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1 There is moderate attention by researchers to the role of the dog as a vector of the bacteria of the ESKAPE group and to assessing the risk related to the presence of these microorganisms in the dogs involved in Animal-assisted Therapy (AAT), and in Anima
Antonio Santaniello
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Nicole Yin
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Santaniello, A.; Sansone, M.; Fioretti, A.; Menna, L.F. ESKAPE Bacteria in the Dog. Encyclopedia. Available online: https://encyclopedia.pub/entry/861 (accessed on 25 April 2024).
Santaniello A, Sansone M, Fioretti A, Menna LF. ESKAPE Bacteria in the Dog. Encyclopedia. Available at: https://encyclopedia.pub/entry/861. Accessed April 25, 2024.
Santaniello, Antonio, Mario Sansone, Alessandro Fioretti, Lucia Francesca Menna. "ESKAPE Bacteria in the Dog" Encyclopedia, https://encyclopedia.pub/entry/861 (accessed April 25, 2024).
Santaniello, A., Sansone, M., Fioretti, A., & Menna, L.F. (2020, May 18). ESKAPE Bacteria in the Dog. In Encyclopedia. https://encyclopedia.pub/entry/861
Santaniello, Antonio, et al. "ESKAPE Bacteria in the Dog." Encyclopedia. Web. 18 May, 2020.
ESKAPE Bacteria in the Dog
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This entry is adapted from the peer-reviewed paper 10.3390/ijerph17093278

ESKAPE bacteria (i.e., Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are a group of common opportunistic pathogens associated mainly with nosocomial infections.

animal-assisted interventions animal-assisted therapy animal-assisted activity zoonoses dogs one health ESKAPE patients

1. Introduction

The acronym ESKAPE was used for the first time in 2008 by Rice[1] and was coined to reflect these microorganism’s ability to escape killing by antibiotics by developing antimicrobial resistance, and challenge eradication by conventional therapies. The bacteria of the ESKAPE group cause significant morbidity and mortality and increased resource utilization in healthcare facilities[2][3] . Moreover, the World Health Organization (WHO) has recently listed most ESKAPE bacteria in the list of 12 microorganisms against which new antibiotics are urgently needed[4].

2. A Potential Zoonotic Risk in Animal-Assisted Therapies, and In Animal-Assisted Activities in the Health Context 

Animal-assisted interventions (AAIs) are widespread in different contexts worldwide and bring several benefits to users but can also expose them to the risk of infection with potentially zoonotic agents. The dog is the main animal species involved in these interventions, particularly, in animal-assisted therapies and animal-assisted activities implemented in hospitals, rehabilitation centers, and other health facilities. Our work aimed to systematically review (PRISMA) data on the presence of pathogens bacteria ESKAPE in dogs, within the period of 2000 to 2019, focusing on the presence, percentage estimates, type of samples such as swabs and biological samples (i.e., feces, urines), dog category, and geographic distribution of the study (country and continent). The type of sample performed from the dog was highlighted to assess not only the variety of tropism of these bacteria but also to make a prediction of the body regions (of the dog) at risk of contamination and with which the patients/users involved make contact directly or indirectly; in our opinion, it was also noteworthy to consider the category of belonging of the dog (owned and non-owned) since the dogs that are involved in the AAIs, and in particular, in the AAT, are owned dogs.

Enterococcus faecium is a commensal microorganism of the normal gastrointestinal flora in humans and animals. E. faecium can be transmitted to humans via direct contact with livestock as well as companion animals[5]. Recently, the results of some studies highlighted the potential for zoonotic transmission of ampicillin- and vancomycin-resistant E. faecium from the dog[5][6][7][8].

Staphylococcus aureus is part of the cutaneous microbiome of animals and humans and is one of the leading causes of fatal nosocomial infection in humans[9]. It can cause a range of infections, such as mild-to severe skin and soft tissue infections, endocarditis, osteomyelitis, and fatal pneumonia[10]. According to the sensitivity to antibiotic drugs, S. aureus can be divided into methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA). MRSA is one of the most significant bacteria causing both hospital and community-acquired infections in humans[11].

