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Xu, R. Peters Plus Syndrome. Encyclopedia. Available online: https://encyclopedia.pub/entry/5311 (accessed on 28 March 2024).
Xu R. Peters Plus Syndrome. Encyclopedia. Available at: https://encyclopedia.pub/entry/5311. Accessed March 28, 2024.
Xu, Rita. "Peters Plus Syndrome" Encyclopedia, https://encyclopedia.pub/entry/5311 (accessed March 28, 2024).
Xu, R. (2020, December 24). Peters Plus Syndrome. In Encyclopedia. https://encyclopedia.pub/entry/5311
Xu, Rita. "Peters Plus Syndrome." Encyclopedia. Web. 24 December, 2020.
Peters Plus Syndrome
Edit

Peters plus syndrome is an inherited condition that is characterized by eye abnormalities, short stature, an opening in the lip (cleft lip) with or without an opening in the roof of the mouth (cleft palate), distinctive facial features, and intellectual disability.

genetic conditions

1. Introduction

The eye problems in Peters plus syndrome occur in an area at the front part of the eye known as the anterior segment. The anterior segment consists of structures including the lens, the colored part of the eye (iris), and the clear covering of the eye (cornea). An eye problem called Peters anomaly is the most common anterior segment abnormality seen in Peters plus syndrome. Peters anomaly involves abnormal development of the anterior segment, which results in a cornea that is cloudy (opaque) and causes blurred vision. Peters anomaly may also be associated with clouding of the lenses of the eyes (cataracts) or other lens abnormalities. Peters anomaly is usually bilateral, which means that it affects both eyes. The severity of corneal clouding and other eye problems can vary between individuals with Peters plus syndrome, even among members of the same family. Many people with Peters plus syndrome experience vision loss that worsens over time.

All people with Peters plus syndrome have short stature, which is evident before birth. The height of adult males with this condition ranges from 141 centimeters to 155 centimeters (4 feet, 7 inches to 5 feet, 1 inch), and the height of adult females ranges from 128 centimeters to 151 centimeters (4 feet, 2 inches to 4 feet, 11 inches). Individuals with Peters plus syndrome also have shortened upper limbs (rhizomelia) and shortened fingers and toes (brachydactyly).

The characteristic facial features of Peters plus syndrome include a prominent forehead; small, malformed ears; narrow eyes; a long area between the nose and mouth (philtrum); and a pronounced double curve of the upper lip (Cupid's bow). The neck may also be broad and webbed. A cleft lip with or without a cleft palate is present in about half of the people with this condition.

Developmental milestones, such as walking and speech, are delayed in most children with Peters plus syndrome. Most affected individuals also have intellectual disability that can range from mild to severe, although some have normal intelligence. The severity of physical features does not predict the level of intellectual disability.

Less common signs and symptoms of Peters plus syndrome include heart defects, structural brain abnormalities, hearing loss, and kidney or genital abnormalities.

2. Frequency

Peters plus syndrome is a rare disorder; its incidence is unknown. Fewer than 80 people with this condition have been reported worldwide.

3. Causes

Mutations in the B3GLCT gene cause Peters plus syndrome. The B3GLCT gene provides instructions for making an enzyme called beta 3-glucosyltransferase (B3Glc-T), which is involved in the complex process of adding sugar molecules to proteins (glycosylation). Glycosylation modifies proteins so they can perform a wider variety of functions. Most mutations in the B3GLCT gene lead to the production of an abnormally short, nonfunctional version of the B3Glc-T enzyme, which disrupts glycosylation. It is unclear how the loss of functional B3Glc-T enzyme leads to the signs and symptoms of Peters plus syndrome, but impaired glycosylation likely disrupts the function of many proteins, which may contribute to the variety of features.

4. Inheritance

This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.

5. Other Names for This Condition

  • Krause-Kivlin syndrome
  • Krause-van Schooneveld-Kivlin syndrome
  • Peters anomaly-short limb dwarfism syndrome
  • Peters' plus syndrome
  • Peters'-plus syndrome

References

  1. Hess D, Keusch JJ, Oberstein SA, Hennekam RC, Hofsteenge J. Peters Plussyndrome is a new congenital disorder of glycosylation and involves defectiveOmicron-glycosylation of thrombospondin type 1 repeats. J Biol Chem. 2008 Mar21;283(12):7354-60. doi: 10.1074/jbc.M710251200.
  2. Lesnik Oberstein SA, Kriek M, White SJ, Kalf ME, Szuhai K, den Dunnen JT,Breuning MH, Hennekam RC. Peters Plus syndrome is caused by mutations in B3GALTL,a putative glycosyltransferase. Am J Hum Genet. 2006 Sep;79(3):562-6.
  3. Lesnik Oberstein SAJ, Ruivenkamp CAL, Hennekam RC. Peters Plus Syndrome. 2007 Oct 8 [updated 2017 Aug 24]. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, BeanLJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA):University of Washington, Seattle; 1993-2020. Available fromhttp://www.ncbi.nlm.nih.gov/books/NBK1464/
  4. Maillette de Buy Wenniger-Prick LJ, Hennekam RC. The Peters' plus syndrome: a review. Ann Genet. 2002 Apr-Jun;45(2):97-103. Review.
  5. Reis LM, Tyler RC, Abdul-Rahman O, Trapane P, Wallerstein R, Broome D, HoffmanJ, Khan A, Paradiso C, Ron N, Bergner A, Semina EV. Mutation analysis of B3GALTL in Peters Plus syndrome. Am J Med Genet A. 2008 Oct 15;146A(20):2603-10. doi:10.1002/ajmg.a.32498.
  6. Schoner K, Kohlhase J, Müller AM, Schramm T, Plassmann M, Schmitz R, Neesen J,Wieacker P, Rehder H. Hydrocephalus, agenesis of the corpus callosum, and cleftlip/palate represent frequent associations in fetuses with Peters' plus syndrome and B3GALTL mutations. Fetal PPS phenotypes, expanded by Dandy Walker cyst andencephalocele. Prenat Diagn. 2013 Jan;33(1):75-80. doi: 10.1002/pd.4012.
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