2. A-Ring Heteroaromatic Hybrid Chalcone Synthesis
This section catalogues several representative conventional and green processes by which hybrid chalcones bearing a heteroaromatic species at ring A may be prepared. Heteroaromatic components of the chalcone products include a variety of single-ring (furan, pyrrole, thiazole, thiophene, pyridine, pyrimidine) and fused-ring (indole, benzimidazole, benzothiazole, benzofuran, pyrazolopyridine, quinoline) systems.
2.1. Claisen–Schmidt Condensations
The Claisen–Schmidt (C-S) condensation has been widely used to prepare chalcones for many years. This reaction, which can be catalyzed by acids or bases, offers mild conditions that tolerate a wide scope of functionality in both the ketone donors and aldehyde acceptors.
2.1.1. Base-Catalyzed C-S Condensations
The hydroxide bases KOH, NaOH and to a lesser extent Ba(OH)
2 are the bases used to promote the condensations depicted below in Scheme 1, Scheme 2, Scheme 3, Scheme 4, Scheme 5, Scheme 6, Scheme 7, Scheme 8, Scheme 9, Scheme 10, Scheme 11 and Scheme 12. These bases may be introduced to the reaction medium as dilute or concentrated aqueous solutions or as solids. Ethanol or methanol are the solvents of choice in most reactions depicted herein. The reaction temperatures vary from 0 °C to those obtained by refluxing the alcoholic solvents. The reaction times range from less than a minute in the case of selected microwave-mediated reactions and can extend to 72 h for the conventional condensations.
Scheme 1. Synthesis of pyrrolyl chalcone.
Scheme 2. Synthesis of furyl chalcone.
Scheme 3. Synthesis of furyl chalcone derivatives.
Scheme 4. Synthesis of thienyl chalcone.
Scheme 5. Synthesis of pyridyl chalcone.
Scheme 6. Synthesis of thiazolyl chalcones.
Scheme 7. Synthesis of indolyl chalcones.
Scheme 8. Synthesis of benzimidazolyl chalcones.
Scheme 9. Synthesis of thiazolyl and benzothiazolyl chalcones.
Scheme 10. Synthesis of benzofuryl chalcones.
Scheme 11. Synthesis of heteroaromatic dehydroabietic acid-chalcone hybrids.
Scheme 12. Green synthesis of pyridyl chalcone.
In first entry, three room-temperature C-S preparations of pyrrolyl chalcone
3 are presented that have differing reaction times and different base concentrations. Sweeting et al. (Scheme 1a) used strongly basic conditions (60% aqueous KOH) and centrifugation mixing to prepare the pyrrolyl chalcone
3 in a modest yield. The low yield is likely attributed to the short reaction time. Ref.
[29] Robinson et al. reported that increasing the reaction time (
[30], Scheme 1b) using NaOH (aq) in ethanol increased the yield of the pyrrolyl chalcone. Using 20 mol % NaOH (aq) in ethanol, Song et al. obtained a 91% yield in the preparation of the chalcone (Scheme 1c). Ref.
[31] Lokeshwari’s team (Scheme 2a) and Liu’s group prepared furyl chalone
5 in an 87% yield using 0.1 mol % KOH (aq) in 4 h, while Liu’s group (Scheme 2b) obtained equally high yields with 20 mol% NaOH (aq) in 6 h
[32][33]. Robinson et al. (Scheme 3) condensed 2-acetylfuran and 2-acetyl-5-methylfuran with assorted benzaldehydes at room temperature en route to the twelve furyl chalcones
8 in modest to medium yields
[34].
Parveen et al. reported a nearly quantitative conversion for the room-temperature C-S condensation of 2-acetylthiophene and benzaldehyde using aqueous KOH (Scheme 4) in ethanol to the thienyl chalcone
10 [35].
Sunduru et al. reported the preparation of pyridyl chalcone derivatives
13 by condensing 4-acetylpyridine with the respective aromatic aldehyde (Scheme 5)
[36]. In this reaction, one equivalent of 4-acetylpyridine was added dropwise to a cooled methanolic solution containing 10% aqueous NaOH. Then, one equivalent of aldehyde was added slowly at 0 °C. After workup and recrystallization, the pyridyl chalcones were obtained in yields ranging from 67 to 76% (Scheme 5).