K.pneumoniae is a Gram-negative member of the Enterobacteriaceae, considered one of the common opportunistic agents causing respiratory and urinary tract infections in humans and dogs[12][13][14][15][16]. K. pneumoniae strains have a significant ability to acquire resistance to antibiotics, and as such, it is of a public health concern[17]. Marques et al.[18] reported the fecal colonization and sharing of K. pneumoniae clonal lineages between healthy humans and dogs living in close contact, suggesting the role of dogs as reservoirs of this bacterium.

A. baumannii is the most clinically significant pathogen implicated in human nosocomial infections[18]. In humans, baumannii infections involve mainly the respiratory tract, but meningitis and urinary tract infections may also occur[19][20][21]. Animals represent a potential reservoir of A. baumannii, and the risk of transmission could increase in companion animals which are in direct contact or closer vicinity to humans[22].

P.aeruginosa is increasingly recognized as an opportunistic pathogen causing chronic and recurrent infections in both humans and animals[23]. In humans, it causes nosocomial and healthcare-associated infections in immunocompromised patients[24][25]. Fernandes et al. [26] demonstrated a zoo-anthroponotic transmission (human–to-dog) of VIM-2–producing P. aeruginosa in the household following a person’s hospital discharge.

Enterobacter spp., particularly E. aerogenes and E. cloacae, have been associated with nosocomial foci and are considered opportunistic pathogens[27]. Enterobacter spp. can cause numerous types of infections, including brain abscess, pneumonia, meningitis, septicemia, urinary tract (especially catheter-related) infections, and intestinal infections[28]. Transmission occurs through direct or indirect contact of the mucosal surfaces with the host organism[29].

Although the numerous investigations carried out both in the medical and veterinary fields on the risk by these nosocomial opportunistic bacteria, the studies concerning the dog involved in AAT and AAA in health context are very limited. The lack of standardized control programs to ESKAPE bacteria in the dogs involved in AAT at the international level and in worldwide introduces a knowledge gap in this field and makes it difficult to estimate related risk level for humans and thoroughly investigate potential transmission dynamics of these pathogens.

