Encyclopedia
1000/1000
Hot
Most Recent
Submitted Successfully!
To reward your contribution, here is a gift for you: A free trial for our video production service.
+1 point
Thank you for your contribution! You can also upload a video entry or images related to this topic.
Video Upload Options
Do you have a full video?
Confirm
Are you sure to Delete?
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Li, V. ERAP1 Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/5380 (accessed on 23 April 2024).
Li V. ERAP1 Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/5380. Accessed April 23, 2024.
Li, Vivi. "ERAP1 Gene" Encyclopedia, https://encyclopedia.pub/entry/5380 (accessed April 23, 2024).
Li, V. (2020, December 24). ERAP1 Gene. In Encyclopedia. https://encyclopedia.pub/entry/5380
Li, Vivi. "ERAP1 Gene." Encyclopedia. Web. 24 December, 2020.
Copy Citation
Endoplasmic reticulum aminopeptidase 1
genes
1. Normal Function
The ERAP1 gene (also known as ERAAP and ARTS1) provides instructions for making a protein called endoplasmic reticulum aminopeptidase 1. As its name suggests, this protein is active in a cellular structure called the endoplasmic reticulum, which is involved in protein processing and transport. This protein is an aminopeptidase, which is an enzyme that cuts (cleaves) other proteins into smaller fragments called peptides.
Endoplasmic reticulum aminopeptidase 1 has two major functions, both of which are important for normal immune system function. First, endoplasmic reticulum aminopeptidase 1 cleaves several proteins called cytokine receptors on the surface of cells. Cleaving these receptors reduces their ability to transmit chemical signals into the cell, which affects the process of inflammation.
Second, endoplasmic reticulum aminopeptidase 1 cleaves many types of proteins into small peptides that can be recognized by the immune system. These peptides are exported to the cell surface, where they attach to major histocompatibility complex (MHC) class I proteins. MHC class I proteins display the peptides to the immune system. If the immune system recognizes the peptides as foreign (such as viral or bacterial peptides), it responds by triggering the infected cell to self-destruct.
2. Health Conditions Related to Genetic Changes
2.1 Ankylosing Spondylitis
Several variations (polymorphisms) in the ERAP1 gene have been found to influence the risk of ankylosing spondylitis. Each of these variations changes a single protein building block (amino acid) in endoplasmic reticulum aminopeptidase 1. Little is known about the effects of these variations, although researchers believe that changes in the protein's structure could alter either of its two major functions. It is unclear how these changes contribute to a person's risk of ankylosing spondylitis. Other genetic and environmental factors, many of which are unknown, also affect the chance of developing this condition.
3. Other Names for This Gene
-
A-LAP
-
adipocyte-derived leucine aminopeptidase
-
ALAP
-
aminopeptidase PILS
-
aminopeptidase regulator of TNFR1 shedding
-
APPILS
-
ARTS-1
-
ARTS1
-
ERAAP
-
ERAAP1
-
ERAP1_HUMAN
-
KIAA0525
-
PILS-AP
-
PILSAP
-
puromycin-insensitive leucyl-specific aminopeptidase
-
type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
References
- Brionez TF, Reveille JD. The contribution of genes outside the majorhistocompatibility complex to susceptibility to ankylosing spondylitis. Curr OpinRheumatol. 2008 Jul;20(4):384-91. doi: 10.1097/BOR.0b013e32830460fe. Review.
- Brown MA. Breakthroughs in genetic studies of ankylosing spondylitis.Rheumatology (Oxford). 2008 Feb;47(2):132-7.
- Chang SC, Momburg F, Bhutani N, Goldberg AL. The ER aminopeptidase, ERAP1,trims precursors to lengths of MHC class I peptides by a "molecular ruler"mechanism. Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17107-12.
- Hammer GE, Gonzalez F, Champsaur M, Cado D, Shastri N. The aminopeptidaseERAAP shapes the peptide repertoire displayed by major histocompatibility complexclass I molecules. Nat Immunol. 2006 Jan;7(1):103-12.
- Saric T, Chang SC, Hattori A, York IA, Markant S, Rock KL, Tsujimoto M,Goldberg AL. An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trimsprecursors to MHC class I-presented peptides. Nat Immunol. 2002Dec;3(12):1169-76.