Sinha and coworkers (Scheme 6) used similar conditions to synthesize eighteen 1,3-thiazolylchalcones
16 in very good overall yields
[37].
Zhao et al. (Scheme 7) used reflux conditions to achieve yields in excess of 60% for the small series of fused-ring indolyl chalcones
18 [38]. In two separate publications, Hsieh and coworkers used base-catalyzed C-S condensations to prepare indolyl (Scheme 8,
[39]), thiazolyl and benzothiazolyl hybrid chalcones (Scheme 9,
[40]).
Saito’s team used 5% KOH in ethanol at room temperature to prepare a series of functionalized benzofuran hybrid chalcones in yields as high as 97% (Scheme 10)
[41].
Grigoropoulou’s team found barium hydroxide octahydrate effective in promoting the condensation of both single- and fused-ring heteroaromatic ketones with dehydroabietic acid methyl ester en route to sixteen hybrid chalcones in good overall yields (Scheme 11)
[42].
Base-catalyzed C-S condensations have also been demonstrated using green principles. These processes include the use of benign solvents including water and microwave irradiation. Mubofu and Engberts reported a C-S condensation reaction of 2-acetylpyridine and benzaldehyde using 10% NaOH (Scheme 12)
[43]. The reagents were finely dispersed in water at 4 °C and after workup the pyridyl chalcone
31 was obtained in a good yield (Scheme 12).
Jianga et al. showed that the condensation of 2-acetylfuran or 2-acetylthiophene and benzaldehyde using 2 mol% NaOH (aq) gave (E)-1-(Furan-2-yl)-3-phenylprop-2-en-1-one or (E)-1-(thiophen-2-yl)-3-phenylprop-2-en-1-one at room temperature in nearly quantitative yields (Scheme 13)
[44].
Scheme 13. Green synthesis of furyl and thienyl chalcones.
Ritter et al. (Scheme 14) used 2-acetylthiophene
9 and assorted benzaldehydes in glycerin solvent to prepare seven 2-thienochalcones
10 and
32a–f in very good yields
[45].
Scheme 14. Green synthesis of 2-thienyl chalcones.
Khan and Asiri (Scheme 15) showed that 3-acetylthiophene
33 underwent a microwave-mediated C-S condensation with several benzaldehydes in less than a minute to give thienyl chalcones
34a–f in yields exceeding 82%
[46].
Scheme 15. Microwave synthesis of 3-thienyl chalcones.
Sarveswari and Vijayakumar (
Scheme 16) conducted a comparative study of conventional and microwave processes in which four examples of highly substituted quinolinyl hybrid chalcones
36a–d were prepared
[47]. Both processes gave the desired chalcones in yields greater than 75%. Particularly noteworthy is the fact that the microwave reaction time is 1/144 of the conventional reaction time.
Scheme 16. Synthesis of quinolinyl chalcones.
Polo et al. demonstrated that sonochemical mediation was very effective in preparing a series of pyrazolopyridyl hybrid chalcones
38a–e (Scheme 17) in high yields that compare favorably with conventional base-catalyzed C-S condensations
[48].
Scheme 17. Sonochemical synthesis of pyrazolopyridyl chalcones.
2.1.2. Acid-Catalyzed C-S Condensations
In the recent literature, Adnan et al. showed that
p-toluenesulfonic acid (PTSA) effectively catalyzed the condensation of 2-acetylthiophene (
9) and
p-tolualdehyde (
2) in a green solventless process in which the reactants were ground in a warm mortar and pestle for 4 min to give the thienyl chalcone
32e in a very good yield
[11]. See
Scheme 18.
Scheme 18. PTSA-catalyzed synthesis of thienyl chalcone.