References

  1. Louis B. Rice; Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE. The Journal of Infectious Diseases 2008, 197, 1079-1081, 10.1086/533452.
  2. Friedman, N.D.; Temkin, E.; Carmeli, Y. The negative impact of antibiotic resistance. Clin. Microbiol. Infect. 2016, 22, 416.
  3. Founou, R.C.; Founou, L.L.; Essack, S.Y. Clinical and economic impact of antibiotic resistance in developing countries: A systematic review and meta-analysis. PLoS ONE 2017, 12, e0189621.
  4. Evelina Tacconelli; Elena Carrara; Alessia Savoldi; Stephan Harbarth; Marc Mendelson; Dominique L Monnet; Céline Pulcini; Gunnar Kahlmeter; Jan Kluytmans; Yehuda Carmeli; et al.Marc OuelletteKevin OuttersonJean PatelMarco CavaleriEdward M CoxChris R HouchensM Lindsay GraysonPaul HansenNalini SinghUrsula TheuretzbacherNicola MagriniAaron Oladipo AboderinSeif Salem Al-AbriNordiah Awang JalilNur BenzonanaSanjay BhattacharyaAdrian John BrinkFrancesco Robert BurkertOtto CarsGiuseppe CornagliaOliver James DyarAlex W FriedrichAna C GalesSumanth GandraChristian Georg GiskeDebra A GoffHerman GoossensThomas GottliebManuel Guzman BlancoWaleria HryniewiczDeepthi KattulaTimothy JinksSouha S KanjLawrence KerrMarie-Paule KienyYang Soo KimRoman S KozlovJaime LabarcaRamanan LaxminarayanKarin LederLeonard LeiboviciGabriel Levy-HaraJasper LittmanSurbhi Malhotra-KumarVikas ManchandaLorenzo MojaBabacar NdoyeAngelo PanDavid L PatersonMical PaulHaibo QiuPilar Ramon-PardoJesús Rodríguez-BañoMaurizio SanguinettiSharmila SenguptaMike SharlandMassinissa Si-MehandLynn L SilverWonkeung SongMartin SteinbakkJens ThomsenGuy E ThwaitesJos Wm Van Der MeerNguyen Van KinhSilvio VegaMaria Virginia VillegasAgnes Wechsler-FördösHeiman Frank Louis WertheimEvelyn WesangulaNeil WoodfordFidan O YilmazAnna Zorzet Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. The Lancet Infectious Diseases 2018, 18, 318-327, 10.1016/s1473-3099(17)30753-3.
  5. Kiman Bang; Jae-Uk An; Woohyun Kim; Hee-Jin Dong; Junhyung Kim; Seongbeom Cho; Antibiotic resistance patterns and genetic relatedness ofEnterococcus faecalisandEnterococcus faeciumisolated from military working dogs in Korea. Journal of Veterinary Science 2017, 18, 229-236, 10.4142/jvs.2017.18.2.229.
  6. G. Van Den Bunt; J Top; J Hordijk; S C De Greeff; L Mughini-Gras; J Corander; W Van Pelt; M J M Bonten; A C Fluit; Rob J. L. Willems; et al. Intestinal carriage of ampicillin- and vancomycin-resistant Enterococcus faecium in humans, dogs and cats in the Netherlands. Journal of Antimicrobial Chemotherapy 2017, 73, 607-614, 10.1093/jac/dkx455.
  7. Espinosa-Gongora, C.; Shah, S.Q.; Jessen, L.R.; Bortolaia, V.; Langebæk, R.; Bjørnvad, C.R.; Guardabassi, L. Quantitative assessment of faecal shedding of beta-lactam-resistant Escherichia coli and enterococci in dogs. Vet. Microbiol. 2015, 181, 298–302.
  8. Iseppi, R.; Messi, P.; Anacarso, I.; Bondi, M.; Sabia, C.; Condò, C.; deNiederhausern, S. Antimicrobial resistance and virulence traits in Enterococcus strains isolated from dogs and cats. New Microbiol. 2015, 38, 369–378.
  9. Igor Loncaric; Alexander Tichy; Silvia Handler; Michael P. Szostak; Mareike Tickert; Magda Diab-Elschahawi; Joachim Spergser; Frank Künzel; Prevalence of Methicillin-Resistant Staphylococcus sp. (MRS) in Different Companion Animals and Determination of Risk Factors for Colonization with MRS. Antibiotics 2019, 8, 36, 10.3390/antibiotics8020036.
  10. Yunlei Guo; Guanghui Song; Meiling Sun; Juan Wang; Yi Wang; Prevalence and Therapies of Antibiotic-Resistance in Staphylococcus aureus. Frontiers in Cellular and Infection Microbiology 2020, 10, 107, 10.3389/fcimb.2020.00107.
  11. I Ghasemzadeh; Sh Namazi; Review of bacterial and viral zoonotic infections transmitted by dogs. Journal of Medicine and Life 1970, 8, 1-5.
  12. Reyes, J.; Aguilar, A.C.; Caicedo, A. Carbapenem-Resistant Klebsiella pneumoniae: Microbiology Key Points for Clinical Practice. Int. J. Gen. Med. 2019, 12, 437–446.
  13. Liu, Y.; Yang, Y.; Chen, Y.; Xia, Z. Antimicrobial resistance profiles and genotypes of extended-spectrum b-lactamase- and AmpC b-lactamase-producing Klebsiella pneumoniae isolated from dogs in Beijing, China. J. Glob. Antimicrob. Resist. 2017, 10, 219–222.
