To date, the scientific literature on health variables for Escherichia coli antimicrobial resistance (AMR) has been investigated throughout several systematic reviews, often with a focus on only one aspect of the One Health variables: human, animal, or environment.
Variable | Subcategory | Number of Participants (Number of Studies Investigating Variable) |
Magnitude of Association OR (95% CI) |
Importance Rating * |
---|
Variable | Subcategory | Number of Participants (Number of Studies Investigating Variable) |
Magnitude of Association OR (95% CI) |
Importance Rating * |
||
---|---|---|---|---|---|---|
Antibiotic use | General antibiotic use | 6 studies (NR) | 1.51 (1.17–1.94) [15] | + | ||
Living standards | Lower socioeconomic status | 2775 (1 study) | 1.33 (1.07–1.75) [34] | + | ||
1528 (6 studies) | 1.58 ** (1.16–2.16) [46][24 | |||||
2775 (1 study) | ] | |||||
2.47 (1.08–5.66) | [34] | 1297 (5 studies) | 1.63 ** (1.19–2.24) [46][24] | |||
Day-care attendance | NR (6 studies) | 1.49 (1.17–1.91) [ | 449 (1 study) | 1.8 (1.0–3.1) [48][23] | ||
88 studies (NR) | 2.33 (2.19–2.49) [36][30] | |||||
NR (5 studies) | 2.65 (1.70–4.12) [41][31] | |||||
172 (1 study) | 3.1 (1.4–6.7) [48][23] | |||||
484 (1 study) | 4.0 (1.6–10.0) [48][23] | |||||
300 (1 study) | 4.6 (1.9–11.0) [48][23] | |||||
140 (1 study) | 5.6 (2.1–14.8) [48][23] | |||||
Trimethoprim and β-lactams | 179 (2 studies) | 3.2 (0.9–10.8) [35][25] | 0 | |||
Beta-Lactam | 290 (1 study) | 4.5 (1.8–11.0) [48][23] | +++ | |||
510 (1 study) | 4.6 (2.0–10.7) [48][23] | |||||
(Fluoro)Quinolone | 449 (1 study) | 2.1 (0.6–7.3) [48][23] | + | |||
200 (1 study) | 2.6 (1.3–5.1) [48][23] | |||||
140 (1 study) | 9.9 (2.2–44.6) [48][23] | |||||
290 (1 study) | 19.0 (3.3–111.4) [48][23] | |||||
Penicillin | 7170 (1 study) | 0.9 (0.5–1.7) [48][23] | 0 | |||
408 (1 study) | 2.7 (1.2–6.3) [48][23] | |||||
Cephalosporin | 74 (1 study) | 1.5 (5.4–85.2) [48][23] | + | |||
200 (1 study) | 2.2 (1.01–5.0) [48][23] | |||||
408 (1 study) | 2.2 (1.1–4.5) [48][23] | |||||
200 (1 study) | 3.9 (1.8–8.5) [48][23] | |||||
Macrolides | 7170 (1 study) | 1.5 (1.1–2.2) [48][23] | 0 | |||
41 | ] | [31] | 0 | |||
Living in Northern vs. Southern Europe | 7170 (1 study) | 0.4 (0.2–0.7) [48][23] | 0 | |||
Travel | International travel | 1887 (6 studies) | 4.06 ** (1.33–2.41) [46][24] | +++ | ||
834 (1 study) | 21 (4.5–97) [48][23] | |||||
To Asia | NR (4 studies) | 1.78 (0.64–4.98) [15] | ++ | Nitrofurantoin | 7170 (1 study) | 1.54 (1.1–2.3) [ |
Animal | Subcategory | Number of Studies Investigating Variable (Number of Participants) |
Magnitude of Association OR (95% CI) |
Importance of Rating * | ||||
---|---|---|---|---|---|---|---|---|
Pets | Pet owner | 963 (5 studies) | 1.39 ** (0.89–2.18) [44,[2446]][40] | − | ||||
9403 (12 studies) | 1.18 ** (0.83–1.68) [44][40] | |||||||
5159 (4 studies) | 1.15 (0.33–4.06) [15] | |||||||
Dog owner | 9403 (12 studies) | 0.88 ** (0.56–1.40) [44][40] | − | |||||
Cat owner | 9403 (12 studies) | 1.16 ** (0.58–2.34) [44][40] | − | |||||
Rodent owner | 9403 (12 studies) | 1.34 ** (0.43–4.18) [44][40] | ||||||
NR (12 studies) | 14.16 (5.50–36.45) [54][35] | |||||||
− | 370 (1 study) | 30.0 (6.3–147.2) [45][36] | ||||||
To Africa | NR (3 studies) | |||||||
Bird owner | 9403 (12 studies) | 0.91 ** (0.38–2.18) 0.94 ** (0.14–6.17) [46][24] | − | |||||
48 | ||||||||
] | ||||||||
[ | ||||||||
23 | ||||||||
