Isolated Hyperchlorhidrosis

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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/isolated-hyperchlorhidrosis

Isolated hyperchlorhidrosis is characterized by the excessive loss of salt (sodium chloride or NaCl) in sweat.

genetic conditions

1. Introduction

In particular, "hyperchlorhidrosis" refers to the high levels of chloride found in sweat, although both sodium and chloride are released. Because the salt is abnormally released from the body in sweat, there are lower than normal levels of sodium in fluids inside the body (hyponatremia). Most infants with isolated hyperchlorhidrosis experience one or more episodes of dehydration with low levels of sodium in the blood (hyponatremic dehydration), which can require hospitalization. These episodes typically follow a mild illness that causes vomiting or diarrhea. Affected infants also have poor feeding and an inability to grow and gain weight at the expected rate (failure to thrive). By early childhood, though, weight and height usually catch up to normal, although the abnormal loss of salt still remains. These individuals may still experience dangerous hyponatremia when they sweat excessively, for example in warm temperatures or when exercising.

While hyperchlorhidrosis can occur as one of several features of other conditions, such as cystic fibrosis, people with isolated hyperchlorhidrosis do not have the additional signs and symptoms of these other conditions.

2. Frequency

Isolated hyperchlorhidrosis is a rare condition, although its prevalence is unknown. The condition has been found mostly in the Bedouin population of southern Israel.

3. Causes

Isolated hyperchlorhidrosis is caused by a mutation in the CA12 gene. This gene provides instructions for making a protein called carbonic anhydrase 12 (CA 12), which belongs to a family of related proteins known as carbonic anhydrases. These proteins carry out a chemical reaction that involves the molecules carbon dioxide and water and produces a negatively charged bicarbonate molecule (bicarbonate ion) and a positively charged hydrogen atom (known as a proton). The presence of protons and bicarbonate affect the relative acidity (pH) of cells, which is important for several cellular processes, including the transport of salt into and out of cells. Researchers suggest that by regulating cellular pH in the sweat glands, CA 12 is able to control the amount of salt released in sweat.

The CA12 gene mutation involved in isolated hyperchlorhidrosis leads to reduction of CA 12 protein function. Researchers speculate that the altered CA 12 is less able to regulate pH, and it loses its ability to control how much salt is released in sweat, leading to hyperchlorhidrosis.

4. Inheritance

This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.

5. Other Names for This Condition

carbonic anhydrase XII deficiency

References

Chiche J, Ilc K, Laferrière J, Trottier E, Dayan F, Mazure NM, Brahimi-HornMC, Pouysségur J. Hypoxia-inducible carbonic anhydrase IX and XII promote tumorcell growth by counteracting acidosis through the regulation of the intracellularpH. Cancer Res. 2009 Jan 1;69(1):358-68. doi: 10.1158/0008-5472.CAN-08-2470.
Feinstein Y, Yerushalmi B, Loewenthal N, Alkrinawi S, Birk OS, Parvari R,Hershkovitz E. Natural history and clinical manifestations of hyponatremia andhyperchlorhidrosis due to carbonic anhydrase XII deficiency. Horm Res Paediatr.2014;81(5):336-42. doi: 10.1159/000358327.
Feldshtein M, Elkrinawi S, Yerushalmi B, Marcus B, Vullo D, Romi H, Ofir R,Landau D, Sivan S, Supuran CT, Birk OS. Hyperchlorhidrosis caused by homozygousmutation in CA12, encoding carbonic anhydrase XII. Am J Hum Genet. 2010 Nov12;87(5):713-20. doi: 10.1016/j.ajhg.2010.10.008.
Muhammad E, Leventhal N, Parvari G, Hanukoglu A, Hanukoglu I, Chalifa-Caspi V,Feinstein Y, Weinbrand J, Jacoby H, Manor E, Nagar T, Beck JC, Sheffield VC,Hershkovitz E, Parvari R. Autosomal recessive hyponatremia due to isolated saltwasting in sweat associated with a mutation in the active site of CarbonicAnhydrase 12. Hum Genet. 2011 Apr;129(4):397-405. doi: 10.1007/s00439-010-0930-4.

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Subjects: Genetics & Heredity

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Camila Xu

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Entry Collection: MedlinePlus

Update Date: 23 Dec 2020

Table of Contents

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1. Introduction

2. Frequency

3. Causes

4. Inheritance

5. Other Names for This Condition

References

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1. Introduction

2. Frequency

3. Causes

3.1. The gene associated with Isolated hyperchlorhidrosis

4. Inheritance

5. Other Names for This Condition

References