Shaik et al. reported an acid-catalyzed condensation reaction of 2,4-dimethyl-5-acetylthiazole with 2,4-difluorobenzaldehyde to prepare (E)-1-(2′,4′-dimethyl)-(5-acetylthiazole)-(2,4″-difluorophenyl)-prop-2-en-1-one (Scheme 19)
[21].
Scheme 19. Acid-catalyzed synthesis of thiazolyl chalcone.
2.2. Non C-S Condensations
The final installment of A-ring hybrid chalcone synthesis is an interesting green coupling reaction between a series of arylacetylene derivatives (
42a–j) and various pyridine and benzopyridine carboxaldehydes (Scheme 20). Yadav’s group showed that a copper-based silica-coated magnetic nanocatalyst (Cu@DBM@ASMNPs) used in conjunction with a piperidine base was very effective in preparing ten hybrid chalcones in yields ranging from 49 to 94%
[49]. A noteworthy feature of this reaction was the ability to recover the catalyst via a magnet. The catalyst was reported to be efficient for up to seven reaction cycles.
Scheme 20. Cu-based nanocatalyzed A3 synthesis of pyridyl- and benzopyridyl chalcones.
3. B-Ring Heteroaromatic Hybrid Chalcone Synthesis
This section catalogues selected conventional and green processes by which hybrid chalcones containing a heteroaromatic component at ring B may be prepared. In addition, examples of tandem ring-opening dipolar additions to obtain ring B heteroaromatic substituted chalcones are presented. The heteroaromatic components of the chalcone products highlighted in this section include a variety of single-ring (furan, pyrrole, pyrazole, thiazole, thiophene, pyridine) and fused-ring (indole, benzimidazole, benzothiazole, benzofuran, quinoline, imidazo [1,2-a]pyrimidine or imidazo [1,2-a]pyridine, quinoxaline, carbazole) systems.
3.1. Claisen–Schmidt Condensations
As in the preceding section, Claisen–Schmidt (C-S) condensation has been widely used to prepare B-ring heteroaromatic chalcones. This reaction, which can be catalyzed by bases or acids, offers mild conditions that tolerate a wide scope of functionality in both the ketone donors and aldehyde acceptors.
Base-Catalyzed C-S Condensations
In the preparations shown below, NaOH and KOH are the bases of choice. Shown in Scheme 21, Li et al. used dilute aqueous KOH to prepare pyrrolyl chalcone (
46) in a very good yield. Using mild conditions, Robinson et al. (Scheme 22) condensed acetophenones
47 and furfural derivatives
48 to prepare five furyl chalcones (
49a–e) that show promise as monoamine oxidase inhibitors in low to medium yields
[34].
Scheme 21. Pyrrolyl chalcone synthesis.
Scheme 22. Furyl chalcone synthesis.
In Scheme 23, Fu and coworkers reacted 1,2,3-triazole-substituted acetophenones
50 with furfural
48 and thiophene-2-carbaldehyde
51 in ethanolic KOH for 3 h to prepare hybrid chalcones
52a and
52b in satisfactory yields. Condensation of
50 and pyridine carbaldehydes
53a–b under the same conditions provided eight additional pyridyl hybrid chalcone examples
54a–h in yields ranging from 50 to 79%
[50].
Scheme 23. Furyl, thienyl and pyridyl chalcone synthesis.
Gadhave and Uphade demonstrated the satisfactory condensation of 4-morpholinoacetophenone
55 with 4-pyrazolocarbaldehydes
56 conducted at room temperature, which provided five examples of 4-pyrazolylchalcones
57 [51]. See Scheme 24.
Scheme 24. Pyrazolyl chalcone synthesis.
An interesting study conducted by Mallik and associates involves the preparation of pyrrole-substituted hybrid chalcones from the C-S condensation of several acetophenones
58 and 2-formylpyrrole
44 under different molar ratios of
58:
44 [52]. As Scheme 25 shows, the desired product
59 predominated when the reactant molar ratios were 1:1, but when the ratio was lowered to 1:2, a nearly equal proportion of the product mixture was found to be the heteroaromatic ketone
60. Upon increasing the molar proportion of
58 to four times that of
44, ketone
60 was the major product. The authors propose an interesting mechanism by which
60 is formed—a twin aldol addition—intramolecular cyclization-dehydration.