] | ||||||||
0 | ||||||||
Longer duration of course | ||||||||
(>7 days vs. <7 days amoxicillin and trimethoprim) | ||||||||
[ | 44 | ] | [ | To India | 182 (3 studies) | 2.4 ** (1.26–4.58) [46][24] | + | |
40 | NR (3 studies) | 3.80 (2.23–6.47) [15] | ||||||
] | − | Health while traveling | Inflammatory bowel disease | 5253 (20 studies) | 2.09 (1.16–3.77) [43][37] | 0 | ||
Diarrhea | NR (4 studies) | 1.65 (1.02–2.68) [15] | + | |||||
5253 (20 studies) | 1.69 (1.25–2.30) [43][37] | 1521 (2 studies) | 1.50 (0.76–2.92) | |||||
NR (12 studies) | 2.02 (1.45–2.81) [54][35] | |||||||
430 (1 study) | 31.0 (2.7–358.1) [45][36] | |||||||
Environment | Contact with healthcare while traveling | 5253 (20 studies) | 1.53 (1.09–2.15) [43][37] | 0 | ||||
Antibiotic use | 5253 (20 studies) | 2.38 (1.88–3.00) [43][37] | + | [42][26] | 0 | |||
NR (12 studies) | 2.78 (1.76–4.39) [54][35] | |||||||
NR (4 studies) | 2.81 (1.47–5.36) [15] | |||||||
99 (1 study) | 3.0 (1.4–6.7) [45][36] | |||||||
99 (1 study) | ||||||||
Freshwater | Swimming | 290 (1 study) | 2.1 (1.02–4.3) [48][23] | 0 | 5.0 (1.1–26.2) [45][36] | |||
Traveler demographics | Backpackers compared to other travelers | 5253 (20 studies) | 1.46 (1.20–1.78) [43][37] | 0 | ||||
Vegetarian diet | 5253 (20 studies) | 1.41 (1.01–1.96) [43][37] | + | 1521 (2 studies) | 2.89 (1.44–5.78) [42][26] | |||
Multiple courses (>3 courses vs. 1 course, trimethoprim, amoxicillin, trimethoprim) |
1521 (2 studies) | 0.4 (0.12–1.31) [42][ | ||||||
NR (3 studies) | 26 | ] | ++ | |||||
1.92 (1.13–3.26) | [15] | 1521 (2 studies) | 3.95 (1.06–14.72) [ | |||||
Diet associated with risk (pastry, meals from stalls, etc.) | NR (12 studies) | 1.27 (0.67–2.41) [54]42][26] | ||||||
1521 (2 studies) |
Variable | Subcategory | Number of Studies Investigating Variable (Number of Participants) |
Magnitude of Association OR (95% CI) |
Importance of Rating * | |||
---|---|---|---|---|---|---|---|
Time after antibiotic use |
One week | 129 (2 studies) | 7.1 (4.2–12) [35][25] | 0 | |||
Two weeks | NR (6 studies) | 1.08 (0.6–1.96) [38][42] | + | ||||
NR (1 study) | 6.12 (3.18–11.76) [39][41] | ||||||
One month | NR (6 studies) | 1.38 (1.16–1.64) [38][42] | ++ | ||||
93 (1 study) | 1.8 (0.9–3.6) [35][25] | ||||||
NR (1 study) | 6.20 (2.14–15.96) [39][41] | ||||||
NR (2 studies) | 8.38 (2.84–24.77) [39][41] | ||||||
1208 (3 studies) | 11.21 (7.13–17.63) [51][32] | ||||||
Two months | 14,348 (5 studies) | 2.5 (2.1–2.9) [42][26] | + | ||||
NR (1 study) | 5.08 (2.70–9.56) [38 | ||||||
3.62 (1.25–10.48) | |||||||
[ | |||||||
42 | |||||||
] | |||||||
[ | |||||||
26 | |||||||
] | |||||||
] | [42] | ||||||
Mass administration | |||||||
NR (1 study) | |||||||
3.64 (2.38–5.78) | |||||||
[ | |||||||
51 | |||||||
] | |||||||
[ | |||||||
32 | |||||||
] | +++ | ||||||
NR (5 studies) | 7.8 (3.0–20.2) [52][27] | ||||||
NR (5 studies) | 10.2 (5.9–17.8) [52][27 | ||||||
] | |||||||
NR (5 studies) | 17.1 (2.3–127.7) [52][27] | ||||||
Three months | NR (6 studies) | 1.65 (1.36–2.0) | [38][42] | ++ | |||
NR (1 study) | 3.38 (2.05–5.55) [39][41] | ||||||
1208 (3 studies) | 10.64 (3.79–29.92) [51][32] | [35 | |||||
Six months | NR (1 study) | 3.16 (1.65–6.06) [39][41] | +++ | ] | |||
1208 (3 studies) | 4.76 (1.52–14.90) [51][32] | ||||||
NR (1 study) | 13.23 (7.84–22.31) [39][41] | ||||||
12 months 11, 51, 54, 59, 60 | 14,348 (5 studies) | 1.33 (1.2–1.5) [42][− | |||||
