Vaccination is usually proposed as a safe and sustainable strategy to overcome problems related to tick infestation and disease transmission. However, progress in anti-vector vaccine development has been slow and patchy, and currently, only a handful of vaccines targeting ectoparasites have been developed and tested successfully.
Name | Target Tick Species | Cross-Protected Tick Species/Host | Vaccine Efficacy/Infestation Stage | References | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bm86 and orthologs | R. (B.) microplus | Hyalomma anatolicum anatolicum | (Koch, 1844)/cattle | 36.5% (L) | [36] | ||||||||
H. a. anatolicum | R. (B.) microplus | /cattle | 26.8% (L); 25.1% (AF) | [36] | |||||||||
R. (B.) microplus | Hyalomma dromedarii | (Koch, 1844)/cattle | 89% | a | , 98% | a | (L); 29% | a | , 36% | a | (AF) | [26] | |
R. (B.) microplus | H. dromedarii | /camel | 26.7% | a | , 31.3% | a | 38.6% | a | (AF) | [26] | |||
Subolesin and orthologs | Ornithodoros erraticus | (Lucas, 1849) | d | Ornithodoros moubata | (Murray, 1877)/rabbit | ~40.0% (L, N, AF) | [37] | ||||||
O. moubatad | O. erraticus | /rabbit | 50.3% (L, N, AF) | [37] | |||||||||
H. a. anatolicum | R. (B.) microplus | /cattle | 54% (L) | [38] | |||||||||
Rhipicephalus appendiculatus | (Neumann, 1901) | Amblyomma variegatum | (Fabricius, 1794)/cattle | b | 50% and 89% (L) | [39] | |||||||
R. appendiculatus | Rhipicephalus (Boophilus) decoloratus | (Koch, 1844)/cattle | c | 51% (L) | [39] | ||||||||
A | . | variegatum | R. appendiculatus | /cattle | b | 86% and 83% (L) | [39] | ||||||
A. variegatum | R. (B.) decoloratus | /cattle | c | 72% (L) | [39] | ||||||||
R. (B.) decoloratus | R. appendiculatus | /cattle | b | 66% and 89% (L) | [39] | ||||||||
R. (B.) decoloratus | A. variegatum | /cattle | b | 58% and 94% (L) | [39] | ||||||||
Rhipicephalus haemaphysaloides | (Supino, 1897) | Haemaphysalis longicornis | (Neumann, 1901) | 79.3% and 86.6% (AF) | [40] | ||||||||
R. (B.) decoloratus | R. appendiculatus | /cattle | 99% (L, N, AF) | [41] | |||||||||
Calreticulin | H. a. anatolicum | R. (B.) microplus | /cattle | 37.56% (L) | [38] | ||||||||
CathL | H. a. anatolicum | R. (B.) microplus | /cattle | 22.21% (L) | [38] | ||||||||
GST | H. longicornis | R. appendiculatus | /rabbit | 67% (AF) | [42] | ||||||||
R. (B.) decoloratus | / | A. variegatum | e | Rhipicephalus sanguineus | s.l. (Latreille, 1806)/rabbit | 35% (AF) | [43] | ||||||
P0 | R. sanguineus | s.l./ | R. (B.) microplus | d | R. (B.) microplus | /cattle | 96% (L) | [44] | |||||
R. sanguineus | s.l./ | R. (B.) microplus | d | Amblyomma mixtum | (Koch, 1844)/rabbit | 54% (L) | [45] | ||||||
Aquaporin | R. (B.) microplus | R. sanguineus | s.l./dog | 7.2% (L); 4.5% (N) | [46] | ||||||||
O. erraticus | O. moubata | /rabbit | 9.3% (AF) | [47] | |||||||||
ABC transporter | O. erraticus | O. moubata | /rabbit | 26.7% (AF); 15.4% (AM) | [47] | ||||||||
Selenoprotein T | O. erraticus | O. moubata | /rabbit | 18.6% (AM) | [47] | ||||||||
Ferritin | Ixodes persulcatus | (Schulze, 1930) | Ixodes ovatus | (Neumann, 1899)/guinea pig | ~40% (AF) | [48] | |||||||
Cystatin | R. (B.) microplus | R. appendiculatus | /rabbit | 11.5% (AF) | [49] | ||||||||
Chitinase | O. erraticus | O. moubata | /rabbit | 19.6% (AF) | [50] | ||||||||
Secreted protein PK-4 | O. erraticus | O. moubata | /rabbit | 8.1% (N, AM) | [50] | ||||||||
OM03, OM85 and OM99 peptides | O. moubata | O. erraticus | /rabbit | 20.7% to 66.1% (N, AF, AM) | [51] |