Scheme 25. Pyrrolyl chalcone synthesis.
Fused-ring heteroaromatic aldehydes have also been successfully condensed with various acetophenones to prepare B-ring hybrid chalcones under typical C-S reaction conditions. Zhao et al. prepared indole hybrid chalcones
63a–e (Scheme 26) from assorted acetophenones and N-methylindolycarbaldehydes
62 in yields ranging from 60 to 90%
[38].
Scheme 26. Indolyl chalcone synthesis.
Bandgar and coworkers (Scheme 27) synthesized a diverse library of carbazole hybrid chalcones
66 [28], while Bindu’s team condensed acetophenone derivatives with quinoline carboxaldehdes
68 under mild C-S conditions (Scheme 28) to prepare eight examples of B-ring-substituted quinolinoid hybrid chalcones
68a–h [53]. Abonia et al. prepared the chromen-4-one—quinoline hybrid chalcone
71 under similar conditions
[54]. See Scheme 29.
Scheme 27. Carbazolyl hybrid chalcone synthesis.
Scheme 28. Quinolinyl hybrid chalcone synthesis.
Scheme 29. Quinoxalinyl hybrid chalcone synthesis.
Desai and coworkers used mild C-S reaction conditions to prepare a series of thirteen quinoxalinyl hybrid chalcones
73a–m in yields ranging from 60 to 95%, as shown in Scheme 29
[22].
In a study of microtubule polymerization inhibition, Sun et al. synthesized a library of fused-ring heteroaromatic chalcones featuring indoles, benzofurans, dibenzofurans, benzothiophenes, dibenzothiophenes, and benzimidazoles
[55]. See
Figure 4. Of particular note were the numerous methods used in the preparation of these hybrid chalcones, which included both base-promoted processes (piperidine, NaOH, KOH, NaOMe, Cs
2CO
3 and NaH) in methanolic and ethanolic solvents, Lewis acid catalysis (BF
3•etherate) in dioxane solvent and Brønsted (glacial acetic acid) acid catalysis in toluene. Scheme 30 depicts the scope.
Figure 4. Hybrid chalcone heteroaromatic components prepared by Sun et al.
Scheme 30. N, O, S Fused-ring heteroaromatic hybrid chalcone synthesis.
Base-catalyzed C-S condensations that employ green chemistry principles to produce B-ring-substituted hybrid chalcones have also been successfully conducted. See Scheme 31. These processes include the use of benign solvents, solvent-free reactions, microwave irradiation, ultrasound and ball milling. For example, Ashok’s group compared a typical base-catalyzed C-S condensation of
83 and
84 with a solvent-free, microwave-mediated process to prepare a series of carbazolyl hybrid chalcones
85 [56]. The yields for the short-duration microwave-mediated reactions exceeded those of the lengthy conventional C-S reactions in every case. Bhatt et al. prepared the furyl chalcone
87 using both conventional C-S and ultrasound processes to condense furfural
48 and 2,4-dihydroxyacetophenone
86 [57]. The effectiveness of sonication is evident—a 10% increase in yield in 1/20 the reaction time. Jadhava’s team used PEG-400 as a benign solvent to mediate the condensation of 4-fluoroacetophenone 84 and a series of pyrazole carbaldehydes
85 en route to eight fluorinated pyrazolyl hybrid chalcones 86
[58]. Kudlickova and coworkers employed a mechanochemical ball-milling process to prepare a series of indoylchalcones
92 in yields ranging from 28 to 79% in only 30 min
[59]. Nimmala’s group used a solventless process to condense various acetophenones and imidazo [1,2-a]pyrimidine
93 or imidazo [1,2-a]pyridine
95 en route to hybrid chalcones
94a–f and
96a–f, respectively, in very good yields
[60]. Joshi and Saglani employed ultrasound to assist in the condensation of the fused-ring ketone
97 and a series of quinoline carbaldehydes
98 to prepare the quinolinyl hybrid chalcones
99 [61].
