Cannabis sativa L. for Treatment: Comparison
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Please note this is a comparison between Version 2 by Vivi Li and Version 1 by Judyta Cielecka-Piontek.

Cannabis sativa 

L. turned out to be a valuable source of chemical compounds of various structures, showing pharmacological activity. The most important groups of compounds include phytocannabinoids and terpenes. The pharmacological activity of 

Cannabis

(in epilepsy, sclerosis multiplex (SM), vomiting and nausea, pain, appetite loss, inflammatory bowel diseases (IBDs), Parkinson’s disease, Tourette’s syndrome, schizophrenia, glaucoma, and coronavirus disease 2019 (COVID-19), which has been proven so far, results from the affinity of these compounds predominantly for the receptors of the endocannabinoid system (the cannabinoid receptor type 1 (CB

1

), type two (CB

2

), and the G protein-coupled receptor 55 (GPR

55

) but, also, for peroxisome proliferator-activated receptor (PPAR), glycine receptors, serotonin receptors (5-HT), transient receptor potential channels (TRP), and GPR, opioid receptors. The synergism of action of phytochemicals present in 

Cannabis

sp. raw material is also expressed in their increased bioavailability and penetration through the blood–brain barrier. 

  • Cannabis
  • phytocannabinoids (THC and CBD)
  • terpenes
  • multitarget
  • receptors
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