- Wellcome Trust Case Control Consortium; Australo-Anglo-American SpondylitisConsortium (TASC), Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P,Duncanson A, Kwiatkowski DP, McCarthy MI, Ouwehand WH, Samani NJ, Todd JA,Donnelly P, Barrett JC, Davison D, Easton D, Evans DM, Leung HT, Marchini JL,Morris AP, Spencer CC, Tobin MD, Attwood AP, Boorman JP, Cant B, Everson U,Hussey JM, Jolley JD, Knight AS, Koch K, Meech E, Nutland S, Prowse CV, StevensHE, Taylor NC, Walters GR, Walker NM, Watkins NA, Winzer T, Jones RW, McArdle WL,Ring SM, Strachan DP, Pembrey M, Breen G, St Clair D, Caesar S, Gordon-Smith K,Jones L, Fraser C, Green EK, Grozeva D, Hamshere ML, Holmans PA, Jones IR, Kirov G, Moskivina V, Nikolov I, O'Donovan MC, Owen MJ, Collier DA, Elkin A, Farmer A, Williamson R, McGuffin P, Young AH, Ferrier IN, Ball SG, Balmforth AJ, BarrettJH, Bishop TD, Iles MM, Maqbool A, Yuldasheva N, Hall AS, Braund PS, Dixon RJ,Mangino M, Stevens S, Thompson JR, Bredin F, Tremelling M, Parkes M, Drummond H, Lees CW, Nimmo ER, Satsangi J, Fisher SA, Forbes A, Lewis CM, Onnie CM, Prescott NJ, Sanderson J, Matthew CG, Barbour J, Mohiuddin MK, Todhunter CE, Mansfield JC,Ahmad T, Cummings FR, Jewell DP, Webster J, Brown MJ, Lathrop MG, Connell J,Dominiczak A, Marcano CA, Burke B, Dobson R, Gungadoo J, Lee KL, Munroe PB,Newhouse SJ, Onipinla A, Wallace C, Xue M, Caulfield M, Farrall M, Barton A;Biologics in RA Genetics and Genomics Study Syndicate (BRAGGS) SteeringCommittee, Bruce IN, Donovan H, Eyre S, Gilbert PD, Hilder SL, Hinks AM, John SL,Potter C, Silman AJ, Symmons DP, Thomson W, Worthington J, Dunger DB, Widmer B,Frayling TM, Freathy RM, Lango H, Perry JR, Shields BM, Weedon MN, Hattersley AT,Hitman GA, Walker M, Elliott KS, Groves CJ, Lindgren CM, Rayner NW, Timpson NJ,Zeggini E, Newport M, Sirugo G, Lyons E, Vannberg F, Hill AV, Bradbury LA, FarrarC, Pointon JJ, Wordsworth P, Brown MA, Franklyn JA, Heward JM, Simmonds MJ, GoughSC, Seal S; Breast Cancer Susceptibility Collaboration (UK), Stratton MR, Rahman N, Ban M, Goris A, Sawcer SJ, Compston A, Conway D, Jallow M, Newport M, SirugoG, Rockett KA, Bumpstead SJ, Chaney A, Downes K, Ghori MJ, Gwilliam R, Hunt SE,Inouye M, Keniry A, King E, McGinnis R, Potter S, Ravindrarajah R, Whittaker P,Widden C, Withers D, Cardin NJ, Davison D, Ferreira T, Pereira-Gale J,Hallgrimsdo'ttir IB, Howie BN, Su Z, Teo YY, Vukcevic D, Bentley D, Brown MA,Compston A, Farrall M, Hall AS, Hattersley AT, Hill AV, Parkes M, Pembrey M,Stratton MR, Mitchell SL, Newby PR, Brand OJ, Carr-Smith J, Pearce SH, McGinnisR, Keniry A, Deloukas P, Reveille JD, Zhou X, Sims AM, Dowling A, Taylor J, Doan T, Davis JC, Savage L, Ward MM, Learch TL, Weisman MH, Brown M. Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants.Nat Genet. 2007 Nov;39(11):1329-37.
- York IA, Brehm MA, Zendzian S, Towne CF, Rock KL. Endoplasmic reticulumaminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and playsan important role in immunodominance. Proc Natl Acad Sci U S A. 2006 Jun13;103(24):9202-7.
- York IA, Chang SC, Saric T, Keys JA, Favreau JM, Goldberg AL, Rock KL. The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopesto 8-9 residues. Nat Immunol. 2002 Dec;3(12):1177-84.
More
Information
Subjects:
Genetics & Heredity
Contributor
MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register
:
View Times:
398
Entry Collection:
MedlinePlus
Update Date:
29 Dec 2020
Table of Contents