Scheme 31. Green syntheses of B-ring heteroaromatic hybrid chalcones.
3.2. Non C-S Condensations
The final entries describing ring-B-substituted heteroaromatic hybrid chalcones feature unique tandem reactions involving pyrylium tetrafluoroborate derivatives. Devi and colleagues conducted a very interesting examination of a single-pot, base-mediated, tandem-ring-opening, 1,3-dipolar addition reaction between several electron withdrawing group (EWG)-substituted diazo compounds
101 with tri-substituted pyrylium salts
100, producing an extensive array of pyrazole hybrid chalcones
102 in moderate to high yields, as shown in Scheme 32
[62].
Scheme 32. Synthesis of pyrazole hybrid Z-chalcones via a pyrilium.ring-opening dipolar addition.
Tan and Wang leveraged a similar pyrilium ring-opening strategy in a single-pot 3+2 reductive annulation with benzil derivatives
103 to prepare a comprehensive library of tetra-substituted Furano chalcones
105a–ii in yields as high as 70%
[63]. See Scheme 33. A noteworthy observation in both works was the finding that
Z-chalcone derivatives were the major or sole product in all instances.
Scheme 33. Synthesis of furanyl hybrid Z-chalcones via pyrilium ring-opening benzil-derivative reductive 3+2 annulation.
4. A–B Ring Dual Heteroaromatic Hybrid Chalcone Synthesis
This section catalogues selected processes by which hybrid chalcones bearing a heteroaromatic species at both rings A and B may be prepared. Of particular note is the incredibly diverse array of chalcones produced that feature 21 different heteroaromatic A–B ring-substituted groups on the hybrid chalcones shown in Scheme 34, Scheme 35, Scheme 36, Scheme 37, Scheme 38, Scheme 39, Scheme 40, Scheme 41, Scheme 42, Scheme 43, Scheme 44, Scheme 45 and Scheme 46.
Scheme 34. Synthesis of pyrrolyl–thienyl hybrid chalcones.
Scheme 35. Synthesis of thiazolyl–furyl hybrid chalcones.
Scheme 36. Synthesis of pyridyl– and thienyl–carbazole hybrid chalcones.
Scheme 37. Synthesis of pyridyl–quinoxazolyl hybrid chalcone.
Scheme 38. Synthesis of pyrrole–[(2-pyrrolyl)-3H-pyrrolizinyl] hybrid chalcone.
Scheme 39. Synthesis of pyrazinyl hybrid chalcones.
Scheme 40. Synthesis of furyl–triazolyl hybrid chalcones.
Scheme 41. Synthesis of pyrrolyl–pyridyl hybrid chalcones.
Scheme 42. Synthesis of thienyl–pyrazolyl/carbazolyl hybrid chalcones.
Scheme 43. Synthesis of quinolinyl–pyridyl/thienyl hybrid chalcones.
Scheme 44. Synthesis of pyrazolopyridyl–heteroaryl hybrid chalcones.
Scheme 45. Synthesis of twin indolyl hybrid chalcones.
Scheme 46. Synthesis of twin thienyl hybrid chalcone.
4.1. Claisen–Schmidt Condensations
As noted in the preceding sections, the Claisen–Schmidt (C-S) condensation is the most common method used to prepare A–B ring heteroaromatic chalcones. This reaction, which can be catalyzed by bases or acids, offers mild conditions that tolerate a wide scope of functionality in both the ketone donors and aldehyde acceptors.
4.1.1. Base-Catalyzed C-S Condensations
In most instances, NaOH and KOH are the most widely used bases. Sweeting’s group synthesized and obtained an X-ray crystal structure for the pyrrolyl–thienyl hybrid chalcone
106 as part of a chalcone solubility and stability study
[28]. See Scheme 34. While the use of centrifuging to mix the reagents is of interest, the low yield is likely attributable to the limited reaction time of 30 min. Sinha and coworkers prepared two thiazolyl–furyl hybrid chalcones in high yields (Scheme 35) while investigating potential ant-lipoxygenase agents
[35].