  14. Geovana Brenner Michael; Heike Kaspar; Amanda K. Siqueira; Eduardo De Freitas Costa; Luís Gustavo Corbellini; Kristina Kadlec; Stefan Schwarz; Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolates collected from diseased food-producing animals in the GERM-Vet monitoring program 2008-2014.. Veterinary Microbiology 2016, 200, 142-150, 10.1016/j.vetmic.2016.08.023.
  15. Cátia Marques; Adriana Belas; Andreia Franco; Catarina Aboim; Luís Telo Gama; Constança Pomba; Increase in antimicrobial resistance and emergence of major international high-risk clonal lineages in dogs and cats with urinary tract infection: 16 year retrospective study. Journal of Antimicrobial Chemotherapy 2017, 73, 377-384, 10.1093/jac/dkx401.
  16. Surveillance of Antimicrobial Resistance in Europe 2018. (ECDC). Available online: https://www.ecdc.europa.eu/sites/default/files/documents/surveillance-antimicrobial-resistance-Europe-2018.pdf
  17. Clement Yaw Effah; Tongwen Sun; Shaohua Liu; Yongjun Wu; Klebsiella pneumoniae: an increasing threat to public health.. Annals of Clinical Microbiology and Antimicrobials 2020, 19, 1-9, 10.1186/s12941-019-0343-8.
  18. Nina M. Clark; George G. Zhanel; Joseph P. Lynch; Emergence of antimicrobial resistance among Acinetobacter species. Current Opinion in Critical Care 2016, 22, 491-499, 10.1097/mcc.0000000000000337.
  19. Gerald L. Murray; Anton Y. Peleg; Yohei Doi; Acinetobacter baumannii: Evolution of Antimicrobial Resistance—Treatment Options. Seminars in Respiratory and Critical Care Medicine 2015, 36, 085-098, 10.1055/s-0034-1398388.
  20. Anton Y. Peleg; Harald Seifert; David L. Paterson; Acinetobacter baumannii: Emergence of a Successful Pathogen. Clinical Microbiology Reviews 2008, 21, 538-582, 10.1128/cmr.00058-07.
  21. Qiang Chen; Hua Cao; Heng Lu; Zhihuang Qiu; Jia-Jun He; Bioprosthetic tricuspid valve endocarditis caused by Acinetobacter baumannii complex, a case report and brief review of the literature.. Journal of Cardiothoracic Surgery 2015, 10, 149, 10.1186/s13019-015-0377-8.
  22. J. H. (Han) Van Der Kolk; Andrea Endimiani; Claudia Nicole Graubner; Vincent Gerber; Vincent Perreten; Acinetobacter in veterinary medicine, with an emphasis on Acinetobacter baumannii.. Journal of Global Antimicrobial Resistance 2018, 16, 59-71, 10.1016/j.jgar.2018.08.011.
  23. J. L. Hall; M. A. Holmes; S. J. Baines; Prevalence and antimicrobial resistance of canine urinary tract pathogens. Veterinary Record 2013, 173, 549-549, 10.1136/vr.101482.
  24. Raman, G.; Avendano, E.E.; Chan, J.; Merchant, S.; Puzniak, L. Risk factors for hospitalized patients with resistant or multidrug-resistant Pseudomonas aeruginosa infections: A systematic review and meta-analysis. Antimicr. Resist. Infect. Control 2018, 7, 79.
  25. Lin, D.; Foley, S.L.; Qi, Y.; Han, J.; Ji, C.; Li, R.;Wu, C.; Shen, J.;Wang, Y. Characterization of antimicrobial resistance of Pseudomonas aeruginosa isolated from canine infections. J. App. Microbiol. 2012, 113, 16–23.
  26. Miriam R. Fernandes; Fábio P. Sellera; Quézia Moura; Marcelo P.N. Carvalho; Paula N. Rosato; Louise Cerdeira; Nilton Lincopan; Zooanthroponotic Transmission of Drug-Resistant Pseudomonas aeruginosa, Brazil. Emerging Infectious Diseases 2018, 24, 1160-1162, 10.3201/eid2406.180335.
  27. Anne Davin-Regli; Jean-Marie Pagã¨s; Enterobacter aerogenes and Enterobacter cloacae; versatile bacterial pathogens confronting antibiotic treatment. Frontiers in Microbiology 2015, 6, 392, 10.3389/fmicb.2015.00392.
  28. Hanna Sidjabat; Nancy D. Hanson; Ellen Smith-Moland; Jan M. Bell; J.S. Gibson; Lucio J. Filippich; Darren J. Trott; Identification of plasmid-mediated extended-spectrum and AmpC β-lactamases in Enterobacter spp. isolated from dogs. Journal of Medical Microbiology 2007, 56, 426-434, 10.1099/jmm.0.46888-0.
  29. Karen Smith; Iain S. Hunter; Efficacy of common hospital biocides with biofilms of multi-drug resistant clinical isolates. Journal of Medical Microbiology 2008, 57, 966-973, 10.1099/jmm.0.47668-0.
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Subjects: Microbiology; Others
Contributors MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
Antonio Santaniello
,
Mario Sansone
,
Alessandro Fioretti
,
Lucia Francesca Menna
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Revisions: 2 times (View History)
Update Date: 30 Oct 2020
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