26 | ] | + | |||||
NR (1 study) | 0.94 (0.57–1.56) [39][41] | ||||||
10,079 (13 studies) | 1.84 (1.35–2.51) [15] | ||||||
NR (1 study) | 1.89 (1.04–3.42) [39][41] | Street food consumption | |||||
Over 12 months | NR (1 study) | 0.94 (0.57–1.56) [39][41] | − | ||||
Time after return from travel |
Six weeks | 290 (1 study) | 16.4 (3.4–78.8) [48][23] | + | |||
Between six weeks and two years | 290 (1 study) | 2.2 (1.1–4.3) [48][23] | 0 | NR (2 studies) | 0.92 (0.49–1.74) [15] | + | |
NR (2 studies) | 1.37 (1.08–1.73) [15] | ||||||
NR (2 studies) | 2.09 (1.30–3.38) [15] | ||||||
Raw vegetable consumption | NR (2 studies) | 0.34 (0.12–0.93) [15] | − | ||||
NR (2 studies) | 0.58 (0.33–1.07) [15] | ||||||
NR (2 studies) | 2.18 (1.29–3.68) [15] | ||||||
Protective measures while traveling | Consuming bottled water | 5253 (20 studies) | 1.29 (0.50–3.34) [43][37] | − | Higher dose (each 200 mg trimethoprim tablet extra and 500 mg instead of 250 mg amoxicillin) |
1521 (2 studies) | 1.01 (1.01–1.02) [42][26] |
General protective measures (disposable gloves, bottled water, etc.) | NR (12 studies) | 0.83 (0.61–1.13) [ | + | ||||
54 | ] | [35] | − | 1521 (2 studies) | 2.26 (1.13–4.55) [42][26] | ||
Meticulous hand hygiene | 5253 (20 studies) | 1.10 (0.81–1.49) | Comorbidities | Previous/recurrent UTI | 7170 (1 study) | 1.3 (1.01–1.6) [48][23] | ++ |
408 (1 study) | 3.4 (1.8–6.7) [48][23] | ||||||
[ | 43 | ][37] | − | ||||
Probiotics | 5253 (20 studies) | 1.06 (0.78–1.45) [43][37] | 510 (1 study) | 3.8 (1.8–8.1) [48][23] | |||
Previous/recurrent pyelonephritis | 300 (1 study) | 1.7 (0.7–3.9) [48][23] | − | ||||
Previous catheterization | 408 (1 study) | 3.3 (1.7–6.6) [48][23] | + | ||||
Diarrhea symptoms | 5144 (7 studies) | 1.53 (1.27–1.84) [15] | 0 | ||||
Diabetes | 300 (1 study) | 1.7 (0.8–3.4) [48][23] | ++ | ||||
290 (1 study) | 3.7 (1.1–12.7) [48][23] | ||||||
484 (1 study) | 3.0 (1.1–8.0) [48][23] | ||||||
− | Recurrent acute pyelonephritis and a history of diabetes | 300 (1 study) | 4.2 (1.3–16.9) [48][23] | + | |||
Renal or urological disorder | 7170 (1 study) | 1.6 (1.0–2.5) [48][23] | − | ||||
484 (1 study) | 3.5 (1.0–11.5) [48][23] | ||||||
History prostatic disease | 510 (1 study) | 9.6 (2.1–44.8) [48][23] | + | ||||
Chronic disease | 2323 (3 studies) | 0.91 (0.13–6.53) [15] | − | ||||
Medication use | Immunosuppressive therapy | 7170 (1 study) | 1.5 (1.1–2.1) [48][23] | 0 | |||
Corticosteroids | 172 (1 study) | 24.3 (2.4–246.9) [48][23] | + | ||||
Acid suppressants | 4111 (3 studies) | 1.31 (0.11–15.5) [15] | 0 | ||||
NR (4 studies) | 1.41 (1.07–1.87) [55][33] | ||||||
Hospitalization | Previous hospitalization | 1379 (5 studies) | 1.18 ** (0.78–1.81) [46][24] | + | |||
1163 (4 studies) | 1.28 ** (0.82–2.03) [46][24] | ||||||
7170 (1 study) | 1.7 (1.3–2.3) [48][23] | ||||||
172 (1 study) | 2.9 (1.3–6.6) [48][23] | ||||||
7170 (1 study) | 3.9 (2.6–5.8) [48][23] | ||||||
449 (1 study) | 3.9 (1.2–12.7) [48][23] | ||||||
Prior surgery | 172 (1 study) | 2.8 (1.9–8.0) [48][23] | 0 | ||||
Diet | Vegetarian | 6802 (5 studies) | 1.60 (1.0043–2.5587) [15] | 0 | |||
Raw milk | 226 (1 study) | 7.54 (2.41–23.45) [15] | + | ||||
Fish | 290 (1 study) | 0.6 (0.5–0.9) [48][23] | 0 | ||||
Sex and age | Older age | 300 (1 study) | 2.0 (1.02–3.5) [48][23] | 0 | |||
Male sex | NR (9 studies) | 0.96 (0.74–1.24) [41][31] | 0 | ||||
7170 (1 study) | 1.6 (1.2–2.1) [48][23] |