Fused-ring A–B hybrid chalcone examples have also been successfully prepared under very mild, base-catalyzed C-S conditions. Bandgar’s team prepared the pyridyl and thienyl–carbazolyl heteroaromatic hybrid chalcones
108–109 in very good yields (Scheme 36)
[27]. While investigating ACP reductase inhibition, Desai’s group prepared the pyridyl/quinoxazolyl chalcone
110 in a good yield as shown in Scheme 37
[21]. Mallik et al. found that when one equivalent of acetone and four equivalents of 2-pyrrole carbaldehyde were condensed in 20% KOH, the unusual pyrrolizinyl–pyrrolyl chalcone
112 was formed in modest yield (32%), accompanied by the acetylpyrrolizine
113 (17%)
[51]. See Scheme 38. This finding is complementary to the work shown in Scheme 25 in which similar pyrrolizine products were formed. In an examination of chalcones with potential anticancer properties, Bukhari prepared a diverse set of furyl-, thienyl-, benzofuryl, and benzothienyl-1,4-pyrazinyl chalcones
116 in yields ranging from 42 to 75%. Extending that work to include condensations of 4-heteroaromatic acetophenones
117 with pyrazine carbaldehyde
115 gave rise to an array of hybrid chalcones
118 in moderate yields
[16]. See Scheme 39.
4.1.2. Green C-S Condensations
The recent literature reports a number of green, base-promoted C-S condensations used to prepare A–B ring heteroaromatic hybrid chalcones. While studying potential antimicrobial agents, Kumar et al. synthesized ten furyl-triazolyl chalcones
120a–j via a continuous-flow reactor
[64]. Of note are the exceptional yields (84–90%) obtained in only 15 min. See Scheme 40. Moreover, in pursuit of suitable chalcones that have antimicrobial properties, Usta’s team prepared two pyrrole–pyridyl chalcones using both conventional and microwave processes
[25]. The yields reported were as high as 90% after only 3 min of irradiation. See Scheme 41.
Several syntheses of A–B ring heteroaromatic chalcones having fused-ring systems have also been reported. Khan and Asiri prepared two hybrid chalcones and tested them for antibacterial activity, a thienyl–pyrazole chalcone as well as a thienyl–carbazolyl chalcone using a microwave oven
[44]. See Scheme 42. The base-catalyzed process, completed in only 45 s, provided the chalcones in 89–90%. Quinolinyl chalcones, such as those prepared by Sarveswari and Vijayakumar in Scheme 43, have also shown promise as antibacterial and antifungal agents
[45]. Again, yields for the short-duration, microwave-mediated process was on par with or exceeded those obtained by the conventional C-S reactions conducted in their comparative study.
Acetylated pyrazolo pyridines
37 and
128 were condensed with five heteroaryl aldehydes by Polo et al. under both ultrasonic and conventional conditions to prepare interesting A–B ring hybrid chalcones substituted with furyl, pyridyl, imidazolyl and quinolinyl groups
[46]. See Scheme 44. Chalcone series
38 was part of a larger study discussed earlier in the review (Scheme 17). Yields for the short-duration ultrasound-assisted condensation met or exceeded those obtained by the conventional, base-promoted C-S condensations performed by the group.
In Scheme 45, Kumar et al. employed piperidine base to catalyze the microwave-mediated condensation of indoles
131 and
132 en route to a large array of highly differentially functionalized twin indolyl hybrid chalcones
133 [65]. The yields reported were excellent, ranging from 72 to 92%, especially given the reaction time of 5 min.
The final entry in this section is a green, solid-state, acid-catalyzed condensation of 2-acetylthiophene
9 and the thienyl carboxaldehyde
51 conducted by Adnan and associates, which produced the twin thienyl chalcone
134 in an excellent yield
[11]. See Scheme 46.
5. Heteroaromatic Bis Chalcone Hybrid Synthesis
This section catalogues several processes by which heteroaromatic bis chalcone hybrids bearing two or more heteroaromatic species have been prepared. The reactions feature both heteroaromatic donors and acceptors as the linker unit in the bis hybrid chalcone systems. Conventional and green condensations as well as a unique Wittig preparation are discussed.
