.; Cheung, L.C.; Law, W.L. Is bridge to surgery stenting a safe alternative to emergency surgery in malignant colonic obstruction: A meta-analysis of randomized control trials. Surg. Endosc. 2019, 33, 293–302.
Jain, S.R.; Yaow, C.Y.L.; Ng, C.H.; Neo, V.S.Q.; Lim, F.; Foo, F.J.; Wong, N.W.; Chong, C.S. Comparison of colonic stents, stomas and resection for obstructive left colon cancer: A meta-analysis. Tech Coloproctol. 2020, 24, 1121–1136.
Kanaka, S.; Matsuda, A.; Yamada, T.; Ohta, R.; Sonoda, H.; Shinji, S.; Takahashi, G.; Iwai, T.; Takeda, K.; Ueda, K.; et al. Colonic stent as a bridge to surgery versus emergency resection for right-sided malignant large bowel obstruction: A meta-analysis. Surg. Endosc. 2022, 36, 2760–2770.
Matsuda, A.; Miyashita, M.; Matsumoto, S.; Matsutani, T.; Sakurazawa, N.; Takahashi, G.; Kishi, T.; Uchida, E. Comparison of long-term outcomes of colonic stent as “bridge to surgery” and emergency surgery for malignant large-bowel obstruction: A meta-analysis. Ann. Surg. Oncol. 2015, 22, 497–504.
McKechnie, T.; Springer, J.E.; Cloutier, Z.; Archer, V.; Alavi, K.; Doumouras, A.; Hong, D.; Eskicioglu, C. Management of left-sided malignant colorectal obstructions with curative intent: A network meta-analysis. Surg. Endosc. 2023, 37, 4159–4178.