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Topic review
Updated time: 25 Apr 2021
Submitted by: Ibon Eguíluz-Gracia
Definition: Asthma is an inflammatory condition of the bronchial mucosa affecting 10% of children and 5% of adults in Western countries.
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Topic review
Updated time: 14 Mar 2021
Submitted by: Shima Tavakoli
Definition: This review presents the common commercially available skin substitutes and their clinical use. Moreover, the choice of an appropriate hydrogel type to prepare cell-laden skin substitutes is discussed. Additionally, we present recent advances in the field of bioengineered human skin substitutes using three-dimensional (3D) bioprinting techniques. Finally, we discuss different skin substitute developments to meet different criteria for optimal wound healing.
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Topic review
Updated time: 10 May 2021
Submitted by: Carmen de Jesús Gil
Definition: Psoriasis is a T cell-mediated skin disease resulting from epithelial and immunological cells’ interactions, which affects around 2% of the population worldwide. Its onset is influenced by genetic and environmental factors, particularly infections among which Streptococcus pyogenes is the best characterized. However, the commensal fungusCandida albicans has been also associated to triggering psoriasis. Here we discuss what it is known about the link betweeen Candida and psoriasis pathogenesis.
Entry Collection : Skin Pathologies
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Topic review
Updated time: 02 Feb 2021
Submitted by: Vincenzo Piccolo
Definition: Neurofibromatosis type 1 (NF1) is a complex autosomal dominant disorder associated with germline mutations in the NF1 tumor suppressor gene. NF1 belongs to a class of congenital anomaly syndromes called RASopathies, a group of rare genetic conditions caused by mutations in the Ras/mitogen-activated protein kinase pathway. Generally, NF1 patients present with dermatologic manifestations.
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Topic review
Updated time: 27 Oct 2020
Submitted by: Daniel Vasile Balaban
Definition: Pancreatic pathology, comprising acute and chronic pancreatitis, autoimmune pancreatitis and pancreatic neoplasms, primarily presents with gastrointestinal symptoms and signs; however, it is well recognized that it can also associate a wide range of extra-digestive features. Among these systemic manifestations, cutaneous involvement plays an important role both as a diagnostic clue for the pancreatic disease itself and serving as a prognostic factor for the severity of the condition.
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Topic review
Updated time: 13 Dec 2020
Submitted by: Tak-Wah Wong
Definition: Daylight photodynamic therapy (dPDT) uses sunlight as a light source to treat superficial skin cancer. Using sunlight as a therapeutic device has been present for centuries, forming the basis of photodynamic therapy in the 20th century. Compared to conventional PDT, dPDT can be a less painful, more convenient and an effective alternative. The first clinical uses of dPDT on skin cancers began in Copenhagen in 2008. Currently, aminolevulinic acid-mediated dPDT has been approved to treat actinic keratosis patients in Europe.
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Topic review
Updated time: 07 Feb 2021
Submitted by: Tsvetelina Velikova
Definition: Dermatitis herpetiformis (DH) is a blistering dermatosis, which shares common immunologic features with celiac disease (CD).
Entry Collection : Gastrointestinal Disease
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Topic review
Updated time: 26 Oct 2020
Submitted by: Isabel Andia
Definition: Skin is a large and complex organ that serves protective and regulatory functions and is responsible for communication between the external environment and the inner organism. To fulfill these functions, skin has evolved as an organ with a complex anatomy derived from both the ectoderm (epidermis) and mesoderm (dermis). The skin includes not only these two major compartments but also important appendages, including hair follicles, sweat and sebaceous glands, nerve endings, and blood vessels, all of which have intricate spatial arrangements that render fabrication of the full skin organ challenging.
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Topic review
Updated time: 27 Apr 2021
Submitted by: Miriana d'Alessandro
Definition: The house dust mite (HDM) is globally ubiquitous in human habitats. The present entry summarizes information about the role of Der p 1 as key coordinator of the HDM-induced allergic response and reports a series of Italian patients allergic to HDM. Our study offers insights into the role of Der p groups in a population of patients with allergic rhinitis and asthma who were candidate for ITS. Interestingly, Der p1 positivity was associated with bronchial asthma and co-sensitization.
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Topic review
Updated time: 23 Dec 2020
Submitted by: Chien-Chin Chen
Definition: Hydroa vacciniforme (HV) is a rare form of photosensitivity disorder in children or adolescence and is frequently associated with Epstein–Barr virus (EBV) infection, whereas HV-like lymphoproliferative disorders (HVLPD) describe a spectrum of EBV-associated T-cell or natural killer (NK)-cell lymphoproliferations with HV-like cutaneous manifestations, including EBV-positive HV, atypical HV, and HV-like lymphoma.
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