5.1. Claisen–Schmidt Condensations
The Claisen–Schmidt (C-S) condensation is the most widely used method to prepare heteroaromatic bis chalcone hybrids. In this section, base-promoted condensations were present that tolerate a wide scope of functionality in both the bis-ketone donors and bis-aldehyde acceptors.
5.1.1. Base-Catalyzed C-S Condensations
As seen in the previous sections, NaOH and KOH are the most widely used bases. Methanol and ethanol are the solvents of choice in these condensations. In the first entry of bis hybrid chalcone preparation (Scheme 47), Alidmat et al. prepared three examples of mono- and dichlorinated bis-thienyl chalcones with potential as anticancer agents
[66]. Of note is the one-pot preparation of the non-symmetric bis hybrid chalcone
138 from the condensation of 4-formylbenzaldehyde
135 (1 mole) and equimolar quantities of acetylthiophenes
136 and
137. In contrast, the condensation of
135 (1 mole) with two moles of
136 or
137 resulted in the symmetric bis hybrid chalcones
139 or
141, respectively.
Scheme 47. Synthesis of bis thienyl hybrid chalcones.
While investigating photoinitiators with applications in 3D/4D printing, Chen’s group prepared several bis hybrid chalcones that show promise as light-sensitive photoinitiators. See Scheme 48. 4,4′-diacetylbiphenyl
142 was condensed with 2-formylthiophene under mild, base-promoted conditions to synthesize the bis thienyl biphenyl chalcone
143 in a good yield
[15]. Under the same reaction conditions, 2,6-diacetylpyridine
144 was condensed with several substituted benzaldehydes
145 en route to three pyridyl bis aryl hybrid chalcones
146a–
c in yields ranging from 58 to 86%.
Scheme 48. Synthesis of biphenyl bis thienyl and pyridyl bis aryl hybrid chalcones.
While investigating lung cancer cell growth inhibitors, Zhao et al. prepared the indole bis phenyl chalcone
148 by condensing 1,2-diacetyl-3-methylindole
147 with benzaldehyde in 60% yield
[52]. See Scheme 49.
Scheme 49. Synthesis of indolyl bis aryl hybrid chalcones.
Presented in Scheme 50 and Scheme 51 are green methods used to prepare bis heteroaromatic chalcones. Asir and coworkers used sonochemical mediation to prepare examples of bis thienyl and bis furyl hybrid chalcones
150a–b. The reaction time of 5 min was sufficient to give product yields in excess of 70%.
[67] In a study of the anti-inflammatory activity of 3,4-bis-chalcone-N-arylpyrazoles, Abdel-Aziz et al. prepared eight examples of assorted aryl- and heteroaryl-substituted chalcone pyrazoles
152 using an aqueous KOH/EtOH medium at 60 °C and microwave irradiation
[68]. The total reaction time reported was only four minutes to achieve yields ranging from 70 to 93%. Analogous conventional C-S condensations were also carried out over a 12 h period; the yields obtained were about 75–85% of those obtained with
μwave mediation.
Scheme 50. Sonochemical synthesis of bis thienyl and bis furyl hybrid chalcones.
Scheme 51. Microwave-mediated synthesis of bis aryl/heteroaryl chalcone pyrazoles.
5.1.2. Non C-S Condensations
The final installment for the bis hybrid chalcone section is an early example published by Saikachi and Muto in 1971
[69]. Their work, shown in Scheme 52, which focused on the preparation and utility of bisphosphoranes in oligimerization studies, exemplified how the bis-Wittig reagents
153,
155 and
157 could be successfully coupled with furan or thienylcarbaldehydes to provide a series of bis heteroaromatic chalcones
154,
156 and
158 in yields ranging from 45 to 99%. This was unique in providing the bis hybrid chalcone system with benzene, biphenyl, diphenyl ether, diphenylmethylene, and diphenylethylene linker units.
Scheme 52. Wittig synthesis of bis thienyl and bis furyl hybrid chalcones.